Reactome news

News
March 16, 2010 Version 32 Released Version 32 includes the new topic the role of CDO in Myogenesis. Topics revised and updated with new events and/or revisions to existing events in this release include: Synaptic Transmission (Activation of Kainate receptors upon glutamate binding), Signaling by insulin receptor (Energy dependent regulation of mTOR by LKB1-AMPK ), DNA repair (Fanconi Anemia Pathway), Toll Receptor Cascades (Toll Like Receptor 3(TLR3) cascade), Olfactory Signaling Pathway, Cell Cycle Pathways, metabolic pathways for Amino Acids, Carbohydrates, and Nucleotides, and the TCA cycle. P Katajisto, T Makela, and J Wu are our external authors in this release. T Huang, R Krauss, D Tukey, L Vosshall, and B Zheng are our external reviewers. As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MITAB format. Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format. Reactome is now on Facebook, Twitter, and LinkedIn. January 15, 2010 Feedback Request - Target Species for Orthology Inference Reactome provides orthology-based pathway projections from human to other species. We are currently reviewing the list of target species. Please let us know if you would like to include a species that's not in the planned target species list. December 15, 2009 Version 31 Released Version 31 includes the new topics Metabolism of mRNA and Cell junction organization. Topics revised and updated with new events in this release include Transmembrane transport of small molecules (SLC-mediated transmembrane transport), Muscle contraction (Smooth muscle contraction), Hemostasis, Nuclear receptor transcription pathway, and Olfactory Signaling Pathway. JW Akkerman, is our external author in this release. L Freedman, L He, A Poole, M Rush, A Sonnenberg, D Tukey, L Vosshall, J Wilusz, and C Wu are our external reviewers. As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MOD format. Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format. Reactome is now on Facebook, Twitter, and LinkedIn. December 3, 2009 Reactome Webinar on December 16, 1:30 pm EST OICR and OGI are co-hosting a 1 hour webinar about Reactome. You can register here. October 5, 2009 Dr. Elizabeth Blackburn, Reactome author, wins Nobel Reactome congratulates Elizabeth H. Blackburn, 2009 Nobel laureate in Physiology or Medicine, and thanks her again for her group's contributions to the Reactome Telomerase module. September 30, 2009 Version 30 Released Version 30 includes a new topic cell-cell adhesion systems with annotations of adherens junctions interactions and tight junction interactions. Pathway topics revised and updated with new curated events in this release include downstream events in GPCR signaling and olfactory signaling, Costimulation by the CD28 family, SLC-mediated transmembrane transport of small molecules, Clathrin derived vesicle budding in membrane trafficking, signaling by Robo receptors in axon guidance and gene expression (Nuclear Receptor pathway). New metabolism topics include sphingolipid metabolism and three topics of special relevance to diabetes, regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPARalpha), synthesis, secretion, and deacylation of ghrelin , and regulation of insulin secretion by free fatty acids. JW Akkerman, JA Bluestone, K Ebnet, JH Esensten, L Freedman, YA Hannun, L He, T Kidd, S Kersten, H Kikutani, A Kumanogoh, V Poitout, J Simpson, L Vosshall, and W Zhang are our external reviewers in this release. Reactome pathways are now available through NCBI BioSystems. Human protein-protein interaction data are now available for download in PSI-MITAB format. September 24, 2009 New User Survey Reactome is committed to providing access to high-quality pathway information and useful data analysis tools. With this in mind, we are actively soliciting comments from the research community in order to assess community needs. We are interested to hear about your experience with Reactome, and would like to know a bit about your background and research interests so that we can continue to improve the Reactome site and tools. You can access the survey at: http://tinyurl.com/l48zzq. Thanks for taking part. July 25, 2009 Version 1 of GallusReactome Released The first version of GallusReactome has been released and is accessible at http://gallus.reactome.org. June 24, 2009 Version 29 Released Version 29 includes the new topic, Axon guidance, covering NCAM signaling in neurite outgrowth. Pathway topics updated with new curated events in this release include: Synaptic transmission (Glutamate Binding, Activation of AMPA Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2 and FANCI activity in the Fanconi Anemia pathway), and pathways related to diabetes (Regulation of insulin secretion and Unfolded protein response). With the annotation of receptors for eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules, LPA and lysosphingolipids, opsins, secretins, and GABA and related molecules (class C/3 receptors), our annotation of interactions between G-coupled protein receptors (GPCRs) and their ligands is essentially complete. The Telomere Maintenance pathway has been revised in this release. T Huang, PF Maness, L Vosshall, and E Ziff are our external reviewers in this release. March 31, 2009 Version 28 Released New topics in Version 28 include signaling by PDGF, striated Muscle Contraction, and chaperonin-mediated protein folding and post-chaperonin tubulin folding. (grouped with translation and post-translational protein modification into a new "Metabolism of protein" super-pathway). Pathways updated with new curated events include GPCR signaling, (olfactory signaling, amine and hormone ligand-binding receptor events and additional peptide ligand-binding receptor events), synaptic transmission (Electrical transmission across Gap Junctions), hemostasis and signaling in the immune system (Tie2 signaling events and Basigin interactions. New metabolism topics include the peroxisomal metabolism of lipidsand glyoxylate and Integration of energy metabolism (Glucose Regulation of Insulin Secretion).

News

March 16, 2010 Version 32 Released
Version 32 includes the new topic the role of CDO in Myogenesis. Topics revised and updated with new events and/or revisions to existing events in this release include: Synaptic Transmission (Activation of Kainate receptors upon glutamate binding), Signaling by insulin receptor (Energy dependent regulation of mTOR by LKB1-AMPK ), DNA repair (Fanconi Anemia Pathway), Toll Receptor Cascades (Toll Like Receptor 3(TLR3) cascade), Olfactory Signaling Pathway, Cell Cycle Pathways, metabolic pathways for Amino Acids, Carbohydrates, and Nucleotides, and the TCA cycle.
P Katajisto, T Makela, and J Wu are our external authors in this release. T Huang, R Krauss, D Tukey, L Vosshall, and B Zheng are our external reviewers.
As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MITAB format.
Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format.
Reactome is now on Facebook, Twitter, and LinkedIn.
January 15, 2010 Feedback Request - Target Species for Orthology Inference
Reactome provides orthology-based pathway projections from human to other species. We are currently reviewing the list of target species. Please let us know if you would like to include a species that's not in the planned target species list.
December 15, 2009 Version 31 Released
Version 31 includes the new topics Metabolism of mRNA and Cell junction organization. Topics revised and updated with new events in this release include Transmembrane transport of small molecules (SLC-mediated transmembrane transport), Muscle contraction (Smooth muscle contraction), Hemostasis, Nuclear receptor transcription pathway, and Olfactory Signaling Pathway.
JW Akkerman, is our external author in this release. L Freedman, L He, A Poole, M Rush, A Sonnenberg, D Tukey, L Vosshall, J Wilusz, and C Wu are our external reviewers.
As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MOD format.
Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format.
Reactome is now on Facebook, Twitter, and LinkedIn.
December 3, 2009 Reactome Webinar on December 16, 1:30 pm EST
OICR and OGI are co-hosting a 1 hour webinar about Reactome. You can register here.
October 5, 2009 Dr. Elizabeth Blackburn, Reactome author, wins Nobel
Reactome congratulates Elizabeth H. Blackburn, 2009 Nobel laureate in Physiology or Medicine, and thanks her again for her group's contributions to the Reactome Telomerase module.
September 30, 2009 Version 30 Released
Version 30 includes a new topic cell-cell adhesion systems with annotations of adherens junctions interactions and tight junction interactions. Pathway topics revised and updated with new curated events in this release include downstream events in GPCR signaling and olfactory signaling, Costimulation by the CD28 family, SLC-mediated transmembrane transport of small molecules, Clathrin derived vesicle budding in membrane trafficking, signaling by Robo receptors in axon guidance and gene expression (Nuclear Receptor pathway). New metabolism topics include sphingolipid metabolism and three topics of special relevance to diabetes, regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPARalpha), synthesis, secretion, and deacylation of ghrelin , and regulation of insulin secretion by free fatty acids. JW Akkerman, JA Bluestone, K Ebnet, JH Esensten, L Freedman, YA Hannun, L He, T Kidd, S Kersten, H Kikutani, A Kumanogoh, V Poitout, J Simpson, L Vosshall, and W Zhang are our external reviewers in this release.
Reactome pathways are now available through NCBI BioSystems. Human protein-protein interaction data are now available for download in PSI-MITAB format.
September 24, 2009 New User Survey
Reactome is committed to providing access to high-quality pathway information and useful data analysis tools. With this in mind, we are actively soliciting comments from the research community in order to assess community needs. We are interested to hear about your experience with Reactome, and would like to know a bit about your background and research interests so that we can continue to improve the Reactome site and tools.
You can access the survey at: http://tinyurl.com/l48zzq. Thanks for taking part.
July 25, 2009 Version 1 of GallusReactome Released
The first version of GallusReactome has been released and is accessible at http://gallus.reactome.org.
June 24, 2009 Version 29 Released
Version 29 includes the new topic, Axon guidance, covering NCAM signaling in neurite outgrowth. Pathway topics updated with new curated events in this release include: Synaptic transmission (Glutamate Binding, Activation of AMPA Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2 and FANCI activity in the Fanconi Anemia pathway), and pathways related to diabetes (Regulation of insulin secretion and Unfolded protein response). With the annotation of receptors for eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules, LPA and lysosphingolipids, opsins, secretins, and GABA and related molecules (class C/3 receptors), our annotation of interactions between G-coupled protein receptors (GPCRs) and their ligands is essentially complete. The Telomere Maintenance pathway has been revised in this release.
T Huang, PF Maness, L Vosshall, and E Ziff are our external reviewers in this release.
March 31, 2009 Version 28 Released
New topics in Version 28 include signaling by PDGF, striated Muscle Contraction, and chaperonin-mediated protein folding and post-chaperonin tubulin folding. (grouped with translation and post-translational protein modification into a new "Metabolism of protein" super-pathway). Pathways updated with new curated events include GPCR signaling, (olfactory signaling, amine and hormone ligand-binding receptor events and additional peptide ligand-binding receptor events), synaptic transmission (Electrical transmission across Gap Junctions), hemostasis and signaling in the immune system (Tie2 signaling events and Basigin interactions. New metabolism topics include the peroxisomal metabolism of lipidsand glyoxylate and Integration of energy metabolism (Glucose Regulation of Insulin Secretion).