Reactome | Sialic acid [plasma membrane]

Sialic acid [plasma membrane]

Stable Identifier

R-ALL-1006168

Type

Chemical Compound [SimpleEntity]

Compartment

plasma membrane

Synonyms

9-O-acetylneuraminic acid

Locations in the PathwayBrowser

for Species:

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
    - Sialic acid binds SIGLEC (Mus musculus)
      - Sialic acid [plasma membrane]
      - SIGLEC:sialic acid [plasma membrane] (Mus musculus)
        
        Sialic acid [plasma membrane]
- Innate Immune System (Mus musculus)
  - Complement cascade (Mus musculus)
    - Initial triggering of complement (Mus musculus)
      - Conversion of C2 into C2a and C2b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
      - Conversion of C4 into C4a and C4b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
      - Creation of C4 and C2 activators (Mus musculus)
        
        Lectin pathway of complement activation (Mus musculus)
        
        Activation of MASPs (Mus musculus)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Mus musculus)
        
        Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Rattus norvegicus)
    - Sialic acid binds SIGLEC (Rattus norvegicus)
      - Sialic acid [plasma membrane]
      - SIGLEC:sialic acid [plasma membrane] (Rattus norvegicus)
        
        Sialic acid [plasma membrane]
- Innate Immune System (Rattus norvegicus)
  - Complement cascade (Rattus norvegicus)
    - Initial triggering of complement (Rattus norvegicus)
      - Conversion of C2 into C2a and C2b (Rattus norvegicus)
        
        C4 activators [plasma membrane] (Rattus norvegicus)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
      - Conversion of C4 into C4a and C4b (Rattus norvegicus)
        
        C4 activators [plasma membrane] (Rattus norvegicus)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
      - Creation of C4 and C2 activators (Rattus norvegicus)
        
        Lectin pathway of complement activation (Rattus norvegicus)
        
        Activation of MASPs (Rattus norvegicus)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Rattus norvegicus)
        
        Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        FCN1 ligands [plasma membrane]
        
        Sialic acid [plasma membrane]

External Reference Information

External Reference

9-O-acetylneuraminic acid [ChEBI:28879]

Participates

as an input of

as a component of

as a member of

FCN1 ligands [plasma membrane]

Other forms of this molecule

Sialic acid [Golgi membrane]

Cross References

COMPOUND

C03525

ZINC

000004096141, 000004096139

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