Search results for ZFP36

Showing 11 results out of 11

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Protein (5 results from a total of 5)

Identifier: R-HSA-450562
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ZFP36: P26651
Identifier: R-HSA-450496
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P26651
Identifier: R-HSA-450547
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q07352
Identifier: R-HSA-450618
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ZFP36L1: Q07352
Identifier: R-HSA-450384
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q07352

Reaction (4 results from a total of 4)

Identifier: R-HSA-450463
Species: Homo sapiens
Compartment: cytosol
TTP is phosphorylated by MK2 at serines 60 and 186.
Identifier: R-HSA-450431
Species: Homo sapiens
Compartment: cytosol
TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.
Identifier: R-HSA-450400
Species: Homo sapiens
Compartment: cytosol
Tristetraprolin (TTP) binds UUAUUUAUU motifs in the AU-rich elements of mRNAs. TTP binds Transportin-1 (Importin beta-2) which plays a role in shuttling TTP between P-bodies and stress granules.
Identifier: R-HSA-450394
Species: Homo sapiens
Compartment: cytosol
Phosphorylated tristetraproline (TTP) binds 14-3-3, which inhibits the ability of TTP to destabilize RNA. Thus RNAs bound by TTP become stabilized. The binding of 14-3-3 causes TTP to be excluded from stress granules.

Pathway (1 results from a total of 1)

Identifier: R-HSA-450513
Species: Homo sapiens
Compartment: cytosol
Tristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the decapping enzymes DCP1 and DCP2a.
The activity of TTP is regulated by phosphorylation. MK2 phosphorylates TTP, which then binds 14-3-3.The interaction with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound by phosphorylated TTP. Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos). Mice deficient in TTP exhibit arthritis, weight loss, skin lesions, autoimmunity, and myeloid hyperplasia.

Icon (1 results from a total of 1)

TTP

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
TTP icon
mRNA decay activator protein ZFP36
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