Search results for UGT1A9

Showing 5 results out of 5

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Species

Types

Compartments

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Protein (1 results from a total of 1)

UGT1A9

Identifier: R-HSA-400210
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: UGT1A9: O60656

Interactor (1 results from a total of 1)

UGT1A9

Identifier: O60656-1
Species: Homo sapiens
Primary external reference: UniProt: O60656-1

DNA Sequence (1 results from a total of 1)

UGT1A9 gene

Identifier: R-HSA-5649935
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000241119

Reaction (2 results from a total of 2)

Expression of UGT1A9

Identifier: R-HSA-1989758
Species: Homo sapiens
Compartment: nucleoplasm, endoplasmic reticulum membrane
The UGT1A9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UGTs glucuronate APAP to APAP-GlcA

Identifier: R-HSA-158546
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The liver, and to a lesser extent the kidney and intestine, are the major organs implicated in the elimination of acetaminophen (APAP, aka paracetamol) (McGill & Jaeschke 2013). Glucuronidation is the main route of APAP elimination, accounting for 45-55% of APAP metabolism, and is mediated by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut (Mutlib et al. 2006, Court et al. 2001, Navarro et al. 2011). Glucuronidation renders APAP more water-soluble, facilitating its elimination from the body.
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