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Go!
P4 [cytosol]
Stable Identifier
R-ALL-193055
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
progesterone
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Bos taurus)
PGR:P4 [cytosol] (Bos taurus)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Bos taurus)
PGR:P4 [cytosol] (Bos taurus)
P4 [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Endogenous sterols (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
P4 [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
P4 [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)
P4 [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Canis familiaris)
PGR:P4 [cytosol] (Canis familiaris)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Canis familiaris)
PGR:P4 [cytosol] (Canis familiaris)
P4 [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Endogenous sterols (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
P4 [cytosol]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
P4 [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)
P4 [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Danio rerio)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Danio rerio)
PGR:P4 [cytosol] (Danio rerio)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Danio rerio)
PGR:P4 [cytosol] (Danio rerio)
P4 [cytosol]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
P4 [cytosol]
Mineralocorticoid biosynthesis (Danio rerio)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)
P4 [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
P4 [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Metabolism of steroids (Dictyostelium discoideum)
Metabolism of steroid hormones (Dictyostelium discoideum)
Mineralocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
P4 [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Drosophila melanogaster)
PGR:P4 [cytosol] (Drosophila melanogaster)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Drosophila melanogaster)
PGR:P4 [cytosol] (Drosophila melanogaster)
P4 [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
ATP hydrolysis by HSP90 (Gallus gallus)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Gallus gallus)
PGR:P4 [cytosol] (Gallus gallus)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Gallus gallus)
PGR:P4 [cytosol] (Gallus gallus)
P4 [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
Cytochrome P450 - arranged by substrate type (Gallus gallus)
Endogenous sterols (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
P4 [cytosol]
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Metabolism of steroid hormones (Gallus gallus)
Androgen biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
P4 [cytosol]
Mineralocorticoid biosynthesis (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Gallus gallus)
P4 [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
PGR:P4 [cytosol] (Homo sapiens)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
PGR:P4 [cytosol] (Homo sapiens)
P4 [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective CYP17A1 causes AH5 (Homo sapiens)
Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)
P4 [cytosol]
Defective CYP21A2 causes AH3 (Homo sapiens)
Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)
P4 [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
P4 [cytosol]
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
P4 [cytosol]
Mineralocorticoid biosynthesis (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)
P4 [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
ATP hydrolysis by HSP90 (Mus musculus)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Mus musculus)
PGR:P4 [cytosol] (Mus musculus)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Mus musculus)
PGR:P4 [cytosol] (Mus musculus)
P4 [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Endogenous sterols (Mus musculus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
P4 [cytosol]
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Metabolism of steroid hormones (Mus musculus)
Androgen biosynthesis (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
P4 [cytosol]
Mineralocorticoid biosynthesis (Mus musculus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)
P4 [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Plasmodium falciparum)
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Plasmodium falciparum)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Plasmodium falciparum)
PGR:P4 [cytosol] (Plasmodium falciparum)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Plasmodium falciparum)
PGR:P4 [cytosol] (Plasmodium falciparum)
P4 [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Rattus norvegicus)
ATP hydrolysis by HSP90 (Rattus norvegicus)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Rattus norvegicus)
PGR:P4 [cytosol] (Rattus norvegicus)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Rattus norvegicus)
PGR:P4 [cytosol] (Rattus norvegicus)
P4 [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Endogenous sterols (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
P4 [cytosol]
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Metabolism of steroid hormones (Rattus norvegicus)
Androgen biosynthesis (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
P4 [cytosol]
Mineralocorticoid biosynthesis (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)
P4 [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Sus scrofa)
ATP hydrolysis by HSP90 (Sus scrofa)
SH [cytosol]
P4 [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)
SH [cytosol]
P4 [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Sus scrofa)
PGR:P4 [cytosol] (Sus scrofa)
P4 [cytosol]
P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)
P4 [cytosol]
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Sus scrofa)
PGR:P4 [cytosol] (Sus scrofa)
P4 [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Endogenous sterols (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
P4 [cytosol]
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Metabolism of steroid hormones (Sus scrofa)
Androgen biosynthesis (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
P4 [cytosol]
Mineralocorticoid biosynthesis (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
P4 [cytosol]
Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)
P4 [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Metabolism of steroids (Xenopus tropicalis)
Metabolism of steroid hormones (Xenopus tropicalis)
Androgen biosynthesis (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
P4 [cytosol]
External Reference Information
External Reference
progesterone [ChEBI:17026]
Participates
as a component of
PGR:P4 [cytosol] (Homo sapiens)
PGR:P4 [cytosol] (Sus scrofa)
PGR:P4 [cytosol] (Mus musculus)
PGR:P4 [cytosol] (Canis familiaris)
PGR:P4 [cytosol] (Danio rerio)
PGR:P4 [cytosol] (Rattus norvegicus)
PGR:P4 [cytosol] (Gallus gallus)
PGR:P4 [cytosol] (Plasmodium falciparum)
PGR:P4 [cytosol] (Drosophila melanogaster)
PGR:P4 [cytosol] (Bos taurus)
as an input of
Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)
P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)
P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)
P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)
P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)
P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)
P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)
P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)
P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Mus musculus)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Bos taurus)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
as an output of
Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Gallus gallus)
as a member of
SH [cytosol]
Other forms of this molecule
P4 [extracellular region]
P4 [nucleoplasm]
Cross References
Guide to Pharmacology - Ligands
2377
COMPOUND
C00410
HMDB Metabolite
HMDB0001830
ZINC
000004428529
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![P4 [cytosol] icon](/icon/R-ICO-013242.svg){kind=icon}
