Search results for UGT1A10

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Protein (1 results from a total of 1)

Identifier: R-HSA-8933307
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: UGT1A10: Q9HAW8

Reaction (2 results from a total of 2)

Identifier: R-HSA-8941701
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Isoflavones are a class of dietary polyphenols called phytoestrogens which are found in soy and soy foods, alfalfa sprouts and red clover. They possess biological activities ranging from anticancer to cardiovascular protective effects (Zhou et al. 2016). Despite their health claims, making these compounds into chemo-preventive or chemo-therapeutic agents is complicated by their low bioavailabilities (<5%), the result of extensive first-pass metabolism by phase II enzymes including UGTs and SULTs (Hu 2007). Four UDP-glucuronosyltransferase 1A (UGT1A) isoforms share the responsibility of metabolising various isoflavones. UGT1A10 is mainly expressed in the intestine and is located on the ER membrane of these cells. It can transfer the glucuronyl moiety from UDP-GlcA to the isoflavone glycitein (GCTN) to form glycitein 4-O-glucuronide (GCTN4OG) (Tang et al. 2009).
Identifier: R-HSA-158546
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The liver, and to a lesser extent the kidney and intestine, are the major organs implicated in the elimination of acetaminophen (APAP, aka paracetamol) (McGill & Jaeschke 2013). Glucuronidation is the main route of APAP elimination, accounting for 45-55% of APAP metabolism, and is mediated by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut (Mutlib et al. 2006, Court et al. 2001, Navarro et al. 2011). Glucuronidation renders APAP more water-soluble, facilitating its elimination from the body.
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