Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
H2O [cytosol]
Stable Identifier
R-ALL-29356
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Pexophagy (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
H2O [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
ANKLE2 is deacetylated by SIRT2 (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Bos taurus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
H2O [cytosol]
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
Dephosphorylation of CK2-modified condensin I (Bos taurus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Bos taurus)
H2O [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
H2O [cytosol]
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Dephosphorylation of phospho-Cdh1 (Bos taurus)
H2O [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
PP2A dephosphorylates serine-127 of YAP1 (Bos taurus)
H2O [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Bos taurus)
H2O [cytosol]
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Bos taurus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
PRDX1 overoxidizes (Bos taurus)
H2O [cytosol]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
H2O [cytosol]
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)
H2O [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
H2O [cytosol]
L1CAM interactions (Bos taurus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)
H2O [cytosol]
Semaphorin interactions (Bos taurus)
Sema4D in semaphorin signaling (Bos taurus)
Sema4D mediated inhibition of cell attachment and migration (Bos taurus)
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
H2O [cytosol]
Signaling by ROBO receptors (Bos taurus)
Regulation of expression of SLITs and ROBOs (Bos taurus)
USP33 deubiquitinates ROBO1 (Bos taurus)
H2O [cytosol]
SLIT2:ROBO1 increases RHOA activity (Bos taurus)
MYO9B inactivates RHOA (Bos taurus)
H2O [cytosol]
Drug ADME (Bos taurus)
Abacavir ADME (Bos taurus)
Abacavir metabolism (Bos taurus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)
H2O [cytosol]
Aspirin ADME (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
H2O [cytosol]
Atorvastatin ADME (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
H2O [cytosol]
Azathioprine ADME (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Bos taurus)
H2O [cytosol]
Ciprofloxacin ADME (Bos taurus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)
H2O [cytosol]
Paracetamol ADME (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Bos taurus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)
H2O [cytosol]
Prednisone ADME (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Bos taurus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
H2O [cytosol]
Ribavirin ADME (Bos taurus)
ADA deamidates RBV (Bos taurus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)
H2O [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
PRDX1 overoxidizes (Bos taurus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
H2O [cytosol]
Platelet homeostasis (Bos taurus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)
H2O [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Disassembly of COPII coated vesicle (Bos taurus)
H2O [cytosol]
Transport of Antigen peptide in to ER (Bos taurus)
H2O [cytosol]
MHC class II antigen presentation (Bos taurus)
Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
H2O [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Bos taurus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
H2O [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
H2O [cytosol]
Growth hormone receptor signaling (Bos taurus)
PTP1B dephosphorylates GHR (Bos taurus)
H2O [cytosol]
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
OAS antiviral response (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
H2O [cytosol]
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
H2O [cytosol]
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Bos taurus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
Conversion of PA into DAG by PAP-1 (Bos taurus)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Bos taurus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Bos taurus)
H2O [cytosol]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
H2O [cytosol]
Regulation of pyruvate metabolism (Bos taurus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Bos taurus)
H2O [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
H2O [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
AADAC deacetylates PHEN (Bos taurus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
H2O [cytosol]
Amine Oxidase reactions (Bos taurus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Bos taurus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Bos taurus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Bos taurus)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Bos taurus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Eicosanoids (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
H2O [cytosol]
Endogenous sterols (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Bos taurus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Bos taurus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H2O [cytosol]
Vitamins (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)
H2O [cytosol]
Ethanol oxidation (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
H2O [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
ABHD14B hydrolyses PNPB (Bos taurus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
H2O [cytosol]
Glucuronidation (Bos taurus)
Formation of the active cofactor, UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
H2O [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
H2O [cytosol]
Methylation (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Bos taurus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
H2O [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
ASPA deacetylates NAASP to acetate and L-aspartate (Bos taurus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Bos taurus)
H2O [cytosol]
NAALADases hydrolyse NAAG (Bos taurus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
H2O [cytosol]
Carnitine synthesis (Bos taurus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
H2O [cytosol]
Histidine catabolism (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Bos taurus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)
H2O [cytosol]
Metabolism of polyamines (Bos taurus)
Agmatine biosynthesis (Bos taurus)
Agmatine + H2O <=> putrescine + urea (Bos taurus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
H2O [cytosol]
Tyrosine catabolism (Bos taurus)
FAH cleaves 4FAA (Bos taurus)
H2O [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
H2O [cytosol]
Serine biosynthesis (Bos taurus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)
H2O [cytosol]
Sulfur amino acid metabolism (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
H2O [cytosol]
Cysteine formation from homocysteine (Bos taurus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Bos taurus)
Cysteine is degraded to serine and H2S (Bos taurus)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is created (Bos taurus)
H2O [cytosol]
Threonine catabolism (Bos taurus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)
H2O [cytosol]
Tryptophan catabolism (Bos taurus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
H2O [cytosol]
Urea cycle (Bos taurus)
arginine + H2O => ornithine + urea [ARG1] (Bos taurus)
H2O [cytosol]
Metabolism of carbohydrates (Bos taurus)
Fructose metabolism (Bos taurus)
Fructose catabolism (Bos taurus)
ALDH1A1 oxidises GA to DGA (Bos taurus)
H2O [cytosol]
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)
H2O [cytosol]
Glycolysis (Bos taurus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
H2O [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen synthesis (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Bos taurus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
H2O [cytosol]
Pentose phosphate pathway (Bos taurus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
H2O [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
Biosynthesis of D-series resolvins (Bos taurus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Bos taurus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)
H2O [cytosol]
Biosynthesis of maresins (Bos taurus)
Biosynthesis of maresin-like SPMs (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
H2O [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)
H2O [cytosol]
Biosynthesis of protectins (Bos taurus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)
H2O [cytosol]
Biosynthesis of DPA-derived SPMs (Bos taurus)
Biosynthesis of DPAn-3 SPMs (Bos taurus)
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Bos taurus)
Biosynthesis of E-series 18(R)-resolvins (Bos taurus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Bos taurus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
H2O [cytosol]
Biosynthesis of Lipoxins (LX) (Bos taurus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXA4 (Bos taurus)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXB4 (Bos taurus)
H2O [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
FAAH hydrolyses AEA to AA and ETA (Bos taurus)
H2O [cytosol]
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Bos taurus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Bos taurus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Bos taurus)
11,12-EET is hydrolysed to 11,12-DHET by EPHX2 (Bos taurus)
H2O [cytosol]
14,15-EET is hydrolysed to 14,15-DHET by EPHX2 (Bos taurus)
H2O [cytosol]
5,6-EET is hydrolysed to 5,6-DHET by EPHX2 (Bos taurus)
H2O [cytosol]
8,9-EET is hydrolysed to 8.9-DHET by EPHX2 (Bos taurus)
H2O [cytosol]
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Bos taurus)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Bos taurus)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Bos taurus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Bos taurus)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Bos taurus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
H2O [cytosol]
Peroxisomal lipid metabolism (Bos taurus)
Beta-oxidation of very long chain fatty acids (Bos taurus)
Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)
H2O [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis (Bos taurus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Bos taurus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Bos taurus)
H2O [cytosol]
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
H2O [cytosol]
Estrogen biosynthesis (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
H2O [cytosol]
Glucocorticoid biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates PREG (Bos taurus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Bos taurus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H2O [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodeling of DAG and TAG (Bos taurus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PC (Bos taurus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PE (Bos taurus)
ABHD4 hydrolyses NAPE (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PI (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PS (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)
H2O [cytosol]
Hydrolysis of LPC (Bos taurus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
H2O [cytosol]
Synthesis of PA (Bos taurus)
DDHD1,2 hydrolyse PA (Bos taurus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)
H2O [cytosol]
Synthesis of PC (Bos taurus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Bos taurus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
H2O [cytosol]
Synthesis of PE (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
H2O [cytosol]
PI Metabolism (Bos taurus)
Glycerophospholipid catabolism (Bos taurus)
GDE1 hydrolyzes GroPIns (Bos taurus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid catabolism (Bos taurus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Bos taurus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Bos taurus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Bos taurus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)
H2O [cytosol]
Sphingolipid catabolism (Bos taurus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Bos taurus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Bos taurus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Bos taurus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Bos taurus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Bos taurus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Bos taurus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Bos taurus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Bos taurus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)
H2O [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
H2O [cytosol]
Triglyceride catabolism (Bos taurus)
PNPLA4 hydrolyzes TAG (Bos taurus)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
DDAH1 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
H2O [cytosol]
Depalmitoylation of eNOS (Bos taurus)
H2O [cytosol]
eNOS synthesizes NO (Bos taurus)
H2O [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Bos taurus)
H2O [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
H2O [cytosol]
FAICAR => IMP + H2O (Bos taurus)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
H2O [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Bos taurus)
H2O [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Bos taurus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Bos taurus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Bos taurus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Bos taurus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Bos taurus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Bos taurus)
H2O [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
H2O [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)
H2O [cytosol]
Pyrimidine salvage (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
H2O [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
4 PBGs bind to form HMB (Bos taurus)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Bos taurus)
H2O [cytosol]
UROS transforms HMB to URO3 (Bos taurus)
H2O [cytosol]
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Transport of RCbl within the body (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
H2O [cytosol]
Metabolism of folate and pterines (Bos taurus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Bos taurus)
Cyclisation of GTP to precursor Z (Bos taurus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Bos taurus)
H2O [cytosol]
Nicotinate metabolism (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Bos taurus)
H2O [cytosol]
Pyrophosphate hydrolysis (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
H2O [cytosol]
Metabolism of RNA (Bos taurus)
Deadenylation-dependent mRNA decay (Bos taurus)
Deadenylation of mRNA (Bos taurus)
CCR4-NOT complex deadenylates mRNA (Bos taurus)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)
H2O [cytosol]
PARN deadenylates mRNA (Bos taurus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Bos taurus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Bos taurus)
DCP1-DCP2 complex decaps mRNA (Bos taurus)
H2O [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)
H2O [cytosol]
Sialic acid metabolism (Bos taurus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Bos taurus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Bos taurus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
PP6 dephosphorylates SEC24 (Bos taurus)
H2O [cytosol]
Deubiquitination (Bos taurus)
Josephin domain DUBs (Bos taurus)
ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Bos taurus)
H2O [cytosol]
Metalloprotease DUBs (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
H2O [cytosol]
Ovarian tumor domain proteases (Bos taurus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
H2O [cytosol]
UCH proteinases (Bos taurus)
UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
H2O [cytosol]
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Bos taurus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Bos taurus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Bos taurus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Bos taurus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Bos taurus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Bos taurus)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
H2O [cytosol]
Neddylation (Bos taurus)
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Bos taurus)
Synthesis of glycosylphosphatidylinositol (GPI) (Bos taurus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)
H2O [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
H2O [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Termination (Bos taurus)
APEH hydrolyses NAc-Ser-protein (Bos taurus)
H2O [cytosol]
tRNA Aminoacylation (Bos taurus)
Cytosolic tRNA aminoacylation (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
H2O [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
H2O [cytosol]
Physiological factors (Bos taurus)
CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
H2O [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Dopamine clearance from the synaptic cleft (Bos taurus)
Enzymatic degradation of Dopamine by monoamine oxidase (Bos taurus)
MAOA:FAD deaminates DA to DOPAC (Bos taurus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Bos taurus)
Metabolism of serotonin (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
H2O [cytosol]
Neurotransmitter release cycle (Bos taurus)
Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
Catabolism of Noradrenaline (Bos taurus)
H2O [cytosol]
Organelle biogenesis and maintenance (Bos taurus)
Cilium Assembly (Bos taurus)
Cargo trafficking to the periciliary membrane (Bos taurus)
VxPx cargo-targeting to cilium (Bos taurus)
ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
H2O [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD by calcineurin (Bos taurus)
H2O [cytosol]
Protein localization (Bos taurus)
Peroxisomal protein import (Bos taurus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
H2O [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
H2O [cytosol]
The phototransduction cascade (Bos taurus)
Activation of the phototransduction cascade (Bos taurus)
PDE6 hydrolyses cGMP to GMP (Bos taurus)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Bos taurus)
OPN1LW binds 11cRAL (Bos taurus)
H2O [cytosol]
OPN1MW binds 11cRAL (Bos taurus)
H2O [cytosol]
OPN1SW binds 11cRAL (Bos taurus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)
H2O [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
H2O [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
H2O [cytosol]
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
PTEN Regulation (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
H2O [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Bos taurus)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Bos taurus)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Bos taurus)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
H2O [cytosol]
RAF activation (Bos taurus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Bos taurus)
H2O [cytosol]
RAS processing (Bos taurus)
RAS proteins are depalmitoylated (Bos taurus)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Bos taurus)
H2O [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK is dephosphorylated (Bos taurus)
H2O [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Bos taurus)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Bos taurus)
H2O [cytosol]
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
H2O [cytosol]
phospho-PLA2 pathway (Bos taurus)
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Bos taurus)
H2O [cytosol]
Inactivation of PLC beta (Bos taurus)
H2O [cytosol]
PIP2 hydrolysis (Bos taurus)
H2O [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H2O [cytosol]
G alpha (s) signalling events (Bos taurus)
PDE3A hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Bos taurus)
H2O [cytosol]
Signaling by Hedgehog (Bos taurus)
Hedgehog ligand biogenesis (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Down-Regulation (Bos taurus)
PTPN1 dephosphorylates PTK6 (Bos taurus)
H2O [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
H2O [cytosol]
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Bos taurus)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
MDK and PTN in ALK signaling (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Bos taurus)
H2O [cytosol]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
PTPN3 dephosphorylates EPS15 (Bos taurus)
H2O [cytosol]
GAB1 signalosome (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Bos taurus)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
H2O [cytosol]
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
H2O [cytosol]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor recycling (Bos taurus)
Insulin receptor de-phosphorylation (Bos taurus)
H2O [cytosol]
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PKB-mediated events (Bos taurus)
PDE3B signalling (Bos taurus)
p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
H2O [cytosol]
PTPRJ dephosphorylates MET (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Bos taurus)
H2O [cytosol]
Signaling by PDGF (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PKB-mediated events (Bos taurus)
PDE3B signalling (Bos taurus)
p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
eNOS synthesizes NO (Bos taurus)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Miro GTPase Cycle (Bos taurus)
RHOT1 GTPase cycle (Bos taurus)
RHOT1 hydrolyzes GTP (Bos taurus)
H2O [cytosol]
RHOT2 GTPase cycle (Bos taurus)
RHOT2 hydrolyzes GTP (Bos taurus)
H2O [cytosol]
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
H2O [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
H2O [cytosol]
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
H2O [cytosol]
RAC1 GTPase cycle (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
H2O [cytosol]
RAC2 GTPase cycle (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
H2O [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
H2O [cytosol]
RHOA GTPase cycle (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
H2O [cytosol]
RHOC GTPase cycle (Bos taurus)
RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
H2O [cytosol]
RHOD GTPase cycle (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
H2O [cytosol]
RHOF GTPase cycle (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
H2O [cytosol]
RHOG GTPase cycle (Bos taurus)
RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
H2O [cytosol]
RHOJ GTPase cycle (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
H2O [cytosol]
RHOQ GTPase cycle (Bos taurus)
RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
H2O [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Bos taurus)
H2O [cytosol]
TCF dependent signaling in response to WNT (Bos taurus)
Regulation of FZD by ubiquitination (Bos taurus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
H2O [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Bos taurus)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HCO3- transport through ion channel (Bos taurus)
H2O [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
H2O [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
H2O [cytosol]
Aquaporin-mediated transport (Bos taurus)
Passive transport by Aquaporins (Bos taurus)
Aquaporins passively transport water into cells (Bos taurus)
H2O [cytosol]
Aquaporins passively transport water out of cells (Bos taurus)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Bos taurus)
Aquaporin-1 passively transports water into cell (Bos taurus)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Bos taurus)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Bos taurus)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Bos taurus)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)
H2O [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
H2O [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
H2O [cytosol]
Plasma lipoprotein clearance (Bos taurus)
LDL clearance (Bos taurus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Bos taurus)
H2O [cytosol]
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
H2O [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
H2O [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
PP6 dephosphorylates SEC24 (Bos taurus)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-independent Golgi-to-ER retrograde traffic (Bos taurus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)
H2O [cytosol]
Rab regulation of trafficking (Bos taurus)
TBC/RABGAPs (Bos taurus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
H2O [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Initiation of Nuclear Envelope (NE) Reformation (Caenorhabditis elegans)
PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
H2O [cytosol]
Mitotic Prometaphase (Caenorhabditis elegans)
Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)
PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)
H2O [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
H2O [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Caenorhabditis elegans)
PP2A dephosphorylates serine-127 of YAP1 (Caenorhabditis elegans)
H2O [cytosol]
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Caenorhabditis elegans)
PRDX1 overoxidizes (Caenorhabditis elegans)
H2O [cytosol]
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
H2O [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
H2O [cytosol]
Drug ADME (Caenorhabditis elegans)
Abacavir ADME (Caenorhabditis elegans)
Abacavir metabolism (Caenorhabditis elegans)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)
H2O [cytosol]
Aspirin ADME (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
H2O [cytosol]
Atorvastatin ADME (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
H2O [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
H2O [cytosol]
Ciprofloxacin ADME (Caenorhabditis elegans)
ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)
H2O [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)
H2O [cytosol]
Ribavirin ADME (Caenorhabditis elegans)
ADA deamidates RBV (Caenorhabditis elegans)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)
H2O [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
PRDX1 overoxidizes (Caenorhabditis elegans)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
H2O [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)
H2O [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
H2O [cytosol]
Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
Co-inhibition by CTLA4 (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
H2O [cytosol]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
OAS antiviral response (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
H2O [cytosol]
Innate Immune System (Caenorhabditis elegans)
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Role of phospholipids in phagocytosis (Caenorhabditis elegans)
Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)
H2O [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
H2O [cytosol]
Regulation of pyruvate metabolism (Caenorhabditis elegans)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Caenorhabditis elegans)
H2O [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
H2O [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
AADAC deacetylates PHEN (Caenorhabditis elegans)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Endogenous sterols (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H2O [cytosol]
Vitamins (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)
H2O [cytosol]
Ethanol oxidation (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
H2O [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
ABHD14B hydrolyses PNPB (Caenorhabditis elegans)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Glucuronidation (Caenorhabditis elegans)
Formation of the active cofactor, UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
H2O [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
H2O [cytosol]
Methylation (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)
H2O [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)
H2O [cytosol]
NAALADases hydrolyse NAAG (Caenorhabditis elegans)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
H2O [cytosol]
Carnitine synthesis (Caenorhabditis elegans)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
H2O [cytosol]
Histidine catabolism (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Caenorhabditis elegans)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
H2O [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
FAH cleaves 4FAA (Caenorhabditis elegans)
H2O [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
H2O [cytosol]
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
H2O [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)
H2O [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
H2O [cytosol]
Cysteine formation from homocysteine (Caenorhabditis elegans)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)
H2O [cytosol]
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Cysteine is degraded to serine and H2S (Caenorhabditis elegans)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)
H2O [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is created (Caenorhabditis elegans)
H2O [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
H2O [cytosol]
Urea cycle (Caenorhabditis elegans)
arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Fructose metabolism (Caenorhabditis elegans)
Fructose catabolism (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
H2O [cytosol]
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)
H2O [cytosol]
Glycolysis (Caenorhabditis elegans)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen synthesis (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
H2O [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of D-series resolvins (Caenorhabditis elegans)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Caenorhabditis elegans)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of maresins (Caenorhabditis elegans)
Biosynthesis of maresin-like SPMs (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of protectins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of E-series 18(R)-resolvins (Caenorhabditis elegans)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Caenorhabditis elegans)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
H2O [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonate metabolism (Caenorhabditis elegans)
FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Caenorhabditis elegans)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Caenorhabditis elegans)
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Caenorhabditis elegans)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Caenorhabditis elegans)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Caenorhabditis elegans)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Caenorhabditis elegans)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Caenorhabditis elegans)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
H2O [cytosol]
Peroxisomal lipid metabolism (Caenorhabditis elegans)
Beta-oxidation of very long chain fatty acids (Caenorhabditis elegans)
Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Recycling of bile acids and salts (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of steroid hormones (Caenorhabditis elegans)
Estrogen biosynthesis (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H2O [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Acyl chain remodeling of DAG and TAG (Caenorhabditis elegans)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PC (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PE (Caenorhabditis elegans)
ABHD4 hydrolyses NAPE (Caenorhabditis elegans)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PG (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PI (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PS (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PA (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Caenorhabditis elegans)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Caenorhabditis elegans)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PC (Caenorhabditis elegans)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PE (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
H2O [cytosol]
PI Metabolism (Caenorhabditis elegans)
Glycerophospholipid catabolism (Caenorhabditis elegans)
GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid catabolism (Caenorhabditis elegans)
ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid catabolism (Caenorhabditis elegans)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Caenorhabditis elegans)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Caenorhabditis elegans)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Caenorhabditis elegans)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)
H2O [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
H2O [cytosol]
Triglyceride catabolism (Caenorhabditis elegans)
PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
H2O [cytosol]
FAICAR => IMP + H2O (Caenorhabditis elegans)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Heme degradation (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Transport of RCbl within the body (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
H2O [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
H2O [cytosol]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of RNA (Caenorhabditis elegans)
Deadenylation-dependent mRNA decay (Caenorhabditis elegans)
mRNA decay by 3' to 5' exoribonuclease (Caenorhabditis elegans)
DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Caenorhabditis elegans)
DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Caenorhabditis elegans)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)
H2O [cytosol]
Deubiquitination (Caenorhabditis elegans)
Josephin domain DUBs (Caenorhabditis elegans)
ATXN3 family cleave Ub chains (Caenorhabditis elegans)
H2O [cytosol]
UCH proteinases (Caenorhabditis elegans)
UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
H2O [cytosol]
Ub-specific processing proteases (Caenorhabditis elegans)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Caenorhabditis elegans)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Caenorhabditis elegans)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
H2O [cytosol]
Neddylation (Caenorhabditis elegans)
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Caenorhabditis elegans)
Synthesis of glycosylphosphatidylinositol (GPI) (Caenorhabditis elegans)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)
H2O [cytosol]
Surfactant metabolism (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
H2O [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Termination (Caenorhabditis elegans)
APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)
H2O [cytosol]
tRNA Aminoacylation (Caenorhabditis elegans)
Cytosolic tRNA aminoacylation (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Physiological factors (Caenorhabditis elegans)
CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
H2O [cytosol]
Protein localization (Caenorhabditis elegans)
Peroxisomal protein import (Caenorhabditis elegans)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Caenorhabditis elegans)
H2O [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
11cRAL binds to opsin to form 11c-retinyl:RHO (Caenorhabditis elegans)
H2O [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
H2O [cytosol]
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Caenorhabditis elegans)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Caenorhabditis elegans)
OPN1LW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
OPN1MW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
OPN1SW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Caenorhabditis elegans)
H2O [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
H2O [cytosol]
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN stability and activity (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
H2O [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
H2O [cytosol]
RAF/MAP kinase cascade (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
H2O [cytosol]
RAF activation (Caenorhabditis elegans)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
H2O [cytosol]
RAS processing (Caenorhabditis elegans)
RAS proteins are depalmitoylated (Caenorhabditis elegans)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)
H2O [cytosol]
MTOR signalling (Caenorhabditis elegans)
Energy dependent regulation of mTOR by LKB1-AMPK (Caenorhabditis elegans)
AMPK is dephosphorylated (Caenorhabditis elegans)
H2O [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
DARPP-32 events (Caenorhabditis elegans)
PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)
H2O [cytosol]
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
H2O [cytosol]
Inactivation of PLC beta (Caenorhabditis elegans)
H2O [cytosol]
PIP2 hydrolysis (Caenorhabditis elegans)
H2O [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H2O [cytosol]
G alpha (s) signalling events (Caenorhabditis elegans)
PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
H2O [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PKB-mediated events (Caenorhabditis elegans)
PDE3B signalling (Caenorhabditis elegans)
p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
PTPRJ dephosphorylates MET (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PKB-mediated events (Caenorhabditis elegans)
PDE3B signalling (Caenorhabditis elegans)
p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Miro GTPase Cycle (Caenorhabditis elegans)
RHOT1 GTPase cycle (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
H2O [cytosol]
RHOT2 GTPase cycle (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
H2O [cytosol]
RHOBTB3 ATPase cycle (Caenorhabditis elegans)
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
CDC42 GTPase cycle (Caenorhabditis elegans)
CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC2 GTPase cycle (Caenorhabditis elegans)
RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC3 GTPase cycle (Caenorhabditis elegans)
RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOB GTPase cycle (Caenorhabditis elegans)
RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOD GTPase cycle (Caenorhabditis elegans)
RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOF GTPase cycle (Caenorhabditis elegans)
RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOG GTPase cycle (Caenorhabditis elegans)
RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOJ GTPase cycle (Caenorhabditis elegans)
RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
ABC transporters in lipid homeostasis (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
HCO3- transport through ion channel (Caenorhabditis elegans)
H2O [cytosol]
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
H2O [cytosol]
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Aquaporin-mediated transport (Caenorhabditis elegans)
Passive transport by Aquaporins (Caenorhabditis elegans)
Aquaporins passively transport water into cells (Caenorhabditis elegans)
H2O [cytosol]
Aquaporins passively transport water out of cells (Caenorhabditis elegans)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Caenorhabditis elegans)
Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)
H2O [cytosol]
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Caenorhabditis elegans)
Erythrocytes take up carbon dioxide and release oxygen (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Caenorhabditis elegans)
Plasma lipoprotein clearance (Caenorhabditis elegans)
LDL clearance (Caenorhabditis elegans)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)
H2O [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-independent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
TBC/RABGAPs (Caenorhabditis elegans)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
H2O [cytosol]
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Pexophagy (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
H2O [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Initiation of Nuclear Envelope (NE) Reformation (Canis familiaris)
ANKLE2 is deacetylated by SIRT2 (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Canis familiaris)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Canis familiaris)
RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Canis familiaris)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)
H2O [cytosol]
Mitotic Prometaphase (Canis familiaris)
Condensation of Prometaphase Chromosomes (Canis familiaris)
Dephosphorylation of CK2-modified condensin I (Canis familiaris)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Canis familiaris)
H2O [cytosol]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
H2O [cytosol]
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
H2O [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
PP2A dephosphorylates serine-127 of YAP1 (Canis familiaris)
H2O [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Canis familiaris)
H2O [cytosol]
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Canis familiaris)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
PRDX1 overoxidizes (Canis familiaris)
H2O [cytosol]
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
H2O [cytosol]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)
H2O [cytosol]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
H2O [cytosol]
L1CAM interactions (Canis familiaris)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)
H2O [cytosol]
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D mediated inhibition of cell attachment and migration (Canis familiaris)
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
H2O [cytosol]
Signaling by ROBO receptors (Canis familiaris)
SLIT2:ROBO1 increases RHOA activity (Canis familiaris)
MYO9B inactivates RHOA (Canis familiaris)
H2O [cytosol]
Drug ADME (Canis familiaris)
Abacavir ADME (Canis familiaris)
Abacavir metabolism (Canis familiaris)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)
H2O [cytosol]
Aspirin ADME (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
H2O [cytosol]
Atorvastatin ADME (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
H2O [cytosol]
Azathioprine ADME (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Canis familiaris)
H2O [cytosol]
Ciprofloxacin ADME (Canis familiaris)
ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)
H2O [cytosol]
Paracetamol ADME (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Canis familiaris)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)
H2O [cytosol]
Prednisone ADME (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
H2O [cytosol]
Ribavirin ADME (Canis familiaris)
ADA deamidates RBV (Canis familiaris)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)
H2O [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
PRDX1 overoxidizes (Canis familiaris)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
H2O [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
H2O [cytosol]
Platelet homeostasis (Canis familiaris)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)
H2O [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Canis familiaris)
Disassembly of COPII coated vesicle (Canis familiaris)
H2O [cytosol]
MHC class II antigen presentation (Canis familiaris)
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
H2O [cytosol]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Canis familiaris)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
H2O [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
PTPRJ dephosphorylates active FLT3 (Canis familiaris)
H2O [cytosol]
Growth hormone receptor signaling (Canis familiaris)
PTP1B dephosphorylates GHR (Canis familiaris)
H2O [cytosol]
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
OAS antiviral response (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
H2O [cytosol]
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
H2O [cytosol]
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
H2O [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Canis familiaris)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
Conversion of PA into DAG by PAP-1 (Canis familiaris)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Canis familiaris)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Canis familiaris)
H2O [cytosol]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
H2O [cytosol]
Regulation of pyruvate metabolism (Canis familiaris)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Canis familiaris)
H2O [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
H2O [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
AADAC deacetylates PHEN (Canis familiaris)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
H2O [cytosol]
Amine Oxidase reactions (Canis familiaris)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Canis familiaris)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Canis familiaris)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Canis familiaris)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Eicosanoids (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
H2O [cytosol]
Endogenous sterols (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H2O [cytosol]
Vitamins (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)
H2O [cytosol]
Ethanol oxidation (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
H2O [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
ABHD14B hydrolyses PNPB (Canis familiaris)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
H2O [cytosol]
Glucuronidation (Canis familiaris)
Formation of the active cofactor, UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
H2O [cytosol]
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
H2O [cytosol]
Methylation (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Canis familiaris)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
H2O [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Acetylcholine regulates insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Canis familiaris)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
H2O [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
ASPA deacetylates NAASP to acetate and L-aspartate (Canis familiaris)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)
H2O [cytosol]
NAALADases hydrolyse NAAG (Canis familiaris)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
H2O [cytosol]
Carnitine synthesis (Canis familiaris)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
H2O [cytosol]
Histidine catabolism (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Canis familiaris)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)
H2O [cytosol]
Metabolism of polyamines (Canis familiaris)
Agmatine biosynthesis (Canis familiaris)
Agmatine + H2O <=> putrescine + urea (Canis familiaris)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
H2O [cytosol]
Tyrosine catabolism (Canis familiaris)
FAH cleaves 4FAA (Canis familiaris)
H2O [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
H2O [cytosol]
Selenocysteine synthesis (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
H2O [cytosol]
Serine biosynthesis (Canis familiaris)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)
H2O [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
H2O [cytosol]
Cysteine formation from homocysteine (Canis familiaris)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)
H2O [cytosol]
Degradation of cysteine and homocysteine (Canis familiaris)
Cysteine is degraded to serine and H2S (Canis familiaris)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is created (Canis familiaris)
H2O [cytosol]
Threonine catabolism (Canis familiaris)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)
H2O [cytosol]
Tryptophan catabolism (Canis familiaris)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
H2O [cytosol]
Urea cycle (Canis familiaris)
arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)
H2O [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Fructose metabolism (Canis familiaris)
Fructose catabolism (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
H2O [cytosol]
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)
H2O [cytosol]
Glycolysis (Canis familiaris)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Canis familiaris)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)
H2O [cytosol]
Glycogen metabolism (Canis familiaris)
Glycogen synthesis (Canis familiaris)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Canis familiaris)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
H2O [cytosol]
Pentose phosphate pathway (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
H2O [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
Biosynthesis of D-series resolvins (Canis familiaris)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)
H2O [cytosol]
Biosynthesis of maresins (Canis familiaris)
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
H2O [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)
H2O [cytosol]
Biosynthesis of protectins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)
H2O [cytosol]
Biosynthesis of DPA-derived SPMs (Canis familiaris)
Biosynthesis of DPAn-3 SPMs (Canis familiaris)
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Canis familiaris)
Biosynthesis of E-series 18(R)-resolvins (Canis familiaris)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Canis familiaris)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
H2O [cytosol]
Biosynthesis of Lipoxins (LX) (Canis familiaris)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXA4 (Canis familiaris)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXB4 (Canis familiaris)
H2O [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
FAAH hydrolyses AEA to AA and ETA (Canis familiaris)
H2O [cytosol]
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Canis familiaris)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Canis familiaris)
11,12-EET is hydrolysed to 11,12-DHET by EPHX2 (Canis familiaris)
H2O [cytosol]
14,15-EET is hydrolysed to 14,15-DHET by EPHX2 (Canis familiaris)
H2O [cytosol]
5,6-EET is hydrolysed to 5,6-DHET by EPHX2 (Canis familiaris)
H2O [cytosol]
8,9-EET is hydrolysed to 8.9-DHET by EPHX2 (Canis familiaris)
H2O [cytosol]
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Canis familiaris)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Canis familiaris)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Canis familiaris)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Canis familiaris)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Canis familiaris)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
H2O [cytosol]
Peroxisomal lipid metabolism (Canis familiaris)
Beta-oxidation of very long chain fatty acids (Canis familiaris)
Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)
H2O [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Recycling of bile acids and salts (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis (Canis familiaris)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Canis familiaris)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
H2O [cytosol]
Squalene is oxidized to its epoxide (Canis familiaris)
H2O [cytosol]
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
H2O [cytosol]
Estrogen biosynthesis (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
H2O [cytosol]
Glucocorticoid biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Canis familiaris)
H2O [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H2O [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodeling of DAG and TAG (Canis familiaris)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PC (Canis familiaris)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PE (Canis familiaris)
ABHD4 hydrolyses NAPE (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PI (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PS (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)
H2O [cytosol]
Hydrolysis of LPC (Canis familiaris)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
H2O [cytosol]
Synthesis of PA (Canis familiaris)
DDHD1,2 hydrolyse PA (Canis familiaris)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)
H2O [cytosol]
Synthesis of PC (Canis familiaris)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)
H2O [cytosol]
Synthesis of PE (Canis familiaris)
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)
H2O [cytosol]
PI Metabolism (Canis familiaris)
Glycerophospholipid catabolism (Canis familiaris)
GDE1 hydrolyzes GroPIns (Canis familiaris)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Canis familiaris)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid catabolism (Canis familiaris)
ASAH2 hydrolyzes ceramide (plasma membrane) (Canis familiaris)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Canis familiaris)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Canis familiaris)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)
H2O [cytosol]
Sphingolipid catabolism (Canis familiaris)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Canis familiaris)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Canis familiaris)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Canis familiaris)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Canis familiaris)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Canis familiaris)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Canis familiaris)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)
H2O [cytosol]
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
H2O [cytosol]
Triglyceride catabolism (Canis familiaris)
PNPLA4 hydrolyzes TAG (Canis familiaris)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Canis familiaris)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
DDAH1 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
H2O [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
H2O [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
H2O [cytosol]
FAICAR => IMP + H2O (Canis familiaris)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
H2O [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
H2O [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Canis familiaris)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Canis familiaris)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Canis familiaris)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Canis familiaris)
H2O [cytosol]
Pyrimidine catabolism (Canis familiaris)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
H2O [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)
H2O [cytosol]
Pyrimidine salvage (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
H2O [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
4 PBGs bind to form HMB (Canis familiaris)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
H2O [cytosol]
UROS transforms HMB to URO3 (Canis familiaris)
H2O [cytosol]
Heme degradation (Canis familiaris)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Transport of RCbl within the body (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Canis familiaris)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
H2O [cytosol]
Metabolism of folate and pterines (Canis familiaris)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
Cyclisation of GTP to precursor Z (Canis familiaris)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
H2O [cytosol]
Nicotinate metabolism (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Canis familiaris)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
PANK4 hydrolyzes PPANT to pantetheine (Canis familiaris)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
H2O [cytosol]
Pyrophosphate hydrolysis (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
H2O [cytosol]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
H2O [cytosol]
Metabolism of RNA (Canis familiaris)
Deadenylation-dependent mRNA decay (Canis familiaris)
Deadenylation of mRNA (Canis familiaris)
CCR4-NOT complex deadenylates mRNA (Canis familiaris)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
H2O [cytosol]
PARN deadenylates mRNA (Canis familiaris)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Canis familiaris)
DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Canis familiaris)
DCP1-DCP2 complex decaps mRNA (Canis familiaris)
H2O [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)
H2O [cytosol]
Sialic acid metabolism (Canis familiaris)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Canis familiaris)
DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
PP6 dephosphorylates SEC24 (Canis familiaris)
H2O [cytosol]
Deubiquitination (Canis familiaris)
Josephin domain DUBs (Canis familiaris)
ATXN3 deubiquitinates polyUb-PARK2 (Canis familiaris)
H2O [cytosol]
ATXN3 family cleave Ub chains (Canis familiaris)
H2O [cytosol]
Metalloprotease DUBs (Canis familiaris)
BRISC complex deubiquitinates NLRP3 (Canis familiaris)
H2O [cytosol]
Ovarian tumor domain proteases (Canis familiaris)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
H2O [cytosol]
UCH proteinases (Canis familiaris)
UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
H2O [cytosol]
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Canis familiaris)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Canis familiaris)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Canis familiaris)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Canis familiaris)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Canis familiaris)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)
H2O [cytosol]
USP5 cleaves polyubiquitin (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Canis familiaris)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
H2O [cytosol]
Neddylation (Canis familiaris)
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Canis familiaris)
Synthesis of glycosylphosphatidylinositol (GPI) (Canis familiaris)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)
H2O [cytosol]
Surfactant metabolism (Canis familiaris)
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
H2O [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Termination (Canis familiaris)
APEH hydrolyses NAc-Ser-protein (Canis familiaris)
H2O [cytosol]
tRNA Aminoacylation (Canis familiaris)
Cytosolic tRNA aminoacylation (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
H2O [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
H2O [cytosol]
Physiological factors (Canis familiaris)
CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
H2O [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Dopamine clearance from the synaptic cleft (Canis familiaris)
Enzymatic degradation of Dopamine by monoamine oxidase (Canis familiaris)
MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Canis familiaris)
Metabolism of serotonin (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
H2O [cytosol]
Neurotransmitter release cycle (Canis familiaris)
Norepinephrine Neurotransmitter Release Cycle (Canis familiaris)
Catabolism of Noradrenaline (Canis familiaris)
H2O [cytosol]
Organelle biogenesis and maintenance (Canis familiaris)
Cilium Assembly (Canis familiaris)
Cargo trafficking to the periciliary membrane (Canis familiaris)
VxPx cargo-targeting to cilium (Canis familiaris)
ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)
H2O [cytosol]
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation of BH3-only proteins (Canis familiaris)
Activation of BAD and translocation to mitochondria (Canis familiaris)
Activation of BAD by calcineurin (Canis familiaris)
H2O [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
11cRAL binds to opsin to form 11c-retinyl:RHO (Canis familiaris)
H2O [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
H2O [cytosol]
The phototransduction cascade (Canis familiaris)
Activation of the phototransduction cascade (Canis familiaris)
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Canis familiaris)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Canis familiaris)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Canis familiaris)
OPN1LW binds 11cRAL (Canis familiaris)
H2O [cytosol]
OPN1MW binds 11cRAL (Canis familiaris)
H2O [cytosol]
OPN1SW binds 11cRAL (Canis familiaris)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)
H2O [cytosol]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
H2O [cytosol]
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
H2O [cytosol]
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
H2O [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Canis familiaris)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Canis familiaris)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Canis familiaris)
H2O [cytosol]
RAS processing (Canis familiaris)
RAS proteins are depalmitoylated (Canis familiaris)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Canis familiaris)
H2O [cytosol]
MTOR signalling (Canis familiaris)
Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
AMPK is dephosphorylated (Canis familiaris)
H2O [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Canis familiaris)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Canis familiaris)
H2O [cytosol]
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
H2O [cytosol]
phospho-PLA2 pathway (Canis familiaris)
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Canis familiaris)
H2O [cytosol]
Inactivation of PLC beta (Canis familiaris)
H2O [cytosol]
PIP2 hydrolysis (Canis familiaris)
H2O [cytosol]
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H2O [cytosol]
G alpha (s) signalling events (Canis familiaris)
PDE3A hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Canis familiaris)
H2O [cytosol]
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
H2O [cytosol]
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Canis familiaris)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
MDK and PTN in ALK signaling (Canis familiaris)
PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Canis familiaris)
H2O [cytosol]
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Canis familiaris)
H2O [cytosol]
GAB1 signalosome (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Canis familiaris)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
H2O [cytosol]
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
H2O [cytosol]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor recycling (Canis familiaris)
Insulin receptor de-phosphorylation (Canis familiaris)
H2O [cytosol]
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PKB-mediated events (Canis familiaris)
PDE3B signalling (Canis familiaris)
p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
H2O [cytosol]
PTPRJ dephosphorylates MET (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Canis familiaris)
H2O [cytosol]
Signaling by PDGF (Canis familiaris)
PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PKB-mediated events (Canis familiaris)
PDE3B signalling (Canis familiaris)
p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Miro GTPase Cycle (Canis familiaris)
RHOT1 GTPase cycle (Canis familiaris)
RHOT1 hydrolyzes GTP (Canis familiaris)
H2O [cytosol]
RHOBTB3 ATPase cycle (Canis familiaris)
RHOBTB3 hydrolyzes ATP (Canis familiaris)
H2O [cytosol]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate Formins (Canis familiaris)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
H2O [cytosol]
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC1 GTPase cycle (Canis familiaris)
RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC2 GTPase cycle (Canis familiaris)
RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC3 GTPase cycle (Canis familiaris)
RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)
H2O [cytosol]
RHOA GTPase cycle (Canis familiaris)
RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
H2O [cytosol]
RHOB GTPase cycle (Canis familiaris)
RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
H2O [cytosol]
RHOC GTPase cycle (Canis familiaris)
RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
H2O [cytosol]
RHOD GTPase cycle (Canis familiaris)
RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
H2O [cytosol]
RHOF GTPase cycle (Canis familiaris)
RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
H2O [cytosol]
RHOG GTPase cycle (Canis familiaris)
RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
H2O [cytosol]
RHOJ GTPase cycle (Canis familiaris)
RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
H2O [cytosol]
RHOQ GTPase cycle (Canis familiaris)
RHOQ GAPs stimulate RHOQ GTPase activity (Canis familiaris)
H2O [cytosol]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
H2O [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
H2O [cytosol]
TCF dependent signaling in response to WNT (Canis familiaris)
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
H2O [cytosol]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABC transporters in lipid homeostasis (Canis familiaris)
ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Canis familiaris)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HCO3- transport through ion channel (Canis familiaris)
H2O [cytosol]
Mitochondrial ABC transporters (Canis familiaris)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
H2O [cytosol]
The ABCC family mediates organic anion transport (Canis familiaris)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
H2O [cytosol]
Aquaporin-mediated transport (Canis familiaris)
Passive transport by Aquaporins (Canis familiaris)
Aquaporins passively transport water into cells (Canis familiaris)
H2O [cytosol]
Aquaporins passively transport water out of cells (Canis familiaris)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Canis familiaris)
Aquaporin-1 passively transports water into cell (Canis familiaris)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)
H2O [cytosol]
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
H2O [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
HDL assembly (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein clearance (Canis familiaris)
LDL clearance (Canis familiaris)
NCEH1 hydrolyzes cholesterol esters (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein remodeling (Canis familiaris)
HDL remodeling (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
H2O [cytosol]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
H2O [cytosol]
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
PP6 dephosphorylates SEC24 (Canis familiaris)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
Golgi-to-ER retrograde transport (Canis familiaris)
COPI-independent Golgi-to-ER retrograde traffic (Canis familiaris)
PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)
H2O [cytosol]
Rab regulation of trafficking (Canis familiaris)
TBC/RABGAPs (Canis familiaris)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)
H2O [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Nuclear Envelope (NE) Reassembly (Danio rerio)
Initiation of Nuclear Envelope (NE) Reformation (Danio rerio)
ANKLE2 is deacetylated by SIRT2 (Danio rerio)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Danio rerio)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Danio rerio)
RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
H2O [cytosol]
Regulation of mitotic cell cycle (Danio rerio)
APC/C-mediated degradation of cell cycle proteins (Danio rerio)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
H2O [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to mechanical stimuli (Danio rerio)
Response of endothelial cells to shear stress (Danio rerio)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Danio rerio)
PP2A dephosphorylates serine-127 of YAP1 (Danio rerio)
H2O [cytosol]
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Danio rerio)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Danio rerio)
Nuclear events mediated by NFE2L2 (Danio rerio)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Danio rerio)
PRDX1 overoxidizes (Danio rerio)
H2O [cytosol]
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
H2O [cytosol]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
H2O [cytosol]
L1CAM interactions (Danio rerio)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)
H2O [cytosol]
Semaphorin interactions (Danio rerio)
Sema4D in semaphorin signaling (Danio rerio)
Sema4D mediated inhibition of cell attachment and migration (Danio rerio)
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
H2O [cytosol]
Drug ADME (Danio rerio)
Abacavir ADME (Danio rerio)
Abacavir metabolism (Danio rerio)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)
H2O [cytosol]
Aspirin ADME (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
H2O [cytosol]
Atorvastatin ADME (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
H2O [cytosol]
Azathioprine ADME (Danio rerio)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
H2O [cytosol]
Paracetamol ADME (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)
H2O [cytosol]
Prednisone ADME (Danio rerio)
CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
H2O [cytosol]
Ribavirin ADME (Danio rerio)
ADA deamidates RBV (Danio rerio)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
H2O [cytosol]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
PRDX1 overoxidizes (Danio rerio)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)
H2O [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
ABCC4 accumulation of dense granule contents (Danio rerio)
H2O [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
H2O [cytosol]
Cytokine Signaling in Immune system (Danio rerio)
Growth hormone receptor signaling (Danio rerio)
PTP1B dephosphorylates GHR (Danio rerio)
H2O [cytosol]
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)
H2O [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
H2O [cytosol]
Regulation of pyruvate metabolism (Danio rerio)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Danio rerio)
H2O [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
H2O [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
H2O [cytosol]
Amine Oxidase reactions (Danio rerio)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)
MAOB:FAD oxidatively deaminates TYR (Danio rerio)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Danio rerio)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Danio rerio)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
H2O [cytosol]
Endogenous sterols (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Danio rerio)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H2O [cytosol]
Vitamins (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
H2O [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Cytosolic sulfonation of small molecules (Danio rerio)
ABHD14B hydrolyses PNPB (Danio rerio)
H2O [cytosol]
Glucuronidation (Danio rerio)
Formation of the active cofactor, UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
H2O [cytosol]
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
H2O [cytosol]
Methylation (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Danio rerio)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Danio rerio)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
H2O [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Aspartate and asparagine metabolism (Danio rerio)
ASPA deacetylates NAASP to acetate and L-aspartate (Danio rerio)
H2O [cytosol]
NAALADases hydrolyse NAAG (Danio rerio)
H2O [cytosol]
Carnitine synthesis (Danio rerio)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
H2O [cytosol]
Histidine catabolism (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Danio rerio)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)
H2O [cytosol]
Metabolism of polyamines (Danio rerio)
Agmatine biosynthesis (Danio rerio)
Agmatine + H2O <=> putrescine + urea (Danio rerio)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
H2O [cytosol]
Selenoamino acid metabolism (Danio rerio)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
H2O [cytosol]
Selenocysteine synthesis (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
H2O [cytosol]
Serine biosynthesis (Danio rerio)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)
H2O [cytosol]
Sulfur amino acid metabolism (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
H2O [cytosol]
Cysteine formation from homocysteine (Danio rerio)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)
H2O [cytosol]
Degradation of cysteine and homocysteine (Danio rerio)
Cysteine is degraded to serine and H2S (Danio rerio)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is created (Danio rerio)
H2O [cytosol]
Tryptophan catabolism (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
H2O [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)
H2O [cytosol]
Glycolysis (Danio rerio)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)
H2O [cytosol]
Glycogen metabolism (Danio rerio)
Glycogen synthesis (Danio rerio)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)
H2O [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
Biosynthesis of D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)
H2O [cytosol]
Biosynthesis of maresins (Danio rerio)
Biosynthesis of maresin-like SPMs (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
H2O [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)
H2O [cytosol]
Biosynthesis of protectins (Danio rerio)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)
H2O [cytosol]
Biosynthesis of DPA-derived SPMs (Danio rerio)
Biosynthesis of DPAn-3 SPMs (Danio rerio)
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Danio rerio)
Biosynthesis of E-series 18(R)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
H2O [cytosol]
Biosynthesis of Lipoxins (LX) (Danio rerio)
ALOX12 oxidises LTA4 to LXA4 (Danio rerio)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXB4 (Danio rerio)
H2O [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonate metabolism (Danio rerio)
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Danio rerio)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Danio rerio)
11,12-EET is hydrolysed to 11,12-DHET by EPHX2 (Danio rerio)
H2O [cytosol]
14,15-EET is hydrolysed to 14,15-DHET by EPHX2 (Danio rerio)
H2O [cytosol]
5,6-EET is hydrolysed to 5,6-DHET by EPHX2 (Danio rerio)
H2O [cytosol]
8,9-EET is hydrolysed to 8.9-DHET by EPHX2 (Danio rerio)
H2O [cytosol]
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Danio rerio)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Danio rerio)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Danio rerio)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Danio rerio)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Danio rerio)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)
H2O [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Recycling of bile acids and salts (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis (Danio rerio)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Danio rerio)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
H2O [cytosol]
Squalene is oxidized to its epoxide (Danio rerio)
H2O [cytosol]
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
H2O [cytosol]
Estrogen biosynthesis (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
H2O [cytosol]
Glucocorticoid biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates PREG (Danio rerio)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H2O [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Acyl chain remodeling of DAG and TAG (Danio rerio)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PC (Danio rerio)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PE (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PG (Danio rerio)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PI (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PS (Danio rerio)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)
H2O [cytosol]
Hydrolysis of LPC (Danio rerio)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
H2O [cytosol]
Hydrolysis of LPE (Danio rerio)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
H2O [cytosol]
Synthesis of PA (Danio rerio)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)
H2O [cytosol]
Synthesis of PC (Danio rerio)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Danio rerio)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)
H2O [cytosol]
Synthesis of PE (Danio rerio)
PA is dephosphorylated to DAG by LPIN (Danio rerio)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)
H2O [cytosol]
PI Metabolism (Danio rerio)
Glycerophospholipid catabolism (Danio rerio)
GDE1 hydrolyzes GroPIns (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
Sphingolipid metabolism (Danio rerio)
Glycosphingolipid metabolism (Danio rerio)
Glycosphingolipid catabolism (Danio rerio)
ASAH2 hydrolyzes ceramide (plasma membrane) (Danio rerio)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Danio rerio)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)
H2O [cytosol]
Sphingolipid catabolism (Danio rerio)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Danio rerio)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Danio rerio)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Danio rerio)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Danio rerio)
DEGS1 dehydrogenates dihydroceramide (Danio rerio)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)
H2O [cytosol]
Triglyceride metabolism (Danio rerio)
Triglyceride biosynthesis (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
H2O [cytosol]
Triglyceride catabolism (Danio rerio)
PNPLA5 hydrolyzes TAG (Danio rerio)
H2O [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Danio rerio)
H2O [cytosol]
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
H2O [cytosol]
FAICAR => IMP + H2O (Danio rerio)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
H2O [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Danio rerio)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Danio rerio)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Danio rerio)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Danio rerio)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
H2O [cytosol]
Pyrimidine catabolism (Danio rerio)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
H2O [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)
H2O [cytosol]
Pyrimidine salvage (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
H2O [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ALAD condenses 2 dALAs to form PBG (Danio rerio)
H2O [cytosol]
UROS transforms HMB to URO3 (Danio rerio)
H2O [cytosol]
Heme degradation (Danio rerio)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
H2O [cytosol]
Nicotinate metabolism (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Danio rerio)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Danio rerio)
AOX1 oxidises PXL to PDXate (Danio rerio)
H2O [cytosol]
Pyrophosphate hydrolysis (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
H2O [cytosol]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
H2O [cytosol]
Metabolism of RNA (Danio rerio)
Deadenylation-dependent mRNA decay (Danio rerio)
mRNA decay by 5' to 3' exoribonuclease (Danio rerio)
DCP1-DCP2 complex decaps mRNA (Danio rerio)
H2O [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Danio rerio)
DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Danio rerio)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Danio rerio)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Danio rerio)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
H2O [cytosol]
Deubiquitination (Danio rerio)
Josephin domain DUBs (Danio rerio)
ATXN3 family cleave Ub chains (Danio rerio)
H2O [cytosol]
Ovarian tumor domain proteases (Danio rerio)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)
H2O [cytosol]
UCH proteinases (Danio rerio)
UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
H2O [cytosol]
Ub-specific processing proteases (Danio rerio)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Danio rerio)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Danio rerio)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Danio rerio)
H2O [cytosol]
USP5 cleaves polyubiquitin (Danio rerio)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
H2O [cytosol]
Neddylation (Danio rerio)
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
H2O [cytosol]
Translation (Danio rerio)
tRNA Aminoacylation (Danio rerio)
Cytosolic tRNA aminoacylation (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
H2O [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
H2O [cytosol]
Physiological factors (Danio rerio)
CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
H2O [cytosol]
Organelle biogenesis and maintenance (Danio rerio)
Cilium Assembly (Danio rerio)
Cargo trafficking to the periciliary membrane (Danio rerio)
VxPx cargo-targeting to cilium (Danio rerio)
ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)
H2O [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
H2O [cytosol]
The phototransduction cascade (Danio rerio)
Inactivation, recovery and regulation of the phototransduction cascade (Danio rerio)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Danio rerio)
OPN1LW binds 11cRAL (Danio rerio)
H2O [cytosol]
OPN1MW binds 11cRAL (Danio rerio)
H2O [cytosol]
OPN1SW binds 11cRAL (Danio rerio)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)
H2O [cytosol]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
PTEN Regulation (Danio rerio)
Regulation of PTEN stability and activity (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
H2O [cytosol]
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
RAF activation (Danio rerio)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)
H2O [cytosol]
RAS processing (Danio rerio)
RAS proteins are depalmitoylated (Danio rerio)
H2O [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
PLC beta mediated events (Danio rerio)
Ca-dependent events (Danio rerio)
phospho-PLA2 pathway (Danio rerio)
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Danio rerio)
H2O [cytosol]
G alpha (q) signalling events (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H2O [cytosol]
G alpha (s) signalling events (Danio rerio)
cAMP degradation by Phosphodiesterases (Danio rerio)
H2O [cytosol]
Signaling by Hedgehog (Danio rerio)
Hedgehog ligand biogenesis (Danio rerio)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)
H2O [cytosol]
Signaling by Nuclear Receptors (Danio rerio)
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Danio rerio)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Downregulation of ERBB2 signaling (Danio rerio)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)
H2O [cytosol]
Signaling by PDGF (Danio rerio)
PTPN12 dephosphorylates PDGFRB at Y1021 (Danio rerio)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Miro GTPase Cycle (Danio rerio)
RHOT1 GTPase cycle (Danio rerio)
RHOT1 hydrolyzes GTP (Danio rerio)
H2O [cytosol]
RHOT2 GTPase cycle (Danio rerio)
RHOT2 hydrolyzes GTP (Danio rerio)
H2O [cytosol]
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate Formins (Danio rerio)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)
H2O [cytosol]
RHO GTPase cycle (Danio rerio)
CDC42 GTPase cycle (Danio rerio)
CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
H2O [cytosol]
RAC1 GTPase cycle (Danio rerio)
RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
H2O [cytosol]
RAC2 GTPase cycle (Danio rerio)
RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
H2O [cytosol]
RAC3 GTPase cycle (Danio rerio)
RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
H2O [cytosol]
RHOA GTPase cycle (Danio rerio)
RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
H2O [cytosol]
RHOD GTPase cycle (Danio rerio)
RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
H2O [cytosol]
RHOF GTPase cycle (Danio rerio)
RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
H2O [cytosol]
RHOG GTPase cycle (Danio rerio)
RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)
H2O [cytosol]
RHOQ GTPase cycle (Danio rerio)
RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)
H2O [cytosol]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
ABC transporters in lipid homeostasis (Danio rerio)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Danio rerio)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
HCO3- transport through ion channel (Danio rerio)
H2O [cytosol]
The ABCC family mediates organic anion transport (Danio rerio)
H2O [cytosol]
Aquaporin-mediated transport (Danio rerio)
Passive transport by Aquaporins (Danio rerio)
Aquaporins passively transport water into cells (Danio rerio)
H2O [cytosol]
Aquaporins passively transport water out of cells (Danio rerio)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
Aquaporin-1 passively transports water into cell (Danio rerio)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Danio rerio)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Danio rerio)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)
H2O [cytosol]
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)
H2O [cytosol]
Iron uptake and transport (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Transferrin endocytosis and recycling (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Danio rerio)
Erythrocytes take up carbon dioxide and release oxygen (Danio rerio)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Danio rerio)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
Plasma lipoprotein assembly (Danio rerio)
HDL assembly (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
H2O [cytosol]
Plasma lipoprotein clearance (Danio rerio)
LDL clearance (Danio rerio)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Danio rerio)
H2O [cytosol]
Plasma lipoprotein remodeling (Danio rerio)
HDL remodeling (Danio rerio)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
H2O [cytosol]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Intra-Golgi and retrograde Golgi-to-ER traffic (Danio rerio)
Golgi-to-ER retrograde transport (Danio rerio)
COPI-independent Golgi-to-ER retrograde traffic (Danio rerio)
PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)
H2O [cytosol]
Rab regulation of trafficking (Danio rerio)
TBC/RABGAPs (Danio rerio)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)
H2O [cytosol]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Metaphase and Anaphase (Dictyostelium discoideum)
Mitotic Anaphase (Dictyostelium discoideum)
Nuclear Envelope (NE) Reassembly (Dictyostelium discoideum)
Sealing of the nuclear envelope (NE) by ESCRT-III (Dictyostelium discoideum)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)
H2O [cytosol]
Mitotic Prometaphase (Dictyostelium discoideum)
Condensation of Prometaphase Chromosomes (Dictyostelium discoideum)
Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Dictyostelium discoideum)
PPP1CC dephosphorylates PLK1 (Dictyostelium discoideum)
H2O [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Dictyostelium discoideum)
Nuclear events mediated by NFE2L2 (Dictyostelium discoideum)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Dictyostelium discoideum)
PRDX1 overoxidizes (Dictyostelium discoideum)
H2O [cytosol]
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
Drug ADME (Dictyostelium discoideum)
Aspirin ADME (Dictyostelium discoideum)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
H2O [cytosol]
Azathioprine ADME (Dictyostelium discoideum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
H2O [cytosol]
Ciprofloxacin ADME (Dictyostelium discoideum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)
H2O [cytosol]
Paracetamol ADME (Dictyostelium discoideum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)
H2O [cytosol]
Prednisone ADME (Dictyostelium discoideum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)
H2O [cytosol]
Ribavirin ADME (Dictyostelium discoideum)
ADA deamidates RBV (Dictyostelium discoideum)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)
H2O [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
PRDX1 overoxidizes (Dictyostelium discoideum)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
H2O [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
H2O [cytosol]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Regulation of T cell activation by CD28 family (Dictyostelium discoideum)
Co-inhibition by CTLA4 (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
H2O [cytosol]
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
Generation of second messenger molecules (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
H2O [cytosol]
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-1 family signaling (Dictyostelium discoideum)
Interleukin-1 signaling (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Innate Immune System (Dictyostelium discoideum)
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
CLEC7A (Dectin-1) signaling (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Role of phospholipids in phagocytosis (Dictyostelium discoideum)
Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)
H2O [cytosol]
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
H2O [cytosol]
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
H2O [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
AADAC deacetylates PHEN (Dictyostelium discoideum)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
H2O [cytosol]
Amine Oxidase reactions (Dictyostelium discoideum)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H2O [cytosol]
Vitamins (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H2O [cytosol]
Ethanol oxidation (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
H2O [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Cytosolic sulfonation of small molecules (Dictyostelium discoideum)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
H2O [cytosol]
Methylation (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Acetylcholine regulates insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Aspartate and asparagine metabolism (Dictyostelium discoideum)
ASPG hydrolyses L-Asn to L-Asp (Dictyostelium discoideum)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
H2O [cytosol]
Histidine catabolism (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Dictyostelium discoideum)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
H2O [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
FAH cleaves 4FAA (Dictyostelium discoideum)
H2O [cytosol]
Selenoamino acid metabolism (Dictyostelium discoideum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
H2O [cytosol]
Selenocysteine synthesis (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
H2O [cytosol]
Serine biosynthesis (Dictyostelium discoideum)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)
H2O [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
H2O [cytosol]
Cysteine formation from homocysteine (Dictyostelium discoideum)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)
H2O [cytosol]
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
Cysteine is degraded to serine and H2S (Dictyostelium discoideum)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is created (Dictyostelium discoideum)
H2O [cytosol]
Threonine catabolism (Dictyostelium discoideum)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)
H2O [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
H2O [cytosol]
Urea cycle (Dictyostelium discoideum)
arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Fructose metabolism (Dictyostelium discoideum)
Fructose catabolism (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
H2O [cytosol]
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)
H2O [cytosol]
Glycolysis (Dictyostelium discoideum)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Dictyostelium discoideum)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Dictyostelium discoideum)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)
H2O [cytosol]
Pentose phosphate pathway (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of D-series resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of maresins (Dictyostelium discoideum)
Biosynthesis of maresin-like SPMs (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
H2O [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of protectins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of E-series 18(R)-resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of Lipoxins (LX) (Dictyostelium discoideum)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXA4 (Dictyostelium discoideum)
H2O [cytosol]
ALOX12 oxidises LTA4 to LXB4 (Dictyostelium discoideum)
H2O [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonate metabolism (Dictyostelium discoideum)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Dictyostelium discoideum)
11,12-EET is hydrolysed to 11,12-DHET by EPHX2 (Dictyostelium discoideum)
H2O [cytosol]
14,15-EET is hydrolysed to 14,15-DHET by EPHX2 (Dictyostelium discoideum)
H2O [cytosol]
5,6-EET is hydrolysed to 5,6-DHET by EPHX2 (Dictyostelium discoideum)
H2O [cytosol]
8,9-EET is hydrolysed to 8.9-DHET by EPHX2 (Dictyostelium discoideum)
H2O [cytosol]
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Dictyostelium discoideum)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Dictyostelium discoideum)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Dictyostelium discoideum)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Dictyostelium discoideum)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Dictyostelium discoideum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Dictyostelium discoideum)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
H2O [cytosol]
Peroxisomal lipid metabolism (Dictyostelium discoideum)
Beta-oxidation of very long chain fatty acids (Dictyostelium discoideum)
Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Recycling of bile acids and salts (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Cholesterol biosynthesis (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Dictyostelium discoideum)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
H2O [cytosol]
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of steroid hormones (Dictyostelium discoideum)
Glucocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)
H2O [cytosol]
Mineralocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H2O [cytosol]
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Acyl chain remodeling of DAG and TAG (Dictyostelium discoideum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PC (Dictyostelium discoideum)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PE (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PI (Dictyostelium discoideum)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)
H2O [cytosol]
Hydrolysis of LPC (Dictyostelium discoideum)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PA (Dictyostelium discoideum)
DDHD1,2 hydrolyse PA (Dictyostelium discoideum)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PC (Dictyostelium discoideum)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PE (Dictyostelium discoideum)
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
H2O [cytosol]
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the ER membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid catabolism (Dictyostelium discoideum)
ASAH2 hydrolyzes ceramide (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid catabolism (Dictyostelium discoideum)
ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Dictyostelium discoideum)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Dictyostelium discoideum)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)
H2O [cytosol]
Triglyceride metabolism (Dictyostelium discoideum)
Triglyceride biosynthesis (Dictyostelium discoideum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
Depalmitoylation of eNOS (Dictyostelium discoideum)
H2O [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
FAICAR => IMP + H2O (Dictyostelium discoideum)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Dictyostelium discoideum)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Purine salvage (Dictyostelium discoideum)
ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine salvage (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
H2O [cytosol]
UROS transforms HMB to URO3 (Dictyostelium discoideum)
H2O [cytosol]
Heme degradation (Dictyostelium discoideum)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Transport of RCbl within the body (Dictyostelium discoideum)
ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Dictyostelium discoideum)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of folate and pterines (Dictyostelium discoideum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Dictyostelium discoideum)
Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
H2O [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
H2O [cytosol]
Pyrophosphate hydrolysis (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of RNA (Dictyostelium discoideum)
Deadenylation-dependent mRNA decay (Dictyostelium discoideum)
mRNA decay by 3' to 5' exoribonuclease (Dictyostelium discoideum)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Dictyostelium discoideum)
DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
GDP-fucose biosynthesis (Dictyostelium discoideum)
GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Dictyostelium discoideum)
DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Dictyostelium discoideum)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
H2O [cytosol]
Deubiquitination (Dictyostelium discoideum)
Josephin domain DUBs (Dictyostelium discoideum)
ATXN3 family cleave Ub chains (Dictyostelium discoideum)
H2O [cytosol]
UCH proteinases (Dictyostelium discoideum)
UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
H2O [cytosol]
Ub-specific processing proteases (Dictyostelium discoideum)
USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Dictyostelium discoideum)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Dictyostelium discoideum)
H2O [cytosol]
USP5 cleaves polyubiquitin (Dictyostelium discoideum)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
H2O [cytosol]
Neddylation (Dictyostelium discoideum)
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Dictyostelium discoideum)
Synthesis of glycosylphosphatidylinositol (GPI) (Dictyostelium discoideum)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)
H2O [cytosol]
Surfactant metabolism (Dictyostelium discoideum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
H2O [cytosol]
Translation (Dictyostelium discoideum)
Eukaryotic Translation Termination (Dictyostelium discoideum)
APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)
H2O [cytosol]
tRNA Aminoacylation (Dictyostelium discoideum)
Cytosolic tRNA aminoacylation (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Muscle contraction (Dictyostelium discoideum)
Cardiac conduction (Dictyostelium discoideum)
Physiological factors (Dictyostelium discoideum)
CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
H2O [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter clearance (Dictyostelium discoideum)
Dopamine clearance from the synaptic cleft (Dictyostelium discoideum)
Enzymatic degradation of Dopamine by monoamine oxidase (Dictyostelium discoideum)
MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Dictyostelium discoideum)
Metabolism of serotonin (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
H2O [cytosol]
Neurotransmitter release cycle (Dictyostelium discoideum)
Norepinephrine Neurotransmitter Release Cycle (Dictyostelium discoideum)
Catabolism of Noradrenaline (Dictyostelium discoideum)
H2O [cytosol]
Protein localization (Dictyostelium discoideum)
Peroxisomal protein import (Dictyostelium discoideum)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)
H2O [cytosol]
Sensory Perception (Dictyostelium discoideum)
Visual phototransduction (Dictyostelium discoideum)
The canonical retinoid cycle in rods (twilight vision) (Dictyostelium discoideum)
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
H2O [cytosol]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
DAG and IP3 signaling (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
Cam-PDE 1 activation (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
H2O [cytosol]
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN stability and activity (Dictyostelium discoideum)
USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)
H2O [cytosol]
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
RAF/MAP kinase cascade (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
DARPP-32 events (Dictyostelium discoideum)
PDE4A,C,D hydrolyse cAMP (Dictyostelium discoideum)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)
H2O [cytosol]
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
Ca-dependent events (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
Cam-PDE 1 activation (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
H2O [cytosol]
Inactivation of PLC beta (Dictyostelium discoideum)
H2O [cytosol]
PIP2 hydrolysis (Dictyostelium discoideum)
H2O [cytosol]
G alpha (q) signalling events (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H2O [cytosol]
G alpha (s) signalling events (Dictyostelium discoideum)
PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Retinoic Acid (Dictyostelium discoideum)
RA biosynthesis pathway (Dictyostelium discoideum)
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor signalling cascade (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
PKB-mediated events (Dictyostelium discoideum)
PDE3B signalling (Dictyostelium discoideum)
p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Dictyostelium discoideum)
IGF1R signaling cascade (Dictyostelium discoideum)
IRS-related events triggered by IGF1R (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
PKB-mediated events (Dictyostelium discoideum)
PDE3B signalling (Dictyostelium discoideum)
p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Miro GTPase Cycle (Dictyostelium discoideum)
RHOT1 GTPase cycle (Dictyostelium discoideum)
RHOT1 hydrolyzes GTP (Dictyostelium discoideum)
H2O [cytosol]
RHOT2 GTPase cycle (Dictyostelium discoideum)
RHOT2 hydrolyzes GTP (Dictyostelium discoideum)
H2O [cytosol]
RHOBTB3 ATPase cycle (Dictyostelium discoideum)
RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase cycle (Dictyostelium discoideum)
CDC42 GTPase cycle (Dictyostelium discoideum)
CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC1 GTPase cycle (Dictyostelium discoideum)
RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC2 GTPase cycle (Dictyostelium discoideum)
RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC3 GTPase cycle (Dictyostelium discoideum)
RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RHOJ GTPase cycle (Dictyostelium discoideum)
RHOJ GAPs stimulate RHOJ GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RHOQ GTPase cycle (Dictyostelium discoideum)
RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
ABC transporters in lipid homeostasis (Dictyostelium discoideum)
ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
H2O [cytosol]
ABCAs mediate lipid efflux (Dictyostelium discoideum)
H2O [cytosol]
ABCAs mediate lipid influx (Dictyostelium discoideum)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
HCO3- transport through ion channel (Dictyostelium discoideum)
H2O [cytosol]
The ABCC family mediates organic anion transport (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-mediated transport (Dictyostelium discoideum)
Passive transport by Aquaporins (Dictyostelium discoideum)
Aquaporins passively transport water into cells (Dictyostelium discoideum)
H2O [cytosol]
Aquaporins passively transport water out of cells (Dictyostelium discoideum)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Dictyostelium discoideum)
Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)
H2O [cytosol]
Ion channel transport (Dictyostelium discoideum)
Ion transport by P-type ATPases (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
Iron uptake and transport (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Dictyostelium discoideum)
Plasma lipoprotein clearance (Dictyostelium discoideum)
LDL clearance (Dictyostelium discoideum)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)
H2O [cytosol]
Plasma lipoprotein remodeling (Dictyostelium discoideum)
HDL remodeling (Dictyostelium discoideum)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
H2O [cytosol]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
H2O [cytosol]
Rab regulation of trafficking (Dictyostelium discoideum)
TBC/RABGAPs (Dictyostelium discoideum)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
H2O [cytosol]
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
Selective autophagy (Drosophila melanogaster)
Pexophagy (Drosophila melanogaster)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
H2O [cytosol]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
Initiation of Nuclear Envelope (NE) Reformation (Drosophila melanogaster)
ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Drosophila melanogaster)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Drosophila melanogaster)
RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
H2O [cytosol]
Mitotic Prometaphase (Drosophila melanogaster)
Condensation of Prometaphase Chromosomes (Drosophila melanogaster)
Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)
PPP1CC dephosphorylates PLK1 (Drosophila melanogaster)
H2O [cytosol]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
H2O [cytosol]
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
H2O [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Drosophila melanogaster)
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Drosophila melanogaster)
H2O [cytosol]
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Drosophila melanogaster)
PRDX1 overoxidizes (Drosophila melanogaster)
H2O [cytosol]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
H2O [cytosol]
Signaling by ROBO receptors (Drosophila melanogaster)
Regulation of expression of SLITs and ROBOs (Drosophila melanogaster)
USP33 deubiquitinates ROBO1 (Drosophila melanogaster)
H2O [cytosol]
Drug ADME (Drosophila melanogaster)
Abacavir ADME (Drosophila melanogaster)
Abacavir metabolism (Drosophila melanogaster)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)
H2O [cytosol]
Aspirin ADME (Drosophila melanogaster)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
H2O [cytosol]
Azathioprine ADME (Drosophila melanogaster)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
H2O [cytosol]
Ciprofloxacin ADME (Drosophila melanogaster)
ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)
H2O [cytosol]
Paracetamol ADME (Drosophila melanogaster)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)
H2O [cytosol]
Ribavirin ADME (Drosophila melanogaster)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)
H2O [cytosol]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
PRDX1 overoxidizes (Drosophila melanogaster)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
H2O [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Regulation of T cell activation by CD28 family (Drosophila melanogaster)
Co-inhibition by CTLA4 (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
H2O [cytosol]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
H2O [cytosol]
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
OAS antiviral response (Drosophila melanogaster)
PDE12 cleaves 2'-5' oligoadenylates (Drosophila melanogaster)
H2O [cytosol]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
CLEC7A (Dectin-1) induces NFAT activation (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Role of phospholipids in phagocytosis (Drosophila melanogaster)
Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Drosophila melanogaster)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)
H2O [cytosol]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
H2O [cytosol]
Regulation of pyruvate metabolism (Drosophila melanogaster)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Drosophila melanogaster)
H2O [cytosol]
Biological oxidations (Drosophila melanogaster)
Aflatoxin activation and detoxification (Drosophila melanogaster)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)
H2O [cytosol]
Phase I - Functionalization of compounds (Drosophila melanogaster)
ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Drosophila melanogaster)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Drosophila melanogaster)
Endogenous sterols (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H2O [cytosol]
Vitamins (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)
H2O [cytosol]
Ethanol oxidation (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
H2O [cytosol]
Phase II - Conjugation of compounds (Drosophila melanogaster)
Cytosolic sulfonation of small molecules (Drosophila melanogaster)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Glucuronidation (Drosophila melanogaster)
Formation of the active cofactor, UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
H2O [cytosol]
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
H2O [cytosol]
Methylation (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)
H2O [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Aspartate and asparagine metabolism (Drosophila melanogaster)
ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
H2O [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
FAH cleaves 4FAA (Drosophila melanogaster)
H2O [cytosol]
Selenoamino acid metabolism (Drosophila melanogaster)
Selenocysteine synthesis (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
H2O [cytosol]
Serine biosynthesis (Drosophila melanogaster)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)
H2O [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
H2O [cytosol]
Cysteine formation from homocysteine (Drosophila melanogaster)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)
H2O [cytosol]
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Cysteine is degraded to serine and H2S (Drosophila melanogaster)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)
H2O [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is created (Drosophila melanogaster)
H2O [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
H2O [cytosol]
Urea cycle (Drosophila melanogaster)
arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)
H2O [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Fructose metabolism (Drosophila melanogaster)
Fructose catabolism (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
H2O [cytosol]
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)
H2O [cytosol]
Glycolysis (Drosophila melanogaster)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Drosophila melanogaster)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Glycogen metabolism (Drosophila melanogaster)
Glycogen synthesis (Drosophila melanogaster)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)
H2O [cytosol]
Pentose phosphate pathway (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Biosynthesis of specialized proresolving mediators (SPMs) (Drosophila melanogaster)
Biosynthesis of DHA-derived SPMs (Drosophila melanogaster)
Biosynthesis of D-series resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of maresins (Drosophila melanogaster)
Biosynthesis of maresin-like SPMs (Drosophila melanogaster)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Drosophila melanogaster)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of protectins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Drosophila melanogaster)
Biosynthesis of E-series 18(R)-resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)
H2O [cytosol]
Fatty acid metabolism (Drosophila melanogaster)
Arachidonate metabolism (Drosophila melanogaster)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Drosophila melanogaster)
LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Drosophila melanogaster)
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Drosophila melanogaster)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Drosophila melanogaster)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Drosophila melanogaster)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Drosophila melanogaster)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Drosophila melanogaster)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Drosophila melanogaster)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
H2O [cytosol]
Peroxisomal lipid metabolism (Drosophila melanogaster)
Beta-oxidation of very long chain fatty acids (Drosophila melanogaster)
Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)
H2O [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Recycling of bile acids and salts (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
Cholesterol biosynthesis (Drosophila melanogaster)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of steroid hormones (Drosophila melanogaster)
Estrogen biosynthesis (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H2O [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Acyl chain remodeling of DAG and TAG (Drosophila melanogaster)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PC (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Drosophila melanogaster)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PE (Drosophila melanogaster)
ABHD4 hydrolyses NAPE (Drosophila melanogaster)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PG (Drosophila melanogaster)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PI (Drosophila melanogaster)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PS (Drosophila melanogaster)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PA (Drosophila melanogaster)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Drosophila melanogaster)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Drosophila melanogaster)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PC (Drosophila melanogaster)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PE (Drosophila melanogaster)
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)
H2O [cytosol]
PI Metabolism (Drosophila melanogaster)
Glycerophospholipid catabolism (Drosophila melanogaster)
GDE1 hydrolyzes GroPIns (Drosophila melanogaster)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid catabolism (Drosophila melanogaster)
ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Drosophila melanogaster)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid catabolism (Drosophila melanogaster)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Drosophila melanogaster)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Drosophila melanogaster)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Drosophila melanogaster)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)
H2O [cytosol]
Triglyceride metabolism (Drosophila melanogaster)
Triglyceride biosynthesis (Drosophila melanogaster)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Triglyceride catabolism (Drosophila melanogaster)
PNPLA5 hydrolyzes TAG (Drosophila melanogaster)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
DDAH1 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
H2O [cytosol]
Depalmitoylation of eNOS (Drosophila melanogaster)
H2O [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
H2O [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
H2O [cytosol]
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
H2O [cytosol]
FAICAR => IMP + H2O (Drosophila melanogaster)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
H2O [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
H2O [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine salvage (Drosophila melanogaster)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
H2O [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
4 PBGs bind to form HMB (Drosophila melanogaster)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
H2O [cytosol]
UROS transforms HMB to URO3 (Drosophila melanogaster)
H2O [cytosol]
Heme degradation (Drosophila melanogaster)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Drosophila melanogaster)
Transport of RCbl within the body (Drosophila melanogaster)
ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)
H2O [cytosol]
Metabolism of folate and pterines (Drosophila melanogaster)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Drosophila melanogaster)
Cyclisation of GTP to precursor Z (Drosophila melanogaster)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
H2O [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
H2O [cytosol]
Pyrophosphate hydrolysis (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Reversible hydration of carbon dioxide (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
H2O [cytosol]
Metabolism of RNA (Drosophila melanogaster)
Deadenylation-dependent mRNA decay (Drosophila melanogaster)
mRNA decay by 3' to 5' exoribonuclease (Drosophila melanogaster)
DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Drosophila melanogaster)
DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)
H2O [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
GDP-fucose biosynthesis (Drosophila melanogaster)
GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)
H2O [cytosol]
Sialic acid metabolism (Drosophila melanogaster)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Drosophila melanogaster)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)
H2O [cytosol]
Deubiquitination (Drosophila melanogaster)
Josephin domain DUBs (Drosophila melanogaster)
ATXN3 family cleave Ub chains (Drosophila melanogaster)
H2O [cytosol]
Ovarian tumor domain proteases (Drosophila melanogaster)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)
H2O [cytosol]
UCH proteinases (Drosophila melanogaster)
UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
H2O [cytosol]
Ub-specific processing proteases (Drosophila melanogaster)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)
H2O [cytosol]
USP5 cleaves polyubiquitin (Drosophila melanogaster)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Drosophila melanogaster)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Hypusine synthesis from eIF5A-lysine (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
H2O [cytosol]
Neddylation (Drosophila melanogaster)
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Drosophila melanogaster)
Synthesis of glycosylphosphatidylinositol (GPI) (Drosophila melanogaster)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)
H2O [cytosol]
Surfactant metabolism (Drosophila melanogaster)
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
H2O [cytosol]
Translation (Drosophila melanogaster)
tRNA Aminoacylation (Drosophila melanogaster)
Cytosolic tRNA aminoacylation (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Physiological factors (Drosophila melanogaster)
CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
H2O [cytosol]
Organelle biogenesis and maintenance (Drosophila melanogaster)
Cilium Assembly (Drosophila melanogaster)
Cargo trafficking to the periciliary membrane (Drosophila melanogaster)
VxPx cargo-targeting to cilium (Drosophila melanogaster)
ASAP1 stimulates GTPase activity of ARF4 (Drosophila melanogaster)
H2O [cytosol]
Protein localization (Drosophila melanogaster)
Peroxisomal protein import (Drosophila melanogaster)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)
H2O [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The canonical retinoid cycle in rods (twilight vision) (Drosophila melanogaster)
ABCA4 mediates atRAL transport (Drosophila melanogaster)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
H2O [cytosol]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
H2O [cytosol]
Intracellular signaling by second messengers (Drosophila melanogaster)
DAG and IP3 signaling (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
Cam-PDE 1 activation (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
H2O [cytosol]
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
H2O [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)
H2O [cytosol]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
H2O [cytosol]
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
H2O [cytosol]
RAF activation (Drosophila melanogaster)
PP2A dephosphorylates KSR1 (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
H2O [cytosol]
RAS processing (Drosophila melanogaster)
RAS proteins are depalmitoylated (Drosophila melanogaster)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)
H2O [cytosol]
MTOR signalling (Drosophila melanogaster)
Energy dependent regulation of mTOR by LKB1-AMPK (Drosophila melanogaster)
AMPK is dephosphorylated (Drosophila melanogaster)
H2O [cytosol]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
DARPP-32 events (Drosophila melanogaster)
PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)
H2O [cytosol]
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
Ca-dependent events (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
Cam-PDE 1 activation (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
H2O [cytosol]
Inactivation of PLC beta (Drosophila melanogaster)
H2O [cytosol]
PIP2 hydrolysis (Drosophila melanogaster)
H2O [cytosol]
G alpha (q) signalling events (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H2O [cytosol]
G alpha (s) signalling events (Drosophila melanogaster)
PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Drosophila melanogaster)
H2O [cytosol]
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
H2O [cytosol]
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
H2O [cytosol]
Signaling by Retinoic Acid (Drosophila melanogaster)
RA biosynthesis pathway (Drosophila melanogaster)
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
H2O [cytosol]
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
H2O [cytosol]
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)
H2O [cytosol]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor recycling (Drosophila melanogaster)
Insulin receptor de-phosphorylation (Drosophila melanogaster)
H2O [cytosol]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Miro GTPase Cycle (Drosophila melanogaster)
RHOT1 GTPase cycle (Drosophila melanogaster)
RHOT1 hydrolyzes GTP (Drosophila melanogaster)
H2O [cytosol]
RHOT2 GTPase cycle (Drosophila melanogaster)
RHOT2 hydrolyzes GTP (Drosophila melanogaster)
H2O [cytosol]
RHOBTB3 ATPase cycle (Drosophila melanogaster)
RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)
H2O [cytosol]
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
CDC42 GTPase cycle (Drosophila melanogaster)
CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GAPs stimulate RAC2 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOB GTPase cycle (Drosophila melanogaster)
RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOD GTPase cycle (Drosophila melanogaster)
RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOF GTPase cycle (Drosophila melanogaster)
RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOG GTPase cycle (Drosophila melanogaster)
RHOG GAPs stimulate RHOG GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOJ GTPase cycle (Drosophila melanogaster)
RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOQ GTPase cycle (Drosophila melanogaster)
RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)
H2O [cytosol]
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
H2O [cytosol]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
ABC transporters in lipid homeostasis (Drosophila melanogaster)
ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCA4 mediates atRAL transport (Drosophila melanogaster)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HCO3- transport through ion channel (Drosophila melanogaster)
H2O [cytosol]
Mitochondrial ABC transporters (Drosophila melanogaster)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)
H2O [cytosol]
The ABCC family mediates organic anion transport (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-mediated transport (Drosophila melanogaster)
Passive transport by Aquaporins (Drosophila melanogaster)
Aquaporins passively transport water into cells (Drosophila melanogaster)
H2O [cytosol]
Aquaporins passively transport water out of cells (Drosophila melanogaster)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Drosophila melanogaster)
Aquaporin-1 passively transports water into cell (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)
H2O [cytosol]
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
Iron uptake and transport (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Drosophila melanogaster)
Erythrocytes take up carbon dioxide and release oxygen (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Drosophila melanogaster)
Plasma lipoprotein clearance (Drosophila melanogaster)
LDL clearance (Drosophila melanogaster)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
H2O [cytosol]
Plasma lipoprotein remodeling (Drosophila melanogaster)
HDL remodeling (Drosophila melanogaster)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
H2O [cytosol]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
Golgi-to-ER retrograde transport (Drosophila melanogaster)
COPI-independent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
Rab regulation of trafficking (Drosophila melanogaster)
TBC/RABGAPs (Drosophila melanogaster)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
H2O [cytosol]
Autophagy (Gallus gallus)
Macroautophagy (Gallus gallus)
Selective autophagy (Gallus gallus)
Pexophagy (Gallus gallus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
H2O [cytosol]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Nuclear Envelope (NE) Reassembly (Gallus gallus)
Initiation of Nuclear Envelope (NE) Reformation (Gallus gallus)
ANKLE2 is deacetylated by SIRT2 (Gallus gallus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Gallus gallus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Gallus gallus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
H2O [cytosol]
Mitotic Prometaphase (Gallus gallus)
Condensation of Prometaphase Chromosomes (Gallus gallus)
Dephosphorylation of CK2-modified condensin I (Gallus gallus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Gallus gallus)
H2O [cytosol]
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
Cyclin A/B1/B2 associated events during G2/M transition (Gallus gallus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)
H2O [cytosol]
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
H2O [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to mechanical stimuli (Gallus gallus)
Response of endothelial cells to shear stress (Gallus gallus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Gallus gallus)
PP2A dephosphorylates serine-127 of YAP1 (Gallus gallus)
H2O [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Gallus gallus)
H2O [cytosol]
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Gallus gallus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Gallus gallus)
Nuclear events mediated by NFE2L2 (Gallus gallus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Gallus gallus)
PRDX1 overoxidizes (Gallus gallus)
H2O [cytosol]
Chromatin organization (Gallus gallus)
Chromatin modifying enzymes (Gallus gallus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)
H2O [cytosol]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
H2O [cytosol]
L1CAM interactions (Gallus gallus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)
H2O [cytosol]
Semaphorin interactions (Gallus gallus)
Sema4D in semaphorin signaling (Gallus gallus)
Sema4D mediated inhibition of cell attachment and migration (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
H2O [cytosol]
Signaling by ROBO receptors (Gallus gallus)
SLIT2:ROBO1 increases RHOA activity (Gallus gallus)
MYO9B inactivates RHOA (Gallus gallus)
H2O [cytosol]
Drug ADME (Gallus gallus)
Abacavir ADME (Gallus gallus)
Abacavir metabolism (Gallus gallus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)
H2O [cytosol]
Aspirin ADME (Gallus gallus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
H2O [cytosol]
Atorvastatin ADME (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
H2O [cytosol]
Azathioprine ADME (Gallus gallus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Gallus gallus)
H2O [cytosol]
Paracetamol ADME (Gallus gallus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Gallus gallus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)
H2O [cytosol]
Prednisone ADME (Gallus gallus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Gallus gallus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
H2O [cytosol]
Ribavirin ADME (Gallus gallus)
ADA deamidates RBV (Gallus gallus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)
H2O [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
H2O [cytosol]
PRDX1 overoxidizes (Gallus gallus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)
H2O [cytosol]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Arachidonate production from DAG (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Gallus gallus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
ABCC4 accumulation of dense granule contents (Gallus gallus)
H2O [cytosol]
Platelet homeostasis (Gallus gallus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)
H2O [cytosol]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Gallus gallus)
Disassembly of COPII coated vesicle (Gallus gallus)
H2O [cytosol]
MHC class II antigen presentation (Gallus gallus)
Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)
H2O [cytosol]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
H2O [cytosol]
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)
Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Gallus gallus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
H2O [cytosol]
Cytokine Signaling in Immune system (Gallus gallus)
Growth hormone receptor signaling (Gallus gallus)
PTP1B dephosphorylates GHR (Gallus gallus)
H2O [cytosol]
Interferon Signaling (Gallus gallus)
Antiviral mechanism by IFN-stimulated genes (Gallus gallus)
OAS antiviral response (Gallus gallus)
PDE12 cleaves 2'-5' oligoadenylates (Gallus gallus)
H2O [cytosol]
Interferon alpha/beta signaling (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
H2O [cytosol]
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)
H2O [cytosol]
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
CLEC7A (Dectin-1) induces NFAT activation (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Gallus gallus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
Conversion of PA into DAG by PAP-1 (Gallus gallus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Gallus gallus)
H2O [cytosol]
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Pyruvate metabolism (Gallus gallus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Gallus gallus)
H2O [cytosol]
Regulation of pyruvate metabolism (Gallus gallus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Gallus gallus)
H2O [cytosol]
Biological oxidations (Gallus gallus)
Aflatoxin activation and detoxification (Gallus gallus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Gallus gallus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)
H2O [cytosol]
Phase I - Functionalization of compounds (Gallus gallus)
AADAC deacetylates PHEN (Gallus gallus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)
H2O [cytosol]
Amine Oxidase reactions (Gallus gallus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Gallus gallus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Gallus gallus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Gallus gallus)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Gallus gallus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Gallus gallus)
Endogenous sterols (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H2O [cytosol]
Vitamins (Gallus gallus)
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Gallus gallus)
H2O [cytosol]
Ethanol oxidation (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)
H2O [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
ABHD14B hydrolyses PNPB (Gallus gallus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)
H2O [cytosol]
Glucuronidation (Gallus gallus)
Formation of the active cofactor, UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
H2O [cytosol]
Glutathione conjugation (Gallus gallus)
Glutathione synthesis and recycling (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Gallus gallus)
H2O [cytosol]
Methylation (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Gallus gallus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Gallus gallus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Gallus gallus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Gallus gallus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)
H2O [cytosol]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Acetylcholine regulates insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Gallus gallus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Aspartate and asparagine metabolism (Gallus gallus)
ASPA deacetylates NAASP to acetate and L-aspartate (Gallus gallus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Gallus gallus)
H2O [cytosol]
NAALADases hydrolyse NAAG (Gallus gallus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
H2O [cytosol]
Carnitine synthesis (Gallus gallus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)
H2O [cytosol]
Histidine catabolism (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate (Gallus gallus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Gallus gallus)
H2O [cytosol]
Metabolism of polyamines (Gallus gallus)
Agmatine biosynthesis (Gallus gallus)
Agmatine + H2O <=> putrescine + urea (Gallus gallus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)
H2O [cytosol]
Tyrosine catabolism (Gallus gallus)
FAH cleaves 4FAA (Gallus gallus)
H2O [cytosol]
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
H2O [cytosol]
Serine biosynthesis (Gallus gallus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Gallus gallus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Gallus gallus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Gallus gallus)
H2O [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
H2O [cytosol]
Cysteine formation from homocysteine (Gallus gallus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Gallus gallus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Gallus gallus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Gallus gallus)
Cysteine is degraded to serine and H2S (Gallus gallus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Gallus gallus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is created (Gallus gallus)
H2O [cytosol]
Threonine catabolism (Gallus gallus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Gallus gallus)
H2O [cytosol]
Tryptophan catabolism (Gallus gallus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Gallus gallus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
H2O [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Fructose metabolism (Gallus gallus)
Fructose catabolism (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
H2O [cytosol]
Glucose metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Gallus gallus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Gallus gallus)
H2O [cytosol]
Glycolysis (Gallus gallus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Gallus gallus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Gallus gallus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Gallus gallus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Gallus gallus)
H2O [cytosol]
Glycogen metabolism (Gallus gallus)
Glycogen synthesis (Gallus gallus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Gallus gallus)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Gallus gallus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Gallus gallus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Gallus gallus)
H2O [cytosol]
Pentose phosphate pathway (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
H2O [cytosol]
Metabolism of lipids (Gallus gallus)
Biosynthesis of specialized proresolving mediators (SPMs) (Gallus gallus)
Biosynthesis of DHA-derived SPMs (Gallus gallus)
Biosynthesis of D-series resolvins (Gallus gallus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Gallus gallus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Gallus gallus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Gallus gallus)
H2O [cytosol]
Biosynthesis of maresins (Gallus gallus)
Biosynthesis of maresin-like SPMs (Gallus gallus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)
H2O [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Gallus gallus)
H2O [cytosol]
Biosynthesis of protectins (Gallus gallus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Gallus gallus)
H2O [cytosol]
Biosynthesis of DPA-derived SPMs (Gallus gallus)
Biosynthesis of DPAn-3 SPMs (Gallus gallus)
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Gallus gallus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Gallus gallus)
Biosynthesis of E-series 18(R)-resolvins (Gallus gallus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Gallus gallus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Gallus gallus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Gallus gallus)
H2O [cytosol]
Biosynthesis of Lipoxins (LX) (Gallus gallus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)
H2O [cytosol]
Fatty acid metabolism (Gallus gallus)
Arachidonate metabolism (Gallus gallus)
FAAH hydrolyses AEA to AA and ETA (Gallus gallus)
H2O [cytosol]
PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine (Gallus gallus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Gallus gallus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Gallus gallus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Gallus gallus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Gallus gallus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Gallus gallus)
H2O [cytosol]
LTC4 is exported from the cytosol by ABCC1 (Gallus gallus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Gallus gallus)
11,12-EET is hydrolysed to 11,12-DHET by EPHX2 (Gallus gallus)
H2O [cytosol]
14,15-EET is hydrolysed to 14,15-DHET by EPHX2 (Gallus gallus)
H2O [cytosol]
5,6-EET is hydrolysed to 5,6-DHET by EPHX2 (Gallus gallus)
H2O [cytosol]
8,9-EET is hydrolysed to 8.9-DHET by EPHX2 (Gallus gallus)
H2O [cytosol]
Arachidonate is epoxidated to 11,12-EET by CYP(5) (Gallus gallus)
H2O [cytosol]
Arachidonate is epoxidated to 14,15-EET by CYP(5) (Gallus gallus)
H2O [cytosol]
Arachidonate is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)
H2O [cytosol]
Arachidonate is epoxidated to 8,9-EET by CYP(5) (Gallus gallus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Gallus gallus)
Conversion of malonyl-CoA and acetyl-CoA to palmitate (Gallus gallus)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Gallus gallus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Gallus gallus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Gallus gallus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)
H2O [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Recycling of bile acids and salts (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Gallus gallus)
27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis (Gallus gallus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Gallus gallus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Gallus gallus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Gallus gallus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Gallus gallus)
H2O [cytosol]
Metabolism of steroid hormones (Gallus gallus)
Androgen biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Gallus gallus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Gallus gallus)
H2O [cytosol]
Estrogen biosynthesis (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)
H2O [cytosol]
Glucocorticoid biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Gallus gallus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Gallus gallus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H2O [cytosol]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Acyl chain remodeling of DAG and TAG (Gallus gallus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Gallus gallus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Gallus gallus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PC (Gallus gallus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PE (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Gallus gallus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PG (Gallus gallus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Gallus gallus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Gallus gallus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PI (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Gallus gallus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Gallus gallus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PS (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Gallus gallus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Gallus gallus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Gallus gallus)
H2O [cytosol]
Hydrolysis of LPC (Gallus gallus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
H2O [cytosol]
Synthesis of PA (Gallus gallus)
DDHD1,2 hydrolyse PA (Gallus gallus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Gallus gallus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Gallus gallus)
H2O [cytosol]
Synthesis of PC (Gallus gallus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Gallus gallus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Gallus gallus)
H2O [cytosol]
Synthesis of PE (Gallus gallus)
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Gallus gallus)
H2O [cytosol]
PI Metabolism (Gallus gallus)
Glycerophospholipid catabolism (Gallus gallus)
GDE1 hydrolyzes GroPIns (Gallus gallus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Gallus gallus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Gallus gallus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
H2O [cytosol]
Sphingolipid metabolism (Gallus gallus)
Glycosphingolipid metabolism (Gallus gallus)
Glycosphingolipid catabolism (Gallus gallus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Gallus gallus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Gallus gallus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Gallus gallus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Gallus gallus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Gallus gallus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Gallus gallus)
H2O [cytosol]
Sphingolipid catabolism (Gallus gallus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Gallus gallus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Gallus gallus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Gallus gallus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Gallus gallus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Gallus gallus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Gallus gallus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Gallus gallus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Gallus gallus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Gallus gallus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Gallus gallus)
H2O [cytosol]
Triglyceride metabolism (Gallus gallus)
Triglyceride biosynthesis (Gallus gallus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Gallus gallus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)
H2O [cytosol]
Triglyceride catabolism (Gallus gallus)
PNPLA4 hydrolyzes TAG (Gallus gallus)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Gallus gallus)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Gallus gallus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
DDAH1 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)
H2O [cytosol]
Depalmitoylation of eNOS (Gallus gallus)
H2O [cytosol]
eNOS synthesizes NO (Gallus gallus)
H2O [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
H2O [cytosol]
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
H2O [cytosol]
FAICAR => IMP + H2O (Gallus gallus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
H2O [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Gallus gallus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Gallus gallus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Gallus gallus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Gallus gallus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Gallus gallus)
H2O [cytosol]
Pyrimidine catabolism (Gallus gallus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Gallus gallus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Gallus gallus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)
H2O [cytosol]
Nucleotide salvage (Gallus gallus)
Purine salvage (Gallus gallus)
ADA catalyzes the deamination of (deoxy)adenosine (Gallus gallus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Gallus gallus)
H2O [cytosol]
Pyrimidine salvage (Gallus gallus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)
H2O [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme biosynthesis (Gallus gallus)
4 PBGs bind to form HMB (Gallus gallus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Gallus gallus)
H2O [cytosol]
UROS transforms HMB to URO3 (Gallus gallus)
H2O [cytosol]
Heme degradation (Gallus gallus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Transport of RCbl within the body (Gallus gallus)
ABCC1 transports cytosolic RCbl to extracellular region (Gallus gallus)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Gallus gallus)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Gallus gallus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Gallus gallus)
H2O [cytosol]
Metabolism of folate and pterines (Gallus gallus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Gallus gallus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Gallus gallus)
Cyclisation of GTP to precursor Z (Gallus gallus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Gallus gallus)
H2O [cytosol]
Nicotinate metabolism (Gallus gallus)
NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
2xTRAP hydrolyzes FMN to RIB (Gallus gallus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
PANK4 hydrolyzes PPANT to pantetheine (Gallus gallus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Gallus gallus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Gallus gallus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Gallus gallus)
H2O [cytosol]
Pyrophosphate hydrolysis (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)
H2O [cytosol]
Metabolism of RNA (Gallus gallus)
Deadenylation-dependent mRNA decay (Gallus gallus)
Deadenylation of mRNA (Gallus gallus)
CCR4-NOT complex deadenylates mRNA (Gallus gallus)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)
H2O [cytosol]
PARN deadenylates mRNA (Gallus gallus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Gallus gallus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Gallus gallus)
DCP1-DCP2 complex decaps mRNA (Gallus gallus)
H2O [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
GDP-fucose biosynthesis (Gallus gallus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)
H2O [cytosol]
Sialic acid metabolism (Gallus gallus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Gallus gallus)
DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Gallus gallus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Gallus gallus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Gallus gallus)
ER to Golgi Anterograde Transport (Gallus gallus)
COPII-mediated vesicle transport (Gallus gallus)
PP6 dephosphorylates SEC24 (Gallus gallus)
H2O [cytosol]
Deubiquitination (Gallus gallus)
Josephin domain DUBs (Gallus gallus)
ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Gallus gallus)
H2O [cytosol]
Metalloprotease DUBs (Gallus gallus)
BRISC complex deubiquitinates NLRP3 (Gallus gallus)
H2O [cytosol]
Ovarian tumor domain proteases (Gallus gallus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
H2O [cytosol]
UCH proteinases (Gallus gallus)
UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
H2O [cytosol]
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Gallus gallus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Gallus gallus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Gallus gallus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Gallus gallus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Gallus gallus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Gallus gallus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Hypusine synthesis from eIF5A-lysine (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
H2O [cytosol]
Neddylation (Gallus gallus)
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Gallus gallus)
Synthesis of glycosylphosphatidylinositol (GPI) (Gallus gallus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)
H2O [cytosol]
Surfactant metabolism (Gallus gallus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
H2O [cytosol]
Translation (Gallus gallus)
Eukaryotic Translation Termination (Gallus gallus)
APEH hydrolyses NAc-Ser-protein (Gallus gallus)
H2O [cytosol]
tRNA Aminoacylation (Gallus gallus)
Cytosolic tRNA aminoacylation (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
H2O [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
H2O [cytosol]
Physiological factors (Gallus gallus)
CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
H2O [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Dopamine clearance from the synaptic cleft (Gallus gallus)
Enzymatic degradation of Dopamine by monoamine oxidase (Gallus gallus)
MAOA:FAD deaminates DA to DOPAC (Gallus gallus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Gallus gallus)
MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Gallus gallus)
Metabolism of serotonin (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
H2O [cytosol]
Neurotransmitter release cycle (Gallus gallus)
Norepinephrine Neurotransmitter Release Cycle (Gallus gallus)
Catabolism of Noradrenaline (Gallus gallus)
H2O [cytosol]
Organelle biogenesis and maintenance (Gallus gallus)
Cilium Assembly (Gallus gallus)
Cargo trafficking to the periciliary membrane (Gallus gallus)
VxPx cargo-targeting to cilium (Gallus gallus)
ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)
H2O [cytosol]
Protein localization (Gallus gallus)
Peroxisomal protein import (Gallus gallus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)
H2O [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
The canonical retinoid cycle in rods (twilight vision) (Gallus gallus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Gallus gallus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
H2O [cytosol]
The phototransduction cascade (Gallus gallus)
Inactivation, recovery and regulation of the phototransduction cascade (Gallus gallus)
PP2A dephosphorylates p-RHO to RHO (Gallus gallus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Gallus gallus)
OPN1LW binds 11cRAL (Gallus gallus)
H2O [cytosol]
OPN1MW binds 11cRAL (Gallus gallus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)
H2O [cytosol]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
![H2O [cytosol] icon](/icon/R-ICO-013527.svg){kind=icon}