Search results for WWTR1

Showing 7 results out of 44

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Reaction (6 results from a total of 24)

Identifier: R-HSA-8985227
Species: Homo sapiens
Compartment: nucleoplasm
Based on studies in mouse cells, the complex of RUNX2 and WWTR1 (TAZ) binds to the promoter of the BGLAP gene, encoding osteocalcin (Hong et al. 2005). Catalytically active protein tyrosine kinase ABL1 promotes association of RUNX2 and WWTR1 and transcription of the BGLAP gene (Matsumoto et al. 2016). RUNX2 binding sites are conserved in the human BGLAP gene promoter.
Identifier: R-HSA-8877922
Species: Homo sapiens
Compartment: nucleoplasm, endoplasmic reticulum lumen
Binding of RUNX2 to the OSE2 element in the promoter of the BGLAP (osteocalcin, OC) gene stimulates BGLAP transcription (Ducy and Karsenty 1995, Ducy et al. 1997). When RUNX2 binds the OSE2 element in complex with the MAF transcription factor, BGLAP transcription is enhanced (Nishikawa et al. 2010). BGLAP gene transcription is also directly stimulated by the complex of RUNX2 and WWTR1 (TAZ) (Hong et al. 2005), as well as the complex of RUNX2 and RB1 (Thomas et al. 2001). Phosphorylation of RUNX2, in the context of the RUNX2:CBFB complex, increases its association with the BGLAP promoter and enhances BGLAP transcription (Wee et al. 2002, Ge et al. 2009). Osteocalcin, a bone-derived hormone, is one of the most abundant non-collagenous proteins of the bone extracellular matrix (reviewed in Karsenty and Olson 2016).
Association of the activated androgen receptor (AR) with RUNX2 prevents binding of RUNX2 to the BGLAP promoter (Baniwal et al. 2009). Based on studies in rat, when YAP1, phosphorylated on an unknown tyrosine residue by SRC and/or YES1, is present in the complex with RUNX2 at the BGLAP gene promoter, transcription of the BGLAP gene is inhibited (Zaidi et al. 2004). Signaling by SRC is known to inhibit osteoblast differentiation (Marzia et al. 2000). Based on studies in mice, binding to ZNF521 (ZNP521) inhibits RUNX2-mediated activation of target promoters, such as BGLAP. HDAC3 is needed for ZNF521 to inhibit RUNX2-mediated transcription from the BGLAP promoter. Action of ZNF521 antagonizes RUNX2 during mesenchymal commitment to the osteoblast lineage and during osteoblast maturation (Hesse et al. 2010).
Identifier: R-HSA-2106579
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.
Identifier: R-HSA-2106591
Species: Homo sapiens
Compartment: nucleoplasm
Knocking down WWTR1 (TAZ) expression by siRNA treatment inhibits TGF-beta-dependent transcription of SMAD7 in human hepatocellular carcinoma cell line Hep G2. Chromatin immunoprecipitation (ChIP) confirmed binding of both WWTR1 and SMAD2/3 to the promoter of SMAD7 gene in response to TGF-beta stimulation (Varelas et al. 2008).
In fish, amphibian and avian species, ATP1B4 (aka X,K ATPase subunit beta m) functions as a subunit of Na/K ATPase, located in the plasma membrane. In mammals, this functionality is lost and ATP1B4 accumulates on the nuclear envelope where it can interact with SNW domain containing protein 1 (SNW1 aka Ski interacting protein, SKIP), a transcriptional regulator. This ATP1B4:SNW1 complex is able to modulate TGF beta mediated transcription by increasing mRNA levels of SMAD7, an inhibitor of TGF beta signalling (Pestov et al. 2007).
Identifier: R-HSA-9736970
Species: Homo sapiens
Compartment: nucleoplasm
Chromatin immunoprecipitation (ChIP) confirmed binding of both WWTR1 and SMAD2,3:SMAD4 complex to the promoter of SMAD7 gene in response to TGF-beta stimulation (Varelas et al. 2008).
Identifier: R-HSA-9736959
Species: Homo sapiens
Compartment: nucleoplasm
By chromatin immunoprecipitation (ChIP) it was shown that both WWTR1 and the SMAD2,3:SMAD4 complex bind to the promoter of SERPINE1 gene in response to TGF-beta stimulation (Varelas et al. 2008).

Complex (1 results from a total of 13)

Identifier: R-HSA-9618555
Species: Homo sapiens
Compartment: nucleoplasm
Cite Us!