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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
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Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
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Search ...
Go!
H+ [mitochondrial intermembrane space]
Stable Identifier
R-ALL-163953
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial intermembrane space
Synonyms
hydron
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Bos taurus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H+ [mitochondrial intermembrane space]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
NNT dimer transfers proton from NADPH to NAD+ (Bos taurus)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Bos taurus)
Enzyme-bound ATP is released (Bos taurus)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Bos taurus)
AAC1 imports a proton (Bos taurus)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Bos taurus)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Bos taurus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Bos taurus)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
CPO transforms COPRO3 to PPGEN9 (Bos taurus)
H+ [mitochondrial intermembrane space]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
RDH13 reduces atRAL to atROL (Bos taurus)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Stimuli-sensing channels (Bos taurus)
SLC9B2 exchanges Na+ for H+ (Bos taurus)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
NNT dimer transfers proton from NADPH to NAD+ (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Caenorhabditis elegans)
Enzyme-bound ATP is released (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Caenorhabditis elegans)
AAC1 imports a proton (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Caenorhabditis elegans)
Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
RDH13 reduces atRAL to atROL (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Stimuli-sensing channels (Caenorhabditis elegans)
SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Canis familiaris)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H+ [mitochondrial intermembrane space]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
NNT dimer transfers proton from NADPH to NAD+ (Canis familiaris)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Canis familiaris)
Enzyme-bound ATP is released (Canis familiaris)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Canis familiaris)
AAC1 imports a proton (Canis familiaris)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Canis familiaris)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Canis familiaris)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Canis familiaris)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
CPO transforms COPRO3 to PPGEN9 (Canis familiaris)
H+ [mitochondrial intermembrane space]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
RDH13 reduces atRAL to atROL (Canis familiaris)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Stimuli-sensing channels (Canis familiaris)
SLC9B2 exchanges Na+ for H+ (Canis familiaris)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Danio rerio)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H+ [mitochondrial intermembrane space]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
NNT dimer transfers proton from NADPH to NAD+ (Danio rerio)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Danio rerio)
Enzyme-bound ATP is released (Danio rerio)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Danio rerio)
AAC1 imports a proton (Danio rerio)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Danio rerio)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Danio rerio)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Danio rerio)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
CPO transforms COPRO3 to PPGEN9 (Danio rerio)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
NNT dimer transfers proton from NADPH to NAD+ (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Dictyostelium discoideum)
AAC1 imports a proton (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Dictyostelium discoideum)
Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
Signaling by Retinoic Acid (Dictyostelium discoideum)
RA biosynthesis pathway (Dictyostelium discoideum)
RDH13 reduces atRAL to atROL (Dictyostelium discoideum)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Formation of ATP by chemiosmotic coupling (Drosophila melanogaster)
Enzyme-bound ATP is released (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Drosophila melanogaster)
AAC1 imports a proton (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Drosophila melanogaster)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Drosophila melanogaster)
Ion channel transport (Drosophila melanogaster)
Stimuli-sensing channels (Drosophila melanogaster)
SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Gallus gallus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
H+ [mitochondrial intermembrane space]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Citric acid cycle (TCA cycle) (Gallus gallus)
NNT dimer transfers proton from NADPH to NAD+ (Gallus gallus)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Gallus gallus)
Enzyme-bound ATP is released (Gallus gallus)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Gallus gallus)
AAC1 imports a proton (Gallus gallus)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Gallus gallus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Gallus gallus)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Gallus gallus)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Gallus gallus)
Heme biosynthesis (Gallus gallus)
CPO transforms COPRO3 to PPGEN9 (Gallus gallus)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Stimuli-sensing channels (Gallus gallus)
SLC9B2 exchanges Na+ for H+ (Gallus gallus)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Homo sapiens)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H+ [mitochondrial intermembrane space]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
NNT dimer transfers proton from NADPH to NAD+ (Homo sapiens)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Homo sapiens)
Enzyme-bound ATP is released (Homo sapiens)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Homo sapiens)
AAC1 imports a proton (Homo sapiens)
H+ [mitochondrial intermembrane space]
The fatty acid cycling model (Homo sapiens)
FA anion picks up a proton (Homo sapiens)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Homo sapiens)
H+ [mitochondrial intermembrane space]
Pyruvate metabolism (Homo sapiens)
MPC1:MPC2 imports PYR, H+ to mitochondrial matrix (Homo sapiens)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
CPO transforms COPRO3 to PPGEN9 (Homo sapiens)
H+ [mitochondrial intermembrane space]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
RA biosynthesis pathway (Homo sapiens)
RDH13 reduces atRAL to atROL (Homo sapiens)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
SLC9B2 exchanges Na+ for H+ (Homo sapiens)
H+ [mitochondrial intermembrane space]
Mitochondrial calcium ion transport (Homo sapiens)
LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Mus musculus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)
H+ [mitochondrial intermembrane space]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
NNT dimer transfers proton from NADPH to NAD+ (Mus musculus)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Mus musculus)
Enzyme-bound ATP is released (Mus musculus)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Mus musculus)
AAC1 imports a proton (Mus musculus)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Mus musculus)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Mus musculus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Mus musculus)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
CPO transforms COPRO3 to PPGEN9 (Mus musculus)
H+ [mitochondrial intermembrane space]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
Signaling by Retinoic Acid (Mus musculus)
RA biosynthesis pathway (Mus musculus)
RDH13 reduces atRAL to atROL (Mus musculus)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Stimuli-sensing channels (Mus musculus)
SLC9B2 exchanges Na+ for H+ (Mus musculus)
H+ [mitochondrial intermembrane space]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Citric acid cycle (TCA cycle) (Plasmodium falciparum)
NNT dimer transfers proton from NADPH to NAD+ (Plasmodium falciparum)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Plasmodium falciparum)
AAC1 imports a proton (Plasmodium falciparum)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Plasmodium falciparum)
Heme biosynthesis (Plasmodium falciparum)
CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)
H+ [mitochondrial intermembrane space]
Signal Transduction (Plasmodium falciparum)
Signaling by Nuclear Receptors (Plasmodium falciparum)
Signaling by Retinoic Acid (Plasmodium falciparum)
RA biosynthesis pathway (Plasmodium falciparum)
RDH13 reduces atRAL to atROL (Plasmodium falciparum)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Cytoprotection by HMOX1 (Rattus norvegicus)
Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
NNT dimer transfers proton from NADPH to NAD+ (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Formation of ATP by chemiosmotic coupling (Rattus norvegicus)
Enzyme-bound ATP is released (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Rattus norvegicus)
AAC1 imports a proton (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Rattus norvegicus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Rattus norvegicus)
Heme biosynthesis (Rattus norvegicus)
CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
Signaling by Retinoic Acid (Rattus norvegicus)
RA biosynthesis pathway (Rattus norvegicus)
RDH13 reduces atRAL to atROL (Rattus norvegicus)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
H+ [mitochondrial intermembrane space]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Mitochondrial Uncoupling (Saccharomyces cerevisiae)
AAC1 imports a proton (Saccharomyces cerevisiae)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Saccharomyces cerevisiae)
Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Saccharomyces cerevisiae)
Heme biosynthesis (Saccharomyces cerevisiae)
CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
H+ [mitochondrial intermembrane space]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Mitochondrial Uncoupling (Schizosaccharomyces pombe)
AAC1 imports a proton (Schizosaccharomyces pombe)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Schizosaccharomyces pombe)
Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Schizosaccharomyces pombe)
Heme biosynthesis (Schizosaccharomyces pombe)
CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Cytoprotection by HMOX1 (Sus scrofa)
Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Sus scrofa)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
TP53 Regulates Metabolic Genes (Sus scrofa)
Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)
H+ [mitochondrial intermembrane space]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Formation of ATP by chemiosmotic coupling (Sus scrofa)
Enzyme-bound ATP is released (Sus scrofa)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Sus scrofa)
AAC1 imports a proton (Sus scrofa)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Sus scrofa)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Sus scrofa)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)
H+ [mitochondrial intermembrane space]
Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Sus scrofa)
Heme biosynthesis (Sus scrofa)
CPO transforms COPRO3 to PPGEN9 (Sus scrofa)
H+ [mitochondrial intermembrane space]
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
Signaling by Retinoic Acid (Sus scrofa)
RA biosynthesis pathway (Sus scrofa)
RDH13 reduces atRAL to atROL (Sus scrofa)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Stimuli-sensing channels (Sus scrofa)
SLC9B2 exchanges Na+ for H+ (Sus scrofa)
H+ [mitochondrial intermembrane space]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Cytoprotection by HMOX1 (Xenopus tropicalis)
Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
TP53 Regulates Metabolic Genes (Xenopus tropicalis)
Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Citric acid cycle (TCA cycle) (Xenopus tropicalis)
NNT dimer transfers proton from NADPH to NAD+ (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Mitochondrial Uncoupling (Xenopus tropicalis)
AAC1 imports a proton (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
UCP1 imports a proton (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Respiratory electron transport (Xenopus tropicalis)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Metabolism of porphyrins (Xenopus tropicalis)
Heme biosynthesis (Xenopus tropicalis)
CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Signal Transduction (Xenopus tropicalis)
Signaling by Nuclear Receptors (Xenopus tropicalis)
Signaling by Retinoic Acid (Xenopus tropicalis)
RA biosynthesis pathway (Xenopus tropicalis)
RDH13 reduces atRAL to atROL (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
Transport of small molecules (Xenopus tropicalis)
Ion channel transport (Xenopus tropicalis)
Stimuli-sensing channels (Xenopus tropicalis)
SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)
H+ [mitochondrial intermembrane space]
External Reference Information
External Reference
hydron [ChEBI:15378]
Participates
as an input of
RDH13 reduces atRAL to atROL (Plasmodium falciparum)
RDH13 reduces atRAL to atROL (Dictyostelium discoideum)
RDH13 reduces atRAL to atROL (Caenorhabditis elegans)
RDH13 reduces atRAL to atROL (Xenopus tropicalis)
RDH13 reduces atRAL to atROL (Sus scrofa)
RDH13 reduces atRAL to atROL (Bos taurus)
RDH13 reduces atRAL to atROL (Canis familiaris)
RDH13 reduces atRAL to atROL (Rattus norvegicus)
RDH13 reduces atRAL to atROL (Mus musculus)
RDH13 reduces atRAL to atROL (Homo sapiens)
Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)
LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
UCP1 imports a proton (Xenopus tropicalis)
UCP1 imports a proton (Danio rerio)
UCP1 imports a proton (Bos taurus)
UCP1 imports a proton (Canis familiaris)
UCP1 imports a proton (Rattus norvegicus)
UCP1 imports a proton (Mus musculus)
UCP1 imports a proton (Homo sapiens)
FA anion picks up a proton (Homo sapiens)
AAC1 imports a proton (Plasmodium falciparum)
AAC1 imports a proton (Saccharomyces cerevisiae)
AAC1 imports a proton (Schizosaccharomyces pombe)
AAC1 imports a proton (Dictyostelium discoideum)
AAC1 imports a proton (Caenorhabditis elegans)
AAC1 imports a proton (Drosophila melanogaster)
AAC1 imports a proton (Gallus gallus)
AAC1 imports a proton (Xenopus tropicalis)
AAC1 imports a proton (Danio rerio)
AAC1 imports a proton (Bos taurus)
AAC1 imports a proton (Canis familiaris)
AAC1 imports a proton (Rattus norvegicus)
AAC1 imports a proton (Mus musculus)
AAC1 imports a proton (Homo sapiens)
AAC1 imports a proton (Sus scrofa)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)
CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)
CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)
CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)
CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)
CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)
CPO transforms COPRO3 to PPGEN9 (Gallus gallus)
CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)
CPO transforms COPRO3 to PPGEN9 (Danio rerio)
CPO transforms COPRO3 to PPGEN9 (Sus scrofa)
CPO transforms COPRO3 to PPGEN9 (Bos taurus)
CPO transforms COPRO3 to PPGEN9 (Canis familiaris)
CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)
CPO transforms COPRO3 to PPGEN9 (Mus musculus)
CPO transforms COPRO3 to PPGEN9 (Homo sapiens)
Enzyme-bound ATP is released (Caenorhabditis elegans)
Enzyme-bound ATP is released (Drosophila melanogaster)
Enzyme-bound ATP is released (Gallus gallus)
Enzyme-bound ATP is released (Danio rerio)
Enzyme-bound ATP is released (Sus scrofa)
Enzyme-bound ATP is released (Bos taurus)
Enzyme-bound ATP is released (Canis familiaris)
Enzyme-bound ATP is released (Mus musculus)
Enzyme-bound ATP is released (Homo sapiens)
NNT dimer transfers proton from NADPH to NAD+ (Canis familiaris)
MPC1:MPC2 imports PYR, H+ to mitochondrial matrix (Homo sapiens)
NNT dimer transfers proton from NADPH to NAD+ (Bos taurus)
NNT dimer transfers proton from NADPH to NAD+ (Homo sapiens)
NNT dimer transfers proton from NADPH to NAD+ (Mus musculus)
NNT dimer transfers proton from NADPH to NAD+ (Danio rerio)
NNT dimer transfers proton from NADPH to NAD+ (Gallus gallus)
NNT dimer transfers proton from NADPH to NAD+ (Caenorhabditis elegans)
NNT dimer transfers proton from NADPH to NAD+ (Dictyostelium discoideum)
NNT dimer transfers proton from NADPH to NAD+ (Plasmodium falciparum)
NNT dimer transfers proton from NADPH to NAD+ (Xenopus tropicalis)
NNT dimer transfers proton from NADPH to NAD+ (Rattus norvegicus)
Enzyme-bound ATP is released (Rattus norvegicus)
as an output of
SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)
SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)
SLC9B2 exchanges Na+ for H+ (Gallus gallus)
SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)
SLC9B2 exchanges Na+ for H+ (Sus scrofa)
SLC9B2 exchanges Na+ for H+ (Bos taurus)
SLC9B2 exchanges Na+ for H+ (Canis familiaris)
SLC9B2 exchanges Na+ for H+ (Mus musculus)
SLC9B2 exchanges Na+ for H+ (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)
Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Mus musculus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)
Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Bos taurus)
Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)
Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Sus scrofa)
Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Danio rerio)
Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)
Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
Electron transfer from ubiquinol to cytochrome c of complex III (Gallus gallus)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Gallus gallus)
Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Drosophila melanogaster)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Rattus norvegicus)
Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)
Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)
Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)
Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Canis familiaris)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Xenopus tropicalis)
Other forms of this molecule
H+ [early endosome]
H+ [synaptic vesicle lumen]
H+ [platelet dense tubular network lumen]
H+ [sperm flagellum]
H+ [clathrin-sculpted acetylcholine transport vesicle lumen]
H+ [endocytic vesicle lumen]
H+ [phagolysosome]
H+ [cytoplasm]
H+ [phagocytic vesicle lumen]
H+ [nuclear envelope]
H+ [mitochondrial inner membrane]
H+ [synaptic vesicle]
H+ [late endosome lumen]
H+ [Golgi lumen]
H+ [early endosome lumen]
H+ [lysosomal lumen]
H+ [melanosome lumen]
H+ [endolysosome lumen]
H+ [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum-Golgi intermediate compartment]
H+ [endosome lumen]
H+ [extracellular region]
H+ [clathrin-sculpted monoamine transport vesicle lumen]
H+ [mitochondrial matrix]
H+ [peroxisomal matrix]
H+ [cytosol]
H+ [nucleoplasm]
Cross References
COMPOUND
C00080
PubChem Substance
8145820
HMDB Metabolite
HMDB0059597
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