- December 2011 Version 39 Released
As a first step toward systematically annotating human disease processes in Reactome, a new topic,
Disease, has been created.
It contains the existing HIV, Influenza, Botulinum neurotoxicity, and Amyloids pathways with the new
Signaling by EGFR in Cancer.
As described in the users' guide,
pathway diagrams have been revised to show the interplay between disease and normal
processes and a new color scheme has been implemented to differentiate the two.
Topics with new or revised events include Immune System (ISG15 antiviral mechanism,
Prolactin receptor signaling,
Defensins, and
Interleukin-7 signaling),
Metabolism (Sulfur amino acid metabolism,
Sphingolipid metabolism,
O-linked glycosylation of mucins, and
Serine biosynthesis),
Signal transduction (Signaling by ERBB2 and
Signaling by ERBB4), and Gene expression.
Annotations of chicken (Gallus gallus) DNA replication and repair, toll receptor signaling, and metabolism available at
gallus.reactome.org with limited browsing and data analysis tools
are now also available,with full functionality, in the Reactome pathway browser
(switch species to "Gallus gallus").
KP Ray and
R Stephan
are our external authors.
A Ferrer,
V Goffin,
H Greulich,
RC Harris,
AM McDermott,
LM Neckers,
J Puck,
F Rauscher,
S Savas,
W Xu,
F Zeng,
and
DE Zhang
are our external reviewers.
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