Search results for WBSCR22

Showing 8 results out of 8

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Protein (3 results from a total of 3)

Identifier: R-HSA-6790981
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: BUD23: O43709
Identifier: R-HSA-6790984
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: TRMT112: Q9UI30
Identifier: R-HSA-6791001
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: DIMT1: Q9UNQ2

Complex (1 results from a total of 1)

Identifier: R-HSA-6790980
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (3 results from a total of 3)

Identifier: R-HSA-6790982
Species: Homo sapiens
Compartment: nucleoplasm
The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 complex in yeast (Ounap et al. 2013), methylates guanosine-1639 of 18S rRNA at the N(7) position of the guanine base (Haag et al. 2015, Zorbas et al. 2015). The WBSCR22:TRMT112 complex but not its methylase activity is required for efficient processing of precursor rRNA at site 2 and site 3 (Haag et al. 2015, Zorbas et al. 2015). Hemizygosity at the region containing WBSCR22 causes Williams-Beuren syndrome (Doll and Grzeschik 2001).
Identifier: R-HSA-6790994
Species: Homo sapiens
Compartment: nucleoplasm
DIMT1 (DIMT1L) dimethylates the N(6) position of adenosine-1850 and adenosine-1851 of a precursor to 18S rRNA in the nucleolus (Zorbas et al. 2015). Dimethylation is observed on the 21S precursor and therefore occurs at this stage of rRNA processing or prior. Dimethylation of adenosine residues appears to occur after N(7)-methylation of guanosine-1639 by WBSCR22:TRMT112 (Zorbas et al. 2015). PNO1 is required for the methylation activity of DIMT1 (Zorbas et al. 2015). DIMT1 protein but not DIMT1 methylase activity is also required for efficient concomitant cleavage of 47S precursor rRNA at site A0 and site 1 (Zorbas et al. 2015).
Identifier: R-HSA-6791223
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
Exonuclease activity of the exosome (Preti et al. 2013) and endonuclease activity of NOB1 (inferred from yeast, Pertschy et al. 2009) process the 3' end of precursor rRNA (pre-rRNA) 18SE to yield mature 18S rRNA. During the processing, pre-rRNA 18SE is bound in the pre-40S ribosome subunit, which contains ribosomal proteins and processing factors such as NOB1 and BYSL. The pre-40S subunit is exported from the nucleus to the cytosol where processing factors are released and recycled back to the nucleus. The kinases RIOK1, RIOK2, CSNK1D and CSNK1E are associated with the pre-40S rRNA subunit in both the nucleus and cytosol and their kinase activity is required for recycling of processing factors back to the nucleus (Zemp et al. 2009, Zemp et al. 2014). RIOK1 and RIOK2 are also required for 18SE processing (Widmann et al. 2012, Zemp et al. 2009). RIOK3 (RIO3) is a cytosolic kinase that associates with the pre-40S ribosomal particle after export from the nucleus and is required for release of processing factors (Baumas et al. 2012).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
WBSCR22 icon
Probable 18S rRNA (guanine-N(7))-methyltransferase
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