Search results for TRAF6

Showing 23 results out of 286

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Protein (4 results from a total of 10)

Identifier: R-HSA-166366
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TRAF6: Q9Y4K3
Identifier: R-HSA-936955
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: TRAF6: Q9Y4K3
Identifier: R-HSA-450272
Species: Homo sapiens
Compartment: endosome membrane
Primary external reference: UniProt: TRAF6: Q9Y4K3
Identifier: R-HSA-2685681
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TRAF6: Q9Y4K3

Reaction (4 results from a total of 142)

Identifier: R-HSA-5607751
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The MALT1 oligomers bound to TRAF6 induce TRAF6 oligomerization and activate TRAF6 E3 ubiquitin ligase activity (Sun et al. 2004).
Identifier: R-HSA-2730903
Species: Homo sapiens
Compartment: plasma membrane, cytosol
BCL10-MALT1 oligomers bind to TRAF6 and this in turn promotes the oligomerization of TRAF6 and activates its E3 ligase activity (Sun et al. 2004).
Identifier: R-HSA-209566
Species: Homo sapiens
Compartment: plasma membrane
The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.
Identifier: R-HSA-202453
Species: Homo sapiens
Compartment: cytosol, plasma membrane
TRAF6 possesses ubiquitin ligase activity and undergoes K-63-linked auto-ubiquitination after its oligomerization. In the first step, ubiquitin is activated by an E1 ubiquitin activating enzyme. The activated ubiquitin is transferred to a E2 conjugating enzyme (a heterodimer of proteins Ubc13 and Uev1A) forming the E2-Ub thioester. Finally, in the presence of ubiquitin-protein ligase E3 (TRAF6, a RING-domain E3), ubiquitin is attached to the target protein (TRAF6 on residue Lysine 124) through an isopeptide bond between the C-terminus of ubiquitin and the epsilon-amino group of a lysine residue in the target protein. In contrast to K-48-linked ubiquitination that leads to the proteosomal degradation of the target protein, K-63-linked polyubiquitin chains act as a scaffold to assemble protein kinase complexes and mediate their activation through proteosome-independent mechanisms. This K63 polyubiquitinated TRAF6 activates the TAK1 kinase complex.

Set (4 results from a total of 10)

Identifier: R-HSA-918188
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-975153
Species: Homo sapiens
Compartment: endosome membrane
Identifier: R-HSA-9758606
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Identifier: R-HSA-5689607
Species: Homo sapiens
Compartment: cytosol

Polymer (2 results from a total of 2)

Identifier: R-HSA-2685708
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5607625
Species: Homo sapiens
Compartment: cytosol

Complex (4 results from a total of 98)

Identifier: R-HSA-421373
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-166867
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-202471
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-1248657
Species: Homo sapiens
Compartment: cytosol

Pathway (4 results from a total of 23)

Identifier: R-HSA-933541
Species: Homo sapiens
Compartment: mitochondrial outer membrane
TRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL6 after infection with RNA virus. Activation of NF-kB and IRF7, but not that of IRF3, was significantly impaired during RIG-like helicases (RLHs) signaling in the absence of TRAF6. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7. These results strongly suggest that the TRAF6- and TRAF3-dependent pathways are likely to bifurcate at IPS-1, but to converge later at IRF7 in order to co-operatively induce sufficient production of type I IFNs during RLH signaling.
Identifier: R-HSA-933542
Species: Homo sapiens
Compartment: mitochondrial outer membrane, cytosol
The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs.
Identifier: R-HSA-975110
Species: Homo sapiens
Compartment: cytosol, endosome membrane
In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).

TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.

Identifier: R-HSA-975138
Species: Homo sapiens
Compartment: cytosol, endosome membrane, nucleoplasm
TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
TRAF6 icon
TNF receptor-associated factor 6
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