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PI(4,5)P2 [plasma membrane]
Stable Identifier
R-ALL-179856
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP2, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, Phosphatidylinositol-4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
CDC42 and PIP2 bind WASL, activating it (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Bos taurus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Bos taurus)
DCC interaction with Ezrin (Bos taurus)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Bos taurus)
p-T567-EZR:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Bos taurus)
Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Bos taurus)
EZR:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)
VAV family:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 processing (Bos taurus)
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Bos taurus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
Pyroptosis (Bos taurus)
GSDMD (1-275) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Bos taurus)
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Bos taurus)
Talin:RIAM complex [plasma membrane] (Bos taurus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Bos taurus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Bos taurus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Caenorhabditis elegans)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
L1 trans-homophilic interaction (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Caenorhabditis elegans)
L1 trans-homodimer [plasma membrane] (Caenorhabditis elegans)
pL1:Ezrin [plasma membrane] (Caenorhabditis elegans)
ERM:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Caenorhabditis elegans)
DCC interaction with Ezrin (Caenorhabditis elegans)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Caenorhabditis elegans)
Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
Syndecan interactions (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
VAV family:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Talin (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex [plasma membrane] (Caenorhabditis elegans)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Caenorhabditis elegans)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Caenorhabditis elegans)
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
WNT mediated activation of DVL (Caenorhabditis elegans)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Canis familiaris)
DCC interaction with Ezrin (Canis familiaris)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Canis familiaris)
EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Canis familiaris)
Non-integrin membrane-ECM interactions (Canis familiaris)
Syndecan interactions (Canis familiaris)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Canis familiaris)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
VAV family:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-stimulation by CD28 (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 processing (Canis familiaris)
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Acetylcholine regulates insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Canis familiaris)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
Pyroptosis (Canis familiaris)
GSDMD (1-275) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Canis familiaris)
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
Talin:RIAM complex [plasma membrane] (Canis familiaris)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Canis familiaris)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Canis familiaris)
WNT mediated activation of DVL (Canis familiaris)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
CDC42 and PIP2 bind WASL, activating it (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Danio rerio)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Danio rerio)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Danio rerio)
DCC interaction with Ezrin (Danio rerio)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Danio rerio)
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Danio rerio)
Regulation of TLR by endogenous ligand (Danio rerio)
HMGB1 release from cells (Danio rerio)
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Danio rerio)
Regulated Necrosis (Danio rerio)
Pyroptosis (Danio rerio)
GSDME (1-270) binds PIPs (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Danio rerio)
GSDME (1-270):PIPs [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Danio rerio)
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Danio rerio)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Danio rerio)
Talin:RIAM complex [plasma membrane] (Danio rerio)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate WASPs and WAVEs (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
PI(4,5)P2 [plasma membrane]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
GPVI-mediated activation cascade (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Dictyostelium discoideum)
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
CLEC7A (Dectin-1) signaling (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Acetylcholine regulates insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
PIP2 hydrolysis (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Dictyostelium discoideum)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Dictyostelium discoideum)
G beta:gamma signalling through PI3Kgamma (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase Effectors (Dictyostelium discoideum)
RHO GTPases Activate WASPs and WAVEs (Dictyostelium discoideum)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
Clathrin-mediated endocytosis (Dictyostelium discoideum)
AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Drosophila melanogaster)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Drosophila melanogaster)
DCC interaction with Ezrin (Drosophila melanogaster)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
p-T567-EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Drosophila melanogaster)
EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Drosophila melanogaster)
Non-integrin membrane-ECM interactions (Drosophila melanogaster)
Syndecan interactions (Drosophila melanogaster)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Drosophila melanogaster)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
VAV family:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex [plasma membrane] (Drosophila melanogaster)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Drosophila melanogaster)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Drosophila melanogaster)
WNT mediated activation of DVL (Drosophila melanogaster)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
CDC42 and PIP2 bind WASL, activating it (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Gallus gallus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Gallus gallus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Gallus gallus)
Translocation of Ezrin to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Gallus gallus)
Non-integrin membrane-ECM interactions (Gallus gallus)
Syndecan interactions (Gallus gallus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Gallus gallus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-stimulation by CD28 (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 processing (Gallus gallus)
Interleukin-1 family are secreted (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Gallus gallus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Gallus gallus)
Regulation of TLR by endogenous ligand (Gallus gallus)
HMGB1 release from cells (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Acetylcholine regulates insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Gallus gallus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Gallus gallus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Gallus gallus)
Regulated Necrosis (Gallus gallus)
Pyroptosis (Gallus gallus)
GSDMD (1-275) binds PIPs (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)
GSDMD (1-275):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Gallus gallus)
GSDME (1-270):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Talin:RIAM complex [plasma membrane] (Gallus gallus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Gallus gallus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
EGFR phosphorylates EPS15 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate WASPs and WAVEs (Gallus gallus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Gallus gallus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Gallus gallus)
WNT mediated activation of DVL (Gallus gallus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Gallus gallus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
PI(4,5)P2 [plasma membrane]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
CDC42 and PIP2 bind WASL, activating it (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Homo sapiens)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
L1 binds ERM family members (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
L1 trans-homophilic interaction (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer [plasma membrane] (Homo sapiens)
pL1:Ezrin [plasma membrane] (Homo sapiens)
ERM:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Homo sapiens)
DCC interaction with Ezrin (Homo sapiens)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Homo sapiens)
p-T567-EZR:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
DCC mediated attractive signaling (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Homo sapiens)
EZR:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of second messengers in netrin-1 signaling (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Diseases of programmed cell death (Homo sapiens)
Defective pyroptosis (Homo sapiens)
GSDME variant does not bind PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)
AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 KD Mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 binds inhibiting VAV (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VAV family:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VAV family:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
HMGB1 release from cells (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
PDPK1 phosphorylates RSKs (Homo sapiens)
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GSDMD (1-275) binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)
GSDMD (1-275):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Homo sapiens)
GSDME (1-270):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Talin:RIAM complex [plasma membrane] (Homo sapiens)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Homo sapiens)
MET activates PI3K/AKT signaling (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
VEGFR2 mediated cell proliferation (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
CDC42 and PIP2 bind WASL, activating it (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Mus musculus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Mus musculus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Mus musculus)
Recycling pathway of L1 (Mus musculus)
L1 trans-homophilic interaction (Mus musculus)
L1 trans-homodimer [plasma membrane] (Mus musculus)
pL1:Ezrin [plasma membrane] (Mus musculus)
ERM:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Mus musculus)
ERM:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Mus musculus)
L1 trans-homodimer [plasma membrane] (Mus musculus)
pL1:Ezrin [plasma membrane] (Mus musculus)
ERM:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Mus musculus)
L1 trans-homodimer [plasma membrane] (Mus musculus)
pL1:Ezrin [plasma membrane] (Mus musculus)
ERM:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Mus musculus)
DCC interaction with Ezrin (Mus musculus)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Mus musculus)
p-T567-EZR:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Mus musculus)
EZR:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Mus musculus)
Non-integrin membrane-ECM interactions (Mus musculus)
Syndecan interactions (Mus musculus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Mus musculus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)
VAV family:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Regulation of T cell activation by CD28 family (Mus musculus)
Co-stimulation by CD28 (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 processing (Mus musculus)
Interleukin-1 family are secreted (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Mus musculus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Mus musculus)
Regulation of TLR by endogenous ligand (Mus musculus)
HMGB1 release from cells (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism (Mus musculus)
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Acetylcholine regulates insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Mus musculus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
Pyroptosis (Mus musculus)
GSDMD (1-275) binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)
GSDMD (1-275):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Mus musculus)
GSDME (1-270):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIPK1-mediated regulated necrosis (Mus musculus)
MLKL binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
Talin:RIAM complex [plasma membrane] (Mus musculus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vinculin bound to PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
G-protein mediated events (Mus musculus)
PLC beta mediated events (Mus musculus)
PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
G alpha (q) signalling events (Mus musculus)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through PI3Kgamma (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
G beta:gamma signalling through PLC beta (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
EGFR phosphorylates EPS15 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PTPN3 dephosphorylates EPS15 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
GAB1 signalosome (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by ERBB4 (Mus musculus)
PI3K events in ERBB4 signaling (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by MET (Mus musculus)
MET activates PI3K/AKT signaling (Mus musculus)
MET bound PI3K generates PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by SCF-KIT (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate WASPs and WAVEs (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Mus musculus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
Ca2+ pathway (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
PI(4,5)P2 [plasma membrane]
TCF dependent signaling in response to WNT (Mus musculus)
WNT mediated activation of DVL (Mus musculus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
BAR domain proteins recruit dynamin (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Clathrin recruits PIK3C2A (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)
PI(4,5)P2 [plasma membrane]
Recruitment of AP-2 complex and clathrin (Mus musculus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
GPVI-mediated activation cascade (Plasmodium falciparum)
PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
TCR signaling (Plasmodium falciparum)
Generation of second messenger molecules (Plasmodium falciparum)
PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Innate Immune System (Plasmodium falciparum)
C-type lectin receptors (CLRs) (Plasmodium falciparum)
CLEC7A (Dectin-1) signaling (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Metabolism (Plasmodium falciparum)
Inositol phosphate metabolism (Plasmodium falciparum)
Synthesis of IP3 and IP4 in the cytosol (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Plasmodium falciparum)
Phospholipid metabolism (Plasmodium falciparum)
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Signal Transduction (Plasmodium falciparum)
Intracellular signaling by second messengers (Plasmodium falciparum)
PIP3 activates AKT signaling (Plasmodium falciparum)
Negative regulation of the PI3K/AKT network (Plasmodium falciparum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Plasmodium falciparum)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PDPK1 binds PIP2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
PDPK1:PIP2 [plasma membrane] (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Vesicle-mediated transport (Plasmodium falciparum)
Membrane Trafficking (Plasmodium falciparum)
Clathrin-mediated endocytosis (Plasmodium falciparum)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)
PI(4,5)P2 [plasma membrane]
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
L1CAM interactions (Rattus norvegicus)
Recycling pathway of L1 (Rattus norvegicus)
L1 trans-homophilic interaction (Rattus norvegicus)
L1 trans-homodimer [plasma membrane] (Rattus norvegicus)
pL1:Ezrin [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
pL1:Ezrin [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Linkage of L1 with treadmilling F-actin (Rattus norvegicus)
L1 trans-homodimer [plasma membrane] (Rattus norvegicus)
pL1:Ezrin [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
pL1:ERM:F-actin [plasma membrane] (Rattus norvegicus)
L1 trans-homodimer [plasma membrane] (Rattus norvegicus)
pL1:Ezrin [plasma membrane] (Rattus norvegicus)
ERM:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Netrin-1 signaling (Rattus norvegicus)
DCC interaction with Ezrin (Rattus norvegicus)
DCC:p-T567-EZR:PIP2 [plasma membrane] (Rattus norvegicus)
p-T567-EZR:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Phosphorylation and activation of Ezrin (Rattus norvegicus)
EZR:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-T567-EZR:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Translocation of Ezrin to plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
EZR:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Extracellular matrix organization (Rattus norvegicus)
Non-integrin membrane-ECM interactions (Rattus norvegicus)
Syndecan interactions (Rattus norvegicus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Rattus norvegicus)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
VAV family:PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3 activation (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Translocation of RIAM to plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Generation of second messenger molecules (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 processing (Rattus norvegicus)
Interleukin-1 family are secreted (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Detachment of WASP/WAVE (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Src phosphorylate WASP,N-WASP (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll-like Receptor Cascades (Rattus norvegicus)
Regulation of TLR by endogenous ligand (Rattus norvegicus)
HMGB1 release from cells (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TIRAP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Metabolism (Rattus norvegicus)
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Acetylcholine regulates insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
Pyroptosis (Rattus norvegicus)
GSDMD (1-275) binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD forms ringâshaped oligomers (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)
GSDMD (1-275):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270) binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomerizes (Rattus norvegicus)
GSDME (1-270):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
HMGB1 release from cells (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Interleukin-1 family are secreted (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIPK1-mediated regulated necrosis (Rattus norvegicus)
MLKL binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Activation of Talin (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Rap1-GTP:PIP2:RIAM [plasma membrane] (Rattus norvegicus)
PI(4,5)P2 [plasma membrane]