Search results for ZFY

Showing 13 results out of 14

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Interactor (6 results from a total of 7)

ZFY

Identifier: P08048
Species: Homo sapiens
Primary external reference: UniProt: P08048
Identifier: O95405
Species: Homo sapiens
Primary external reference: UniProt: ZFYVE9: O95405
Identifier: Q5T4F4
Species: Homo sapiens
Primary external reference: UniProt: Q5T4F4
Identifier: Q9HBF4
Species: Homo sapiens
Primary external reference: UniProt: Q9HBF4
Identifier: Q9BQ24
Species: Homo sapiens
Primary external reference: UniProt: Q9BQ24
Identifier: Q68DK2-5
Species: Homo sapiens
Primary external reference: UniProt: Q68DK2-5

Protein (3 results from a total of 3)

Identifier: R-HSA-201645
Species: Homo sapiens
Compartment: early endosome membrane
Primary external reference: UniProt: ZFYVE16: Q7Z3T8
Identifier: R-HSA-188000
Species: Homo sapiens
Compartment: endosome membrane
Primary external reference: UniProt: RBSN: Q9H1K0
Identifier: R-HSA-206180
Species: Homo sapiens
Compartment: early endosome membrane
Primary external reference: UniProt: ZFYVE9: O95405-1

Complex (1 results from a total of 1)

Identifier: R-HSA-2167884
Species: Homo sapiens
Compartment: early endosome membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-170835
Species: Homo sapiens
Compartment: cytoplasmic side of plasma membrane
The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. ZFYVE9 (SARA) resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.
Identifier: R-HSA-3656523
Species: Homo sapiens
Compartment: cytosol, early endosome membrane, plasma membrane
It is assumed that TGFBR1 kinase domain (KD) mutants found in Ferguson-Smith tumor (multiple self-healing squamous epithelioma, MSSE), which have truncated KD or internal deletions in the KD (Goudie et al. 2011), cannot bind SMAD2 and SMAD3, but this has not been experimentally examined. The interaction with R-SMADs requres the presence of the L45 loop in the TGFBR1 kinase domain (amino acid residues 265-273), which is missing in some of the TGFBR1 KD truncation mutants (Chen et al. 1998). Other kinase domain regions may also be involved in the interaction with SMAD2/3 or the conformation and presentation of the L45 loop.

As TGFBR1 residues phosphorylated by TGFBR2 are upstream of kinase domain (KD) mutations that cause truncations or internal deletions in the TGFBR1 KD (Goudie et al. 2011), it is assumed that TGFBR1 KD mutants can still bind to TGF-beta (TGFB1)-activated TGFBR2 and undergo TGFBR2-mediated phosphorylation, but this has not been experimentally examined.

Icon (1 results from a total of 1)

Species: Homo sapiens
Zinc finger FYVE domain-containing protein 9
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