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TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA

Identifier: R-HSA-71241
Species: Homo sapiens
Compartment: mitochondrial matrix
Trimethyllysine dioxygenase (TMLHE) dimer in the mitochondrial matrix catalyzes the reaction of oxygen, 2-oxoglutarate (2OG), and N6,N6,N6-trimethyl-L-lysine (TMLYS) to form CO2, 3-hydroxy-N6,N6,N6-trimethyl-L-lysine (HTMLYS), and succinate (SUCCA) (Monfregola et al. 2005; Vaz et al. 2001).
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