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4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Stable Identifier
R-ALL-192195
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum membrane
Synonyms
4-cholesten-7alpha, 12alpha-diol-3-one, 7alpha,12alpha-dihydroxycholest-4-en-3-one
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Endogenous sterols (Canis familiaris)
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
Cytochrome P450 - arranged by substrate type (Danio rerio)
Endogenous sterols (Danio rerio)
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Dictyostelium discoideum)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Drosophila melanogaster)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Synthesis of bile acids and bile salts (Gallus gallus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Gallus gallus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Endogenous sterols (Mus musculus)
Sterols are 12-hydroxylated by CYP8B1 (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Synthesis of bile acids and bile salts (Mus musculus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Endogenous sterols (Rattus norvegicus)
Sterols are 12-hydroxylated by CYP8B1 (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Synthesis of bile acids and bile salts (Rattus norvegicus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Metabolism of steroids (Saccharomyces cerevisiae)
Bile acid and bile salt metabolism (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Saccharomyces cerevisiae)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Metabolism of steroids (Schizosaccharomyces pombe)
Bile acid and bile salt metabolism (Schizosaccharomyces pombe)
Synthesis of bile acids and bile salts (Schizosaccharomyces pombe)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Schizosaccharomyces pombe)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Endogenous sterols (Sus scrofa)
Sterols are 12-hydroxylated by CYP8B1 (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Bile acid and bile salt metabolism (Sus scrofa)
Synthesis of bile acids and bile salts (Sus scrofa)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Sus scrofa)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
Cytochrome P450 - arranged by substrate type (Xenopus tropicalis)
Endogenous sterols (Xenopus tropicalis)
Sterols are 12-hydroxylated by CYP8B1 (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
Metabolism of lipids (Xenopus tropicalis)
Metabolism of steroids (Xenopus tropicalis)
Bile acid and bile salt metabolism (Xenopus tropicalis)
Synthesis of bile acids and bile salts (Xenopus tropicalis)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Xenopus tropicalis)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
4CHOL7a,12aDONE [endoplasmic reticulum membrane]
External Reference Information
External Reference
7alpha,12alpha-dihydroxycholest-4-en-3-one [ChEBI:28477]
Participates
as an input of
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Gallus gallus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
as an output of
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
Cross References
COMPOUND
C05457
HMDB Metabolite
HMDB0002197
ZINC
000013543181
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