Search results for TTR

Showing 10 results out of 10

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 2)

TTR

Identifier: R-HSA-6799366
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: TTR: P02766

TTR

Identifier: R-HSA-976883
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P02766

Complex (5 results from a total of 5)

Identifier: R-HSA-2453680
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2453705
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2453850
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2453860
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9628705
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-2404134
Species: Homo sapiens
Compartment: extracellular region
In the bloodstream, circulating retinol binding protein 4 (RBP4, in complex with atROL), binds transthyretin (TTR, a 51 kDa protein) in a 1:1 molar complex (Naylor & Newcomer, 1999). The resultant TTR:RBP4:atROL complex is larger and therefore less susceptible to glomerular filtration, maintaining normal levels of retinoid and RBP4 in the circulation. In TTR-deficient mice, plasma levels of atROL and RBP4 were observed to be 5% of wild type levels, highlighting the importance of TTR binding to RBP4:atROL (Episkopou et al. 1993). TTR is also a transporter for thyroxine in the brain (not shown here) (Herbert et al. 1986).
Identifier: R-HSA-2453876
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
All-trans-retinol (atROL) circulates in the bloodstream in complex with transthyretin (TTR) and retinol- binding protein 4 (RBP4). The receptor Stimulated by retinoic acid gene 6 protein homologue (STRA6) acts as a high-affinity cell-surface receptor for the complex (Berry et al. 2012), removing atROL and transporting it into tissues expressing STRA6, including the eyes (Kawaguchi et al. 2007).

Interactor (1 results from a total of 1)

Identifier: O55245
Primary external reference: UniProt: O55245
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