Search results for USP33

Showing 10 results out of 10

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Species

Types

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Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-5696962
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: USP33: Q8TEY7

Reaction (3 results from a total of 3)

Identifier: R-HSA-8986083
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The ubiquitin protease USP33 deubiquitinates ROBO1, thus stabilizing it and increasing the concentration of ROBO1 at the plasma membrane (Yuasa-Kawada et al. 2009, Huang et al. 2015). USP33 is frequently downregulated in colorectal cancer, which is associated with lymph node metastasis and poor survival (Huang et al. 2015). USP33 is required for SLIT-ROBO1-mediated inhibition of breast cancer cell migration (Yuasa-Kawada et al. 2009). Ubiquitin ligases that ubiquitinate ROBO1 are not known.
Identifier: R-HSA-5696945
Species: Homo sapiens
Compartment: cytosol
USP33 regulates centrosome duplication by mediating deubiquitination and stabilization of CCP110 in S and G2/M phase (Li et al. 2013) and regulates G-protein coupled receptor (GPCR) signaling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) (Shenoy et al. 2009).
Identifier: R-HSA-5696968
Species: Homo sapiens
Compartment: cytosol, endosome membrane
USP20 and USP33 act as a regulators of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of the beta-2 adrenergic receptor (ADRB2), prolonging agonist stimulation and inhibiting lysosomal trafficking (Berthouze et al. 2009).

Set (1 results from a total of 1)

Identifier: R-HSA-5696950
Species: Homo sapiens
Compartment: cytosol

Complex (4 results from a total of 4)

Identifier: R-HSA-6783195
Species: Homo sapiens
Compartment: endosome membrane
Identifier: R-HSA-6783042
Species: Homo sapiens
Compartment: endosome membrane
Identifier: R-HSA-6783074
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6783034
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-9010553
Species: Homo sapiens
Expression of SLIT and ROBO proteins is regulated at the level of transcription, translation and protein localization and stability. LIM-homeodomain transcription factors LHX2, LHX3, LHX4, LHX9 and ISL1 have so far been implicated in a cell type-dependent transcriptional regulation of ROBO1, ROBO2, ROBO3 and SLIT2 (Wilson et al. 2008, Marcos-Mondejar et al. 2012, Kim et al. 2016). Homeobox transcription factor HOXA2 is involved in transcriptional regulation of ROBO2 (Geisen et al. 2008). Transcription of SLIT1 during optic tract development in Xenopus is stimulated by FGF signaling and may also involve the transcription factor HOXA2, but the mechanism has not been established (Atkinson-Leadbeater et al. 2010). PAX6 and the homeodomain transcription factor NKX2.2 are also implicated in regulation of SLIT1 transcription (Genethliou et al. 2009). An RNA binding protein, MSI1, binds ROBO3 mRNA and promotes its translation, thus increasing ROBO3 protein levels (Kuwako et al. 2010). A poorly studied E3 ubiquitin ligase ZSWIM8 promotes degradation of ROBO3 (Wang et al. 2013). ROBO1 is protein half-life is increased via deubiquitination of ROBO1 by a ubiquitin protease USP33 (Yuasa-Kawada et al. 2009, Huang et al. 2015). Interaction of SLIT2 with DAG1 (dystroglycan) is important for proper localization of SLIT2 at the floor plate (Wright et al. 2012). Interaction of SLIT1 with a type IV collagen COL4A5 is important for localization of SLIT1 to the basement membrane of the optical tectum (Xiao et al. 2011).
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