Search results for TNPO1

Showing 12 results out of 12

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Protein (2 results from a total of 2)

Identifier: R-HSA-180743
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TNPO1: Q92973
Identifier: R-HSA-5624896
Species: Homo sapiens
Compartment: cilium
Primary external reference: UniProt: TNPO1: Q92973

Interactor (1 results from a total of 1)

Identifier: Q92973-2
Species: Homo sapiens
Primary external reference: UniProt: Q92973-2

Reaction (5 results from a total of 5)

Identifier: R-HSA-5624951
Species: Homo sapiens
Compartment: cytosol
KIF17 is an alternate kinesin-2 motor that is required in some cell types for anterograde IFT and for the ciliary localization of CNG (Ou et al, 2005; Jenkins et al, 2006; Insinna et al, 2008; Insinna et al, 2009; Li et al, 2010; reviewed in Scholey, 2008; Verhey et al, 2011). KIF17 contains a C-terminal ciliary localization signal that mediates its interaction with nuclear import factor TNPO1 (importin beta-2). This interaction is required for the ciliary targeting of KIF17 and is regulated by RAN GTP levels such that the interaction is promoted in the cytosol where RAN:GTP levels are low, and is destabilized in the cilium where RAN:GTP levels are high (Dishinger et al, 2010). The roles of TNPO1 and the RAN:GTP gradient in promoting ciliary localization of KIF17 are analogous to their roles in nuclear import and provide evidence for the first time of conserved mechanisms governing nuclear and ciliary localization (Dishinger et al, 2010; Devos et al, 2004; Gruss, 2010).
Identifier: R-HSA-9615945
Species: Homo sapiens
Compartment: cytosol
Based on studies with recombinant human proteins and Xenopus egg extracts, RAN:GTP binds to transportin (TNPO1) or importin beta (KPNB1) associated with the Nup107-160 complex (Lau et al. 2009), resulting in release of the latter.
Identifier: R-HSA-5624948
Species: Homo sapiens
Compartment: cilium
Ciliary localization of the alternative kinesin-2 motor KIF17 depends on TNPO1 and the RAN:GDP/RAN:GTP gradient. Once in the cilium, the TNPO1:KIF17 complex is likely dissociated by RAN:GTP binding and subsequent GTP hydrolysis, freeing KIF17 to play its role in anterograde IFT transport (Dishinger et al, 2010).
Identifier: R-NUL-9616174
Species: Homo sapiens, Xenopus laevis
Compartment: cytosol
Recombinant human RAN:GTP binds to recombinant human transportin (TNPO1) associated with the Xenopus Nup107-160 complex and displaces Nup107-160 (Lau et al. 2009).
Identifier: R-NUL-9615968
Species: Homo sapiens, Xenopus laevis
Compartment: cytosol
In the absence of Ran:GTP, recombinant human transportin-1 (TNPO1) binds to the Nup107-160 complex in Xenopus egg extracts-based model of nuclear envelope reassembly (Lau et al. 2009).

Set (1 results from a total of 1)

Identifier: R-HSA-9615955
Species: Homo sapiens
Compartment: cytosol

Complex (3 results from a total of 3)

Identifier: R-HSA-9615960
Species: Homo sapiens
Compartment: cytosol
Identifier: R-NUL-9616163
Species: Xenopus laevis, Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9615954
Species: Homo sapiens
Compartment: cytosol
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