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About
What is Reactome ?
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Team
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Our Logo
License Agreement
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Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
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COVID-19 Disease Pathways
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H2O [nucleoplasm]
Stable Identifier
R-ALL-113518
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Nuclear Envelope Breakdown (Bos taurus)
Depolymerization of the Nuclear Lamina (Bos taurus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)
H2O [nucleoplasm]
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Bos taurus)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Bos taurus)
PP2A mediated localization of RB1 protein in chromatin (Bos taurus)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Bos taurus)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
Myosin phosphatase dephosphorylates PLK1 (Bos taurus)
H2O [nucleoplasm]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
H2O [nucleoplasm]
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
H2O [nucleoplasm]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Bos taurus)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
H2O [nucleoplasm]
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
HDACs deacetylate histones (Bos taurus)
HDAC10 deacetylates histone (Bos taurus)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Bos taurus)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Bos taurus)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Bos taurus)
H2O [nucleoplasm]
PADI4 deiminates Histones (Bos taurus)
H2O [nucleoplasm]
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
PARG dePARylates PARP1,PARP2 (Bos taurus)
H2O [nucleoplasm]
DNA Damage Bypass (Bos taurus)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
Termination of translesion DNA synthesis (Bos taurus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Bos taurus)
H2O [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
Initial resection of double-strand break ends (Bos taurus)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Bos taurus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
H2O [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
USP45 deubiquitinates ERCC1 (Bos taurus)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
H2O [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
MTA2-NuRD complex deacetylates TP53 (Bos taurus)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
Regulation of RUNX1 Expression and Activity (Bos taurus)
PTPN11 dephosphorylates RUNX1 (Bos taurus)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Bos taurus)
PPM1D dephosphorylates RUNX2 (Bos taurus)
H2O [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
Regulation of IFNG signaling (Bos taurus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)
H2O [nucleoplasm]
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
H2O [nucleoplasm]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
dUTP + H2O => dUMP + pyrophosphate (Bos taurus)
H2O [nucleoplasm]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT16 hydrolyses IDP to IMP (Bos taurus)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)
H2O [nucleoplasm]
Metabolism of RNA (Bos taurus)
mRNA Editing (Bos taurus)
mRNA Editing: A to I Conversion (Bos taurus)
C6 deamination of adenosine (Bos taurus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Bos taurus)
C4 deamination of cytidine (Bos taurus)
H2O [nucleoplasm]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Metalloprotease DUBs (Bos taurus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Bos taurus)
H2O [nucleoplasm]
UCH proteinases (Bos taurus)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)
H2O [nucleoplasm]
Ub-specific processing proteases (Bos taurus)
USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Bos taurus)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Bos taurus)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Bos taurus)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Bos taurus)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Bos taurus)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Bos taurus)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Bos taurus)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Bos taurus)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Bos taurus)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Bos taurus)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)
H2O [nucleoplasm]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
H2O [nucleoplasm]
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
STAT3 nuclear events downstream of ALK signaling (Bos taurus)
HDACs deacetylate p-STAT3 dimers (Bos taurus)
H2O [nucleoplasm]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
H2O [nucleoplasm]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
H2O [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerization of the Nuclear Lamina (Caenorhabditis elegans)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)
H2O [nucleoplasm]
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Caenorhabditis elegans)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Caenorhabditis elegans)
PP2A mediated localization of RB1 protein in chromatin (Caenorhabditis elegans)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Caenorhabditis elegans)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)
H2O [nucleoplasm]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)
H2O [nucleoplasm]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
H2O [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Double-Strand Break Repair (Caenorhabditis elegans)
Homology Directed Repair (Caenorhabditis elegans)
HDR through MMEJ (alt-NHEJ) (Caenorhabditis elegans)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)
H2O [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
H2O [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)
H2O [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF(TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs in the nucleus (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)
H2O [nucleoplasm]
Nucleotide catabolism (Caenorhabditis elegans)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of RNA (Caenorhabditis elegans)
mRNA Editing (Caenorhabditis elegans)
mRNA Editing: A to I Conversion (Caenorhabditis elegans)
C6 deamination of adenosine (Caenorhabditis elegans)
Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)
H2O [nucleoplasm]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
Ub-specific processing proteases (Caenorhabditis elegans)
USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Caenorhabditis elegans)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Caenorhabditis elegans)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Caenorhabditis elegans)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
H2O [nucleoplasm]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
STAT3 nuclear events downstream of ALK signaling (Caenorhabditis elegans)
HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)
H2O [nucleoplasm]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
H2O [nucleoplasm]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
H2O [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Prophase (Canis familiaris)
Nuclear Envelope Breakdown (Canis familiaris)
Depolymerization of the Nuclear Lamina (Canis familiaris)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)
H2O [nucleoplasm]
G1/S Transition (Canis familiaris)
Cyclin E associated events during G1/S transition (Canis familiaris)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Canis familiaris)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Canis familiaris)
PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Canis familiaris)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
H2O [nucleoplasm]
S Phase (Canis familiaris)
Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)
H2O [nucleoplasm]
Chromosome Maintenance (Canis familiaris)
Telomere Maintenance (Canis familiaris)
Extension of Telomeres (Canis familiaris)
Telomere C-strand (Lagging Strand) Synthesis (Canis familiaris)
Polymerase switching on the C-strand of the telomere (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Canis familiaris)
Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)
H2O [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Canis familiaris)
H2O [nucleoplasm]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
HDACs deacetylate histones (Canis familiaris)
HDAC10 deacetylates histone (Canis familiaris)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Canis familiaris)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Canis familiaris)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Canis familiaris)
H2O [nucleoplasm]
PADI4 deiminates Histones (Canis familiaris)
H2O [nucleoplasm]
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Canis familiaris)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Canis familiaris)
POLB-Dependent Long Patch Base Excision Repair (Canis familiaris)
PARG dePARylates PARP1,PARP2 (Canis familiaris)
H2O [nucleoplasm]
DNA Damage Bypass (Canis familiaris)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Canis familiaris)
Termination of translesion DNA synthesis (Canis familiaris)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
H2O [nucleoplasm]
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Canis familiaris)
H2O [nucleoplasm]
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
Initial resection of double-strand break ends (Canis familiaris)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Canis familiaris)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)
H2O [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
Formation of Incision Complex in GG-NER (Canis familiaris)
USP45 deubiquitinates ERCC1 (Canis familiaris)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
H2O [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Acetylation (Canis familiaris)
MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
H2O [nucleoplasm]
Transcriptional regulation by RUNX1 (Canis familiaris)
Regulation of RUNX1 Expression and Activity (Canis familiaris)
PTPN11 dephosphorylates RUNX1 (Canis familiaris)
H2O [nucleoplasm]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon gamma signaling (Canis familiaris)
Regulation of IFNG signaling (Canis familiaris)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)
H2O [nucleoplasm]
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Metabolism (Canis familiaris)
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)
H2O [nucleoplasm]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT16 hydrolyses IDP to IMP (Canis familiaris)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)
H2O [nucleoplasm]
Metabolism of RNA (Canis familiaris)
mRNA Editing (Canis familiaris)
mRNA Editing: A to I Conversion (Canis familiaris)
C6 deamination of adenosine (Canis familiaris)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Canis familiaris)
C4 deamination of cytidine (Canis familiaris)
H2O [nucleoplasm]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Metalloprotease DUBs (Canis familiaris)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Canis familiaris)
H2O [nucleoplasm]
UCH proteinases (Canis familiaris)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)
H2O [nucleoplasm]
Ub-specific processing proteases (Canis familiaris)
USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Canis familiaris)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Canis familiaris)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Canis familiaris)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Canis familiaris)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Canis familiaris)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Canis familiaris)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Canis familiaris)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Canis familiaris)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
H2O [nucleoplasm]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
H2O [nucleoplasm]
MAPK family signaling cascades (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
STAT3 nuclear events downstream of ALK signaling (Canis familiaris)
HDACs deacetylate p-STAT3 dimers (Canis familiaris)
H2O [nucleoplasm]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
H2O [nucleoplasm]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
H2O [nucleoplasm]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Prophase (Danio rerio)
Nuclear Envelope Breakdown (Danio rerio)
Depolymerization of the Nuclear Lamina (Danio rerio)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Danio rerio)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Danio rerio)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Danio rerio)
G1 Phase (Danio rerio)
Cyclin D associated events in G1 (Danio rerio)
Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Danio rerio)
H2O [nucleoplasm]
G1/S Transition (Danio rerio)
Cyclin E associated events during G1/S transition (Danio rerio)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Danio rerio)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Danio rerio)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Danio rerio)
PP2A mediated localization of RB1 protein in chromatin (Danio rerio)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
Cyclin A/B1/B2 associated events during G2/M transition (Danio rerio)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Danio rerio)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Danio rerio)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Danio rerio)
H2O [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Danio rerio)
Myosin phosphatase dephosphorylates PLK1 (Danio rerio)
H2O [nucleoplasm]
S Phase (Danio rerio)
Cyclin A:Cdk2-associated events at S phase entry (Danio rerio)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Danio rerio)
H2O [nucleoplasm]
Chromosome Maintenance (Danio rerio)
Telomere Maintenance (Danio rerio)
Extension of Telomeres (Danio rerio)
Telomere C-strand (Lagging Strand) Synthesis (Danio rerio)
Polymerase switching on the C-strand of the telomere (Danio rerio)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Danio rerio)
H2O [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Danio rerio)
Formation of the Flap Intermediate on the C-strand (Danio rerio)
H2O [nucleoplasm]
Telomere Extension By Telomerase (Danio rerio)
Disassociation of Telomerase RNP and the Chromosome End (Danio rerio)
H2O [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Danio rerio)
H2O [nucleoplasm]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)
H2O [nucleoplasm]
SIRT1 deacetylates HSF1 (Danio rerio)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Danio rerio)
ATP hydrolysis by HSP90 (Danio rerio)
H2O [nucleoplasm]
Chromatin organization (Danio rerio)
Chromatin modifying enzymes (Danio rerio)
HDACs deacetylate histones (Danio rerio)
HDAC10 deacetylates histone (Danio rerio)
H2O [nucleoplasm]
HDAC1:2-containing complex deacetylate histones (Danio rerio)
H2O [nucleoplasm]
HDAC3 containing complexes deacetylate histone (Danio rerio)
H2O [nucleoplasm]
HDAC8 deacetylates histones (Danio rerio)
H2O [nucleoplasm]
PADI4 deiminates Histones (Danio rerio)
H2O [nucleoplasm]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Danio rerio)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Danio rerio)
POLB-Dependent Long Patch Base Excision Repair (Danio rerio)
PARG dePARylates PARP1,PARP2 (Danio rerio)
H2O [nucleoplasm]
DNA Damage Bypass (Danio rerio)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Danio rerio)
Termination of translesion DNA synthesis (Danio rerio)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Danio rerio)
DNA Double Strand Break Response (Danio rerio)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Danio rerio)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Danio rerio)
H2O [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Danio rerio)
H2O [nucleoplasm]
Homology Directed Repair (Danio rerio)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
Processing of DNA double-strand break ends (Danio rerio)
Initial resection of double-strand break ends (Danio rerio)
H2O [nucleoplasm]
Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)
H2O [nucleoplasm]
PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
H2O [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Danio rerio)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)
H2O [nucleoplasm]
Nucleotide Excision Repair (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
Formation of Incision Complex in GG-NER (Danio rerio)
USP45 deubiquitinates ERCC1 (Danio rerio)
H2O [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
Formation of TC-NER Pre-Incision Complex (Danio rerio)
UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
H2O [nucleoplasm]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Activity through Acetylation (Danio rerio)
MTA2-NuRD complex deacetylates TP53 (Danio rerio)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Danio rerio)
Regulation of TP53 Degradation (Danio rerio)
PP2A-PP2R5C dephosphorylates MDM2 (Danio rerio)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Danio rerio)
H2O [nucleoplasm]
USP7 deubiquitinates MDM2 (Danio rerio)
H2O [nucleoplasm]
USP7 deubiquitinates TP53 and counteracts MDM2 (Danio rerio)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Danio rerio)
PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Danio rerio)
PPM1D dephosphorylates RUNX2 (Danio rerio)
H2O [nucleoplasm]
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Interferon Signaling (Danio rerio)
Interferon gamma signaling (Danio rerio)
Regulation of IFNG signaling (Danio rerio)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)
H2O [nucleoplasm]
Signaling by Interleukins (Danio rerio)
Interleukin-17 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF(TICAM1)-mediated TLR4 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs in the nucleus (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
H2O [nucleoplasm]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
dUTP + H2O => dUMP + pyrophosphate (Danio rerio)
H2O [nucleoplasm]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT16 hydrolyses IDP to IMP (Danio rerio)
H2O [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
H2O [nucleoplasm]
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)
H2O [nucleoplasm]
Metabolism of RNA (Danio rerio)
mRNA Editing (Danio rerio)
mRNA Editing: A to I Conversion (Danio rerio)
C6 deamination of adenosine (Danio rerio)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Danio rerio)
H2O [nucleoplasm]
Deamination at C6 position of adenosine in Editosome (ADAR2) (Danio rerio)
H2O [nucleoplasm]
mRNA Editing: C to U Conversion (Danio rerio)
C4 deamination of cytidine (Danio rerio)
H2O [nucleoplasm]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Deubiquitination (Danio rerio)
Metalloprotease DUBs (Danio rerio)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Danio rerio)
H2O [nucleoplasm]
MYSM1 deubiquitinates Histone H2A (Danio rerio)
H2O [nucleoplasm]
UCH proteinases (Danio rerio)
BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Danio rerio)
H2O [nucleoplasm]
Histone H2A is dubiquitinated by the PR-DUB complex (Danio rerio)
H2O [nucleoplasm]
Ub-specific processing proteases (Danio rerio)
USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)
H2O [nucleoplasm]
USP12, USP26 deubiquitinate AR (Danio rerio)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Danio rerio)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Danio rerio)
H2O [nucleoplasm]
USP2 deubiquitinates MDM2,MDM4 (Danio rerio)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Danio rerio)
H2O [nucleoplasm]
USP24 deubiquitinates DDB2 (Danio rerio)
H2O [nucleoplasm]
USP28 deubiquitinates CLSPN and MYC (Danio rerio)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Danio rerio)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Danio rerio)
H2O [nucleoplasm]
USP48 cleaves polyubiquitin (Danio rerio)
H2O [nucleoplasm]
USP49 deubiquitinates H2B (Danio rerio)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Danio rerio)
H2O [nucleoplasm]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
PTEN Regulation (Danio rerio)
Regulation of PTEN localization (Danio rerio)
USP7 deubiquitinates monoubiquitinated PTEN (Danio rerio)
H2O [nucleoplasm]
MAPK family signaling cascades (Danio rerio)
MAPK6/MAPK4 signaling (Danio rerio)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
STAT3 nuclear events downstream of ALK signaling (Danio rerio)
HDACs deacetylate p-STAT3 dimers (Danio rerio)
H2O [nucleoplasm]
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Nuclear Events (kinase and transcription factor activation) (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
H2O [nucleoplasm]
Signaling by TGFB family members (Danio rerio)
Signaling by TGF-beta Receptor Complex (Danio rerio)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Danio rerio)
PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)
H2O [nucleoplasm]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Prophase (Dictyostelium discoideum)
Nuclear Envelope Breakdown (Dictyostelium discoideum)
Depolymerization of the Nuclear Lamina (Dictyostelium discoideum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
G1 Phase (Dictyostelium discoideum)
Cyclin D associated events in G1 (Dictyostelium discoideum)
Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)
H2O [nucleoplasm]
G1/S Transition (Dictyostelium discoideum)
Cyclin E associated events during G1/S transition (Dictyostelium discoideum)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Dictyostelium discoideum)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Dictyostelium discoideum)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Dictyostelium discoideum)
PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Dictyostelium discoideum)
G2/M Transition (Dictyostelium discoideum)
Cyclin A/B1/B2 associated events during G2/M transition (Dictyostelium discoideum)
PP2A demethylation by PPME1 (Dictyostelium discoideum)
H2O [nucleoplasm]
S Phase (Dictyostelium discoideum)
Cyclin A:Cdk2-associated events at S phase entry (Dictyostelium discoideum)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Dictyostelium discoideum)
H2O [nucleoplasm]
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Dictyostelium discoideum)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)
H2O [nucleoplasm]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Dictyostelium discoideum)
POLB-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)
H2O [nucleoplasm]
Nucleotide Excision Repair (Dictyostelium discoideum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Formation of TC-NER Pre-Incision Complex (Dictyostelium discoideum)
UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
H2O [nucleoplasm]
Immune System (Dictyostelium discoideum)
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-17 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Innate Immune System (Dictyostelium discoideum)
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF(TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Metabolism (Dictyostelium discoideum)
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)
H2O [nucleoplasm]
Nucleotide catabolism (Dictyostelium discoideum)
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)
H2O [nucleoplasm]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Deubiquitination (Dictyostelium discoideum)
Metalloprotease DUBs (Dictyostelium discoideum)
MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Ub-specific processing proteases (Dictyostelium discoideum)
USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)
H2O [nucleoplasm]
USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)
H2O [nucleoplasm]
USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)
H2O [nucleoplasm]
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP44 deubiquitinates CDC20 (Dictyostelium discoideum)
H2O [nucleoplasm]
USP47 deubiquitinates POLB (Dictyostelium discoideum)
H2O [nucleoplasm]
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)
H2O [nucleoplasm]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN localization (Dictyostelium discoideum)
USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
H2O [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by ALK (Dictyostelium discoideum)
STAT3 nuclear events downstream of ALK signaling (Dictyostelium discoideum)
HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)
H2O [nucleoplasm]
Signaling by NTRKs (Dictyostelium discoideum)
Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
Nuclear Events (kinase and transcription factor activation) (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
H2O [nucleoplasm]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Prophase (Drosophila melanogaster)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Depolymerization of the Nuclear Lamina (Drosophila melanogaster)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)
H2O [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)
H2O [nucleoplasm]
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)
H2O [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)
H2O [nucleoplasm]
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
H2O [nucleoplasm]
E2F mediated regulation of DNA replication (Drosophila melanogaster)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Drosophila melanogaster)
PP2A mediated localization of RB1 protein in chromatin (Drosophila melanogaster)
H2O [nucleoplasm]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)
H2O [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
H2O [nucleoplasm]
PP2A demethylation by PPME1 (Drosophila melanogaster)
H2O [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)
H2O [nucleoplasm]
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
H2O [nucleoplasm]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to heat stress (Drosophila melanogaster)
Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Drosophila melanogaster)
H2O [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
H2O [nucleoplasm]
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
POLB-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
H2O [nucleoplasm]
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
H2O [nucleoplasm]
MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)
H2O [nucleoplasm]
Nucleotide Excision Repair (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
H2O [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
H2O [nucleoplasm]
PI5P Regulates TP53 Acetylation (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
H2O [nucleoplasm]
Regulation of TP53 Expression and Degradation (Drosophila melanogaster)
Regulation of TP53 Degradation (Drosophila melanogaster)
USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)
H2O [nucleoplasm]
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates p14-ARF (Drosophila melanogaster)
HDAC4 deacetylates RUNX3 (Drosophila melanogaster)
H2O [nucleoplasm]
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Interferon gamma signaling (Drosophila melanogaster)
Regulation of IFNG signaling (Drosophila melanogaster)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)
H2O [nucleoplasm]
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF(TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
H2O [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
H2O [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)