Search results for TYSND1

Showing 14 results out of 15

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Protein (4 results from a total of 4)

Identifier: R-HSA-9033586
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: TYSND1: Q2T9J0
Identifier: R-HSA-8933309
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: TYSND1: Q2T9J0
Identifier: R-HSA-9033587
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: TYSND1: Q2T9J0
Identifier: R-HSA-9033589
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: TYSND1: Q2T9J0

Reaction (7 results from a total of 8)

Identifier: R-HSA-9033520
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves TYSND1 between amino acid residues 110 and 111, yielding TYSND1(1-110) and TYSND1(111-566) (Okumoto et al. 2011). Self-cleavage of TYSND1 reduces its proteolytic activity.
Identifier: R-HSA-9033529
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves ACAA1 between amino acid residues 26 and 27, yielding ACAA1(1-26) and ACAA1(27-424) (Okumoto et al. 2011). In mice, knockout of Tysnd1 causes reduced localization of Acaa1 to the peroxisome.
Identifier: R-HSA-9033515
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves ACOX1 between amino acid residues 438 and 439, yielding ACOX1(1-438) and ACOX1(439-660) (Okumoto et al. 2011, also inferred from mouse and rat homologs).
Identifier: R-HSA-9033524
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves SCP2 (also known as SCPX) between amino acid residues 424 and 425, yielding SCP2(1-424) and SCP2(425-547) (Okumoto et al. 2011, also inferred from mouse homologs).
Identifier: R-HSA-9033530
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.
Identifier: R-HSA-9033490
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves PHYH between amino acid residues 30 and 31, yielding PHYH(1-30) and PHYH(31-338). In mice, knockout of Tysnd1 causes reduced localization of Phyh to peroxisomes.
Identifier: R-HSA-9033506
Species: Homo sapiens
Compartment: peroxisomal matrix
The trypsin-like serine-type endopeptidase TYSND1 cleaves AGPS between amino acid residues 58 and 59, yielding AGPS(1-58) and AGPS(59-658) (inferred from mouse homologs). In mice, knockout of TYSND1 causes reduced localization of AGPS to the peroxisome.

Pathway (1 results from a total of 1)

Identifier: R-HSA-9033500
Species: Homo sapiens
Compartment: peroxisomal matrix
After proteins are imported into the peroxisome a subset of proteins are cleaved by the protease TYSND1 (Okumoto et al. 2011). Based onmutagenesis of human TYSND1 (Okumoto et al. 2011) and the homolog in Arabidopsis (Schuhmann et al. 2008), TYSND1 appears to be a trypsin-like serine protease containing a conserved histidine aspartate serine triad essential for catalysis. Mice lacking Tysnd1 have reduced peroxisomal localization of some peroxisomal enzymes and exhibit reduced beta-oxidation of fatty acids and metabolism of phytanic acid (Mizuno et al. 2013). Male mice lacking Tysnd1 are sterile due to sperm that lack acrosomal caps.

Set (2 results from a total of 2)

Identifier: R-HSA-9033148
Species: Homo sapiens
Compartment: peroxisomal matrix, peroxisomal membrane
Identifier: R-HSA-9033111
Species: Homo sapiens
Compartment: cytosol
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