Search results for TXN

Showing 8 results out of 54

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (4 results from a total of 16)

Identifier: R-HSA-6799367
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: TXNDC5: Q8NBS9
Identifier: R-HSA-6806246
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: TXNDC5: Q8NBS9
Identifier: R-HSA-71875
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: TXNL4A: P83876
Identifier: R-HSA-9617747
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: TXNIP: Q9H3M7

Reaction (4 results from a total of 21)

Identifier: R-HSA-3322995
Species: Homo sapiens
Compartment: mitochondrial matrix
Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.
Identifier: R-HSA-1250272
Species: Homo sapiens
Compartment: cytosol
Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome.

Heme oxygenase (HMOX1), besides its enzymatic activity of the dimeric membrane protein isoform, also occurs as soluble cytosolic protein. It is probably this form that binds to the NACHT domain of NLRP3, suppressing production of epithelial cell-derived cytokines induced by activation of the NLRP3 inflammasome, and protecting airway epithelium in asthma (Lv et al, 2018).
Identifier: R-HSA-1250264
Species: Homo sapiens
Compartment: cytosol
TXNIP interacts with the redox-active domain of thioredoxin (TRX) and is believed to act as an oxidative stress mediator by inhibiting TRX activity or by limiting its bioavailability (Nishiyama et al. 1999, Liyanage et al. 2007).
Identifier: R-HSA-1250253
Species: Homo sapiens
Compartment: cytosol
ROS induce the dissociation of TXNIP from thioredoxin, freeing TXNIP to subsequently bind NLRP3 and bring about activation of the NLRP3 inflammasome (Zhou et al. 2010).
Cite Us!