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PI(3,4,5)P3 [plasma membrane]
Stable Identifier
R-ALL-179838
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP3, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, Phosphatidylinositol-3,4,5-trisphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Cdc42 by pVav1 (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
BLNK (SLP-65) Signalosome [plasma membrane] (Bos taurus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Bos taurus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Bos taurus)
Bcl10 bound to CARMA1 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Bos taurus)
Activated CARMA1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Bos taurus)
Bcl10 bound to CARMA1 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Bos taurus)
Activated CARMA1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Bos taurus)
CARMA1 bound to PDK1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 processing (Bos taurus)
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Activation of RAC1 by VAV2/3 (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Bos taurus)
Activation of RAC1 by VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Bos taurus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
Pyroptosis (Bos taurus)
GSDMD (1-275) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Bos taurus)
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Bos taurus)
Inhibition of TSC complex formation by PKB (Bos taurus)
Phosphorylation of TSC2 by PKB (Bos taurus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Bos taurus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through BTK (Bos taurus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
Estrogen-stimulated signaling through PRKCZ (Bos taurus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Bos taurus)
GAB1 signalosome (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Bos taurus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
activated FGFR1:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
activated FGFR2:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
activated FGFR3:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Bos taurus)
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Activation of RAC1 (Bos taurus)
p-VAV1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Bos taurus)
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Bos taurus)
PAK1-3 autophosphorylates (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Bos taurus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Bos taurus)
PDPK1 phosphorylates PKN1,2,3 (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Caenorhabditis elegans)
mTORC2 phosphorylates AKT1 on serine-473 (Caenorhabditis elegans)
AKT1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S473-AKT1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Caenorhabditis elegans)
p-S473-AKT1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T308,S473-AKT1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Expression and Degradation (Caenorhabditis elegans)
Regulation of TP53 Degradation (Caenorhabditis elegans)
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
PIP3:VAV1,2,3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Costimulation by the CD28 family (Caenorhabditis elegans)
CD28 co-stimulation (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Caenorhabditis elegans)
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
Role of LAT2/NTAL/LAB on calcium mobilization (Caenorhabditis elegans)
Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-stimulated signaling through PRKCZ (Caenorhabditis elegans)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Caenorhabditis elegans)
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Caenorhabditis elegans)
Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)
activated FGFR1:PLCG1 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)
activated FGFR4:PLCG1 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
PI3K/AKT activation (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Caenorhabditis elegans)
Activation of RAC1 (Caenorhabditis elegans)
p-VAV1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Caenorhabditis elegans)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Caenorhabditis elegans)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Caenorhabditis elegans)
PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PDPK1 phosphorylates SGK1 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Cdc42 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome [plasma membrane] (Canis familiaris)
p-Y223,551-BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Canis familiaris)
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Canis familiaris)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Auto-ubiquitination of TRAF6 (Canis familiaris)
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Canis familiaris)
Bcl10 bound to CARMA1 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Canis familiaris)
Activated CARMA1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Canis familiaris)
Bcl10 bound to CARMA1 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Canis familiaris)
Activated CARMA1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Canis familiaris)
CARMA1 bound to PDK1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 processing (Canis familiaris)
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated NF-kB activation (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
PI3K associates with phosphorylated GAB2 (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
Pyroptosis (Canis familiaris)
GSDMD (1-275) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Canis familiaris)
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through BTK (Canis familiaris)
BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
Estrogen-stimulated signaling through PRKCZ (Canis familiaris)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Canis familiaris)
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)