Reactome: A Curated Pathway Database

Download Data

Reactome provides open-source and open-data. We have continuously supported the major open-data standards, including BioPAXPSI-MITABSBML and SBGN export formats. The Reactome data and source code continues to be publicly accessible under the terms of a Creative Commons Attribution 3.0 Unported License.

The Reactome website can be installed locally on Debian or Ubuntu Linux. This shell script will automate the Reactome local installation. More detailed instructions for local installation of Reactome database and website are also available. The website code can be downloaded as reactome.tar.gz.

GitHub Repository is accessible here.

For those of you requiring access to legacy data, you can download this from the Reactome archive. Otherwise, access to our most recent data release can be found below.

Identifier mapping files:

Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway:

Mapping files link the source database identifier to all levels of the pathway hierarchy:

For more information on these mapping files, please refer to the README file.

Pathway Information:

For more information on these mapping files, please refer to the README file.

MySQL dumps of Reactome databases: 

Interactions derived from Reactome pathways:

Functional interactions (FIs) derived from Reactome, and other pathway and interaction databases:

For details about FIs, please see Wu G, Feng X, Stein L. To use these FI networks, please try our FI Cytoscape PlugIn.

Specialized data formats:

Reactome Web services

Our new RESTful API provides outside users with direct access to pathway data in Reactome. The Reactome pathway analysis tools are also available for integration into third party websites. Note: The RESTful API has been moved to reactomews.oicr.on.ca for better performance.). For details about this API, please see this document: Reactome RESTful API.

Curation Software

Two Java tools are available for Reactome data entry. The Author tool is designed for biologists to input data into Reactome, while the Curator tool is meant for use by curators to annotate biological pathways based on the Reactome schema. N.B. these tools will only wor with a database using our internal database format, the database available from this web page will not work with them. Click on the help link at the top of this page to request a copy of our internal database.

Reactome textbook of biological pathways and processes

The textbook files can be downloaded in: PDF and RTF format. Note: RTF files may be very large, but conversion to PDF or Word generates a file that is much smaller with no loss of information.