Search results for YWHAQ

Showing 10 results out of 10

×

Species

Types

Compartments

Search properties

Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-1445116
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: YWHAQ: P27348

Complex (3 results from a total of 3)

Identifier: R-HSA-2262714
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9614628
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9614572
Species: Homo sapiens
Compartment: cytosol

Set (2 results from a total of 2)

Identifier: R-HSA-9614627
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9614573
Species: Homo sapiens
Compartment: cytosol

Reaction (4 results from a total of 4)

Identifier: R-HSA-9614423
Species: Homo sapiens
Compartment: cytosol
Nuclear exclusion and cytoplasmic retention of AKT-phosphorylated FOXO1 is promoted by binding of FOXO1 to 14-3-3 proteins: YWHAZ (14-3-3 zeta), YWHAQ (14-3-3 theta), YWHAB (14-3-3 beta) and YWHAG (14-3-3 gamma) (Rena et al. 2001).
Identifier: R-HSA-9614562
Species: Homo sapiens
Compartment: cytosol
Nuclear exclusion and cytoplasmic retention of AKT-phosphorylated FOXO3 is promoted by binding of FOXO3 to 14-3-3 proteins: YWHAZ (14-3-3 zeta), YWHAQ (14-3-3 theta), and SFN (14-3-3 sigma) (Brunet et al. 1999, Arimoto-Ishida et al. 2004).
Identifier: R-HSA-5632732
Species: Homo sapiens
Compartment: cytosol
Phosphorylation of TSC2 by AKT enables association of TSC2 with 14-3-3 proteins YWHAB (14-3-3 protein beta/alpha), YWHAQ (14-3-3 protein theta), YWHAG (14-3-3 protein gamma), YWHAH (14-3-3 protein eta), YWHAE (14-3-3 protein epsilon), YWHAZ (14-3-3 protein zeta/delta) or SFN (14-3-3 protein sigma) (Liu et al. 2002). Binding to 14-3-3 proteins sequesters TSC2 to the cytosol and prevents its association with TSC1 (Cai et al. 2006).
Identifier: R-HSA-139899
Species: Homo sapiens
Compartment: cytosol
14-3-3 proteins bind BAD phosphorylated by activated AKT on serine residue S99 (corresponds to mouse Bad serine residue S136). Binding of 14-3-3 proteins to p-S99-BAD facilitates subsequent phosphorylation of BAD on serine residue S118 (corresponds to mouse serine S155), which disrupts binding of BAD to BCL2 proteins and promotes cell survival (Datta et al. 2000). Caspase-3 mediated cleavage of 14-3-3 proteins releases BAD and promotes apoptosis (Won et al. 2003). All known 14-3-3 protein isoforms (beta/alpha i.e. YWHAB, gamma i.e. YWHAG, zeta/delta i.e. YWHAZ, epsilon i.e. YWHAE, eta i.e. YWHAH, sigma i.e. SFN and theta i.e. YWHAQ) can interact with BAD and inhibit it (Subramanian et al. 2001, Chen et al. 2005).
Cite Us!