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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Developer's Zone
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Pathway Diagrams
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FAQ
Linking to Us
Citing us
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Analyse gene expression
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ATP [cytosol]
Stable Identifier
R-ALL-113592
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Adenosine 5'-triphosphate, ATP(4-)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)
ATP [cytosol]
Active MTORC1 phosphorylates ULK1 (Bos taurus)
ATP [cytosol]
Beclin-1 complex phosphorylates PtdIns (Bos taurus)
ATP [cytosol]
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
PINK1-PRKN Mediated Mitophagy (Bos taurus)
PINK1 is autophosphorylated (Bos taurus)
ATP [cytosol]
PINK1 phosphorylates PRKN at S65 (Bos taurus)
ATP [cytosol]
PINK1 phosphorylates Ub on MOM proteins (Bos taurus)
ATP [cytosol]
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Bos taurus)
ATP [cytosol]
p-S-TBK1 phosphorylates OPTN (Bos taurus)
ATP [cytosol]
Receptor Mediated Mitophagy (Bos taurus)
FUNDC1 is phosphorylated by CK2 (Bos taurus)
ATP [cytosol]
FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)
ATP [cytosol]
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)
ATP [cytosol]
Thr-180 of ULK1 is phosphorylated (Bos taurus)
ATP [cytosol]
ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)
ATP [cytosol]
ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)
ATP [cytosol]
ULK1 phosphorylates Beclin-1 (Bos taurus)
ATP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
ATP [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G2/M Checkpoints (Bos taurus)
G2/M DNA replication checkpoint (Bos taurus)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)
ATP [cytosol]
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
CDK1 phosphorylates LBR (Bos taurus)
ATP [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
ATP [cytosol]
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
CK2 phosphorylates condensin I subunits (Bos taurus)
ATP [cytosol]
EML4 and NUDC in mitotic spindle formation (Bos taurus)
NEK6 and NEK7 phosphorylate EML4 (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates NUDC (Bos taurus)
ATP [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
ATP [cytosol]
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates FIRMM at S744 (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates FIRRM at S43 (Bos taurus)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)
ATP [cytosol]
Mitotic Prophase (Bos taurus)
Golgi Cisternae Pericentriolar Stack Reorganization (Bos taurus)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates GORASP1 (Bos taurus)
ATP [cytosol]
Nuclear Envelope Breakdown (Bos taurus)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Bos taurus)
CDK1:CCNB phosphorylates NEK9 (Bos taurus)
ATP [cytosol]
NEK9 phosphorylates NEK6/NEK7 (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates NEK9 (Bos taurus)
ATP [cytosol]
Nuclear Pore Complex (NPC) Disassembly (Bos taurus)
CDK1 phosphorylates NUP98 (Bos taurus)
ATP [cytosol]
NEK6/NEK7 phosphorylates NUP98 (Bos taurus)
ATP [cytosol]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)
ATP [cytosol]
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ATP [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
AURKA Activation by TPX2 (Bos taurus)
TPX2 promotes AURKA autophosphorylation (Bos taurus)
ATP [cytosol]
Centrosome maturation (Bos taurus)
Loss of proteins required for interphase microtubule organization from the centrosome (Bos taurus)
Loss of Nlp from mitotic centrosomes (Bos taurus)
Plk1-mediated phosphorylation of Nlp (Bos taurus)
ATP [cytosol]
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)
ATP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)
ATP [cytosol]
Interaction between PHLDA1 and AURKA (Bos taurus)
AURKA phosphorylates PHLDA1 (Bos taurus)
ATP [cytosol]
Polo-like kinase mediated events (Bos taurus)
Activation of Cdc25C (Bos taurus)
ATP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
AJUBA facilitates AURKA autophosphorylation (Bos taurus)
ATP [cytosol]
AURKA phosphorylates PLK1 (Bos taurus)
ATP [cytosol]
CDK1 phosphorylates BORA (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates BORA (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates OPTN (Bos taurus)
ATP [cytosol]
The role of GTSE1 in G2/M progression after G2 checkpoint (Bos taurus)
Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Bos taurus)
ATP [cytosol]
PLK1 phosphorylates GTSE1 (Bos taurus)
ATP [cytosol]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ATP [cytosol]
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
ATP [cytosol]
Cell-Cell communication (Bos taurus)
Cell junction organization (Bos taurus)
Cell-extracellular matrix interactions (Bos taurus)
MigFilin associates with Filamin and F-actin (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Migfilin:Filamin A:F-actin [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Nephrin family interactions (Bos taurus)
Phosphorylation of nephrin by FYN (Bos taurus)
ATP [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Bos taurus)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Bos taurus)
ATP [cytosol]
PKA phosphorylates NOS3 (eNOS) on serine-633 (Bos taurus)
ATP [cytosol]
Phosphorylation of PDPK1 on serine-241 (Bos taurus)
ATP [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Bos taurus)
ATP [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Bos taurus)
ATP [cytosol]
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Bos taurus)
ATP [cytosol]
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Bos taurus)
ATP [cytosol]
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Bos taurus)
ATP [cytosol]
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Bos taurus)
ATP [cytosol]
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
Oxidative Stress Induced Senescence (Bos taurus)
MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
ATP [cytosol]
PRKAA2 phosphorylates nuclear NFE2L2 (Bos taurus)
ATP [cytosol]
PRKCI phosphorylates NFE2L2 (Bos taurus)
ATP [cytosol]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
Constitutive phosphorylation by pERK1/2 (Bos taurus)
ATP [cytosol]
Constitutive phosphorylation by GSK3 (Bos taurus)
ATP [cytosol]
HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)
ATP [cytosol]
HSP70s:ATP [cytosol] (Bos taurus)
HSPA12A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA13:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA14:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA5:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA6:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA9:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
HSP70s:ATP [cytosol] (Bos taurus)
HSPA12A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA13:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA14:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA5:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA6:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA9:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Hikeshi binds HSP70s:ATP (Bos taurus)
HSP70s:ATP [cytosol] (Bos taurus)
HSPA12A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA13:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA14:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA5:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA6:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA9:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Hikeshi:HSP70s:ATP [cytosol] (Bos taurus)
HSP70s:ATP [cytosol] (Bos taurus)
HSPA12A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA13:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA14:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA5:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA6:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA9:ATP [cytosol] (Bos taurus)
ATP [cytosol]
MAPKAPK2 phosphorylates HSF1 (Bos taurus)
ATP [cytosol]
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)
Hikeshi:HSP70s:ATP [cytosol] (Bos taurus)
HSP70s:ATP [cytosol] (Bos taurus)
HSPA12A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA13:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA14:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA5:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA6:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA9:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
AR binds AR agonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Bos taurus)
ATP [cytosol]
AR binds AR antagonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Bos taurus)
ATP [cytosol]
ATP binding to HSP90 triggers conformation change (Bos taurus)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
ATP hydrolysis by HSP70 (Bos taurus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Bos taurus)
ATP [cytosol]
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP70 binds to HSP40:nascent protein (Bos taurus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP70:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Bos taurus)
ATP [cytosol]
NR3C1 binds NR3C1 agonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Bos taurus)
ATP [cytosol]
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Bos taurus)
ATP [cytosol]
NR3C2 binds NR3C2 antagonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Bos taurus)
ATP [cytosol]
NR3C2:NR3C2 antagonists [cytosol] (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Bos taurus)
ATP [cytosol]
NR3C2 binds fludrocortisone (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Bos taurus)
ATP [cytosol]
NR3C2:fludrocortisone [cytosol] (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Bos taurus)
ATP [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
ATP [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Bos taurus)
ATP [cytosol]
PGR binds PGR agonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Bos taurus)
ATP [cytosol]
PGR:PGR agonists [cytosol] (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Bos taurus)
ATP [cytosol]
PGR binds PGR antagonists (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Bos taurus)
ATP [cytosol]
PGR:PGR antagonists [cytosol] (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Bos taurus)
ATP [cytosol]
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)
HSP70:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)
HSP70:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90 dimer:ATP:nascent protein [cytosol] (Bos taurus)
ATP [cytosol]
Mitochondrial unfolded protein response (UPRmt) (Bos taurus)
HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization (Bos taurus)
ATP [cytosol]
Unfolded Protein Response (UPR) (Bos taurus)
IRE1alpha activates chaperones (Bos taurus)
IRE1 dimer autophosphorylates (Bos taurus)
ATP [cytosol]
PERK regulates gene expression (Bos taurus)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)
ATP [cytosol]
DNA Replication (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Assembly of the pre-replicative complex (Bos taurus)
Assembly of the ORC complex at the origin of replication (Bos taurus)
ORC6 is phosphorylated on T195 (Bos taurus)
ATP [cytosol]
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
ATP [cytosol]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
MAPK-dependent phosphorylation of KARS (Bos taurus)
ATP [cytosol]
MARK3 phosphorylates MITF-M on S173 (Bos taurus)
ATP [cytosol]
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPH receptors autophosphorylate (Bos taurus)
ATP [cytosol]
EPH-ephrin mediated repulsion of cells (Bos taurus)
SFKs phosphorylate VAV2,3 (Bos taurus)
ATP [cytosol]
EPHB-mediated forward signaling (Bos taurus)
N-WASP binds ARP2/3 and G-actin (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
PAK1 autophosphorylates (Bos taurus)
ATP [cytosol]
p-EPHB phosphorylates SDC2 (Bos taurus)
ATP [cytosol]
Ephrin signaling (Bos taurus)
PAKs autophosphorylate (Bos taurus)
ATP [cytosol]
PAKs phosphorylate MLC (Bos taurus)
ATP [cytosol]
L1CAM interactions (Bos taurus)
Recycling pathway of L1 (Bos taurus)
Phosphorylation of L1 by ERK (Bos taurus)
ATP [cytosol]
Signal transduction by L1 (Bos taurus)
Interaction of PAK1 with Rac1-GTP (Bos taurus)
ATP [cytosol]
MAP2K1 phosphorylates MAPK3 (Bos taurus)
ATP [cytosol]
MAP2K2 phosphorylates MAPK1 (Bos taurus)
ATP [cytosol]
Netrin-1 signaling (Bos taurus)
DCC mediated attractive signaling (Bos taurus)
Phosphorylation of DCC by Fyn (Bos taurus)
ATP [cytosol]
Phosphorylation and activation of Ezrin (Bos taurus)
ATP [cytosol]
RET signaling (Bos taurus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
ATP [cytosol]
PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)
ATP [cytosol]
RET tyrosine phosphorylation (Bos taurus)
ATP [cytosol]
Reelin signalling pathway (Bos taurus)
FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)
ATP [cytosol]
Semaphorin interactions (Bos taurus)
CRMPs in Sema3A signaling (Bos taurus)
Phosphorylation of CRMPs by Cdk5 (Bos taurus)
ATP [cytosol]
Phosphorylation of CRMPs by GSK3beta (Bos taurus)
ATP [cytosol]
Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)
ATP [cytosol]
Sema3A PAK dependent Axon repulsion (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
ATP [cytosol]
Phosphorylation of LIMK-1 by PAK (Bos taurus)
ATP [cytosol]
Transphosphorylation of pLIMK1 (Bos taurus)
ATP [cytosol]
Sema4D in semaphorin signaling (Bos taurus)
Sema4D induced cell migration and growth-cone collapse (Bos taurus)
SEMA4D interacts with Plexin-B1:ErbB2 (Bos taurus)
ATP [cytosol]
Sema4D mediated inhibition of cell attachment and migration (Bos taurus)
SEMA4D interacts with Plexin-B1:Met (Bos taurus)
ATP [cytosol]
Signaling by ROBO receptors (Bos taurus)
Role of ABL in ROBO-SLIT signaling (Bos taurus)
Phosphorylation of ROBO1 by ABL kinase (Bos taurus)
ATP [cytosol]
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
ATP [cytosol]
Azathioprine ADME (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
ATP [cytosol]
GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)
ATP [cytosol]
GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Bos taurus)
ATP [cytosol]
Ciprofloxacin ADME (Bos taurus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)
ATP [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)
ATP [cytosol]
Paracetamol ADME (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
ATP [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
ATP [cytosol]
Prednisone ADME (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
ATP [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
ATP [cytosol]
ABCB1 transports xenobiotics out of the cell (Bos taurus)
ATP [cytosol]
Ribavirin ADME (Bos taurus)
ADK phosphorylates RBV (Bos taurus)
ATP [cytosol]
NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)
ATP [cytosol]
Extracellular matrix organization (Bos taurus)
Non-integrin membrane-ECM interactions (Bos taurus)
Formation of the dystrophin-glycoprotein complex (DGC) (Bos taurus)
DGC complex binds AGRN and HSPG2 (Bos taurus)
DGC complex:laminins:F-actin [plasma membrane] (Bos taurus)
F-actin (all) [cytosol] (Bos taurus)
actins:ATP [cytosol] (Bos taurus)
ATP [cytosol]
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Bos taurus)
DGC complex:laminins:F-actin [plasma membrane] (Bos taurus)
F-actin (all) [cytosol] (Bos taurus)
actins:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
ATP [cytosol]
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)
PLK2 phosphorylates CENPJ (Bos taurus)
ATP [cytosol]
PLK2 phosphorylates NPM1 (Bos taurus)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
ATP [cytosol]
Transcriptional regulation by RUNX3 (Bos taurus)
Regulation of RUNX3 expression and activity (Bos taurus)
SRC phosphorylates RUNX3 (Bos taurus)
ATP [cytosol]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
PECAM1 interactions (Bos taurus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)
ATP [cytosol]
Factors involved in megakaryocyte development and platelet production (Bos taurus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)
ATP [cytosol]
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)
ATP [cytosol]
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)
ATP [cytosol]
Kinesins (Bos taurus)
Kinesins move along microtubules consuming ATP (Bos taurus)
ATP [cytosol]
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ATP [cytosol]
GPVI-mediated activation cascade (Bos taurus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
ATP [cytosol]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
SYK autophosphorylates (Bos taurus)
ATP [cytosol]
Syk activation leads to SLP-76 activation (Bos taurus)
ATP [cytosol]
Syk/Lck phosphorylate LAT (Bos taurus)
ATP [cytosol]
Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)
ATP [cytosol]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
ATP [cytosol]
Autophosphorylation of SRC (Bos taurus)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Bos taurus)
ATP [cytosol]
SYK activation by SRC (Bos taurus)
ATP [cytosol]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
ATP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Disinhibition of SNARE formation (Bos taurus)
Phosphorylation of Platelet Sec-1 (Bos taurus)
ATP [cytosol]
Phosphorylation of Syntaxin-4 (Bos taurus)
ATP [cytosol]
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
ATP [cytosol]
Signal amplification (Bos taurus)
ADP signalling through P2Y purinoceptor 1 (Bos taurus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
ATP [cytosol]
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
FGR binds and phosphorylates LRP8 (Bos taurus)
ATP [cytosol]
Fgr may phosphorylate p38 MAPK (Bos taurus)
ATP [cytosol]
PECAM1 is phosphorylated (Bos taurus)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
ATP [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Transport of Antigen peptide in to ER (Bos taurus)
ATP [cytosol]
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
E1 mediated ubiquitin activation (Bos taurus)
ATP [cytosol]
Polyubiquitination of substrate (Bos taurus)
ATP [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
ATP [cytosol]
MHC class II antigen presentation (Bos taurus)
Transport of antigen loaded MHC II molecules to surface (Bos taurus)
ATP [cytosol]
Rap1 signalling (Bos taurus)
PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)
ATP [cytosol]
Regulation of T cell activation by CD28 family (Bos taurus)
Co-inhibition by CTLA4 (Bos taurus)
Phosphorylation of CTLA-4 (Bos taurus)
ATP [cytosol]
Co-inhibition by PD-1 (Bos taurus)
Phosphorylation of PD-1 (Bos taurus)
ATP [cytosol]
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
p-S400-Cot phosphorylates NIK (Bos taurus)
ATP [cytosol]
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Vav1 (Bos taurus)
ATP [cytosol]
Phosphorylation of CD28 (Bos taurus)
ATP [cytosol]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
ATP [cytosol]
SYK autophosphorylates at the activated BCR (Bos taurus)
ATP [cytosol]
p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
ATP [cytosol]
CD22 mediated BCR regulation (Bos taurus)
LYN phosphorylates CD22 (Bos taurus)
ATP [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
Activated IKK phosphorylates I-kappaB (Bos taurus)
ATP [cytosol]
PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)
ATP [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
ATP [cytosol]
Activation of TAK1-TAB2 complex (Bos taurus)
ATP [cytosol]
Change of PKC theta conformation (Bos taurus)
ATP [cytosol]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phosphorylation of Bcl10 (Bos taurus)
ATP [cytosol]
Phosphorylation of CARMA1 (Bos taurus)
ATP [cytosol]
Phosphorylation of PKC theta (Bos taurus)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ATP [cytosol]
Generation of second messenger molecules (Bos taurus)
Phosphorylation of PLC-gamma1 (Bos taurus)
ATP [cytosol]
Phosphorylation of SLP-76 (Bos taurus)
ATP [cytosol]
Phosphorylation of TBSMs in LAT (Bos taurus)
ATP [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Activation of Lck (Bos taurus)
ATP [cytosol]
Inactivation of Lck by Csk (Bos taurus)
ATP [cytosol]
Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
ATP [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
Activation of ZAP-70 (Bos taurus)
ATP [cytosol]
Phosphorylation of ZAP-70 by Lck (Bos taurus)
ATP [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3 phosphorylates CDKN1B (Bos taurus)
ATP [cytosol]
FLT3 phosphorylates GRB10 (Bos taurus)
ATP [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
ATP [cytosol]
Negative regulation of FLT3 (Bos taurus)
FLT3 phosphorylates CBL (Bos taurus)
ATP [cytosol]
Growth hormone receptor signaling (Bos taurus)
Lyn activates ERK (Bos taurus)
ATP [cytosol]
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
ISG15 antiviral mechanism (Bos taurus)
Activation of ISG15 by UBA7 E1 ligase (Bos taurus)
ATP [cytosol]
ISGylation of E2 conjugating enzymes (Bos taurus)
ATP [cytosol]
ISGylation of IRF3 (Bos taurus)
ATP [cytosol]
ISGylation of host protein filamin B (Bos taurus)
ATP [cytosol]
ISGylation of host proteins (Bos taurus)
ATP [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)
ATP [cytosol]
OAS antiviral response (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
ATP [cytosol]
2'-5' oligoadenylate [cytosol] (Homo sapiens)
ATP [cytosol]
RNASEL cleaves cellular ssRNA (Bos taurus)
RNASEL:2'-5' oligoadenylate [cytosol] (Bos taurus)
2'-5' oligoadenylate [cytosol] (Homo sapiens)
ATP [cytosol]
PKR-mediated signaling (Bos taurus)
ISGylation of PKR (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates CDK1 (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates DHX9 (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates ILF3:ILF2 (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates MKK6 (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates PPP2R5A (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates PTPN2 (Bos taurus)
ATP [cytosol]
p-PKR dimer phosphorylates SNCA (Bos taurus)
ATP [cytosol]
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
ATP [cytosol]
Formation of p-STAT1 homodimer (Bos taurus)
ATP [cytosol]
Phosphorylation of INFAR1 by TYK2 (Bos taurus)
ATP [cytosol]
Phosphorylation of STAT2 (Bos taurus)
ATP [cytosol]
Interferon gamma signaling (Bos taurus)
IFNG signaling activates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
ATP [cytosol]
JAK1-mediated phosphorylation of RAF1 (Bos taurus)
ATP [cytosol]
JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)
ATP [cytosol]
Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)
ATP [cytosol]
Phosphorylation of JAK2 (Bos taurus)
ATP [cytosol]
Phosphorylation of STAT1 at Ser727 (Bos taurus)
ATP [cytosol]
Phosphorylation of STAT1 by JAK kinases (Bos taurus)
ATP [cytosol]
Transphosphorylation of JAK1 (Bos taurus)
ATP [cytosol]
Modulation of host responses by IFN-stimulated genes (Bos taurus)
ISGylation of DDX58 (RIG-I) (Bos taurus)
ATP [cytosol]
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
ATP [cytosol]
IRAK4 is activated by autophosphorylation (Bos taurus)
ATP [cytosol]
IRAK4 phosphorylates IRAK1 (Bos taurus)
ATP [cytosol]
IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
TAK1 phosphorylates MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2 (Bos taurus)
ATP [cytosol]
Interleukin-37 signaling (Bos taurus)
STAT3 phosphorylation (Bos taurus)
ATP [cytosol]
TBK1 phosphorylation (Bos taurus)
ATP [cytosol]
Interleukin-38 signaling (Bos taurus)
MAPK8 phosphorylation (Bos taurus)
ATP [cytosol]
Interleukin-10 signaling (Bos taurus)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)
ATP [cytosol]
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)
ATP [cytosol]
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)
ATP [cytosol]
Interleukin-12 family signaling (Bos taurus)
Interleukin-12 signaling (Bos taurus)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Bos taurus)
ATP [cytosol]
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Bos taurus)
ATP [cytosol]
Interleukin-23 signaling (Bos taurus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)
ATP [cytosol]
Interleukin-27 signaling (Bos taurus)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)
ATP [cytosol]
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
ATP [cytosol]
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)
ATP [cytosol]
Interleukin-35 Signalling (Bos taurus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Bos taurus)
ATP [cytosol]
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Bos taurus)
ATP [cytosol]
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)
ATP [cytosol]
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)
ATP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
ATP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)
ATP [cytosol]
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Bos taurus)
ATP [cytosol]
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)
ATP [cytosol]
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ATP [cytosol]
Interleukin-15 signaling (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)
ATP [cytosol]
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)
ATP [cytosol]
Interleukin-2 signaling (Bos taurus)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)
ATP [cytosol]
Recruited STAT5 is phosphorylated (Bos taurus)
ATP [cytosol]
SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)
ATP [cytosol]
SYK is a substrate for JAK1 (Bos taurus)
ATP [cytosol]
Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)
ATP [cytosol]
Interleukin-21 signaling (Bos taurus)
IL21 receptor JAK phosphorylation (Bos taurus)
ATP [cytosol]
IL21 receptor STAT phosphorylation (Bos taurus)
ATP [cytosol]
Interleukin-9 signaling (Bos taurus)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)
ATP [cytosol]
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)
ATP [cytosol]
IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)
ATP [cytosol]
Interleukin-20 family signaling (Bos taurus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
ATP [cytosol]
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)
ATP [cytosol]
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)
ATP [cytosol]
IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ATP [cytosol]
IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)
ATP [cytosol]
IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
ATP [cytosol]
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)
ATP [cytosol]
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)
ATP [cytosol]
IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ATP [cytosol]
IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Bos taurus)
ATP [cytosol]
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)
ATP [cytosol]
JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)
ATP [cytosol]
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Activation of STAT5a/b by JAK2 (Bos taurus)
ATP [cytosol]
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ATP [cytosol]
JAK2 is phosphorylated, activated (Bos taurus)
ATP [cytosol]
Tyrosine kinases phosphorylate the receptor (Bos taurus)
ATP [cytosol]
Interleukin-4 and Interleukin-13 signaling (Bos taurus)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)
ATP [cytosol]
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)
ATP [cytosol]
JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
ATP [cytosol]
STAT1,STAT3,STAT6 phosphorylation (Bos taurus)
ATP [cytosol]
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
IL6ST is tyrosine phosphorylated (Bos taurus)
ATP [cytosol]
JAK activation (Bos taurus)
ATP [cytosol]
PTPN11 is phosphorylated (Bos taurus)
ATP [cytosol]
Serine phosphorylation of STATs (Bos taurus)
ATP [cytosol]
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
ATP [cytosol]
Interleukin-7 signaling (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)
ATP [cytosol]
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)
ATP [cytosol]
STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)
ATP [cytosol]
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
ATP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ATP [cytosol]
NIK autophosphorylates on T559 (Bos taurus)
ATP [cytosol]
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1 phosphorylates TIFA (Bos taurus)
ATP [cytosol]
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
ATP [cytosol]
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
ATP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ATP [cytosol]
K63polyUb-TAK1 autophosphorylates (Bos taurus)
ATP [cytosol]
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)
ATP [cytosol]
PKC-delta phosphorylates CARD9 (Bos taurus)
ATP [cytosol]
SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ATP [cytosol]
Dectin-2 family (Bos taurus)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)
ATP [cytosol]
SYK autophosphorylates (Bos taurus)
ATP [cytosol]
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)
ATP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
IRF3 is phosphorylated by TBK1 (Bos taurus)
ATP [cytosol]
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
ATP [cytosol]
STAT6-mediated induction of chemokines (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
ATP [cytosol]
TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)
ATP [cytosol]
p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)
ATP [cytosol]
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
RIP-mediated NFkB activation via ZBP1 (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
ATP [cytosol]
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated NF-kB activation (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Autophosphorylation of LYN kinase (Bos taurus)
ATP [cytosol]
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
ATP [cytosol]
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
ATP [cytosol]
FCERI mediated MAPK activation (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
ATP [cytosol]
Phosphorylation and activation of VAV (Bos taurus)
ATP [cytosol]
Phosphorylation of MEK4 by MEKK1 (Bos taurus)
ATP [cytosol]
Phosphorylation of SHC by SYK kinase (Bos taurus)
ATP [cytosol]
Phosphorylation of SLP-76 by p-SYK (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
FCERI mediated NF-kB activation (Bos taurus)
Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)
ATP [cytosol]
Autophosphorylation of PKC-theta (Bos taurus)
ATP [cytosol]
Phosphorylation of CARMA1 by PKC-theta (Bos taurus)
ATP [cytosol]
Phosphorylation of IKK-beta by TAK1 (Bos taurus)
ATP [cytosol]
Phosphorylation of PKC-theta (Bos taurus)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ATP [cytosol]
Phosphorylation of LAT by p-SYK (Bos taurus)
ATP [cytosol]
Phosphorylation of beta and gamma subunits by LYN (Bos taurus)
ATP [cytosol]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)
ATP [cytosol]
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
ATP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
FCGR activation (Bos taurus)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Bos taurus)
ATP [cytosol]
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
ABL phosphorylates WAVEs (Bos taurus)
ATP [cytosol]
Autophosphorylation of PAK1 (Bos taurus)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)
ATP [cytosol]
Actin filament bound Myosin-X [plasma membrane] (Bos taurus)
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
PAK1 phosphorylates LIMK1 (Bos taurus)
ATP [cytosol]
Phosphorylation of VAV (Bos taurus)
ATP [cytosol]
Role of myosins in phagosome formation (Bos taurus)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Myosin-Actin filaments [cytosol] (Bos taurus)
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Bos taurus)
ATP [cytosol]
Transphosphorylation of pLIMK1 (Bos taurus)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
ATP [cytosol]
Role of phospholipids in phagocytosis (Bos taurus)
DAG stimulates protein kinase C-delta (Bos taurus)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phosphorylation and activation of PLCG (Bos taurus)
ATP [cytosol]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
Inflammasomes (Bos taurus)
The NLRP1 inflammasome (Bos taurus)
MDP:NLRP1 binds ATP (Bos taurus)
ATP [cytosol]
MDP:NLRP1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
NLRP1 oligomerizes (Bos taurus)
MDP:NLRP1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
MDP:NLRP1:ATP oligomer [cytosol] (Bos taurus)
MDP:NLRP1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
NOD1/2 Signaling Pathway (Bos taurus)
Activation of p38 MAPK (Bos taurus)
ATP [cytosol]
TAK1 phosphorylates MKK6 (Bos taurus)
ATP [cytosol]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Bos taurus)
ATP [cytosol]
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Bos taurus)
ATP [cytosol]
TBK1 is phosphorylated within the activated TLR4 complex (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
ATP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
SLC15A4:TASL-dependent IRF5 activation (Bos taurus)
TASL is phosphorylated (Bos taurus)
ATP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Bos taurus)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
ATP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ATP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
ATP [cytosol]
SLC15A4:TASL-dependent IRF5 activation (Bos taurus)
TASL is phosphorylated (Bos taurus)
ATP [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Mitochondrial Uncoupling (Bos taurus)
UCP1 imports a proton (Bos taurus)
Purine nucleotide [cytosol]
ATP [cytosol]
Pyruvate metabolism (Bos taurus)
PKM dephosphorylates PEP to PYR (Bos taurus)
ATP [cytosol]
Regulation of pyruvate metabolism (Bos taurus)
NEK1 phosphorylates ME1 (Bos taurus)
ATP [cytosol]
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Ethanol oxidation (Bos taurus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)
ATP [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
ATP [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
ATP [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Bos taurus)
ATP [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
ATP [cytosol]
Methylation (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
ATP [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
ATP [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)
ATP [cytosol]
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
ATP [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
ATP [cytosol]
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
ATP [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)
ATP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ATP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ATP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)
ATP [cytosol]
I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)
ATP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)
ATP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ATP [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Free fatty acids regulate insulin secretion (Bos taurus)
Intracellular metabolism of fatty acids regulates insulin secretion (Bos taurus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)
ATP [cytosol]
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
ATP [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
ATP [cytosol]
Creatine metabolism (Bos taurus)
creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)
ATP [cytosol]
creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)
ATP [cytosol]
Glutamate and glutamine metabolism (Bos taurus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
ATP [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ATP [cytosol]
Histidine catabolism (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
ATP [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
ATP [cytosol]
Serine biosynthesis (Bos taurus)
PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)
ATP [cytosol]
PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)
ATP [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
ATP [cytosol]
Urea cycle (Bos taurus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
ATP [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
XYLB phosphorylates D-xylulose (Bos taurus)
ATP [cytosol]
Fructose metabolism (Bos taurus)
Fructose catabolism (Bos taurus)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)
ATP [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)
ATP [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
ATP [cytosol]
Galactose catabolism (Bos taurus)
GALK1 phosphorylates Gal to Gal1P (Bos taurus)
ATP [cytosol]
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Bos taurus)
ATP [cytosol]
Glycolysis (Bos taurus)
1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)
ATP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
ATP [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)
ATP [cytosol]
PKM dephosphorylates PEP to PYR (Bos taurus)
ATP [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)
ATP [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen breakdown (glycogenolysis) (Bos taurus)
PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)
ATP [cytosol]
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)
ATP [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)
ATP [cytosol]
Glycosaminoglycan metabolism (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
ATP [cytosol]
Pentose phosphate pathway (Bos taurus)
5-Phosphoribose 1-diphosphate biosynthesis (Bos taurus)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)
ATP [cytosol]
RBKS phosphorylates ribose to R5P (Bos taurus)
ATP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
ATP [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
ATP [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Bos taurus)
ATP [cytosol]
Carnitine shuttle (Bos taurus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
ATP [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
ATP [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
ATP [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)
ATP [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Bos taurus)
ATP [cytosol]
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)
ATP [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
ATP [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
ATP [cytosol]
Peroxisomal lipid metabolism (Bos taurus)
Alpha-oxidation of phytanate (Bos taurus)
PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)
ATP [cytosol]
Beta-oxidation of very long chain fatty acids (Bos taurus)
Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)
ATP [cytosol]
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
ATP [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
ATP [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
ATP [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
ATP [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
ATP [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
ATP [cytosol]
Cholesterol biosynthesis (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ATP [cytosol]
Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)
ATP [cytosol]
Mevalonate-5-phosphate is further phosphorylated (Bos taurus)
ATP [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
Casein kinase II phosphorylates STARD10 (Bos taurus)
ATP [cytosol]
Cho is phosphorylated to PCho by CHK dimer (Bos taurus)
ATP [cytosol]
Synthesis of PE (Bos taurus)
ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)
ATP [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the ER membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)
ATP [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Bos taurus)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)
ATP [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
ATP [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
ATP [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
BMX phosphorylates RUFY1 (Bos taurus)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)
ATP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)
ATP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
ATP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
ATP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)
ATP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ATP [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid biosynthesis (Bos taurus)
CERK phosphorylates CERA to form C1P (Bos taurus)
ATP [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
ATP [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Bos taurus)
ATP [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)
ATP [cytosol]
SPHK1 phosphorylates sphingoid (Bos taurus)
ATP [cytosol]
SPHK2 phosphorylates sphingoid (Bos taurus)
ATP [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)
ATP [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
ATP [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)
ATP [cytosol]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)
ATP [cytosol]
(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)
ATP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)
ATP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)
ATP [cytosol]
(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)
ATP [cytosol]
(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)
ATP [cytosol]
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)
ATP [cytosol]
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)
ATP [cytosol]
ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)
ATP [cytosol]
AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
ATP [cytosol]
AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)
ATP [cytosol]
NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Bos taurus)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
ATP [cytosol]
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)
ATP [cytosol]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)
ATP [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
ATP [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
ATP [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
ATP [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
ATP [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
ATP [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer transforms L-Gln to CAP (Bos taurus)
ATP [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)
ATP [cytosol]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)
ATP [cytosol]
Pyrimidine salvage (Bos taurus)
(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)
ATP [cytosol]
UCKL1 phosphorylates urindine, cytidine (Bos taurus)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)
ATP [cytosol]
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)
ATP [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
ATP [cytosol]
Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)
ATP [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Biotin transport and metabolism (Bos taurus)
HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)
ATP [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)
ATP [cytosol]
HLCS biotinylates ACACA:Mn2+ (Bos taurus)
ATP [cytosol]
HLCS biotinylates ACACB (Bos taurus)
ATP [cytosol]
HLCS biotinylates PC:Mn2+ (Bos taurus)
ATP [cytosol]
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Transport of RCbl within the body (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
ATP [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
ATP [cytosol]
Uptake of dietary cobalamins into enterocytes (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
ATP [cytosol]
Metabolism of folate and pterines (Bos taurus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
ATP [cytosol]
FPGS-2 transforms THF to THFPG (Bos taurus)
ATP [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
ATP [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
ATP [cytosol]
Molybdenum cofactor biosynthesis (Bos taurus)
Molybdenum ion transfer onto molybdopterin (Bos taurus)
ATP [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
ATP [cytosol]
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)
ATP [cytosol]
NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
ATP [cytosol]
NMRK1 phosphorylates NR to yield NMN (Bos taurus)
ATP [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
ATP [cytosol]
NMRK2 phosphorylates NR to yield NMN (Bos taurus)
ATP [cytosol]
Vitamin B1 (thiamin) metabolism (Bos taurus)
2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)
ATP [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
FLAD1 phosphorylates FMN (Bos taurus)
ATP [cytosol]
RFK:Mg2+ phosphorylates RIB (Bos taurus)
ATP [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
2xPPCS ligates PPanK with Cys (Bos taurus)
ATP [cytosol]
COASY phosphorylates DP-CoA (Bos taurus)
ATP [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
ATP [cytosol]
DCAKD phosphorylates DP-CoA (Bos taurus)
ATP [cytosol]
PANK1/3 phosphorylate PanK (Bos taurus)
ATP [cytosol]
PANK2 phosphorylates PanK (Bos taurus)
ATP [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)
ATP [cytosol]
Metabolism of RNA (Bos taurus)
Nonsense-Mediated Decay (NMD) (Bos taurus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
ATP [cytosol]
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates BRF1 (Bos taurus)
ATP [cytosol]
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)
ATP [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)
ATP [cytosol]
Sialic acid metabolism (Bos taurus)
GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
ATP [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ATP [cytosol]
Synthesis of GDP-mannose (Bos taurus)
HK1 phosphorylates Mannose to Man6P (Bos taurus)
ATP [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
ATP [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
GBF1 stimulates ARF nucleotide exchange (Bos taurus)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
ATP [cytosol]
COPII-mediated vesicle transport (Bos taurus)
CSNK1D phosphorylates SEC23 (Bos taurus)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
ATP [cytosol]
Carboxyterminal post-translational modifications of tubulin (Bos taurus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)
ATP [cytosol]
TTLLs polyglutamylate tubulin (Bos taurus)
ATP [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)
ATP [cytosol]
Synthesis of diphthamide-EEF2 (Bos taurus)
DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)
ATP [cytosol]
Neddylation (Bos taurus)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)
ATP [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)
ATP [cytosol]
Protein ubiquitination (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
ATP [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
ATP [cytosol]
Protein folding (Bos taurus)
Chaperonin-mediated protein folding (Bos taurus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Bos taurus)
ATP binds G-protein beta associated TRiC/CCT (Bos taurus)
ATP [cytosol]
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Bos taurus)
CCT/TriC:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Bos taurus)
CCT/TriC:ATP [cytosol] (Bos taurus)
ATP [cytosol]
CK2 phosphorylates PDCL (Bos taurus)
ATP [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ATP [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Bos taurus)
Ribosomal scanning and start codon recognition (Bos taurus)
Ribosomal scanning (Bos taurus)
ATP [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
ATP [cytosol]
PRKACA phosphorylates PLN (Bos taurus)
ATP [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)
ATP [cytosol]
Smooth Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Bos taurus)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Bos taurus)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Calcium Binds Caldesmon (Bos taurus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Inactive Myosin Actin Contractile Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Myosin Binds ATP (Bos taurus)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Bos taurus)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)
ATP [cytosol]
Release Of ADP From Myosin (Bos taurus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Bos taurus)
(ACTA2,ACTG2):ATP [cytosol] (Bos taurus)
ATP [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ATP Bound Myosin Complex [cytosol] (Bos taurus)
ATP [cytosol]
Myosin Binds ATP (Bos taurus)
ATP [cytosol]
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ATP Bound Myosin Complex [cytosol] (Bos taurus)
ATP [cytosol]
Neuronal System (Bos taurus)
Potassium Channels (Bos taurus)
Inwardly rectifying K+ channels (Bos taurus)
ATP sensitive Potassium channels (Bos taurus)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)
ATP [cytosol]
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
Activation of RAC1 downstream of NMDARs (Bos taurus)
CaMKK autophosphorylates in the cytosol (Bos taurus)
ATP [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
Trafficking of AMPA receptors (Bos taurus)
Trafficking of GluR1-containing AMPA receptors (Bos taurus)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors (Bos taurus)
Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)
ATP [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ATP [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Dependence Receptors in the absence of ligand (Bos taurus)
Activation of caspase-3 (Bos taurus)
ATP [cytosol]
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BIM and translocation to mitochondria (Bos taurus)
Phosphorylation of BIM by JNK (Bos taurus)
ATP [cytosol]
Activation of BMF and translocation to mitochondria (Bos taurus)
Phosphorylation of DLC2 by MAPK8 (Bos taurus)
ATP [cytosol]
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Activation of caspases through apoptosome-mediated cleavage (Bos taurus)
Cleavage of Procaspase-3 by the apoptosome (Bos taurus)
ATP [cytosol]
Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
ATP [cytosol]
Formation of apoptosome (Bos taurus)
CYCS binds to APAF1 (Bos taurus)
ATP [cytosol]
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
CYCS:APAF1 binds procaspase-9 (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Procaspase 9 forms dimer (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Regulation of the apoptosome activity (Bos taurus)
APAF1:CYCS binds APIP (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
APAF1:CYCS:ATP:APIP [cytosol] (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
CASP9 is phosphorylated at T412 (Bos taurus)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:p-T412-CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
RIPK1 is phosphorylated (Bos taurus)
ATP [cytosol]
RIPK3 is phosphorylated (Bos taurus)
ATP [cytosol]
RIPK3 phosphorylates MLKL (Bos taurus)
ATP [cytosol]
Regulation of necroptotic cell death (Bos taurus)
ATP binds MLKL (Bos taurus)
ATP [cytosol]
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Bos taurus)
MLKL:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Protein localization (Bos taurus)
Peroxisomal protein import (Bos taurus)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)
ATP [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
ABCA4 mediates atRAL transport (Bos taurus)
ATP [cytosol]
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)
ATP [cytosol]
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)
ATP [cytosol]
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
ATP [cytosol]
MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)
ATP [cytosol]
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
ATP [cytosol]
ULK1 phosphorylates RIPK1 at S357 (Bos taurus)
ATP [cytosol]
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
GTP-bound RAC contributes to JNK activation (Bos taurus)
ATP [cytosol]
JNK phosphorylates BIM, BAD and other targets (Bos taurus)
ATP [cytosol]
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta is activated (Bos taurus)
ATP [cytosol]
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
ATP [cytosol]
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
ATP [cytosol]
Autophosphorylation of SRC (Bos taurus)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Bos taurus)
ATP [cytosol]
SYK activation by SRC (Bos taurus)
ATP [cytosol]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
ATP [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
ATP [cytosol]
PKC phosphorylates GRK2 (Bos taurus)
ATP [cytosol]
DAG stimulates protein kinase C-delta (Bos taurus)
ATP [cytosol]
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)
ATP [cytosol]
MAPKs phosphorylate PP2A (Bos taurus)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
PTEN Regulation (Bos taurus)
Regulation of PTEN gene transcription (Bos taurus)
mTORC1 phosphorylates MAF1 (Bos taurus)
ATP [cytosol]
Regulation of PTEN stability and activity (Bos taurus)
Casein kinase II phosphorylates PTEN (Bos taurus)
ATP [cytosol]
FRK phosphorylates PTEN (Bos taurus)
ATP [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
ATP [cytosol]
MAPK3 (ERK1) activation (Bos taurus)
Inactivation of MAP2K1 by CDK1 (Bos taurus)
ATP [cytosol]
MAP2K1 phosphorylates MAPK3 (Bos taurus)
ATP [cytosol]
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
ATP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
ATP [cytosol]
MAP2Ks phosphorylate MAPKs (Bos taurus)
ATP [cytosol]
RAF phosphorylates MAP2K dimer (Bos taurus)
ATP [cytosol]
Negative regulation of MAPK pathway (Bos taurus)
MAPK12 phosphorylates PTPN3 (Bos taurus)
ATP [cytosol]
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPKs phosphorylate BRAF (Bos taurus)
ATP [cytosol]
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
ATP [cytosol]
RAF activation (Bos taurus)
MARK3 phosphorylates KSR1 (Bos taurus)
ATP [cytosol]
Phosphorylation of RAF (Bos taurus)
ATP [cytosol]
RAS processing (Bos taurus)
KRAS4B is phosphorylated on serine 181 (Bos taurus)
ATP [cytosol]
MAPK6/MAPK4 signaling (Bos taurus)
Autophosphorylation of PAK1,2,3 (Bos taurus)
ATP [cytosol]
PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)
ATP [cytosol]
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Bos taurus)
ATP [cytosol]
p-S MAPKAPK5 phosphorylates HSPB1 (Bos taurus)
ATP [cytosol]
p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)
ATP [cytosol]
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)
ATP [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
ATP [cytosol]
Activation of cytosolic AMPK by phosphorylation (Bos taurus)
ATP [cytosol]
p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
ATP [cytosol]
Inhibition of TSC complex formation by PKB (Bos taurus)
Phosphorylation of TSC2 by PKB (Bos taurus)
ATP [cytosol]
Phosphorylation of complexed TSC2 by PKB (Bos taurus)
ATP [cytosol]
mTORC1 phosphorylates AKT1S1 (Bos taurus)
ATP [cytosol]
mTORC1-mediated signalling (Bos taurus)
Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)
ATP [cytosol]
Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)
ATP [cytosol]
Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)
ATP [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
ATP [cytosol]
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)
ATP [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
ATP [cytosol]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
ATP [cytosol]
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)
ATP [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Bos taurus)
ATP [cytosol]
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)
ATP [cytosol]
PKA phosphorylates PDE4B (Bos taurus)
ATP [cytosol]
G-protein mediated events (Bos taurus)
Adenylate cyclase activating pathway (Bos taurus)
Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)
ATP [cytosol]
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
ATP [cytosol]
PKC phosphorylates GRK2 (Bos taurus)
ATP [cytosol]
phospho-PLA2 pathway (Bos taurus)
Phosphorylation of cPLA2 by ERK-2 (Bos taurus)
ATP [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ATP [cytosol]
G alpha (s) signalling events (Bos taurus)
ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)
ATP [cytosol]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
CK1 phosphorylates p-GLI3 (Bos taurus)
ATP [cytosol]
GSK3 phosphorylates p-GLI3 (Bos taurus)
ATP [cytosol]
PKA phosphorylates GLI3 (Bos taurus)
ATP [cytosol]
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)
ATP [cytosol]
Hedgehog ligand biogenesis (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
ATP [cytosol]
Signaling by Hippo (Bos taurus)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Bos taurus)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Bos taurus)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)
ATP [cytosol]
Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Bos taurus)
ATP [cytosol]
Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)
ATP [cytosol]
Phosphorylation of YAP by LATS1 (Bos taurus)
ATP [cytosol]
Phosphorylation of YAP by LATS2 (Bos taurus)
ATP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
ATP [cytosol]
PTK6 Activates STAT3 (Bos taurus)
PTK6 phosphorylates STAP2 (Bos taurus)
ATP [cytosol]
PTK6 phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
PTK6 Down-Regulation (Bos taurus)
SRMS phosphorylates PTK6 (Bos taurus)
ATP [cytosol]
PTK6 Regulates Cell Cycle (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ATP [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
PTK6 phosphorylates ARHGAP35 (Bos taurus)
ATP [cytosol]
PTK6 phosphorylates BCAR1 (Bos taurus)
ATP [cytosol]
PTK6 phosphorylates PXN (Bos taurus)
ATP [cytosol]
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Bos taurus)
PTK6 phosphorylates ARAP1 (Bos taurus)
ATP [cytosol]
PTK6 phosphorylates CBL (Bos taurus)
ATP [cytosol]
PTK6 phosphorylates DOK1 (Bos taurus)
ATP [cytosol]
PTK6 promotes HIF1A stabilization (Bos taurus)
EGFR phosphorylates GPNMB (Bos taurus)
ATP [cytosol]
LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)
ATP [cytosol]
LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Bos taurus)
ATP [cytosol]
LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)
ATP [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
ESR-associated SRC autophosphorylates (Bos taurus)
ATP [cytosol]
Estrogen-stimulated signaling through PRKCZ (Bos taurus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
ATP [cytosol]
PTK2 autophosphorylates downstream of EGFR (Bos taurus)
ATP [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ATP [cytosol]
Active ALK phosphorylates IRS1 (Bos taurus)
ATP [cytosol]
Active ALK phosphorylates JAK3 (Bos taurus)
ATP [cytosol]
Active ALK phosphorylates PLCG1 (Bos taurus)
ATP [cytosol]
Active ALK phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
ATP [cytosol]
Signaling by EGFR (Bos taurus)
EGFR autophosphorylation (Bos taurus)
ATP [cytosol]
EGFR downregulation (Bos taurus)
EGFR phosphorylates EPS15 (Bos taurus)
ATP [cytosol]
Phosphorylation of CBL (EGFR:CBL) (Bos taurus)
ATP [cytosol]
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
ATP [cytosol]
EGFR interacts with phospholipase C-gamma (Bos taurus)
EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
ATP [cytosol]
GAB1 signalosome (Bos taurus)
GAB1 phosphorylation by EGFR kinase (Bos taurus)
ATP [cytosol]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
ATP [cytosol]
Phosphorylation of EGFR by SRC kinase (Bos taurus)
ATP [cytosol]
SHC1 events in EGFR signaling (Bos taurus)
SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
ATP [cytosol]
Signaling by ERBB2 (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
ATP [cytosol]
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
ATP [cytosol]
SHC1 events in ERBB2 signaling (Bos taurus)
SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)
ATP [cytosol]
SRC family kinases phosphorylate ERBB2 (Bos taurus)
ATP [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)
ATP [cytosol]
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)
ATP [cytosol]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
ATP [cytosol]
SHC1 events in ERBB4 signaling (Bos taurus)
Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)
ATP [cytosol]
Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)
ATP [cytosol]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1 phosphorylates FRS2 (Bos taurus)
ATP [cytosol]
Activated FGFR1 phosphorylates FRS3 (Bos taurus)
ATP [cytosol]
Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)
ATP [cytosol]
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
ATP [cytosol]
SHC-mediated cascade:FGFR1 (Bos taurus)
Activated FGFR1 phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
FGFR1 ligand binding and activation (Bos taurus)
FGFR1b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR1b (Bos taurus)
ATP [cytosol]
FGFR1c and Klotho ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)
ATP [cytosol]
FGFR1c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR1c (Bos taurus)
ATP [cytosol]
Negative regulation of FGFR1 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Bos taurus)
ATP [cytosol]
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ATP [cytosol]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2 phosphorylates FRS2 (Bos taurus)
ATP [cytosol]
Activated FGFR2 phosphorylates FRS3 (Bos taurus)
ATP [cytosol]
Activated FGFR2 phosphorylates PPTN11 (Bos taurus)
ATP [cytosol]
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
ATP [cytosol]
SHC-mediated cascade:FGFR2 (Bos taurus)
Activated FGFR2 phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
FGFR2 ligand binding and activation (Bos taurus)
FGFR2b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR2b (Bos taurus)
ATP [cytosol]
FGFR2c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR2c (Bos taurus)
ATP [cytosol]
Negative regulation of FGFR2 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
ATP [cytosol]
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ATP [cytosol]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3 phosphorylates FRS2 (Bos taurus)
ATP [cytosol]
Activated FGFR3 phosphorylates FRS3 (Bos taurus)
ATP [cytosol]
Activated FGFR3 phosphorylates PPTN11 (Bos taurus)
ATP [cytosol]
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
ATP [cytosol]
SHC-mediated cascade:FGFR3 (Bos taurus)
Activated FGFR3 phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
FGFR3 ligand binding and activation (Bos taurus)
FGFR3b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR3b (Bos taurus)
ATP [cytosol]
FGFR3c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR3c (Bos taurus)
ATP [cytosol]
Negative regulation of FGFR3 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Bos taurus)
ATP [cytosol]
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ATP [cytosol]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 phosphorylates FRS2 (Bos taurus)
ATP [cytosol]
Activated FGFR4 phosphorylates FRS3 (Bos taurus)
ATP [cytosol]
Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
ATP [cytosol]
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
ATP [cytosol]
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4 phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
FGFR4 ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR4 (Bos taurus)
ATP [cytosol]
betaKlotho-mediated ligand binding (Bos taurus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)
ATP [cytosol]
Negative regulation of FGFR4 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Bos taurus)
ATP [cytosol]
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ATP [cytosol]
Signaling by Insulin receptor (Bos taurus)
Autophosphorylation of insulin receptor (Bos taurus)
ATP [cytosol]
Insulin receptor signalling cascade (Bos taurus)
IRS activation (Bos taurus)
Phosphorylation of IRS (Bos taurus)
ATP [cytosol]
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
PDPK1 phosphorylates AKT2 (Bos taurus)
ATP [cytosol]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phosphorylation of SHC1 (Bos taurus)
ATP [cytosol]
Signal attenuation (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
ATP [cytosol]
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
ATP [cytosol]
Signaling by MET (Bos taurus)
MET Receptor Activation (Bos taurus)
MET dimers autophosphorylate (Bos taurus)
ATP [cytosol]
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
ATP [cytosol]
MET phosphorylates GAB1 (Bos taurus)
ATP [cytosol]
MET activates RAS signaling (Bos taurus)
MET phosphorylates SHC1-2 (Bos taurus)
ATP [cytosol]
MET activates STAT3 (Bos taurus)
MET phosphorylates STAT3 (Bos taurus)
ATP [cytosol]
MET promotes cell motility (Bos taurus)
MET activates PTK2 signaling (Bos taurus)
MET phosphorylates PTK2 (Bos taurus)
ATP [cytosol]
PTK2 autophosphorylates (Bos taurus)
ATP [cytosol]
SRC phosphorylates PTK2 (Bos taurus)
ATP [cytosol]
Negative regulation of MET activity (Bos taurus)
MET phosphorylates CBL (Bos taurus)
ATP [cytosol]
Signaling by MST1 (Bos taurus)
MST1R autophosphorylates (Bos taurus)
ATP [cytosol]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
ATP [cytosol]
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
ARMS-mediated activation (Bos taurus)
ARMS is phosphorylated by active TrkA receptor (Bos taurus)
ATP [cytosol]
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
ATP [cytosol]
BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)
ATP [cytosol]
FRS2 is phosphorylated by active TrkA receptor (Bos taurus)
ATP [cytosol]
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
ATP [cytosol]
Signalling to RAS (Bos taurus)
p38MAPK events (Bos taurus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
ATP [cytosol]
Signaling by NTRK3 (TRKC) (Bos taurus)
Activated NTRK3 signals through PI3K (Bos taurus)
Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)
ATP [cytosol]
NTF3 activates NTRK3 signaling (Bos taurus)
NTRK3 dimers trans-autophosphorylate (Bos taurus)
ATP [cytosol]
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
ATP [cytosol]
Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)
ATP [cytosol]
Autophosphorylation of PDGF beta receptors (Bos taurus)
ATP [cytosol]
Downstream signal transduction (Bos taurus)
Activation of Src (Bos taurus)
ATP [cytosol]
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
ATP [cytosol]
Signaling by SCF-KIT (Bos taurus)
Autophosphorylation of KIT (Bos taurus)
ATP [cytosol]
Phosphorylation and activation of VAV1 (Bos taurus)
ATP [cytosol]
Phosphorylation of GAB2 by SFKs (Bos taurus)
ATP [cytosol]
Phosphorylation of JAK2 (Bos taurus)
ATP [cytosol]
Phosphorylation of SHP2 by SFKs (Bos taurus)
ATP [cytosol]
Phosphorylation of STATs (Bos taurus)
ATP [cytosol]
Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
ATP [cytosol]
Regulation of KIT signaling (Bos taurus)
Phosphorylation of APS (Bos taurus)
ATP [cytosol]
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
ATP [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1,2:IGF1R autophosphorylates (Bos taurus)
ATP [cytosol]
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)
ATP [cytosol]
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
PDPK1 phosphorylates AKT2 (Bos taurus)
ATP [cytosol]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
SHC-related events triggered by IGF1R (Bos taurus)
IGF1R phosphorylates SHC1 (Bos taurus)
ATP [cytosol]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
AXL autophosphorylates on Y779 and Y821 (Bos taurus)
ATP [cytosol]
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)
ATP [cytosol]
FYN autophosphorylates (Bos taurus)
ATP [cytosol]
FYN phosphorylates PAK2 (Bos taurus)
ATP [cytosol]
PAK2 autophorylates (Bos taurus)
ATP [cytosol]
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)
ATP [cytosol]
PTK2 autophosphorylates (Bos taurus)
ATP [cytosol]
Phosphorylation of SRC-1 (Bos taurus)
ATP [cytosol]
SRC-1 phosphorylates PTK2-beta (Bos taurus)
ATP [cytosol]
SRC-1 phosphorylates SHB (Bos taurus)
ATP [cytosol]
SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)
ATP [cytosol]
Src kinases phosphorylate VAV (Bos taurus)
ATP [cytosol]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ATP [cytosol]
VEGFR2 autophosphorylates (Bos taurus)
ATP [cytosol]
VEGFR2 mediated cell proliferation (Bos taurus)
PDK1 phosphorylates PKC (Bos taurus)
ATP [cytosol]
PKC autophosphorylates (Bos taurus)
ATP [cytosol]
PKC phosphorylates sphingosine kinase 1 (Bos taurus)
ATP [cytosol]
SFKs phosphorylate PLCG1 (Bos taurus)
ATP [cytosol]
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)
ATP [cytosol]
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
ATP [cytosol]
PAK1-3 autophosphorylates (Bos taurus)
ATP [cytosol]
PAK1-3 phosphorylates VE-cadherin (Bos taurus)
ATP [cytosol]
p-MAPK2/3 phosphorylates HSP27 (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
HSP27 oligomer:F-actin [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)
ATP [cytosol]
p-Y420-FYN is phosphorylated on S21 (Bos taurus)
ATP [cytosol]
p38 MAPK activation by VEGFR (Bos taurus)
ATP [cytosol]
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
ATP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 binds ATP (Bos taurus)
ATP [cytosol]
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Bos taurus)
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
RHOBTB3 hydrolyzes ATP (Bos taurus)
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)
ATP [cytosol]
Activated FMNL3 binds G-actin (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
RHOC:GTP:FMNL3:G-actin [plasma membrane] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Association of profilin with monomeric actin (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)
CDC42:FMNL2:Profilin:G-actin [plasma membrane] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Profilin:G-actin binds MKL1 (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Profilin:G-actin:MKL1 [cytosol] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Bos taurus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Bos taurus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Bos taurus)
Profilin:G-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
RHO GTPases Activate NADPH Oxidases (Bos taurus)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)
ATP [cytosol]
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)
ATP [cytosol]
PIK3C3:PIK3R4 phosphorylates PI to PI3P (Bos taurus)
ATP [cytosol]
PKC phosphorylates NCF1 (Bos taurus)
ATP [cytosol]
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
ABL phosphorylates WAVEs (Bos taurus)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Bos taurus)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
ATP [cytosol]
RHO GTPases activate IQGAPs (Bos taurus)
IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Bos taurus)
F-actin [cytosol] (Bos taurus)
G-actin [cytosol] (Bos taurus)
ATP [cytosol]
RHO GTPases activate PAKs (Bos taurus)
Autophosphorylation of PAK1,2,3 (Bos taurus)
ATP [cytosol]
PAK1 or PAK2 phosphorylates MYLK (Bos taurus)
ATP [cytosol]
PAK1 phosphorylates FLNA (Bos taurus)
ATP [cytosol]
PAK1 phosphorylates LIMK1 (Bos taurus)
ATP [cytosol]
PAK1 phosphorylates myosin phosphatase (Bos taurus)
ATP [cytosol]
PAK2 phosphorylates myosin regulatory light chain (MRLC) (Bos taurus)
ATP [cytosol]
RHO GTPases activate PKNs (Bos taurus)
PDPK1 phosphorylates PKN1,2,3 (Bos taurus)
ATP [cytosol]
p-T774-PKN1 phosphorylates CDC25C (Bos taurus)
ATP [cytosol]
p-T774-PKN1 phosphorylates PPP1R14A (Bos taurus)
ATP [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by Activin (Bos taurus)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)
ATP [cytosol]
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)
ATP [cytosol]
Signaling by BMP (Bos taurus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)
ATP [cytosol]
Type II receptor phosphorylates type I receptor (Bos taurus)
ATP [cytosol]
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)
ATP [cytosol]
TGFBR2 phosphorylates TGFBR1 (Bos taurus)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
ATP [cytosol]
Signaling by TGFBR3 (Bos taurus)
TGFBR3 regulates TGF-beta signaling (Bos taurus)
TGFBR3 phosphorylation by TGFBR2 complex (Bos taurus)
ATP [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Activation of NLK (Bos taurus)
ATP [cytosol]
Autophosphorylation and activation of CAMK2 (Bos taurus)
ATP [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)
ATP [cytosol]
PCP/CE pathway (Bos taurus)
WNT5A-dependent internalization of FZD4 (Bos taurus)
DVL2 is phosphorylated by PKC (Bos taurus)
ATP [cytosol]
Degradation of beta-catenin by the destruction complex (Bos taurus)
AXIN is phosphorylated in the destruction complex (Bos taurus)
ATP [cytosol]
Beta-catenin phosphorylation cascade (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
ATP [cytosol]
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Bos taurus)
ATP [cytosol]
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
ATP [cytosol]
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
ATP [cytosol]
Phosphorylation of APC component of the destruction complex (Bos taurus)
ATP [cytosol]
TCF dependent signaling in response to WNT (Bos taurus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Bos taurus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)
ATP [cytosol]
WNT mediated activation of DVL (Bos taurus)
CSNK2-mediated phosphorylation of DVL (Bos taurus)
ATP [cytosol]
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
ATP [cytosol]
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)
ATP [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ATP [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
ATP [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
ATP [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ATP [cytosol]
ABCG4 may mediate cholesterol efflux (Bos taurus)
ATP [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
ATP [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
ATP [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
ATP [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
HCO3- transport through ion channel (Bos taurus)
ATP [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
ATP [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
ATP [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
ATP [cytosol]
Aquaporin-mediated transport (Bos taurus)
Vasopressin regulates renal water homeostasis via Aquaporins (Bos taurus)
Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)
ATP [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
ATP [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
ATP [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
ATP [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
ATP [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
ATP [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
ATP [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
ATP [cytosol]
Stimuli-sensing channels (Bos taurus)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)
ATP [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
ATP [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
ATP [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
ATP [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
ATP [cytosol]
PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)
ATP [cytosol]
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ATP [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Cellular hexose transport (Bos taurus)
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
ATP [cytosol]
GLUT1 tetramer binds 4xATP (Bos taurus)
ATP [cytosol]
GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)
ATP [cytosol]
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Bos taurus)
ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)
ATP [cytosol]
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)
ATP [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
ATP [cytosol]
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
ADBRK1,2 phosphorylate AVPR2 (Bos taurus)
ATP [cytosol]
Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
ATP [cytosol]
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
HSPA8:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
ATP [cytosol]
RAB5 and GAPVD1 bind AP-2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
ARP2/3 complex [cytosol] (Bos taurus)
ACTR2:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ACTR3:ATP [cytosol] (Bos taurus)
ATP [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
GBF1 stimulates ARF nucleotide exchange (Bos taurus)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
ATP [cytosol]
COPII-mediated vesicle transport (Bos taurus)
CSNK1D phosphorylates SEC23 (Bos taurus)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
ATP [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Bos taurus)
ESCRT Disassembly (Bos taurus)
ATP [cytosol]
Gap junction trafficking and regulation (Bos taurus)
Regulation of gap junction activity (Bos taurus)
Phosphorylation of Cx43 by c-src (Bos taurus)
ATP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-dependent Golgi-to-ER retrograde traffic (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)
ATP [cytosol]
COPI-independent Golgi-to-ER retrograde traffic (Bos taurus)
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)
ATP [cytosol]
Intra-Golgi traffic (Bos taurus)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)
ATP [cytosol]
Retrograde transport at the Trans-Golgi-Network (Bos taurus)
ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Bos taurus)
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)
ATP [cytosol]
RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Bos taurus)
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
RHOBTB3:ATP [trans-Golgi network membrane] (Bos taurus)
ATP [cytosol]
Rab regulation of trafficking (Bos taurus)
RAB GEFs exchange GTP for GDP on RABs (Bos taurus)
p-ULK1 phosphorylates DENND3 (Bos taurus)
ATP [cytosol]
Autophagy (Caenorhabditis elegans)
Macroautophagy (Caenorhabditis elegans)
AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
ATP [cytosol]
Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)
ATP [cytosol]
Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)
ATP [cytosol]
Selective autophagy (Caenorhabditis elegans)
Mitophagy (Caenorhabditis elegans)
PINK1-PRKN Mediated Mitophagy (Caenorhabditis elegans)
PINK1 is autophosphorylated (Caenorhabditis elegans)
ATP [cytosol]
PINK1 phosphorylates Ub on MOM proteins (Caenorhabditis elegans)
ATP [cytosol]
Receptor Mediated Mitophagy (Caenorhabditis elegans)
FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)
ATP [cytosol]
FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)
ATP [cytosol]
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)
ATP [cytosol]
Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
ATP [cytosol]
ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
ATP [cytosol]
ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
ATP [cytosol]
ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
ATP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
ATP [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle Checkpoints (Caenorhabditis elegans)
G2/M Checkpoints (Caenorhabditis elegans)
G2/M DNA replication checkpoint (Caenorhabditis elegans)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
ATP [cytosol]
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prometaphase (Caenorhabditis elegans)
EML4 and NUDC in mitotic spindle formation (Caenorhabditis elegans)
NEK6 and NEK7 phosphorylate EML4 (Caenorhabditis elegans)
ATP [cytosol]
PLK1 phosphorylates NUDC (Caenorhabditis elegans)
ATP [cytosol]
Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)
ATP [cytosol]
Mitotic Prophase (Caenorhabditis elegans)
Golgi Cisternae Pericentriolar Stack Reorganization (Caenorhabditis elegans)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)
ATP [cytosol]
PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)
ATP [cytosol]
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Caenorhabditis elegans)
CDK1:CCNB phosphorylates NEK9 (Caenorhabditis elegans)
ATP [cytosol]
NEK9 phosphorylates NEK6/NEK7 (Caenorhabditis elegans)
ATP [cytosol]
PLK1 phosphorylates NEK9 (Caenorhabditis elegans)
ATP [cytosol]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
ATP [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)
ATP [cytosol]
Polo-like kinase mediated events (Caenorhabditis elegans)
Activation of Cdc25C (Caenorhabditis elegans)
ATP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
CDK1 phosphorylates BORA (Caenorhabditis elegans)
ATP [cytosol]
PLK1 phosphorylates BORA (Caenorhabditis elegans)
ATP [cytosol]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
ATP [cytosol]
Cell-Cell communication (Caenorhabditis elegans)
Cell junction organization (Caenorhabditis elegans)
Cell-extracellular matrix interactions (Caenorhabditis elegans)
MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Migfilin:Filamin A:F-actin [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Nephrin family interactions (Caenorhabditis elegans)
Phosphorylation of nephrin by FYN (Caenorhabditis elegans)
ATP [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Caenorhabditis elegans)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of PDPK1 on serine-241 (Caenorhabditis elegans)
ATP [cytosol]
mTORC2 phosphorylates AKT1 on serine-473 (Caenorhabditis elegans)
ATP [cytosol]
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Caenorhabditis elegans)
ATP [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Caenorhabditis elegans)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Caenorhabditis elegans)
ATP [cytosol]
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Cellular response to chemical stress (Caenorhabditis elegans)
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
PRKAA2 phosphorylates nuclear NFE2L2 (Caenorhabditis elegans)
ATP [cytosol]
PRKCI phosphorylates NFE2L2 (Caenorhabditis elegans)
ATP [cytosol]
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
Constitutive phosphorylation by pERK1/2 (Caenorhabditis elegans)
ATP [cytosol]
Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)
ATP [cytosol]
HSP110s exchange ATP for ADP on HSP70s:ADP (Caenorhabditis elegans)
ATP [cytosol]
HSP70s:ATP [cytosol] (Caenorhabditis elegans)
HSPA13:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA5:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA6:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA9:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
HSP70s:ATP [cytosol] (Caenorhabditis elegans)
HSPA13:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA5:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA6:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA9:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)
HSP70s:ATP [cytosol] (Caenorhabditis elegans)
HSPA13:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA5:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA6:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA9:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Hikeshi:HSP70s:ATP [cytosol] (Caenorhabditis elegans)
HSP70s:ATP [cytosol] (Caenorhabditis elegans)
HSPA13:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA5:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA6:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA9:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)
ATP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Caenorhabditis elegans)
ATP binding to HSP90 triggers conformation change (Caenorhabditis elegans)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP90 dimer:ATP:nascent protein [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ATP hydrolysis by HSP70 (Caenorhabditis elegans)
HSP40:HSP70:ATP:nascent protein [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)
HSP40:HSP70:ATP:nascent protein [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSP70:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mitochondrial unfolded protein response (UPRmt) (Caenorhabditis elegans)
HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Caenorhabditis elegans)
ATP [cytosol]
Unfolded Protein Response (UPR) (Caenorhabditis elegans)
IRE1alpha activates chaperones (Caenorhabditis elegans)
IRE1 dimer autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
PERK regulates gene expression (Caenorhabditis elegans)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)
ATP [cytosol]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
MARK3 phosphorylates MITF-M on S173 (Caenorhabditis elegans)
ATP [cytosol]
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPH receptors autophosphorylate (Caenorhabditis elegans)
ATP [cytosol]
EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)
ATP [cytosol]
EPHB-mediated forward signaling (Caenorhabditis elegans)
EPHB phosphorylates TIAM1 (Caenorhabditis elegans)
ATP [cytosol]
N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PAK1 autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)
ATP [cytosol]
Ephrin signaling (Caenorhabditis elegans)
PAKs autophosphorylate (Caenorhabditis elegans)
ATP [cytosol]
PAKs phosphorylate MLC (Caenorhabditis elegans)
ATP [cytosol]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
pL1:ERM:F-actin [plasma membrane] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of L1 by ERK (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of L1 by SRC (Caenorhabditis elegans)
ATP [cytosol]
Signal transduction by L1 (Caenorhabditis elegans)
Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)
ATP [cytosol]
MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)
ATP [cytosol]
MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of L1 by CK-II (Caenorhabditis elegans)
ATP [cytosol]
Netrin-1 signaling (Caenorhabditis elegans)
DCC mediated attractive signaling (Caenorhabditis elegans)
Phosphorylation of DCC by Fyn (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
ATP [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
CRMPs in Sema3A signaling (Caenorhabditis elegans)
Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)
ATP [cytosol]
Tyrosine phosphorylation of CRMPs by Fes (Caenorhabditis elegans)
ATP [cytosol]
Sema3A PAK dependent Axon repulsion (Caenorhabditis elegans)
Autophosphorylation of PAK (Caenorhabditis elegans)
ATP [cytosol]
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)
ATP [cytosol]
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)
ATP [cytosol]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
ATP [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
ATP [cytosol]
GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)
ATP [cytosol]
GUK1 phosphorylates 6TdGMP to 6TdGDP (Caenorhabditis elegans)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Caenorhabditis elegans)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)
ATP [cytosol]
Ciprofloxacin ADME (Caenorhabditis elegans)
ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)
ATP [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)
ATP [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
ATP [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
ATP [cytosol]
Ribavirin ADME (Caenorhabditis elegans)
ADK phosphorylates RBV (Caenorhabditis elegans)
ATP [cytosol]
NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)
ATP [cytosol]
Extracellular matrix organization (Caenorhabditis elegans)
Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
Formation of the dystrophin-glycoprotein complex (DGC) (Caenorhabditis elegans)
DGC complex binds AGRN and HSPG2 (Caenorhabditis elegans)
DGC complex:laminins:F-actin [plasma membrane] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Caenorhabditis elegans)
DGC complex:laminins:F-actin [plasma membrane] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Expression and Degradation (Caenorhabditis elegans)
Regulation of TP53 Degradation (Caenorhabditis elegans)
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
ATP [cytosol]
TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)
ATP [cytosol]
Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
Regulation of RUNX3 expression and activity (Caenorhabditis elegans)
SRC phosphorylates RUNX3 (Caenorhabditis elegans)
ATP [cytosol]
Hemostasis (Caenorhabditis elegans)
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
Kinesins (Caenorhabditis elegans)
Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)
ATP [cytosol]
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)
ATP [cytosol]
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
ATP [cytosol]
Autophosphorylation of SRC (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
ATP [cytosol]
SYK activation by SRC (Caenorhabditis elegans)
ATP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Disinhibition of SNARE formation (Caenorhabditis elegans)
Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of Syntaxin-4 (Caenorhabditis elegans)
ATP [cytosol]
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
ATP [cytosol]
Signal amplification (Caenorhabditis elegans)
ADP signalling through P2Y purinoceptor 1 (Caenorhabditis elegans)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)
ATP [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
Platelet sensitization by LDL (Caenorhabditis elegans)
Fgr may phosphorylate p38 MAPK (Caenorhabditis elegans)
ATP [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
ATP [cytosol]
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
E1 mediated ubiquitin activation (Caenorhabditis elegans)
ATP [cytosol]
Polyubiquitination of substrate (Caenorhabditis elegans)
ATP [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
ATP [cytosol]
Rap1 signalling (Caenorhabditis elegans)
PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)
ATP [cytosol]
Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
Co-stimulation by CD28 (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
ATP [cytosol]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
Phosphorylation of PKC theta (Caenorhabditis elegans)
ATP [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
ISG15 antiviral mechanism (Caenorhabditis elegans)
Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)
ATP [cytosol]
ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)
ATP [cytosol]
ISGylation of host protein filamin B (Caenorhabditis elegans)
ATP [cytosol]
ISGylation of host proteins (Caenorhabditis elegans)
ATP [cytosol]
ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)
ATP [cytosol]
OAS antiviral response (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
ATP [cytosol]
2'-5' oligoadenylate [cytosol] (Homo sapiens)
ATP [cytosol]
PKR-mediated signaling (Caenorhabditis elegans)
ISGylation of PKR (Caenorhabditis elegans)
ATP [cytosol]
p-PKR dimer phosphorylates CDK1 (Caenorhabditis elegans)
ATP [cytosol]
p-PKR dimer phosphorylates DHX9 (Caenorhabditis elegans)
ATP [cytosol]
p-PKR dimer phosphorylates ILF3:ILF2 (Caenorhabditis elegans)
ATP [cytosol]
p-PKR dimer phosphorylates MKK6 (Caenorhabditis elegans)
ATP [cytosol]
p-PKR dimer phosphorylates PPP2R5A (Caenorhabditis elegans)
ATP [cytosol]
Interferon gamma signaling (Caenorhabditis elegans)
JAK2-activated MAPKs phosphorylate YBX1 (Caenorhabditis elegans)
ATP [cytosol]
Modulation of host responses by IFN-stimulated genes (Caenorhabditis elegans)
ISGylation of DDX58 (RIG-I) (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-1 family signaling (Caenorhabditis elegans)
Interleukin-1 signaling (Caenorhabditis elegans)
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2 (Caenorhabditis elegans)
ATP [cytosol]
Interleukin-37 signaling (Caenorhabditis elegans)
STAT3 phosphorylation (Caenorhabditis elegans)
ATP [cytosol]
Interleukin-38 signaling (Caenorhabditis elegans)
MAPK8 phosphorylation (Caenorhabditis elegans)
ATP [cytosol]
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CD209 (DC-SIGN) signaling (Caenorhabditis elegans)
PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)
ATP [cytosol]
SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)
ATP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Caenorhabditis elegans)
STING mediated induction of host immune responses (Caenorhabditis elegans)
STAT6-mediated induction of chemokines (Caenorhabditis elegans)
p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)
ATP [cytosol]
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
Autophosphorylation of LYN kinase (Caenorhabditis elegans)
ATP [cytosol]
FCERI mediated MAPK activation (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
FCERI mediated NF-kB activation (Caenorhabditis elegans)
Autophosphorylation of PKC-theta (Caenorhabditis elegans)
ATP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
ATP [cytosol]
Autophosphorylation of PAK1 (Caenorhabditis elegans)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
ATP [cytosol]
Role of phospholipids in phagocytosis (Caenorhabditis elegans)
DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
ATP [cytosol]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Caenorhabditis elegans)
NOD1/2 Signaling Pathway (Caenorhabditis elegans)
Activation of p38 MAPK (Caenorhabditis elegans)
ATP [cytosol]
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ATP [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)
ATP [cytosol]
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Ethanol oxidation (Caenorhabditis elegans)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)
ATP [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
ATP [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
ATP [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)
ATP [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
ATP [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Free fatty acids regulate insulin secretion (Caenorhabditis elegans)
Intracellular metabolism of fatty acids regulates insulin secretion (Caenorhabditis elegans)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
ATP [cytosol]
Glutamate and glutamine metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
ATP [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
ATP [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)
ATP [cytosol]
PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
XYLB phosphorylates D-xylulose (Caenorhabditis elegans)
ATP [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose catabolism (Caenorhabditis elegans)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
ATP [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)
ATP [cytosol]
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Caenorhabditis elegans)
ATP [cytosol]
Glycolysis (Caenorhabditis elegans)
1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)
ATP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)
ATP [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)
ATP [cytosol]
PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)
ATP [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)
ATP [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen breakdown (glycogenolysis) (Caenorhabditis elegans)
PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Caenorhabditis elegans)
ATP [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)
ATP [cytosol]
Glycosaminoglycan metabolism (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
ATP [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)
ATP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonate metabolism (Caenorhabditis elegans)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)
ATP [cytosol]
Carnitine shuttle (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
ATP [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
ATP [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Caenorhabditis elegans)
ATP [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)
ATP [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Caenorhabditis elegans)
ATP [cytosol]
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
ATP [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
ATP [cytosol]
Peroxisomal lipid metabolism (Caenorhabditis elegans)
Beta-oxidation of very long chain fatty acids (Caenorhabditis elegans)
Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)
ATP [cytosol]
Ketone body metabolism (Caenorhabditis elegans)
Synthesis of Ketone Bodies (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Recycling of bile acids and salts (Caenorhabditis elegans)
ABCC3 transports bile salts from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
ATP [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Caenorhabditis elegans)
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
ATP [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
ATP [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
ATP [cytosol]
Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)
ATP [cytosol]
Mevalonate-5-phosphate is further phosphorylated (Caenorhabditis elegans)
ATP [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PC (Caenorhabditis elegans)
Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)
ATP [cytosol]
Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PE (Caenorhabditis elegans)
ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)
ATP [cytosol]
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid biosynthesis (Caenorhabditis elegans)
CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
ATP [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Caenorhabditis elegans)
ATP [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)
ATP [cytosol]
SPHK1 phosphorylates sphingoid (Caenorhabditis elegans)
ATP [cytosol]
SPHK2 phosphorylates sphingoid (Caenorhabditis elegans)
ATP [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)
ATP [cytosol]
(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)
ATP [cytosol]
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)
ATP [cytosol]
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)
ATP [cytosol]
ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)
ATP [cytosol]
AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
ATP [cytosol]
AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)
ATP [cytosol]
NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
ATP [cytosol]
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Caenorhabditis elegans)
ATP [cytosol]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Caenorhabditis elegans)
ATP [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
ATP [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
ATP [cytosol]
FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
ATP [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
ATP [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
ATP [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
ATP [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)
ATP [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)
ATP [cytosol]
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
Heme degradation (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Biotin transport and metabolism (Caenorhabditis elegans)
HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)
ATP [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)
ATP [cytosol]
HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
ATP [cytosol]
HLCS biotinylates ACACB (Caenorhabditis elegans)
ATP [cytosol]
HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
ATP [cytosol]
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Transport of RCbl within the body (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
ATP [cytosol]
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
ATP [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
ATP [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
ATP [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
ATP [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)
ATP [cytosol]
Vitamin B1 (thiamin) metabolism (Caenorhabditis elegans)
2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)
ATP [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
ATP [cytosol]
RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)
ATP [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
Coenzyme A biosynthesis (Caenorhabditis elegans)
2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
ATP [cytosol]
COASY phosphorylates DP-CoA (Caenorhabditis elegans)
ATP [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
ATP [cytosol]
DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)
ATP [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of RNA (Caenorhabditis elegans)
Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
ATP [cytosol]
Regulation of mRNA stability by proteins that bind AU-rich elements (Caenorhabditis elegans)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Caenorhabditis elegans)
MK2 phosphorylates BRF1 (Caenorhabditis elegans)
ATP [cytosol]
Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)
ATP [cytosol]
KSRP (KHSRP) binds and destabilizes mRNA (Caenorhabditis elegans)
Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)
ATP [cytosol]
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Caenorhabditis elegans)
MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)
ATP [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of Dolichyl-phosphate (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of GDP-mannose (Caenorhabditis elegans)
HK1 phosphorylates Mannose to Man6P (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)
ATP [cytosol]
Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPI-mediated anterograde transport (Caenorhabditis elegans)
GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)
ATP [cytosol]
COPII-mediated vesicle transport (Caenorhabditis elegans)
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
ATP [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
FN3K phosphorylates ketosamines (Caenorhabditis elegans)
ATP [cytosol]
FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of diphthamide-EEF2 (Caenorhabditis elegans)
DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)
ATP [cytosol]
Neddylation (Caenorhabditis elegans)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)
ATP [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Caenorhabditis elegans)
ATP [cytosol]
Protein ubiquitination (Caenorhabditis elegans)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Protein folding (Caenorhabditis elegans)
Chaperonin-mediated protein folding (Caenorhabditis elegans)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Caenorhabditis elegans)
ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)
ATP [cytosol]
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Caenorhabditis elegans)
CCT/TriC:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Caenorhabditis elegans)
CCT/TriC:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
CK2 phosphorylates PDCL (Caenorhabditis elegans)
ATP [cytosol]
Surfactant metabolism (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
ATP [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Initiation (Caenorhabditis elegans)
Cap-dependent Translation Initiation (Caenorhabditis elegans)
Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
Ribosomal scanning (Caenorhabditis elegans)
ATP [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)
ATP [cytosol]
Smooth Muscle Contraction (Caenorhabditis elegans)
ATP Hydrolysis By Myosin (Caenorhabditis elegans)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Calcium Binds Caldesmon (Caenorhabditis elegans)
Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Inactive Myosin Actin Contractile Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Myosin Binds ATP (Caenorhabditis elegans)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Release Of ADP From Myosin (Caenorhabditis elegans)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Caenorhabditis elegans)
(ACTA2,ACTG2):ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Post NMDA receptor activation events (Caenorhabditis elegans)
Activation of RAC1 downstream of NMDARs (Caenorhabditis elegans)
CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Caenorhabditis elegans)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
ATP [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
ATP [cytosol]
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
GRK1,4,7 phosphorylate MII to p-MII (Caenorhabditis elegans)
ATP [cytosol]
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signaling (Caenorhabditis elegans)
p75 NTR receptor-mediated signalling (Caenorhabditis elegans)
Cell death signalling via NRAGE, NRIF and NADE (Caenorhabditis elegans)
NRAGE signals death through JNK (Caenorhabditis elegans)
GTP-bound RAC contributes to JNK activation (Caenorhabditis elegans)
ATP [cytosol]
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
ATP [cytosol]
Autophosphorylation of SRC (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
ATP [cytosol]
SYK activation by SRC (Caenorhabditis elegans)
ATP [cytosol]
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
ATP [cytosol]
PKC phosphorylates GRK2 (Caenorhabditis elegans)
ATP [cytosol]
DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
ATP [cytosol]
PIP3 activates AKT signaling (Caenorhabditis elegans)
AKT phosphorylates targets in the cytosol (Caenorhabditis elegans)
AKT phosphorylates MKRN1 (Caenorhabditis elegans)
ATP [cytosol]
AKT phosphorylates caspase-9 (Caenorhabditis elegans)
ATP [cytosol]
AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
ATP [cytosol]
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN gene transcription (Caenorhabditis elegans)
mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)
ATP [cytosol]
Regulation of PTEN stability and activity (Caenorhabditis elegans)
AKT phosphorylates MKRN1 (Caenorhabditis elegans)
ATP [cytosol]
Casein kinase II phosphorylates PTEN (Caenorhabditis elegans)
ATP [cytosol]
FRK phosphorylates PTEN (Caenorhabditis elegans)
ATP [cytosol]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
ATP [cytosol]
TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)
ATP [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
MAPK1 (ERK2) activation (Caenorhabditis elegans)
MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)
ATP [cytosol]
MAPK3 (ERK1) activation (Caenorhabditis elegans)
Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)
ATP [cytosol]
MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)
ATP [cytosol]
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)
ATP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)
ATP [cytosol]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
ATP [cytosol]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
ATP [cytosol]
Negative regulation of MAPK pathway (Caenorhabditis elegans)
MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)
ATP [cytosol]
Negative feedback regulation of MAPK pathway (Caenorhabditis elegans)
Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)
ATP [cytosol]
Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)
ATP [cytosol]
Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)
ATP [cytosol]
RAF activation (Caenorhabditis elegans)
MARK3 phosphorylates KSR1 (Caenorhabditis elegans)
ATP [cytosol]
RAS processing (Caenorhabditis elegans)
KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)
ATP [cytosol]
MAPK6/MAPK4 signaling (Caenorhabditis elegans)
Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)
ATP [cytosol]
PAK1,2,3 phosphorylates MAPK6,4 (Caenorhabditis elegans)
ATP [cytosol]
MTOR signalling (Caenorhabditis elegans)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)
ATP [cytosol]
Energy dependent regulation of mTOR by LKB1-AMPK (Caenorhabditis elegans)
AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)
ATP [cytosol]
mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)
ATP [cytosol]
mTORC1-mediated signalling (Caenorhabditis elegans)
Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)
ATP [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)
ATP [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)
ATP [cytosol]
Opioid Signalling (Caenorhabditis elegans)
DARPP-32 events (Caenorhabditis elegans)
PKA phosphorylates PDE4B (Caenorhabditis elegans)
ATP [cytosol]
G-protein mediated events (Caenorhabditis elegans)
Adenylate cyclase activating pathway (Caenorhabditis elegans)
Adenylate cyclase converts ATP into cyclic AMP (Caenorhabditis elegans)
ATP [cytosol]
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
ATP [cytosol]
PKC phosphorylates GRK2 (Caenorhabditis elegans)
ATP [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Hedgehog (Caenorhabditis elegans)
Hedgehog 'off' state (Caenorhabditis elegans)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Hippo (Caenorhabditis elegans)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by NOTCH (Caenorhabditis elegans)
Signaling by NOTCH4 (Caenorhabditis elegans)
Negative regulation of NOTCH4 signaling (Caenorhabditis elegans)
AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
ATP [cytosol]
PTK6 Down-Regulation (Caenorhabditis elegans)
SRMS phosphorylates PTK6 (Caenorhabditis elegans)
ATP [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)
ATP [cytosol]
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Caenorhabditis elegans)
PTK6 phosphorylates AKT1 (Caenorhabditis elegans)
ATP [cytosol]
PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)
ATP [cytosol]
PTK6 phosphorylates CBL (Caenorhabditis elegans)
ATP [cytosol]
PTK6 phosphorylates DOK1 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-stimulated signaling through PRKCZ (Caenorhabditis elegans)
PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)
ATP [cytosol]
PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
ATP [cytosol]
Signaling by EGFR (Caenorhabditis elegans)
EGFR autophosphorylation (Caenorhabditis elegans)
ATP [cytosol]
EGFR downregulation (Caenorhabditis elegans)
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)
ATP [cytosol]
GAB1 signalosome (Caenorhabditis elegans)
GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)
ATP [cytosol]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)
ATP [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
ATP [cytosol]
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
ATP [cytosol]
SHC1 events in ERBB2 signaling (Caenorhabditis elegans)
SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)
ATP [cytosol]
SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)
ATP [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
ATP [cytosol]
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)
ATP [cytosol]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
ATP [cytosol]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
FRS-mediated FGFR1 signaling (Caenorhabditis elegans)
Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)
ATP [cytosol]
Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)
ATP [cytosol]
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
Phospholipase C-mediated cascade: FGFR1 (Caenorhabditis elegans)
Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)
ATP [cytosol]
SHC-mediated cascade:FGFR1 (Caenorhabditis elegans)
Activated FGFR1 phosphorylates SHC1 (Caenorhabditis elegans)
ATP [cytosol]
FGFR1 ligand binding and activation (Caenorhabditis elegans)
FGFR1b ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR1b (Caenorhabditis elegans)
ATP [cytosol]
FGFR1c and Klotho ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Caenorhabditis elegans)
ATP [cytosol]
FGFR1c ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR1c (Caenorhabditis elegans)
ATP [cytosol]
Negative regulation of FGFR1 signaling (Caenorhabditis elegans)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by FGFR2 (Caenorhabditis elegans)
FGFR2 ligand binding and activation (Caenorhabditis elegans)
FGFR2b ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR2b (Caenorhabditis elegans)
ATP [cytosol]
FGFR2c ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR2c (Caenorhabditis elegans)
ATP [cytosol]
Signaling by FGFR3 (Caenorhabditis elegans)
FGFR3 ligand binding and activation (Caenorhabditis elegans)
FGFR3b ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR3b (Caenorhabditis elegans)
ATP [cytosol]
FGFR3c ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR3c (Caenorhabditis elegans)
ATP [cytosol]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
FRS-mediated FGFR4 signaling (Caenorhabditis elegans)
Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)
ATP [cytosol]
Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)
ATP [cytosol]
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR4 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)
ATP [cytosol]
SHC-mediated cascade:FGFR4 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates SHC1 (Caenorhabditis elegans)
ATP [cytosol]
FGFR4 ligand binding and activation (Caenorhabditis elegans)
Autocatalytic phosphorylation of FGFR4 (Caenorhabditis elegans)
ATP [cytosol]
betaKlotho-mediated ligand binding (Caenorhabditis elegans)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Caenorhabditis elegans)
ATP [cytosol]
Negative regulation of FGFR4 signaling (Caenorhabditis elegans)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by MET (Caenorhabditis elegans)
MET Receptor Activation (Caenorhabditis elegans)
MET dimers autophosphorylate (Caenorhabditis elegans)
ATP [cytosol]
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
ATP [cytosol]
MET phosphorylates GAB1 (Caenorhabditis elegans)
ATP [cytosol]
MET activates STAT3 (Caenorhabditis elegans)
MET phosphorylates STAT3 (Caenorhabditis elegans)
ATP [cytosol]
MET promotes cell motility (Caenorhabditis elegans)
MET activates PTK2 signaling (Caenorhabditis elegans)
MET phosphorylates PTK2 (Caenorhabditis elegans)
ATP [cytosol]
PTK2 autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
SRC phosphorylates PTK2 (Caenorhabditis elegans)
ATP [cytosol]
Negative regulation of MET activity (Caenorhabditis elegans)
MET phosphorylates CBL (Caenorhabditis elegans)
ATP [cytosol]
Signaling by MST1 (Caenorhabditis elegans)
MST1R autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Signalling to ERKs (Caenorhabditis elegans)
Prolonged ERK activation events (Caenorhabditis elegans)
Frs2-mediated activation (Caenorhabditis elegans)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)
ATP [cytosol]
BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)
ATP [cytosol]
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)
ATP [cytosol]
Signalling to RAS (Caenorhabditis elegans)
p38MAPK events (Caenorhabditis elegans)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by PDGF (Caenorhabditis elegans)
Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)
ATP [cytosol]
Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)
ATP [cytosol]
Autophosphorylation of PDGF beta receptors (Caenorhabditis elegans)
ATP [cytosol]
Downstream signal transduction (Caenorhabditis elegans)
Activation of Src (Caenorhabditis elegans)
ATP [cytosol]
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)
ATP [cytosol]
Signaling by SCF-KIT (Caenorhabditis elegans)
Regulation of KIT signaling (Caenorhabditis elegans)
PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)
ATP [cytosol]
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
AXL autophosphorylates on Y779 and Y821 (Caenorhabditis elegans)
ATP [cytosol]
FYN autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
FYN phosphorylates PAK2 (Caenorhabditis elegans)
ATP [cytosol]
PAK2 autophorylates (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of SRC-1 (Caenorhabditis elegans)
ATP [cytosol]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
ATP [cytosol]
VEGFR2 mediated cell proliferation (Caenorhabditis elegans)
PDK1 phosphorylates PKC (Caenorhabditis elegans)
ATP [cytosol]
PKC autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)
ATP [cytosol]
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
ATP [cytosol]
PAK1-3 autophosphorylates (Caenorhabditis elegans)
ATP [cytosol]
PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)
ATP [cytosol]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
ATP [cytosol]
p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSP27 oligomer:F-actin [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
p-Y420-FYN is phosphorylated on S21 (Caenorhabditis elegans)
ATP [cytosol]
p38 MAPK activation by VEGFR (Caenorhabditis elegans)
ATP [cytosol]
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
RHOBTB3 ATPase cycle (Caenorhabditis elegans)
RHOBTB3 binds ATP (Caenorhabditis elegans)
ATP [cytosol]
RHOBTB3:ATP [trans-Golgi network membrane] (Caenorhabditis elegans)
ATP [cytosol]
RHOBTB3 binds interacting proteins at trans-Golgi network (Caenorhabditis elegans)
RHOBTB3:ATP [trans-Golgi network membrane] (Caenorhabditis elegans)
ATP [cytosol]
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Caenorhabditis elegans)
RHOBTB3:ATP [trans-Golgi network membrane] (Caenorhabditis elegans)
ATP [cytosol]
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
RHOBTB3:ATP [trans-Golgi network membrane] (Caenorhabditis elegans)
ATP [cytosol]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate Formins (Caenorhabditis elegans)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Caenorhabditis elegans)
Profilin:G-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Caenorhabditis elegans)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Caenorhabditis elegans)
Profilin:G-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
RHO GTPases Activate NADPH Oxidases (Caenorhabditis elegans)
PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)
ATP [cytosol]
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
ATP [cytosol]
RHO GTPases activate IQGAPs (Caenorhabditis elegans)
IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Caenorhabditis elegans)
F-actin [cytosol] (Caenorhabditis elegans)
G-actin [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
RHO GTPases activate PAKs (Caenorhabditis elegans)
Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)
ATP [cytosol]
PAK1 phosphorylates FLNA (Caenorhabditis elegans)
ATP [cytosol]
PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)
ATP [cytosol]
PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)
ATP [cytosol]
RHO GTPases activate PKNs (Caenorhabditis elegans)
PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
ATP [cytosol]
p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)
ATP [cytosol]
p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)
ATP [cytosol]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by BMP (Caenorhabditis elegans)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)
ATP [cytosol]
Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)
ATP [cytosol]
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
TGF-beta receptor signaling activates SMADs (Caenorhabditis elegans)
Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)
ATP [cytosol]
TGFBR2 phosphorylates TGFBR1 (Caenorhabditis elegans)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)
ATP [cytosol]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)
ATP [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)
ATP [cytosol]
PCP/CE pathway (Caenorhabditis elegans)
WNT5A-dependent internalization of FZD4 (Caenorhabditis elegans)
DVL2 is phosphorylated by PKC (Caenorhabditis elegans)
ATP [cytosol]
Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)
AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)
ATP [cytosol]
Beta-catenin phosphorylation cascade (Caenorhabditis elegans)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)
ATP [cytosol]
Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)
ATP [cytosol]
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Caenorhabditis elegans)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Caenorhabditis elegans)
ATP [cytosol]
WNT mediated activation of DVL (Caenorhabditis elegans)
CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)
ATP [cytosol]
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
ATP [cytosol]
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)
ATP [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
ABC transporters in lipid homeostasis (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
ATP [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
ATP [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
ATP [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)
ATP [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
HCO3- transport through ion channel (Caenorhabditis elegans)
ATP [cytosol]
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
ATP [cytosol]
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
ATP [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
ATP [cytosol]
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
ATP [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
ATP [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
ATP [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
ATP [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
ATP [cytosol]
Stimuli-sensing channels (Caenorhabditis elegans)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)
ATP [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
ATP [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
ATP [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Caenorhabditis elegans)
Plasma lipoprotein assembly (Caenorhabditis elegans)
HDL assembly (Caenorhabditis elegans)
PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Caenorhabditis elegans)
ATP [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Cellular hexose transport (Caenorhabditis elegans)
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
ATP [cytosol]
GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)
ATP [cytosol]
GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)
ATP [cytosol]
Transport of vitamins, nucleosides, and related molecules (Caenorhabditis elegans)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Caenorhabditis elegans)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)
ATP [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
ATP [cytosol]
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
ATP [cytosol]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
HSPA8:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
ATP [cytosol]
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
ARP2/3 complex [cytosol] (Caenorhabditis elegans)
ACTR2:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ACTR3:ATP [cytosol] (Caenorhabditis elegans)
ATP [cytosol]
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPI-mediated anterograde transport (Caenorhabditis elegans)
GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)
ATP [cytosol]
COPII-mediated vesicle transport (Caenorhabditis elegans)
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
ATP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-dependent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)
ATP [cytosol]
COPI-independent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)
ATP [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
RAB GEFs exchange GTP for GDP on RABs (Caenorhabditis elegans)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)
ATP [cytosol]
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)
ATP [cytosol]
Active MTORC1 phosphorylates ULK1 (Canis familiaris)
ATP [cytosol]
Beclin-1 complex phosphorylates PtdIns (Canis familiaris)
ATP [cytosol]
Selective autophagy (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
PINK1 is autophosphorylated (Canis familiaris)
ATP [cytosol]
PINK1 phosphorylates PRKN at S65 (Canis familiaris)
ATP [cytosol]
PINK1 phosphorylates Ub on MOM proteins (Canis familiaris)
ATP [cytosol]
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Canis familiaris)
ATP [cytosol]
p-S-TBK1 phosphorylates OPTN (Canis familiaris)
ATP [cytosol]
Receptor Mediated Mitophagy (Canis familiaris)
FUNDC1 is phosphorylated by CK2 (Canis familiaris)
ATP [cytosol]
FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)
ATP [cytosol]
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Canis familiaris)
ATP [cytosol]
Thr-180 of ULK1 is phosphorylated (Canis familiaris)
ATP [cytosol]
ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)
ATP [cytosol]
ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)
ATP [cytosol]
ULK1 phosphorylates Beclin-1 (Canis familiaris)
ATP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)
ATP [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA replication checkpoint (Canis familiaris)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)
ATP [cytosol]
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Initiation of Nuclear Envelope (NE) Reformation (Canis familiaris)
CDK1 phosphorylates LBR (Canis familiaris)
ATP [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Canis familiaris)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)
ATP [cytosol]
Mitotic Prometaphase (Canis familiaris)
Condensation of Prometaphase Chromosomes (Canis familiaris)
CK2 phosphorylates condensin I subunits (Canis familiaris)
ATP [cytosol]
EML4 and NUDC in mitotic spindle formation (Canis familiaris)
NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates NUDC (Canis familiaris)
ATP [cytosol]
Resolution of Sister Chromatid Cohesion (Canis familiaris)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
ATP [cytosol]
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates FIRMM at S744 (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates FIRRM at S43 (Canis familiaris)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)
ATP [cytosol]
Mitotic Prophase (Canis familiaris)
Golgi Cisternae Pericentriolar Stack Reorganization (Canis familiaris)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates GORASP1 (Canis familiaris)
ATP [cytosol]
Nuclear Envelope Breakdown (Canis familiaris)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Canis familiaris)
CDK1:CCNB phosphorylates NEK9 (Canis familiaris)
ATP [cytosol]
NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates NEK9 (Canis familiaris)
ATP [cytosol]
Nuclear Pore Complex (NPC) Disassembly (Canis familiaris)
CDK1 phosphorylates NUP98 (Canis familiaris)
ATP [cytosol]
NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)
ATP [cytosol]
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)
ATP [cytosol]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
AURKA Activation by TPX2 (Canis familiaris)
TPX2 promotes AURKA autophosphorylation (Canis familiaris)
ATP [cytosol]
Centrosome maturation (Canis familiaris)
Loss of proteins required for interphase microtubule organization from the centrosome (Canis familiaris)
Loss of Nlp from mitotic centrosomes (Canis familiaris)
Plk1-mediated phosphorylation of Nlp (Canis familiaris)
ATP [cytosol]
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)
ATP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)
ATP [cytosol]
Interaction between PHLDA1 and AURKA (Canis familiaris)
AURKA phosphorylates PHLDA1 (Canis familiaris)
ATP [cytosol]
Polo-like kinase mediated events (Canis familiaris)
Activation of Cdc25C (Canis familiaris)
ATP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
AJUBA facilitates AURKA autophosphorylation (Canis familiaris)
ATP [cytosol]
AURKA phosphorylates PLK1 (Canis familiaris)
ATP [cytosol]
CDK1 phosphorylates BORA (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates BORA (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates OPTN (Canis familiaris)
ATP [cytosol]
The role of GTSE1 in G2/M progression after G2 checkpoint (Canis familiaris)
Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Canis familiaris)
ATP [cytosol]
PLK1 phosphorylates GTSE1 (Canis familiaris)
ATP [cytosol]
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
ATP [cytosol]
Cell-Cell communication (Canis familiaris)
Cell junction organization (Canis familiaris)
Cell-extracellular matrix interactions (Canis familiaris)
MigFilin associates with Filamin and F-actin (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Migfilin:Filamin A:F-actin [cytosol] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Nephrin family interactions (Canis familiaris)
Phosphorylation of nephrin by FYN (Canis familiaris)
ATP [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Canis familiaris)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Canis familiaris)
ATP [cytosol]
Phosphorylation of PDPK1 on serine-241 (Canis familiaris)
ATP [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Canis familiaris)
ATP [cytosol]
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Canis familiaris)
ATP [cytosol]
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Canis familiaris)
ATP [cytosol]
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Canis familiaris)
ATP [cytosol]
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Canis familiaris)
ATP [cytosol]
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
Oxidative Stress Induced Senescence (Canis familiaris)
MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
ATP [cytosol]
PRKAA2 phosphorylates nuclear NFE2L2 (Canis familiaris)
ATP [cytosol]
PRKCI phosphorylates NFE2L2 (Canis familiaris)
ATP [cytosol]
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
Constitutive phosphorylation by pERK1/2 (Canis familiaris)
ATP [cytosol]
Constitutive phosphorylation by GSK3 (Canis familiaris)
ATP [cytosol]
HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)
ATP [cytosol]
HSP70s:ATP [cytosol] (Canis familiaris)
HSPA12A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA13:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA14:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA5:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA9:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
HSP70s:ATP [cytosol] (Canis familiaris)
HSPA12A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA13:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA14:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA5:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA9:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Hikeshi binds HSP70s:ATP (Canis familiaris)
HSP70s:ATP [cytosol] (Canis familiaris)
HSPA12A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA13:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA14:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA5:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA9:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Hikeshi:HSP70s:ATP [cytosol] (Canis familiaris)
HSP70s:ATP [cytosol] (Canis familiaris)
HSPA12A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA13:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA14:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA5:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA9:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)
Hikeshi:HSP70s:ATP [cytosol] (Canis familiaris)
HSP70s:ATP [cytosol] (Canis familiaris)
HSPA12A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA12B:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA13:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA14:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA4L:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA5:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA9:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
AR binds AR agonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Canis familiaris)
ATP [cytosol]
AR binds AR antagonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Canis familiaris)
ATP [cytosol]
ATP binding to HSP90 triggers conformation change (Canis familiaris)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Canis familiaris)
HSP90 dimer:ATP:nascent protein [cytosol] (Canis familiaris)
ATP [cytosol]
ATP hydrolysis by HSP70 (Canis familiaris)
HSP40:HSP70:ATP:nascent protein [cytosol] (Canis familiaris)
ATP [cytosol]
Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Canis familiaris)
ATP [cytosol]
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Canis familiaris)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Canis familiaris)
HSP90 dimer:ATP:nascent protein [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Canis familiaris)
HSP90 dimer:ATP:nascent protein [cytosol] (Canis familiaris)
ATP [cytosol]
HSP70 binds to HSP40:nascent protein (Canis familiaris)
HSP40:HSP70:ATP:nascent protein [cytosol] (Canis familiaris)
ATP [cytosol]
HSP70:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C1 binds NR3C1 agonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C2 binds NR3C2 antagonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C2:NR3C2 antagonists [cytosol] (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C2 binds fludrocortisone (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C2:fludrocortisone [cytosol] (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Canis familiaris)
ATP [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
ATP [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Canis familiaris)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Canis familiaris)
ATP [cytosol]
PGR binds PGR agonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Canis familiaris)
ATP [cytosol]
PGR:PGR agonists [cytosol] (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Canis familiaris)
ATP [cytosol]
PGR binds PGR antagonists (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Canis familiaris)
ATP [cytosol]
PGR:PGR antagonists [cytosol] (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Canis familiaris)
ATP [cytosol]
Mitochondrial unfolded protein response (UPRmt) (Canis familiaris)
HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization (Canis familiaris)
ATP [cytosol]
Unfolded Protein Response (UPR) (Canis familiaris)
IRE1alpha activates chaperones (Canis familiaris)
IRE1 dimer autophosphorylates (Canis familiaris)
ATP [cytosol]
PERK regulates gene expression (Canis familiaris)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)
ATP [cytosol]
DNA Replication (Canis familiaris)
DNA Replication Pre-Initiation (Canis familiaris)
Assembly of the pre-replicative complex (Canis familiaris)
Assembly of the ORC complex at the origin of replication (Canis familiaris)
ORC6 is phosphorylated on T195 (Canis familiaris)
ATP [cytosol]
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
ATP [cytosol]
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
MAPK-dependent phosphorylation of KARS (Canis familiaris)
ATP [cytosol]
MARK3 phosphorylates MITF-M on S173 (Canis familiaris)
ATP [cytosol]
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPH receptors autophosphorylate (Canis familiaris)
ATP [cytosol]
EPH-ephrin mediated repulsion of cells (Canis familiaris)
SFKs phosphorylate VAV2,3 (Canis familiaris)
ATP [cytosol]
EPHB-mediated forward signaling (Canis familiaris)
EPHB phosphorylates TIAM1 (Canis familiaris)
ATP [cytosol]
N-WASP binds ARP2/3 and G-actin (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
PAK1 autophosphorylates (Canis familiaris)
ATP [cytosol]
Ephrin signaling (Canis familiaris)
PAKs autophosphorylate (Canis familiaris)
ATP [cytosol]
PAKs phosphorylate MLC (Canis familiaris)
ATP [cytosol]
L1CAM interactions (Canis familiaris)
Recycling pathway of L1 (Canis familiaris)
Phosphorylation of L1 by ERK (Canis familiaris)
ATP [cytosol]
Signal transduction by L1 (Canis familiaris)
Interaction of PAK1 with Rac1-GTP (Canis familiaris)
ATP [cytosol]
MAP2K2 phosphorylates MAPK1 (Canis familiaris)
ATP [cytosol]
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Phosphorylation of DCC by Fyn (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of Ezrin (Canis familiaris)
ATP [cytosol]
RET signaling (Canis familiaris)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)
ATP [cytosol]
PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)
ATP [cytosol]
RET tyrosine phosphorylation (Canis familiaris)
ATP [cytosol]
Reelin signalling pathway (Canis familiaris)
FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)
ATP [cytosol]
Semaphorin interactions (Canis familiaris)
CRMPs in Sema3A signaling (Canis familiaris)
Phosphorylation of CRMPs by Cdk5 (Canis familiaris)
ATP [cytosol]
Phosphorylation of CRMPs by GSK3beta (Canis familiaris)
ATP [cytosol]
Tyrosine phosphorylation of CRMPs by Fes (Canis familiaris)
ATP [cytosol]
Sema3A PAK dependent Axon repulsion (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
ATP [cytosol]
Phosphorylation of LIMK-1 by PAK (Canis familiaris)
ATP [cytosol]
Transphosphorylation of pLIMK1 (Canis familiaris)
ATP [cytosol]
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D induced cell migration and growth-cone collapse (Canis familiaris)
SEMA4D interacts with Plexin-B1:ErbB2 (Canis familiaris)
ATP [cytosol]
Sema4D mediated inhibition of cell attachment and migration (Canis familiaris)
SEMA4D interacts with Plexin-B1:Met (Canis familiaris)
ATP [cytosol]
Signaling by ROBO receptors (Canis familiaris)
ROBO receptors bind AKAP5 (Canis familiaris)
PKC phosphorylates ROBO3.1 (Canis familiaris)
ATP [cytosol]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
ATP [cytosol]
Azathioprine ADME (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
ATP [cytosol]
GUK1 phosphorylates 6TGMP to 6TGDP (Canis familiaris)
ATP [cytosol]
GUK1 phosphorylates 6TdGMP to 6TdGDP (Canis familiaris)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Canis familiaris)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Canis familiaris)
ATP [cytosol]
Ciprofloxacin ADME (Canis familiaris)
ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)
ATP [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)
ATP [cytosol]
Paracetamol ADME (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
ATP [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
ATP [cytosol]
Prednisone ADME (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
ATP [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
ATP [cytosol]
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
ATP [cytosol]
Ribavirin ADME (Canis familiaris)
ADK phosphorylates RBV (Canis familiaris)
ATP [cytosol]
NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)
ATP [cytosol]
Extracellular matrix organization (Canis familiaris)
Non-integrin membrane-ECM interactions (Canis familiaris)
Formation of the dystrophin-glycoprotein complex (DGC) (Canis familiaris)
DGC complex binds AGRN and HSPG2 (Canis familiaris)
DGC complex:laminins:F-actin [plasma membrane] (Canis familiaris)
F-actin (all) [cytosol] (Canis familiaris)
actins:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Canis familiaris)
DGC complex:laminins:F-actin [plasma membrane] (Canis familiaris)
F-actin (all) [cytosol] (Canis familiaris)
actins:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PDPK1 phosphorylates SGK1 (Canis familiaris)
ATP [cytosol]
SGK1 phosphorylates MDM2 (Canis familiaris)
ATP [cytosol]
TORC2 complex phosphorylates SGK1 (Canis familiaris)
ATP [cytosol]
TP53 Regulates Metabolic Genes (Canis familiaris)
p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)
ATP [cytosol]
TP53 Regulates Transcription of Cell Cycle Genes (Canis familiaris)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Canis familiaris)
PLK2 phosphorylates CENPJ (Canis familiaris)
ATP [cytosol]
PLK2 phosphorylates NPM1 (Canis familiaris)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
ATP [cytosol]
Transcriptional regulation by RUNX3 (Canis familiaris)
Regulation of RUNX3 expression and activity (Canis familiaris)
SRC phosphorylates RUNX3 (Canis familiaris)
ATP [cytosol]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
PECAM1 interactions (Canis familiaris)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)
ATP [cytosol]
Factors involved in megakaryocyte development and platelet production (Canis familiaris)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)
ATP [cytosol]
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)
ATP [cytosol]
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)
ATP [cytosol]
Kinesins (Canis familiaris)
Kinesins move along microtubules consuming ATP (Canis familiaris)
ATP [cytosol]
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
DAG kinase produces phosphatidic acid from DAG (Canis familiaris)
ATP [cytosol]
GPVI-mediated activation cascade (Canis familiaris)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)
ATP [cytosol]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
SYK autophosphorylates (Canis familiaris)
ATP [cytosol]
Syk activation leads to SLP-76 activation (Canis familiaris)
ATP [cytosol]
Syk/Lck phosphorylate LAT (Canis familiaris)
ATP [cytosol]
Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)
ATP [cytosol]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
ATP [cytosol]
Autophosphorylation of SRC (Canis familiaris)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
ATP [cytosol]
SYK activation by SRC (Canis familiaris)
ATP [cytosol]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
ATP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Disinhibition of SNARE formation (Canis familiaris)
Phosphorylation of Platelet Sec-1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of Syntaxin-4 (Canis familiaris)
ATP [cytosol]
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
ATP [cytosol]
Signal amplification (Canis familiaris)
ADP signalling through P2Y purinoceptor 1 (Canis familiaris)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)
ATP [cytosol]
Platelet homeostasis (Canis familiaris)
Platelet sensitization by LDL (Canis familiaris)
FGR binds and phosphorylates LRP8 (Canis familiaris)
ATP [cytosol]
Fgr may phosphorylate p38 MAPK (Canis familiaris)
ATP [cytosol]
PECAM1 is phosphorylated (Canis familiaris)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)
ATP [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
E1 mediated ubiquitin activation (Canis familiaris)
ATP [cytosol]
Polyubiquitination of substrate (Canis familiaris)
ATP [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
ATP [cytosol]
MHC class II antigen presentation (Canis familiaris)
Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
ATP [cytosol]
Rap1 signalling (Canis familiaris)
PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)
ATP [cytosol]
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-inhibition by CTLA4 (Canis familiaris)
Phosphorylation of CTLA-4 (Canis familiaris)
ATP [cytosol]
Co-inhibition by PD-1 (Canis familiaris)
Phosphorylation of PD-1 (Canis familiaris)
ATP [cytosol]
Co-stimulation by CD28 (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
p-S400-Cot phosphorylates NIK (Canis familiaris)
ATP [cytosol]
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Vav1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of CD28 (Canis familiaris)
ATP [cytosol]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
ATP [cytosol]
SYK autophosphorylates at the activated BCR (Canis familiaris)
ATP [cytosol]
p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
ATP [cytosol]
CD22 mediated BCR regulation (Canis familiaris)
LYN phosphorylates CD22 (Canis familiaris)
ATP [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
ATP [cytosol]
PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)
ATP [cytosol]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
ATP [cytosol]
Activation of TAK1-TAB2 complex (Canis familiaris)
ATP [cytosol]
Change of PKC theta conformation (Canis familiaris)
ATP [cytosol]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of Bcl10 (Canis familiaris)
ATP [cytosol]
Phosphorylation of CARMA1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of PKC theta (Canis familiaris)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
ATP [cytosol]
Generation of second messenger molecules (Canis familiaris)
Phosphorylation of PLC-gamma1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of SLP-76 (Canis familiaris)
ATP [cytosol]
Phosphorylation of TBSMs in LAT (Canis familiaris)
ATP [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Activation of Lck (Canis familiaris)
ATP [cytosol]
Inactivation of Lck by Csk (Canis familiaris)
ATP [cytosol]
Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
ATP [cytosol]
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
Activation of ZAP-70 (Canis familiaris)
ATP [cytosol]
Phosphorylation of ZAP-70 by Lck (Canis familiaris)
ATP [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Active FLT3 phosphorylates CDKN1B (Canis familiaris)
ATP [cytosol]
FLT3 phosphorylates GRB10 (Canis familiaris)
ATP [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
ATP [cytosol]
Negative regulation of FLT3 (Canis familiaris)
FLT3 phosphorylates CBL (Canis familiaris)
ATP [cytosol]
Growth hormone receptor signaling (Canis familiaris)
JAK2 phosphorylation (Canis familiaris)
ATP [cytosol]
Lyn activates ERK (Canis familiaris)
ATP [cytosol]
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
ISG15 antiviral mechanism (Canis familiaris)
Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)
ATP [cytosol]
OAS antiviral response (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
ATP [cytosol]
2'-5' oligoadenylate [cytosol] (Homo sapiens)
ATP [cytosol]
RNASEL cleaves cellular ssRNA (Canis familiaris)
RNASEL:2'-5' oligoadenylate [cytosol] (Canis familiaris)
2'-5' oligoadenylate [cytosol] (Homo sapiens)
ATP [cytosol]
PKR-mediated signaling (Canis familiaris)
p-PKR dimer phosphorylates CDK1 (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates DHX9 (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates ILF3:ILF2 (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates MAPT (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates MKK6 (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates PPP2R5A (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates PTPN2 (Canis familiaris)
ATP [cytosol]
p-PKR dimer phosphorylates SNCA (Canis familiaris)
ATP [cytosol]
Interferon alpha/beta signaling (Canis familiaris)
Activation of JAK kinases (Canis familiaris)
ATP [cytosol]
Formation of p-STAT1 homodimer (Canis familiaris)
ATP [cytosol]
Phosphorylation of INFAR1 by TYK2 (Canis familiaris)
ATP [cytosol]
Phosphorylation of STAT2 (Canis familiaris)
ATP [cytosol]
Interferon gamma signaling (Canis familiaris)
IFNG signaling activates MAPKs (Canis familiaris)
JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
ATP [cytosol]
JAK1-mediated phosphorylation of RAF1 (Canis familiaris)
ATP [cytosol]
JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)
ATP [cytosol]
Phosphorylation of JAK2 (Canis familiaris)
ATP [cytosol]
Phosphorylation of STAT1 at Ser727 (Canis familiaris)
ATP [cytosol]
Phosphorylation of STAT1 by JAK kinases (Canis familiaris)
ATP [cytosol]
Transphosphorylation of JAK1 (Canis familiaris)
ATP [cytosol]
Prolactin receptor signaling (Canis familiaris)
JAK2 phosphorylation (Canis familiaris)
ATP [cytosol]
PRLR is phosphorylated at Ser-349 (Canis familiaris)
ATP [cytosol]
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
ATP [cytosol]
IRAK4 is activated by autophosphorylation (Canis familiaris)
ATP [cytosol]
IRAK4 phosphorylates IRAK1 (Canis familiaris)
ATP [cytosol]
IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
TAK1 phosphorylates MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2 (Canis familiaris)
ATP [cytosol]
Interleukin-37 signaling (Canis familiaris)
STAT3 phosphorylation (Canis familiaris)
ATP [cytosol]
TBK1 phosphorylation (Canis familiaris)
ATP [cytosol]
Interleukin-38 signaling (Canis familiaris)
MAPK8 phosphorylation (Canis familiaris)
ATP [cytosol]
Interleukin-10 signaling (Canis familiaris)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Canis familiaris)
ATP [cytosol]
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)
ATP [cytosol]
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)
ATP [cytosol]
Interleukin-12 family signaling (Canis familiaris)
Interleukin-12 signaling (Canis familiaris)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)
ATP [cytosol]
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)
ATP [cytosol]
Interleukin-23 signaling (Canis familiaris)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)
ATP [cytosol]
Interleukin-27 signaling (Canis familiaris)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)
ATP [cytosol]
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)
ATP [cytosol]
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)
ATP [cytosol]
Interleukin-35 Signalling (Canis familiaris)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)
ATP [cytosol]
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)
ATP [cytosol]
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)
ATP [cytosol]
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)
ATP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)
ATP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)
ATP [cytosol]
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)
ATP [cytosol]
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)
ATP [cytosol]
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
ATP [cytosol]
Interleukin-15 signaling (Canis familiaris)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Canis familiaris)
ATP [cytosol]
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)
ATP [cytosol]
Interleukin-2 signaling (Canis familiaris)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Canis familiaris)
ATP [cytosol]
Recruited STAT5 is phosphorylated (Canis familiaris)
ATP [cytosol]
SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)
ATP [cytosol]
SYK is a substrate for JAK1 (Canis familiaris)
ATP [cytosol]
Within the IL-2R complex JAK3 phosphorylates JAK1 (Canis familiaris)
ATP [cytosol]
Interleukin-21 signaling (Canis familiaris)
IL21 receptor JAK phosphorylation (Canis familiaris)
ATP [cytosol]
IL21 receptor STAT phosphorylation (Canis familiaris)
ATP [cytosol]
Interleukin-9 signaling (Canis familiaris)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)
ATP [cytosol]
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)
ATP [cytosol]
IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)
ATP [cytosol]
Interleukin-20 family signaling (Canis familiaris)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)
ATP [cytosol]
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)
ATP [cytosol]
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)
ATP [cytosol]
IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)
ATP [cytosol]
IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)
ATP [cytosol]
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)
ATP [cytosol]
IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)
ATP [cytosol]
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)
ATP [cytosol]
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Canis familiaris)
ATP [cytosol]
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Canis familiaris)
ATP [cytosol]
IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)
ATP [cytosol]
IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)
ATP [cytosol]
IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)
ATP [cytosol]
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Canis familiaris)
ATP [cytosol]
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Canis familiaris)
ATP [cytosol]
JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)
ATP [cytosol]
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Activation of STAT5a/b by JAK2 (Canis familiaris)
ATP [cytosol]
Interleukin receptor SHC signaling (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
ATP [cytosol]
JAK2 is phosphorylated, activated (Canis familiaris)
ATP [cytosol]
Tyrosine kinases phosphorylate the receptor (Canis familiaris)
ATP [cytosol]
Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)
ATP [cytosol]
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
ATP [cytosol]
JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
ATP [cytosol]
STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)
ATP [cytosol]
Interleukin-6 family signaling (Canis familiaris)
Interleukin-6 signaling (Canis familiaris)
IL6ST is tyrosine phosphorylated (Canis familiaris)
ATP [cytosol]
JAK activation (Canis familiaris)
ATP [cytosol]
PTPN11 is phosphorylated (Canis familiaris)
ATP [cytosol]
Serine phosphorylation of STATs (Canis familiaris)
ATP [cytosol]
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)
ATP [cytosol]
Interleukin-7 signaling (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Canis familiaris)
ATP [cytosol]
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)
ATP [cytosol]
STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)
ATP [cytosol]
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
ATP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
ATP [cytosol]
NIK autophosphorylates on T559 (Canis familiaris)
ATP [cytosol]
Innate Immune System (Canis familiaris)
Alpha-protein kinase 1 signaling pathway (Canis familiaris)
ALPK1 phosphorylates TIFA (Canis familiaris)
ATP [cytosol]
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)
ATP [cytosol]
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
ATP [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CD209 (DC-SIGN) signaling (Canis familiaris)
PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)
ATP [cytosol]
SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)
ATP [cytosol]
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
ATP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
ATP [cytosol]
K63polyUb-TAK1 autophosphorylates (Canis familiaris)
ATP [cytosol]
K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
ATP [cytosol]
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
ATP [cytosol]
PKC-delta phosphorylates CARD9 (Canis familiaris)
ATP [cytosol]
SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)
ATP [cytosol]
TRAF6 oligomer autoubiquitinates (Canis familiaris)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
ATP [cytosol]
Dectin-2 family (Canis familiaris)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)
ATP [cytosol]
SYK autophosphorylates (Canis familiaris)
ATP [cytosol]
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
ATP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
STING mediated induction of host immune responses (Canis familiaris)
STAT6-mediated induction of chemokines (Canis familiaris)
p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)
ATP [cytosol]
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of BTK by p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of LAT by p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of SYK (Canis familiaris)
ATP [cytosol]
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
Autophosphorylation of LYN kinase (Canis familiaris)
ATP [cytosol]
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
ATP [cytosol]
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
ATP [cytosol]
FCERI mediated MAPK activation (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of VAV (Canis familiaris)
ATP [cytosol]
Phosphorylation of MEK4 by MEKK1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of MEK7 by MEKK1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of SHC by SYK kinase (Canis familiaris)
ATP [cytosol]
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
FCERI mediated NF-kB activation (Canis familiaris)
Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)
ATP [cytosol]
Auto-ubiquitination of TRAF6 (Canis familiaris)
ATP [cytosol]
Autophosphorylation of PKC-theta (Canis familiaris)
ATP [cytosol]
Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)
ATP [cytosol]
Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of PKC-theta (Canis familiaris)
ATP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
ATP [cytosol]
Phosphorylation of LAT by p-SYK (Canis familiaris)
ATP [cytosol]
Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)
ATP [cytosol]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)
ATP [cytosol]
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
ATP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
FCGR activation (Canis familiaris)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)
ATP [cytosol]
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
ABL phosphorylates WAVEs (Canis familiaris)
ATP [cytosol]
Autophosphorylation of PAK1 (Canis familiaris)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:ARP2/3:actin:ADP [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)
ATP [cytosol]
Actin filament bound Myosin-X [plasma membrane] (Canis familiaris)
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
PAK1 phosphorylates LIMK1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of VAV (Canis familiaris)
ATP [cytosol]
Role of myosins in phagosome formation (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Myosin-Actin filaments [cytosol] (Canis familiaris)
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Canis familiaris)
ATP [cytosol]
Transphosphorylation of pLIMK1 (Canis familiaris)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
ATP [cytosol]
Role of phospholipids in phagocytosis (Canis familiaris)
DAG stimulates protein kinase C-delta (Canis familiaris)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of PLCG (Canis familiaris)
ATP [cytosol]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
Inflammasomes (Canis familiaris)
The NLRP1 inflammasome (Canis familiaris)
MDP:NLRP1 binds ATP (Canis familiaris)
ATP [cytosol]
MDP:NLRP1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
NLRP1 oligomerizes (Canis familiaris)
MDP:NLRP1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
MDP:NLRP1:ATP oligomer [cytosol] (Canis familiaris)
MDP:NLRP1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
NOD1/2 Signaling Pathway (Canis familiaris)
Activation of p38 MAPK (Canis familiaris)
ATP [cytosol]
TAK1 phosphorylates MKK6 (Canis familiaris)
ATP [cytosol]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
IRAK1 phosphorylates Pellino (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
IRAK1 phosphorylates Pellino (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
IRAK1 phosphorylates Pellino (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Canis familiaris)
ATP [cytosol]
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
ATP [cytosol]
TBK1 is phosphorylated within the activated TLR4 complex (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Canis familiaris)
Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)
ATP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
IRAK1 phosphorylates Pellino (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
IRAK1 phosphorylates Pellino (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Canis familiaris)
ATP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Canis familiaris)
ATP [cytosol]
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
ATP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
ATP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
ATP [cytosol]
MAP3K8 is phosphorylated (Canis familiaris)
ATP [cytosol]
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
ATP [cytosol]
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
ATP [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Mitochondrial Uncoupling (Canis familiaris)
UCP1 imports a proton (Canis familiaris)
Purine nucleotide [cytosol]
ATP [cytosol]
Pyruvate metabolism (Canis familiaris)
PKM dephosphorylates PEP to PYR (Canis familiaris)
ATP [cytosol]
Regulation of pyruvate metabolism (Canis familiaris)
NEK1 phosphorylates ME1 (Canis familiaris)
ATP [cytosol]
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Ethanol oxidation (Canis familiaris)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)
ATP [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
ATP [cytosol]
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
GCL ligates L-Glu to L-Cys (Canis familiaris)
ATP [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Canis familiaris)
ATP [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
ATP [cytosol]
Methylation (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
ATP [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
ATP [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)
ATP [cytosol]
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)
ATP [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)
ATP [cytosol]
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)
ATP [cytosol]
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Canis familiaris)
ATP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Canis familiaris)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)
ATP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)
ATP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)
ATP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)
ATP [cytosol]
I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)
ATP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)
ATP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)
ATP [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Acetylcholine regulates insulin secretion (Canis familiaris)
Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)
ATP [cytosol]
Free fatty acids regulate insulin secretion (Canis familiaris)
Intracellular metabolism of fatty acids regulates insulin secretion (Canis familiaris)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)
ATP [cytosol]
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)
ATP [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
ATP [cytosol]
Creatine metabolism (Canis familiaris)
creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)
ATP [cytosol]
creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)
ATP [cytosol]
Glutamate and glutamine metabolism (Canis familiaris)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)
ATP [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
ATP [cytosol]
Histidine catabolism (Canis familiaris)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)
ATP [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
ATP [cytosol]
Selenocysteine synthesis (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
ATP [cytosol]
Serine biosynthesis (Canis familiaris)
PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)
ATP [cytosol]
PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)
ATP [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
ATP [cytosol]
Urea cycle (Canis familiaris)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
ATP [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Formation of xylulose-5-phosphate (Canis familiaris)
XYLB phosphorylates D-xylulose (Canis familiaris)
ATP [cytosol]
Fructose metabolism (Canis familiaris)
Fructose catabolism (Canis familiaris)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)
ATP [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)
ATP [cytosol]
Galactose catabolism (Canis familiaris)
GALK1 phosphorylates Gal to Gal1P (Canis familiaris)
ATP [cytosol]
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Canis familiaris)
ATP [cytosol]
Glycolysis (Canis familiaris)
1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)
ATP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)
ATP [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)
ATP [cytosol]
PKM dephosphorylates PEP to PYR (Canis familiaris)
ATP [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Canis familiaris)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)
ATP [cytosol]
Glycogen metabolism (Canis familiaris)
Glycogen breakdown (glycogenolysis) (Canis familiaris)
PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Canis familiaris)
ATP [cytosol]
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)
ATP [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)
ATP [cytosol]
Glycosaminoglycan metabolism (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
ATP [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
ATP [cytosol]
Pentose phosphate pathway (Canis familiaris)
5-Phosphoribose 1-diphosphate biosynthesis (Canis familiaris)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)
ATP [cytosol]
RBKS phosphorylates ribose to R5P (Canis familiaris)
ATP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)
ATP [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)
ATP [cytosol]
Carnitine shuttle (Canis familiaris)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
ATP [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
ATP [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)
ATP [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)
ATP [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Canis familiaris)
ATP [cytosol]
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)
ATP [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)
ATP [cytosol]
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
ATP [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
ATP [cytosol]
Peroxisomal lipid metabolism (Canis familiaris)
Alpha-oxidation of phytanate (Canis familiaris)
PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)
ATP [cytosol]
Beta-oxidation of very long chain fatty acids (Canis familiaris)
Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)
ATP [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Recycling of bile acids and salts (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
ATP [cytosol]
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
ATP [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
ATP [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
ATP [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
ATP [cytosol]
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
ATP [cytosol]
THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
ATP [cytosol]
Cholesterol biosynthesis (Canis familiaris)
MVD decarboxylates MVA5PP to IPPP (Canis familiaris)
ATP [cytosol]
Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)
ATP [cytosol]
Mevalonate-5-phosphate is further phosphorylated (Canis familiaris)
ATP [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Synthesis of PC (Canis familiaris)
Casein kinase II phosphorylates STARD10 (Canis familiaris)
ATP [cytosol]
Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)
ATP [cytosol]
Synthesis of PE (Canis familiaris)
ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)
ATP [cytosol]
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the ER membrane (Canis familiaris)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)
ATP [cytosol]
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)
ATP [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)
ATP [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)
ATP [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
BMX phosphorylates RUFY1 (Canis familiaris)
ATP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
ATP [cytosol]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid biosynthesis (Canis familiaris)
CERK phosphorylates CERA to form C1P (Canis familiaris)
ATP [cytosol]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
ATP [cytosol]
SPHK1 phosphorylates sphingoid (Canis familiaris)
ATP [cytosol]
SPHK2 phosphorylates sphingoid (Canis familiaris)
ATP [cytosol]
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)
ATP [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)
ATP [cytosol]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)
ATP [cytosol]
(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)
ATP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)
ATP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)
ATP [cytosol]
(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Canis familiaris)
ATP [cytosol]
(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)
ATP [cytosol]
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)
ATP [cytosol]
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)
ATP [cytosol]
ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)
ATP [cytosol]
AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)
ATP [cytosol]
AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)
ATP [cytosol]
NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Canis familiaris)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
ATP [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
ATP [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
ATP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
ATP [cytosol]
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)
ATP [cytosol]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)
ATP [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)
ATP [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Canis familiaris)
ATP [cytosol]
FGAM + ATP => AIR + ADP + Pi (Canis familiaris)
ATP [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
ATP [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
ATP [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
ATP [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)
ATP [cytosol]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)
ATP [cytosol]
Pyrimidine salvage (Canis familiaris)
(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)
ATP [cytosol]
UCKL1 phosphorylates urindine, cytidine (Canis familiaris)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)
ATP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)
ATP [cytosol]
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)
ATP [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
Heme degradation (Canis familiaris)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)
ATP [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Biotin transport and metabolism (Canis familiaris)
HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)
ATP [cytosol]
HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)
ATP [cytosol]
HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
ATP [cytosol]
HLCS biotinylates ACACB (Canis familiaris)
ATP [cytosol]
HLCS biotinylates PC:Mn2+ (Canis familiaris)
ATP [cytosol]
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Transport of RCbl within the body (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
ATP [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
ATP [cytosol]
Uptake of dietary cobalamins into enterocytes (Canis familiaris)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
ATP [cytosol]
Metabolism of folate and pterines (Canis familiaris)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
ATP [cytosol]
FPGS-2 transforms THF to THFPG (Canis familiaris)
ATP [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)
ATP [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
ATP [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
ATP [cytosol]
Nicotinate metabolism (Canis familiaris)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
ATP [cytosol]
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
ATP [cytosol]
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)
ATP [cytosol]
NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)
ATP [cytosol]
NMRK1 phosphorylates NR to yield NMN (Canis familiaris)
ATP [cytosol]
Vitamin B1 (thiamin) metabolism (Canis familiaris)
2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)
ATP [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
FLAD1 phosphorylates FMN (Canis familiaris)
ATP [cytosol]
RFK:Mg2+ phosphorylates RIB (Canis familiaris)
ATP [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
Coenzyme A biosynthesis (Canis familiaris)
2xPPCS ligates PPanK with Cys (Canis familiaris)
ATP [cytosol]
COASY phosphorylates DP-CoA (Canis familiaris)
ATP [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
ATP [cytosol]
DCAKD phosphorylates DP-CoA (Canis familiaris)
ATP [cytosol]
PANK1/3 phosphorylate PanK (Canis familiaris)
ATP [cytosol]
PANK2 phosphorylates PanK (Canis familiaris)
ATP [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)
2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)
ATP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)
ATP [cytosol]
Metabolism of RNA (Canis familiaris)
Nonsense-Mediated Decay (NMD) (Canis familiaris)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
ATP [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)
ATP [cytosol]
Sialic acid metabolism (Canis familiaris)
GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)
ATP [cytosol]
Synthesis of Dolichyl-phosphate (Canis familiaris)
MVD decarboxylates MVA5PP to IPPP (Canis familiaris)
ATP [cytosol]
Synthesis of GDP-mannose (Canis familiaris)
HK1 phosphorylates Mannose to Man6P (Canis familiaris)
ATP [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)
ATP [cytosol]
Transport to the Golgi and subsequent modification (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPI-mediated anterograde transport (Canis familiaris)
GBF1 stimulates ARF nucleotide exchange (Canis familiaris)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)
ATP [cytosol]
COPII-mediated vesicle transport (Canis familiaris)
CSNK1D phosphorylates SEC23 (Canis familiaris)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE (Canis familiaris)
ATP [cytosol]
Carboxyterminal post-translational modifications of tubulin (Canis familiaris)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Canis familiaris)
ATP [cytosol]
TTLLs polyglutamylate tubulin (Canis familiaris)
ATP [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
FN3K phosphorylates ketosamines (Canis familiaris)
ATP [cytosol]
FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)
ATP [cytosol]
Synthesis of diphthamide-EEF2 (Canis familiaris)
DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)
ATP [cytosol]
Neddylation (Canis familiaris)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)
ATP [cytosol]
NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)
ATP [cytosol]
Protein ubiquitination (Canis familiaris)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Canis familiaris)
UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
ATP [cytosol]
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
ATP [cytosol]
Protein folding (Canis familiaris)
Chaperonin-mediated protein folding (Canis familiaris)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Canis familiaris)
ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)
ATP [cytosol]
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Canis familiaris)
CCT/TriC:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Canis familiaris)
CCT/TriC:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
CK2 phosphorylates PDCL (Canis familiaris)
ATP [cytosol]
Surfactant metabolism (Canis familiaris)
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
ATP [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Cap-bound mRNA is activated by helicases (Canis familiaris)
ATP [cytosol]
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
ATP [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
ATP [cytosol]
PRKACA phosphorylates PLN (Canis familiaris)
ATP [cytosol]
PRKACA phosphorylates TNNI3 (Canis familiaris)
ATP [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)
ATP [cytosol]
Smooth Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Canis familiaris)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Calcium Binds Caldesmon (Canis familiaris)
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Inactive Myosin Actin Contractile Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Myosin Binds ATP (Canis familiaris)
ATP [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
ATP Bound Smooth Muscle Myosin Complex [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)
ATP [cytosol]
Release Of ADP From Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Canis familiaris)
(ACTA2,ACTG2):ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Striated Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
ATP Bound Myosin Complex [cytosol] (Canis familiaris)
ATP [cytosol]
Myosin Binds ATP (Canis familiaris)
ATP [cytosol]
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
ATP Bound Myosin Complex [cytosol] (Canis familiaris)
ATP [cytosol]
Neuronal System (Canis familiaris)
Potassium Channels (Canis familiaris)
Inwardly rectifying K+ channels (Canis familiaris)
ATP sensitive Potassium channels (Canis familiaris)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)
ATP [cytosol]
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
Activation of NMDA receptors and postsynaptic events (Canis familiaris)
Post NMDA receptor activation events (Canis familiaris)
Activation of RAC1 downstream of NMDARs (Canis familiaris)
CaMKK autophosphorylates in the cytosol (Canis familiaris)
ATP [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
Trafficking of AMPA receptors (Canis familiaris)
Trafficking of GluR1-containing AMPA receptors (Canis familiaris)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors (Canis familiaris)
Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)
ATP [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)
ATP [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Canis familiaris)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Canis familiaris)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
ATP [cytosol]
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
Caspase activation via Dependence Receptors in the absence of ligand (Canis familiaris)
Activation of caspase-3 (Canis familiaris)
ATP [cytosol]
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation of BH3-only proteins (Canis familiaris)
Activation of BIM and translocation to mitochondria (Canis familiaris)
Phosphorylation of BIM by JNK (Canis familiaris)
ATP [cytosol]
Activation of BMF and translocation to mitochondria (Canis familiaris)
Phosphorylation of DLC2 by MAPK8 (Canis familiaris)
ATP [cytosol]
Apoptotic factor-mediated response (Canis familiaris)
Cytochrome c-mediated apoptotic response (Canis familiaris)
Activation of caspases through apoptosome-mediated cleavage (Canis familiaris)
Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)
ATP [cytosol]
Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
ATP [cytosol]
Formation of apoptosome (Canis familiaris)
CYCS binds to APAF1 (Canis familiaris)
ATP [cytosol]
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
CYCS:APAF1 binds procaspase-9 (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Procaspase 9 forms dimer (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Regulation of the apoptosome activity (Canis familiaris)
APAF1:CYCS binds APIP (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
APAF1:CYCS:ATP:APIP [cytosol] (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
CASP9 is phosphorylated at T412 (Canis familiaris)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
APAF1:ATP:CYCS heptamer:p-T412-CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
RIPK1 is phosphorylated (Canis familiaris)
ATP [cytosol]
RIPK3 is phosphorylated (Canis familiaris)
ATP [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
ABCA4 mediates atRAL transport (Canis familiaris)
ATP [cytosol]
The phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
GRK1,4,7 phosphorylate MII to p-MII (Canis familiaris)
ATP [cytosol]
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
ATP [cytosol]
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
ATP [cytosol]
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
ATP [cytosol]
ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)
ATP [cytosol]
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
GTP-bound RAC contributes to JNK activation (Canis familiaris)
ATP [cytosol]
JNK phosphorylates BIM, BAD and other targets (Canis familiaris)
ATP [cytosol]
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
ATP [cytosol]
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
ATP [cytosol]
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
ATP [cytosol]
Autophosphorylation of SRC (Canis familiaris)
ATP [cytosol]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
ATP [cytosol]
SYK activation by SRC (Canis familiaris)
ATP [cytosol]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
ATP [cytosol]
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
ATP [cytosol]
PKC phosphorylates GRK2 (Canis familiaris)
ATP [cytosol]
DAG stimulates protein kinase C-delta (Canis familiaris)
ATP [cytosol]
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)
ATP [cytosol]
MAPKs phosphorylate PP2A (Canis familiaris)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
ATP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
ATP [cytosol]
PDPK1 phosphorylates SGK1 (Canis familiaris)
ATP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
PTEN Regulation (Canis familiaris)
Regulation of PTEN gene transcription (Canis familiaris)
mTORC1 phosphorylates MAF1 (Canis familiaris)
ATP [cytosol]
Regulation of PTEN stability and activity (Canis familiaris)
Casein kinase II phosphorylates PTEN (Canis familiaris)
ATP [cytosol]
FRK phosphorylates PTEN (Canis familiaris)
ATP [cytosol]
TORC2 complex phosphorylates SGK1 (Canis familiaris)
ATP [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
MAPK1 (ERK2) activation (Canis familiaris)
MAP2K2 phosphorylates MAPK1 (Canis familiaris)
ATP [cytosol]
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)
ATP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)
ATP [cytosol]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
ATP [cytosol]
RAF phosphorylates MAP2K dimer (Canis familiaris)
ATP [cytosol]
Negative regulation of MAPK pathway (Canis familiaris)
MAPK12 phosphorylates PTPN3 (Canis familiaris)
ATP [cytosol]
Negative feedback regulation of MAPK pathway (Canis familiaris)
Activated MAPK phosphorylates RAF1 (Canis familiaris)
ATP [cytosol]
Activated MAPKs phosphorylate BRAF (Canis familiaris)
ATP [cytosol]
RAF activation (Canis familiaris)
MARK3 phosphorylates KSR1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of RAF (Canis familiaris)
ATP [cytosol]
RAS processing (Canis familiaris)
KRAS4B is phosphorylated on serine 181 (Canis familiaris)
ATP [cytosol]
MAPK6/MAPK4 signaling (Canis familiaris)
Autophosphorylation of PAK1,2,3 (Canis familiaris)
ATP [cytosol]
PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)
ATP [cytosol]
MTOR signalling (Canis familiaris)
Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
ATP [cytosol]
Activation of cytosolic AMPK by phosphorylation (Canis familiaris)
ATP [cytosol]
p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)
ATP [cytosol]
mTORC1 phosphorylates AKT1S1 (Canis familiaris)
ATP [cytosol]
mTORC1-mediated signalling (Canis familiaris)
Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)
ATP [cytosol]
Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)
ATP [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
ATP [cytosol]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
ATP [cytosol]
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
ATP [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)
ATP [cytosol]
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)
ATP [cytosol]
PKA phosphorylates PDE4B (Canis familiaris)
ATP [cytosol]
G-protein mediated events (Canis familiaris)
Adenylate cyclase activating pathway (Canis familiaris)
Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)
ATP [cytosol]
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
ATP [cytosol]
PKC phosphorylates GRK2 (Canis familiaris)
ATP [cytosol]
phospho-PLA2 pathway (Canis familiaris)
Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)
ATP [cytosol]
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
DAG kinase produces phosphatidic acid from DAG (Canis familiaris)
ATP [cytosol]
G alpha (s) signalling events (Canis familiaris)
ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)
ATP [cytosol]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
GLI3 is processed to GLI3R by the proteasome (Canis familiaris)
CK1 phosphorylates p-GLI3 (Canis familiaris)
ATP [cytosol]
GSK3 phosphorylates p-GLI3 (Canis familiaris)
ATP [cytosol]
PKA phosphorylates GLI3 (Canis familiaris)
ATP [cytosol]
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)
ATP [cytosol]
Hedgehog ligand biogenesis (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
ATP [cytosol]
Signaling by Hippo (Canis familiaris)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)
ATP [cytosol]
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Canis familiaris)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Canis familiaris)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)
ATP [cytosol]
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)
ATP [cytosol]
Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Canis familiaris)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)
ATP [cytosol]
Phosphorylation of YAP by LATS1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of YAP by LATS2 (Canis familiaris)
ATP [cytosol]
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
ESR-associated SRC autophosphorylates (Canis familiaris)
ATP [cytosol]
Estrogen-stimulated signaling through PRKCZ (Canis familiaris)
PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)
ATP [cytosol]
PTK2 autophosphorylates downstream of EGFR (Canis familiaris)
ATP [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
ALK autophosphorylation (Canis familiaris)
ATP [cytosol]
Active ALK phosphorylates IRS1 (Canis familiaris)
ATP [cytosol]
Active ALK phosphorylates JAK3 (Canis familiaris)
ATP [cytosol]
Active ALK phosphorylates PLCG1 (Canis familiaris)
ATP [cytosol]
Active ALK phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
ATP [cytosol]
Signaling by EGFR (Canis familiaris)
EGFR autophosphorylation (Canis familiaris)
ATP [cytosol]
EGFR downregulation (Canis familiaris)
EGFR phosphorylates EPS15 (Canis familiaris)
ATP [cytosol]
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
ATP [cytosol]
Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
ATP [cytosol]
EGFR interacts with phospholipase C-gamma (Canis familiaris)
EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
ATP [cytosol]
GAB1 signalosome (Canis familiaris)
GAB1 phosphorylation by EGFR kinase (Canis familiaris)
ATP [cytosol]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
ATP [cytosol]
Phosphorylation of EGFR by SRC kinase (Canis familiaris)
ATP [cytosol]
SHC1 events in EGFR signaling (Canis familiaris)
SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
ATP [cytosol]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
ATP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
ATP [cytosol]
SHC1 events in ERBB2 signaling (Canis familiaris)
Activated PKC phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
ATP [cytosol]
SRC family kinases phosphorylate ERBB2 (Canis familiaris)
ATP [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
ATP [cytosol]
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)
ATP [cytosol]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
ATP [cytosol]
SHC1 events in ERBB4 signaling (Canis familiaris)
Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
ATP [cytosol]
Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)
ATP [cytosol]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1 phosphorylates FRS2 (Canis familiaris)
ATP [cytosol]
Activated FGFR1 phosphorylates FRS3 (Canis familiaris)
ATP [cytosol]
Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)
ATP [cytosol]
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phospholipase C-mediated cascade: FGFR1 (Canis familiaris)
Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)
ATP [cytosol]
SHC-mediated cascade:FGFR1 (Canis familiaris)
Activated FGFR1 phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
FGFR1 ligand binding and activation (Canis familiaris)
FGFR1b ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR1b (Canis familiaris)
ATP [cytosol]
FGFR1c and Klotho ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Canis familiaris)
ATP [cytosol]
FGFR1c ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR1c (Canis familiaris)
ATP [cytosol]
Negative regulation of FGFR1 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Canis familiaris)
ATP [cytosol]
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)
ATP [cytosol]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
FRS-mediated FGFR2 signaling (Canis familiaris)
Activated FGFR2 phosphorylates FRS2 (Canis familiaris)
ATP [cytosol]
Activated FGFR2 phosphorylates FRS3 (Canis familiaris)
ATP [cytosol]
Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)
ATP [cytosol]
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR2 (Canis familiaris)
Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)
ATP [cytosol]
SHC-mediated cascade:FGFR2 (Canis familiaris)
Activated FGFR2 phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
FGFR2 ligand binding and activation (Canis familiaris)
FGFR2b ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR2b (Canis familiaris)
ATP [cytosol]
FGFR2c ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR2c (Canis familiaris)
ATP [cytosol]
Negative regulation of FGFR2 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)
ATP [cytosol]
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)
ATP [cytosol]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
FRS-mediated FGFR3 signaling (Canis familiaris)
Activated FGFR3 phosphorylates FRS2 (Canis familiaris)
ATP [cytosol]
Activated FGFR3 phosphorylates FRS3 (Canis familiaris)
ATP [cytosol]
Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)
ATP [cytosol]
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR3 (Canis familiaris)
Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)
ATP [cytosol]
SHC-mediated cascade:FGFR3 (Canis familiaris)
Activated FGFR3 phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
FGFR3 ligand binding and activation (Canis familiaris)
FGFR3b ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR3b (Canis familiaris)
ATP [cytosol]
FGFR3c ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR3c (Canis familiaris)
ATP [cytosol]
Negative regulation of FGFR3 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Canis familiaris)
ATP [cytosol]
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)
ATP [cytosol]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4 phosphorylates FRS2 (Canis familiaris)
ATP [cytosol]
Activated FGFR4 phosphorylates FRS3 (Canis familiaris)
ATP [cytosol]
Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)
ATP [cytosol]
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phospholipase C-mediated cascade; FGFR4 (Canis familiaris)
Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
ATP [cytosol]
SHC-mediated cascade:FGFR4 (Canis familiaris)
Activated FGFR4 phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
FGFR4 ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of FGFR4 (Canis familiaris)
ATP [cytosol]
betaKlotho-mediated ligand binding (Canis familiaris)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)
ATP [cytosol]
Negative regulation of FGFR4 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Canis familiaris)
ATP [cytosol]
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)
ATP [cytosol]
SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)
ATP [cytosol]
Signaling by Insulin receptor (Canis familiaris)
Autophosphorylation of insulin receptor (Canis familiaris)
ATP [cytosol]
Insulin receptor signalling cascade (Canis familiaris)
IRS activation (Canis familiaris)
Phosphorylation of IRS (Canis familiaris)
ATP [cytosol]
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of SHC1 (Canis familiaris)
ATP [cytosol]
Signal attenuation (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)
ATP [cytosol]
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)
ATP [cytosol]
Signaling by MET (Canis familiaris)
MET Receptor Activation (Canis familiaris)
MET dimers autophosphorylate (Canis familiaris)
ATP [cytosol]
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
ATP [cytosol]
MET phosphorylates GAB1 (Canis familiaris)
ATP [cytosol]
MET activates RAS signaling (Canis familiaris)
MET phosphorylates SHC1-2 (Canis familiaris)
ATP [cytosol]
MET activates STAT3 (Canis familiaris)
MET phosphorylates STAT3 (Canis familiaris)
ATP [cytosol]
MET promotes cell motility (Canis familiaris)
MET activates PTK2 signaling (Canis familiaris)
MET phosphorylates PTK2 (Canis familiaris)
ATP [cytosol]
PTK2 autophosphorylates (Canis familiaris)
ATP [cytosol]
SRC phosphorylates PTK2 (Canis familiaris)
ATP [cytosol]
Negative regulation of MET activity (Canis familiaris)
MET phosphorylates CBL (Canis familiaris)
ATP [cytosol]
Signaling by MST1 (Canis familiaris)
MST1R autophosphorylates (Canis familiaris)
ATP [cytosol]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
ATP [cytosol]
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
ARMS-mediated activation (Canis familiaris)
ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
ATP [cytosol]
Frs2-mediated activation (Canis familiaris)
FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)
ATP [cytosol]
Signaling by NTRK3 (TRKC) (Canis familiaris)
Activated NTRK3 signals through PI3K (Canis familiaris)
Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)
ATP [cytosol]
NTF3 activates NTRK3 signaling (Canis familiaris)
NTRK3 dimers trans-autophosphorylate (Canis familiaris)
ATP [cytosol]
Signaling by PDGF (Canis familiaris)
Autophosphorylation of PDGF alpha receptors (Canis familiaris)
ATP [cytosol]
Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)
ATP [cytosol]
Autophosphorylation of PDGF beta receptors (Canis familiaris)
ATP [cytosol]
Downstream signal transduction (Canis familiaris)
Activation of Src (Canis familiaris)
ATP [cytosol]
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
ATP [cytosol]
Signaling by SCF-KIT (Canis familiaris)
Autophosphorylation of KIT (Canis familiaris)
ATP [cytosol]
Phosphorylation and activation of VAV1 (Canis familiaris)
ATP [cytosol]
Phosphorylation of GAB2 by SFKs (Canis familiaris)
ATP [cytosol]
Phosphorylation of JAK2 (Canis familiaris)
ATP [cytosol]
Phosphorylation of SHP2 by SFKs (Canis familiaris)
ATP [cytosol]
Phosphorylation of STATs (Canis familiaris)
ATP [cytosol]
Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
ATP [cytosol]
Regulation of KIT signaling (Canis familiaris)
PKC alpha interacts with and phosphorylates KIT (Canis familiaris)
ATP [cytosol]
Phosphorylation of APS (Canis familiaris)
ATP [cytosol]
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
ATP [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1,2:IGF1R autophosphorylates (Canis familiaris)
ATP [cytosol]
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)
ATP [cytosol]
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
SHC-related events triggered by IGF1R (Canis familiaris)
IGF1R phosphorylates SHC1 (Canis familiaris)
ATP [cytosol]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
AXL autophosphorylates on Y779 and Y821 (Canis familiaris)
ATP [cytosol]
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
ATP [cytosol]
FYN autophosphorylates (Canis familiaris)
ATP [cytosol]
FYN phosphorylates PAK2 (Canis familiaris)
ATP [cytosol]
PAK2 autophorylates (Canis familiaris)
ATP [cytosol]
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)
ATP [cytosol]
PTK2 autophosphorylates (Canis familiaris)
ATP [cytosol]
Phosphorylation of SRC-1 (Canis familiaris)
ATP [cytosol]
SRC-1 phosphorylates PTK2-beta (Canis familiaris)
ATP [cytosol]
SRC-1 phosphorylates SHB (Canis familiaris)
ATP [cytosol]
SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)
ATP [cytosol]
Src kinases phosphorylate VAV (Canis familiaris)
ATP [cytosol]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
ATP [cytosol]
VEGFR2 autophosphorylates (Canis familiaris)
ATP [cytosol]
VEGFR2 mediated cell proliferation (Canis familiaris)
PDK1 phosphorylates PKC (Canis familiaris)
ATP [cytosol]
PKC autophosphorylates (Canis familiaris)
ATP [cytosol]
PKC phosphorylates sphingosine kinase 1 (Canis familiaris)
ATP [cytosol]
SFKs phosphorylate PLCG1 (Canis familiaris)
ATP [cytosol]
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Canis familiaris)
ATP [cytosol]
VEGFR2 mediated vascular permeability (Canis familiaris)
PAK1-3 autophosphorylates (Canis familiaris)
ATP [cytosol]
PAK1-3 phosphorylates VE-cadherin (Canis familiaris)
ATP [cytosol]
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)
ATP [cytosol]
p-Y420-FYN is phosphorylated on S21 (Canis familiaris)
ATP [cytosol]
p38 MAPK activation by VEGFR (Canis familiaris)
ATP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
RHOBTB3 ATPase cycle (Canis familiaris)
RHOBTB3 binds ATP (Canis familiaris)
ATP [cytosol]
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Canis familiaris)
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
RHOBTB3 hydrolyzes ATP (Canis familiaris)
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate Formins (Canis familiaris)
AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)
ATP [cytosol]
Activated FMNL3 binds G-actin (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RHOC:GTP:FMNL3:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Association of profilin with monomeric actin (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)
CDC42:FMNL2:Profilin:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Profilin:G-actin binds MKL1 (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Profilin:G-actin:MKL1 [cytosol] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)
Profilin:G-actin:MKL1 [cytosol] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Canis familiaris)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Canis familiaris)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Canis familiaris)
Profilin:G-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Canis familiaris)
ATP [cytosol]
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Canis familiaris)
ATP [cytosol]
PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)
ATP [cytosol]
PKC phosphorylates NCF1 (Canis familiaris)
ATP [cytosol]
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
ABL phosphorylates WAVEs (Canis familiaris)
ATP [cytosol]
Branching and elongation of mother and daughter filaments (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:ARP2/3:actin:ADP [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex:daughter filament [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:ARP2/3:actin:ADP [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Mother filament:branching complex [cytosol] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
ARP2/3 complex (ATP bound) [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
Src phosphorylate WASP,N-WASP (Canis familiaris)
ATP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
ATP [cytosol]
RHO GTPases activate IQGAPs (Canis familiaris)
IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Canis familiaris)
F-actin [cytosol] (Canis familiaris)
G-actin [cytosol] (Canis familiaris)
ATP [cytosol]
RHO GTPases activate PAKs (Canis familiaris)
Autophosphorylation of PAK1,2,3 (Canis familiaris)
ATP [cytosol]
PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)
ATP [cytosol]
PAK1 phosphorylates FLNA (Canis familiaris)
ATP [cytosol]
PAK1 phosphorylates LIMK1 (Canis familiaris)
ATP [cytosol]
PAK1 phosphorylates myosin phosphatase (Canis familiaris)
ATP [cytosol]
RHO GTPases activate PKNs (Canis familiaris)
PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)
ATP [cytosol]
p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)
ATP [cytosol]
p-T774-PKN1 phosphorylates PPP1R14A (Canis familiaris)
ATP [cytosol]
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Canis familiaris)
ATP [cytosol]
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
ATP [cytosol]
Signaling by BMP (Canis familiaris)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)
ATP [cytosol]
Type II receptor phosphorylates type I receptor (Canis familiaris)
ATP [cytosol]
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
ATP [cytosol]
TGFBR2 phosphorylates TGFBR1 (Canis familiaris)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
ATP [cytosol]
Signaling by TGFBR3 (Canis familiaris)
TGFBR3 regulates TGF-beta signaling (Canis familiaris)
TGFBR3 phosphorylation by TGFBR2 complex (Canis familiaris)
ATP [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Activation of NLK (Canis familiaris)
ATP [cytosol]
Autophosphorylation and activation of CAMK2 (Canis familiaris)
ATP [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
ATP [cytosol]
PCP/CE pathway (Canis familiaris)
WNT5A-dependent internalization of FZD4 (Canis familiaris)
DVL2 is phosphorylated by PKC (Canis familiaris)
ATP [cytosol]
Degradation of beta-catenin by the destruction complex (Canis familiaris)
AXIN is phosphorylated in the destruction complex (Canis familiaris)
ATP [cytosol]
Beta-catenin phosphorylation cascade (Canis familiaris)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)
ATP [cytosol]
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)
ATP [cytosol]
Phosphorylation of APC component of the destruction complex (Canis familiaris)
ATP [cytosol]
TCF dependent signaling in response to WNT (Canis familiaris)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Canis familiaris)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)
ATP [cytosol]
WNT mediated activation of DVL (Canis familiaris)
CSNK2-mediated phosphorylation of DVL (Canis familiaris)
ATP [cytosol]
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
ATP [cytosol]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABC transporters in lipid homeostasis (Canis familiaris)
ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
ATP [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
ATP [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)
ATP [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
ATP [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
ATP [cytosol]
ABCG4 may mediate cholesterol efflux (Canis familiaris)
ATP [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
ATP [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
ATP [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
ATP [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
HCO3- transport through ion channel (Canis familiaris)
ATP [cytosol]
Mitochondrial ABC transporters (Canis familiaris)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
ATP [cytosol]
The ABCC family mediates organic anion transport (Canis familiaris)
ATP [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
ATP [cytosol]
Aquaporin-mediated transport (Canis familiaris)
Vasopressin regulates renal water homeostasis via Aquaporins (Canis familiaris)
Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)
ATP [cytosol]
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
ATP [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
ATP [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
ATP [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
ATP [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
ATP [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
ATP [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
ATP [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
ATP [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
ATP [cytosol]
Stimuli-sensing channels (Canis familiaris)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)
ATP [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)
ATP [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
ATP [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
ATP [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
HDL assembly (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
ATP [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
ATP [cytosol]
PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)
ATP [cytosol]
Plasma lipoprotein remodeling (Canis familiaris)
HDL remodeling (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
ATP [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Cellular hexose transport (Canis familiaris)
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
ATP [cytosol]
GLUT1 tetramer binds 4xATP (Canis familiaris)
ATP [cytosol]
GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)
ATP [cytosol]
Transport of vitamins, nucleosides, and related molecules (Canis familiaris)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Canis familiaris)
ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)
ATP [cytosol]
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)
ATP [cytosol]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
ATP [cytosol]
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)
ATP [cytosol]
Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
ATP [cytosol]
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
HSPA8:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
ATP [cytosol]
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
ARP2/3 complex [cytosol] (Canis familiaris)
ACTR2:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ACTR3:ATP [cytosol] (Canis familiaris)
ATP [cytosol]
ER to Golgi Anterograde Transport (Canis familiaris)
COPI-mediated anterograde transport (Canis familiaris)
GBF1 stimulates ARF nucleotide exchange (Canis familiaris)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)
ATP [cytosol]
COPII-mediated vesicle transport (Canis familiaris)
CSNK1D phosphorylates SEC23 (Canis familiaris)
ATP [cytosol]
NSF ATPase activity dissociates cis-SNARE (Canis familiaris)
ATP [cytosol]
Gap junction trafficking and regulation (Canis familiaris)
Regulation of gap junction activity (Canis familiaris)
Phosphorylation of Cx43 by c-src (Canis familiaris)
ATP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
Golgi-to-ER retrograde transport (Canis familiaris)
COPI-dependent Golgi-to-ER retrograde traffic (Canis familiaris)
NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)
ATP [cytosol]
Intra-Golgi traffic (Canis familiaris)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)
ATP [cytosol]
Retrograde transport at the Trans-Golgi-Network (Canis familiaris)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)
ATP [cytosol]
ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Canis familiaris)
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Canis familiaris)
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
RHOBTB3:ATP [trans-Golgi network membrane] (Canis familiaris)
ATP [cytosol]
Rab regulation of trafficking (Canis familiaris)
RAB GEFs exchange GTP for GDP on RABs (Canis familiaris)
p-ULK1 phosphorylates DENND3 (Canis familiaris)
ATP [cytosol]
trans-Golgi Network Vesicle Budding (Canis familiaris)
Golgi Associated Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)
ATP [cytosol]
Lysosome Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)
ATP [cytosol]
Autophagy (Danio rerio)
Macroautophagy (Danio rerio)
Active MTORC1 phosphorylates ULK1 (Danio rerio)
ATP [cytosol]
Selective autophagy (Danio rerio)
Mitophagy (Danio rerio)
PINK1-PRKN Mediated Mitophagy (Danio rerio)
PINK1 is autophosphorylated (Danio rerio)
ATP [cytosol]
PINK1 phosphorylates PRKN at S65 (Danio rerio)
ATP [cytosol]
PINK1 phosphorylates Ub on MOM proteins (Danio rerio)
ATP [cytosol]
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Danio rerio)
ATP [cytosol]
p-S-TBK1 phosphorylates OPTN (Danio rerio)
ATP [cytosol]
Receptor Mediated Mitophagy (Danio rerio)
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)
ATP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)
ATP [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle Checkpoints (Danio rerio)
G2/M Checkpoints (Danio rerio)
G2/M DNA replication checkpoint (Danio rerio)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)
ATP [cytosol]
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Nuclear Envelope (NE) Reassembly (Danio rerio)
Initiation of Nuclear Envelope (NE) Reformation (Danio rerio)
CDK1 phosphorylates LBR (Danio rerio)
ATP [cytosol]
Mitotic Prometaphase (Danio rerio)
EML4 and NUDC in mitotic spindle formation (Danio rerio)
PLK1 phosphorylates NUDC (Danio rerio)
ATP [cytosol]
Resolution of Sister Chromatid Cohesion (Danio rerio)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)
ATP [cytosol]
PLK1 phosphorylates FIRMM at S744 (Danio rerio)
ATP [cytosol]
PLK1 phosphorylates FIRRM at S43 (Danio rerio)
ATP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)
ATP [cytosol]
Mitotic Prophase (Danio rerio)
Golgi Cisternae Pericentriolar Stack Reorganization (Danio rerio)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)
ATP [cytosol]
Mitotic G1 phase and G1/S transition (Danio rerio)
G1 Phase (Danio rerio)
Cyclin D associated events in G1 (Danio rerio)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)
ATP [cytosol]
G1/S Transition (Danio rerio)
Cyclin E associated events during G1/S transition (Danio rerio)
AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)
ATP [cytosol]
SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
PTK6 phosphorylates CDKN1B (Danio rerio)
ATP [cytosol]
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
Cyclin A/B1/B2 associated events during G2/M transition (Danio rerio)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)
ATP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)
ATP [cytosol]
Interaction between PHLDA1 and AURKA (Danio rerio)
AURKA phosphorylates PHLDA1 (Danio rerio)
ATP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Danio rerio)
CDK1 phosphorylates BORA (Danio rerio)
ATP [cytosol]
PLK1 phosphorylates BORA (Danio rerio)
ATP [cytosol]
PLK1 phosphorylates OPTN (Danio rerio)
ATP [cytosol]
The role of GTSE1 in G2/M progression after G2 checkpoint (Danio rerio)
PLK1 phosphorylates GTSE1 (Danio rerio)
ATP [cytosol]
S Phase (Danio rerio)
Cyclin A:Cdk2-associated events at S phase entry (Danio rerio)
AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)
ATP [cytosol]
SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
PTK6 phosphorylates CDKN1B (Danio rerio)
ATP [cytosol]
Cell-Cell communication (Danio rerio)
Nephrin family interactions (Danio rerio)
Phosphorylation of nephrin by FYN (Danio rerio)
ATP [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to mechanical stimuli (Danio rerio)
Response of endothelial cells to shear stress (Danio rerio)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Danio rerio)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Danio rerio)
ATP [cytosol]
Phosphorylation of PDPK1 on serine-241 (Danio rerio)
ATP [cytosol]
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Danio rerio)
ATP [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Danio rerio)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Danio rerio)
ATP [cytosol]
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Danio rerio)
ATP [cytosol]
Cellular responses to stress (Danio rerio)
Cellular Senescence (Danio rerio)
Oxidative Stress Induced Senescence (Danio rerio)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Danio rerio)
ATP [cytosol]
Cellular response to chemical stress (Danio rerio)
KEAP1-NFE2L2 pathway (Danio rerio)
PRKCI phosphorylates NFE2L2 (Danio rerio)
ATP [cytosol]
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)
ATP [cytosol]
HSP70s:ATP [cytosol] (Danio rerio)
HSPA12B:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA13:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA14:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA4:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA5:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA6:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA8:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA9:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
HSP70s:ATP [cytosol] (Danio rerio)
HSPA12B:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA13:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA14:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA4:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA5:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA6:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA8:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA9:ATP [cytosol] (Danio rerio)
ATP [cytosol]
Hikeshi binds HSP70s:ATP (Danio rerio)
HSP70s:ATP [cytosol] (Danio rerio)
HSPA12B:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA13:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA14:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA4:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA5:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA6:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA8:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA9:ATP [cytosol] (Danio rerio)
ATP [cytosol]
Hikeshi:HSP70s:ATP [cytosol] (Danio rerio)
HSP70s:ATP [cytosol] (Danio rerio)
HSPA12B:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA13:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA14:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1A:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA1L:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA4:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA5:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA6:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA8:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSPA9:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Danio rerio)
AR binds AR agonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Danio rerio)
ATP [cytosol]
AR binds AR antagonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Danio rerio)
ATP [cytosol]
ATP binding to HSP90 triggers conformation change (Danio rerio)
ATP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Danio rerio)
HSP90 dimer:ATP:nascent protein [cytosol] (Danio rerio)
ATP [cytosol]
ATP hydrolysis by HSP70 (Danio rerio)
HSP40:HSP70:ATP:nascent protein [cytosol] (Danio rerio)
ATP [cytosol]
Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Danio rerio)
ATP [cytosol]
HSP70 binds to HSP40:nascent protein (Danio rerio)
HSP40:HSP70:ATP:nascent protein [cytosol] (Danio rerio)
ATP [cytosol]
HSP70:ATP [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Danio rerio)
ATP [cytosol]
NR3C1 binds NR3C1 agonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Danio rerio)
ATP [cytosol]
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Danio rerio)
ATP [cytosol]
NR3C2 binds NR3C2 antagonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Danio rerio)
ATP [cytosol]
NR3C2:NR3C2 antagonists [cytosol] (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Danio rerio)
ATP [cytosol]
NR3C2 binds fludrocortisone (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Danio rerio)
ATP [cytosol]
NR3C2:fludrocortisone [cytosol] (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Danio rerio)
ATP [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
ATP [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Danio rerio)
ATP [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Danio rerio)
ATP [cytosol]
PGR binds PGR agonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Danio rerio)
ATP [cytosol]
PGR:PGR agonists [cytosol] (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Danio rerio)
ATP [cytosol]
PGR binds PGR antagonists (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Danio rerio)
ATP [cytosol]
PGR:PGR antagonists [cytosol] (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Danio rerio)
ATP [cytosol]
Mitochondrial unfolded protein response (UPRmt) (Danio rerio)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Danio rerio)
ATP [cytosol]
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Danio rerio)
ATP [cytosol]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPH receptors autophosphorylate (Danio rerio)
ATP [cytosol]
EPH-ephrin mediated repulsion of cells (Danio rerio)
SFKs phosphorylate VAV2,3 (Danio rerio)
ATP [cytosol]
EPHB-mediated forward signaling (Danio rerio)
N-WASP binds ARP2/3 and G-actin (Danio rerio)
ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
ACTR2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
ACTR3:ATP [cytosol] (Danio rerio)
ATP [cytosol]
G-actin [cytosol] (Danio rerio)
ATP [cytosol]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Danio rerio)
ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
ACTR2:ATP [cytosol] (Danio rerio)
ATP [cytosol]
ACTR3:ATP [cytosol] (Danio rerio)
ATP [cytosol]
G-actin [cytosol] (Danio rerio)
ATP [cytosol]
p-EPHB phosphorylates SDC2 (Danio rerio)
ATP [cytosol]
L1CAM interactions (Danio rerio)
Signal transduction by L1 (Danio rerio)
MAP2K1 phosphorylates MAPK3 (Danio rerio)
ATP [cytosol]
MAP2K2 phosphorylates MAPK1 (Danio rerio)
ATP [cytosol]
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Phosphorylation of DCC by Fyn (Danio rerio)
ATP [cytosol]
Semaphorin interactions (Danio rerio)
CRMPs in Sema3A signaling (Danio rerio)
Phosphorylation of CRMPs by Cdk5 (Danio rerio)
ATP [cytosol]
Sema3A PAK dependent Axon repulsion (Danio rerio)
Autophosphorylation of PAK (Danio rerio)
ATP [cytosol]
Phosphorylation of LIMK-1 by PAK (Danio rerio)
ATP [cytosol]
Transphosphorylation of pLIMK1 (Danio rerio)
ATP [cytosol]
Drug ADME (Danio rerio)
Aspirin ADME (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
ATP [cytosol]
Azathioprine ADME (Danio rerio)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
ATP [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
ATP [cytosol]
GUK1 phosphorylates 6TGMP to 6TGDP (Danio rerio)
ATP [cytosol]
GUK1 phosphorylates 6TdGMP to 6TdGDP (Danio rerio)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Danio rerio)
ATP [cytosol]
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Danio rerio)
ATP [cytosol]
Paracetamol ADME (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
ATP [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
ATP [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
ATP [cytosol]
Ribavirin ADME (Danio rerio)
ADK phosphorylates RBV (Danio rerio)
ATP [cytosol]
NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)
ATP [cytosol]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Expression and Degradation (Danio rerio)
Regulation of TP53 Degradation (Danio rerio)
AKT phosphorylates MDM2 (Danio rerio)
ATP [cytosol]
PDPK1 phosphorylates SGK1 (Danio rerio)
ATP [cytosol]
SGK1 phosphorylates MDM2 (Danio rerio)
ATP [cytosol]
TP53 Regulates Transcription of Cell Cycle Genes (Danio rerio)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Danio rerio)
PLK2 phosphorylates CENPJ (Danio rerio)
ATP [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Danio rerio)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Danio rerio)
ATP [cytosol]
Transcriptional regulation by RUNX3 (Danio rerio)
Regulation of RUNX3 expression and activity (Danio rerio)
SRC phosphorylates RUNX3 (Danio rerio)
ATP [cytosol]
Hemostasis (Danio rerio)
Factors involved in megakaryocyte development and platelet production (Danio rerio)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)
ATP [cytosol]
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)
ATP [cytosol]
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)
ATP [cytosol]
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
ATP [cytosol]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
ATP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Disinhibition of SNARE formation (Danio rerio)
Phosphorylation of Syntaxin-4 (Danio rerio)
ATP [cytosol]
Platelet degranulation (Danio rerio)
ABCC4 accumulation of dense granule contents (Danio rerio)
ATP [cytosol]
Signal amplification (Danio rerio)
ADP signalling through P2Y purinoceptor 1 (Danio rerio)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)
ATP [cytosol]
Platelet homeostasis (Danio rerio)
Platelet sensitization by LDL (Danio rerio)
Fgr may phosphorylate p38 MAPK (Danio rerio)
ATP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)
ATP [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
E1 mediated ubiquitin activation (Danio rerio)
ATP [cytosol]
Polyubiquitination of substrate (Danio rerio)
ATP [cytosol]
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
ATP [cytosol]
Rap1 signalling (Danio rerio)
PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)
ATP [cytosol]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)
ATP [cytosol]
Cytokine Signaling in Immune system (Danio rerio)
Growth hormone receptor signaling (Danio rerio)
JAK2 phosphorylation (Danio rerio)
ATP [cytosol]
JAK2 phosphorylation of GHR (Danio rerio)
ATP [cytosol]
Lyn activates ERK (Danio rerio)
ATP [cytosol]
Interferon Signaling (Danio rerio)
Antiviral mechanism by IFN-stimulated genes (Danio rerio)
PKR-mediated signaling (Danio rerio)
p-PKR dimer phosphorylates CDK1 (Danio rerio)
ATP [cytosol]
p-PKR dimer phosphorylates ILF3:ILF2 (Danio rerio)
ATP [cytosol]
p-PKR dimer phosphorylates MKK6 (Danio rerio)
ATP [cytosol]
p-PKR dimer phosphorylates PTPN2 (Danio rerio)