Search results for TYR

Showing 20 results out of 254

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Types

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Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 23)

TYR

Identifier: R-HSA-5617243
Species: Homo sapiens
Compartment: melanosome membrane
Primary external reference: UniProt: TYR: P14679
Identifier: R-HSA-198087
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: TYROBP: O43914

Chemical Compound (2 results from a total of 6)

TYR

Identifier: R-ALL-5696181
Compartment: extracellular region
Primary external reference: ChEBI: tyramine: 15760

TYR

Identifier: R-ALL-500606
Compartment: cytosol
Primary external reference: ChEBI: tyramine: 15760

DNA Sequence (2 results from a total of 2)

Identifier: R-HSA-9824596
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000077498
Identifier: R-HSA-9824600
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000107165

Reaction (2 results from a total of 131)

Identifier: R-HSA-5696146
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Retina-specific copper amine oxidase (AOC2) is present on the cell surface of most cells but especially retinal cells. It is classed as a semicarbazide-sensitive amine oxidase (SSAO) and catalyses the oxidative deamination of aromatic amines such as tyramine (TYR, shown here), 2-phenylethylamine and tryptamine (Kaitaniemi et al. 2009, Bour et al. 2007). Overexpression of AOC2 could result in tissue destruction seen in ocular pathologies.
Identifier: R-HSA-141202
Species: Homo sapiens
Compartment: cytosol, mitochondrial outer membrane
Monoamine oxidases (MAOA and B), present in the outer mitochondrial membrane, catalyse the oxidation of biogenic amines, releasing hydrogen peroxide (H2O2). H2O2 produced during the oxidative deamination of these amines appears to be involved in the progress of neurodegenerative disorders such as Parkinson disease, presumably via oxidative damage to the mitochondrial membrane. MAOB (also MAOA but not show here), with FAD as cofactor, can deaminate tyramine (TYR), a naturally-occuring monoamine that can act as a catecholamine releasing agent (Pearce & Roth 1985).

Interactor (2 results from a total of 3)

Identifier: P14679-2
Species: Homo sapiens
Primary external reference: UniProt: P14679-2
Identifier: EBI-9998887
Primary external reference: IntAct: EBI-9998887

Genes and Transcripts (2 results from a total of 13)

Identifier: R-HSA-379785
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-379755
Species: Homo sapiens
Compartment: mitochondrial matrix

Complex (2 results from a total of 39)

Identifier: R-HSA-5662696
Species: Homo sapiens
Compartment: melanosome membrane
Identifier: R-HSA-210222
Species: Homo sapiens
Compartment: plasma membrane

Set (2 results from a total of 16)

Identifier: R-HSA-6790218
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-6790181
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (2 results from a total of 16)

Identifier: R-HSA-8963684
Species: Homo sapiens
Cytosolic tyrosine is transaminated to form 3-(4-hydroxyphenyl)pyruvate which in four further reactions is converted to fumarate and acetoacetate. Tyrosine is thus both a glucogenic (fumarate) and a ketogenic (acetoacetate) amino acid. Defects in any of the steps lead to metabolic diseases with accumulation of tyrosine (tyrosinemia) (Mitchell et al. 2001; Held, 2006).
Identifier: R-HSA-8963691
Species: Homo sapiens
The hydroxylation of phenylalanine, an essential amino acid, to form tyrosine is a major source of the latter amino acid in the body under normal conditions and is also the first step in phenylalanine catabolism. To continue the catabolic process, tyrosine is transaminated to 3-(4-hydroxyphenyl)pyruvate which is broken down to fumarate and acetoacetate (Blau et al. 2001; Mitchell et al. 2001).

RNA Sequence (2 results from a total of 2)

Identifier: R-HSA-6793016
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: ENSEMBL: ENSEMBL:ENST00000387409
Identifier: R-HSA-6793005
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: ENSEMBL: ENSEMBL:ENST00000387409
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