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What is Reactome ?
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License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
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O2 [cytosol]
Stable Identifier
R-ALL-29368
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Oxygen, dioxygen
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
O2 [cytosol]
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
O2 [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
O2 [cytosol]
Cellular response to hypoxia (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
O2 [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
O2 [cytosol]
Hemostasis (Bos taurus)
Platelet homeostasis (Bos taurus)
Nitric oxide stimulates guanylate cyclase (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
O2 [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
ROS and RNS production in phagocytes (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
O2 [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
O2 [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
O2 [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
O2 [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
O2 [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
O2 [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
Amine Oxidase reactions (Bos taurus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
O2 [cytosol]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Eicosanoids (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
O2 [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
O2 [cytosol]
Endogenous sterols (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
O2 [cytosol]
CYP1B1 4-hydroxylates EST17b (Bos taurus)
O2 [cytosol]
CYP21A2 21-hydroxylates PROG (Bos taurus)
O2 [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
O2 [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
O2 [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
O2 [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
O2 [cytosol]
Vitamins (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
O2 [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
O2 [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Tyrosine is hydroxylated to dopa (Bos taurus)
O2 [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Tryptophan is hydroxylated (Bos taurus)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
homogentisate + O2 => maleylacetoacetate (Bos taurus)
O2 [cytosol]
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
ADO oxidises 2AET to HTAU (Bos taurus)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)
O2 [cytosol]
Tryptophan catabolism (Bos taurus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)
O2 [cytosol]
IDO1 dioxygenates L-Trp to NFK (Bos taurus)
O2 [cytosol]
IDO2 dioxygenates L-Trp to NFK (Bos taurus)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
O2 [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)
O2 [cytosol]
ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)
O2 [cytosol]
Biosynthesis of maresins (Bos taurus)
Biosynthesis of maresin-like SPMs (Bos taurus)
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
O2 [cytosol]
Biosynthesis of protectins (Bos taurus)
ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)
O2 [cytosol]
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
O2 [cytosol]
Biosynthesis of DPA-derived SPMs (Bos taurus)
Biosynthesis of DPAn-3 SPMs (Bos taurus)
Biosynthesis of DPAn-3-derived maresins (Bos taurus)
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)
O2 [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Bos taurus)
ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)
O2 [cytosol]
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)
O2 [cytosol]
Biosynthesis of DPAn-6 SPMs (Bos taurus)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)
O2 [cytosol]
ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)
O2 [cytosol]
Biosynthesis of EPA-derived SPMs (Bos taurus)
Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)
O2 [cytosol]
Biosynthesis of E-series 18(R)-resolvins (Bos taurus)
ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)
O2 [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Bos taurus)
ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)
O2 [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Bos taurus)
Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)
O2 [cytosol]
PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)
O2 [cytosol]
PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)
O2 [cytosol]
Synthesis of Lipoxins (LX) (Bos taurus)
ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)
O2 [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)
O2 [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
O2 [cytosol]
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)
O2 [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Bos taurus)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)
O2 [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
O2 [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
O2 [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
O2 [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
O2 [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
O2 [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
O2 [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
O2 [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
CYP7A1 7-hydroxylates CHOL (Bos taurus)
O2 [cytosol]
Cholesterol biosynthesis (Bos taurus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
O2 [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
O2 [cytosol]
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
O2 [cytosol]
Cholesterol biosynthesis via lathosterol (Bos taurus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
O2 [cytosol]
Squalene is oxidized to its epoxide (Bos taurus)
O2 [cytosol]
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
O2 [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
O2 [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
O2 [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
O2 [cytosol]
Estrogen biosynthesis (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
O2 [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
O2 [cytosol]
Glucocorticoid biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates PREG (Bos taurus)
O2 [cytosol]
CYP21A2 oxidises 17HPROG (Bos taurus)
O2 [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
O2 [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
O2 [cytosol]
Sphingolipid metabolism (Bos taurus)
Sphingolipid de novo biosynthesis (Bos taurus)
FA2H hydroxylates CERA (Bos taurus)
O2 [cytosol]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Bos taurus)
O2 [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
O2 [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme degradation (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
O2 [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
O2 [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Vitamins B6 activation to pyridoxal phosphate (Bos taurus)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)
O2 [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
O2 [cytosol]
AOX1 oxidises PXL to PDXate (Bos taurus)
O2 [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
O2 [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Dopamine clearance from the synaptic cleft (Bos taurus)
Enzymatic degradation of Dopamine by monoamine oxidase (Bos taurus)
MAOA:FAD deaminates DA to DOPAC (Bos taurus)
O2 [cytosol]
Enzymatic degradation of dopamine by COMT (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
O2 [cytosol]
Serotonin clearance from the synaptic cleft (Bos taurus)
Metabolism of serotonin (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
O2 [cytosol]
Neurotransmitter release cycle (Bos taurus)
Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
Metabolism of Noradrenaline (Bos taurus)
O2 [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
O2 [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
O2 [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
O2 [cytosol]
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
O2 [cytosol]
Transport of small molecules (Bos taurus)
Intracellular oxygen transport (Bos taurus)
Myoglobin binds oxygen (Bos taurus)
O2 [cytosol]
MB:ferroheme b:O2 [cytosol] (Bos taurus)
O2 [cytosol]
Myoglobin:oxygen dissociates (Bos taurus)
O2 [cytosol]
MB:ferroheme b:O2 [cytosol] (Bos taurus)
O2 [cytosol]
Neuroglobin binds oxygen (Bos taurus)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Bos taurus)
O2 [cytosol]
Neuroglobin:oxygen dissociates (Bos taurus)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Bos taurus)
O2 [cytosol]
Iron uptake and transport (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
O2 [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
O2 [cytosol]
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)
O2 [cytosol]
OxyHbA [cytosol] (Bos taurus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Bos taurus)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Bos taurus)
O2 [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)
O2 [cytosol]
OxyHbA [cytosol] (Bos taurus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Bos taurus)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Bos taurus)
O2 [cytosol]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
O2 [cytosol]
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
O2 [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
O2 [cytosol]
Hemostasis (Caenorhabditis elegans)
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)
O2 [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Eicosanoids (Caenorhabditis elegans)
CYP4F2, 4F3 20-hydroxylate LTB4 (Caenorhabditis elegans)
O2 [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Caenorhabditis elegans)
O2 [cytosol]
Endogenous sterols (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
O2 [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
O2 [cytosol]
Vitamins (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
O2 [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
O2 [cytosol]
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Tryptophan is hydroxylated (Caenorhabditis elegans)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
O2 [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)
O2 [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)
O2 [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)
O2 [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is oxidized to MOB (Caenorhabditis elegans)
O2 [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)
O2 [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of maresins (Caenorhabditis elegans)
Biosynthesis of maresin-like SPMs (Caenorhabditis elegans)
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
O2 [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Caenorhabditis elegans)
O2 [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Caenorhabditis elegans)
O2 [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Caenorhabditis elegans)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
O2 [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
O2 [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of steroid hormones (Caenorhabditis elegans)
Estrogen biosynthesis (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
O2 [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
O2 [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
FA2H hydroxylates CERA (Caenorhabditis elegans)
O2 [cytosol]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Caenorhabditis elegans)
O2 [cytosol]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Caenorhabditis elegans)
O2 [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
CYGB binds O2 (Caenorhabditis elegans)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
CYGB dioxygenates NO (Caenorhabditis elegans)
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
O2 [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleobase catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Caenorhabditis elegans)
O2 [cytosol]
Xanthine + H2O + O2 => Urate + H2O2 (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of fat-soluble vitamins (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Vitamins B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)
O2 [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
O2 [cytosol]
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
O2 [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
O2 [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
O2 [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
O2 [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
O2 [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
O2 [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Intracellular oxygen transport (Caenorhabditis elegans)
CYGB binds O2 (Caenorhabditis elegans)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
CYGB:O2 dissociates (Caenorhabditis elegans)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
Neuroglobin binds oxygen (Caenorhabditis elegans)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
Neuroglobin:oxygen dissociates (Caenorhabditis elegans)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Caenorhabditis elegans)
O2 [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
O2 [cytosol]
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
O2 [cytosol]
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
O2 [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
O2 [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
O2 [cytosol]
Cellular response to hypoxia (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
O2 [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
O2 [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
O2 [cytosol]
Hemostasis (Canis familiaris)
Factors involved in megakaryocyte development and platelet production (Canis familiaris)
MICAL1 produces NADP+, H2O2 (Canis familiaris)
O2 [cytosol]
Platelet homeostasis (Canis familiaris)
Nitric oxide stimulates guanylate cyclase (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
O2 [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
ROS and RNS production in phagocytes (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
O2 [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
O2 [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
O2 [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
O2 [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
O2 [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
Amine Oxidase reactions (Canis familiaris)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
O2 [cytosol]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Eicosanoids (Canis familiaris)
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
O2 [cytosol]
Endogenous sterols (Canis familiaris)
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
O2 [cytosol]
CYP21A2 21-hydroxylates PROG (Canis familiaris)
O2 [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
O2 [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
O2 [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
O2 [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
O2 [cytosol]
Vitamins (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
O2 [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
MIOX oxidises Ins to GlcA (Canis familiaris)
O2 [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Carnitine synthesis (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
O2 [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Serotonin and melatonin biosynthesis (Canis familiaris)
Tryptophan is hydroxylated (Canis familiaris)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
O2 [cytosol]
Tyrosine catabolism (Canis familiaris)
homogentisate + O2 => maleylacetoacetate (Canis familiaris)
O2 [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)
O2 [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
ADO oxidises 2AET to HTAU (Canis familiaris)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)
O2 [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is oxidized to MOB (Canis familiaris)
O2 [cytosol]
Tryptophan catabolism (Canis familiaris)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)
O2 [cytosol]
IDO1 dioxygenates L-Trp to NFK (Canis familiaris)
O2 [cytosol]
IDO2 dioxygenates L-Trp to NFK (Canis familiaris)
O2 [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
O2 [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)
O2 [cytosol]
Biosynthesis of D-series resolvins (Canis familiaris)
ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Canis familiaris)
O2 [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)
O2 [cytosol]
Biosynthesis of maresins (Canis familiaris)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)
O2 [cytosol]
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
O2 [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
O2 [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
O2 [cytosol]
Biosynthesis of protectins (Canis familiaris)
ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)
O2 [cytosol]
Biosynthesis of DPA-derived SPMs (Canis familiaris)
Biosynthesis of DPAn-3 SPMs (Canis familiaris)
Biosynthesis of DPAn-3-derived 13-series resolvins (Canis familiaris)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)
O2 [cytosol]
Biosynthesis of DPAn-3-derived maresins (Canis familiaris)
ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)
O2 [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Canis familiaris)
ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)
O2 [cytosol]
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)
O2 [cytosol]
Biosynthesis of DPAn-6 SPMs (Canis familiaris)
ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)
O2 [cytosol]
Biosynthesis of EPA-derived SPMs (Canis familiaris)
Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Canis familiaris)
O2 [cytosol]
Biosynthesis of E-series 18(R)-resolvins (Canis familiaris)
ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)
O2 [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Canis familiaris)
ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)
O2 [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Canis familiaris)
ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Canis familiaris)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)
O2 [cytosol]
PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)
O2 [cytosol]
PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)
O2 [cytosol]
Synthesis of Lipoxins (LX) (Canis familiaris)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)
O2 [cytosol]
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)
O2 [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)
O2 [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)
O2 [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
O2 [cytosol]
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)
O2 [cytosol]
Synthesis of 5-eicosatetraenoic acids (Canis familiaris)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)
O2 [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
O2 [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
O2 [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
O2 [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
O2 [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
O2 [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
O2 [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
O2 [cytosol]
Cholesterol biosynthesis (Canis familiaris)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
O2 [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
O2 [cytosol]
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
O2 [cytosol]
Cholesterol biosynthesis via lathosterol (Canis familiaris)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
O2 [cytosol]
Squalene is oxidized to its epoxide (Canis familiaris)
O2 [cytosol]
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
O2 [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
O2 [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
O2 [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
O2 [cytosol]
Glucocorticoid biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
O2 [cytosol]
CYP21A2 oxidises 17HPROG (Canis familiaris)
O2 [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
O2 [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
O2 [cytosol]
Sphingolipid metabolism (Canis familiaris)
Sphingolipid de novo biosynthesis (Canis familiaris)
FA2H hydroxylates CERA (Canis familiaris)
O2 [cytosol]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Canis familiaris)
O2 [cytosol]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Canis familiaris)
O2 [cytosol]
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
O2 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
CYGB binds O2 (Canis familiaris)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
CYGB dioxygenates NO (Canis familiaris)
CYGB dimer:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleobase catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Canis familiaris)
O2 [cytosol]
Xanthine + H2O + O2 => Urate + H2O2 (Canis familiaris)
O2 [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme degradation (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
O2 [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
O2 [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Vitamins B6 activation to pyridoxal phosphate (Canis familiaris)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)
O2 [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
O2 [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
O2 [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Dopamine clearance from the synaptic cleft (Canis familiaris)
Enzymatic degradation of Dopamine by monoamine oxidase (Canis familiaris)
MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
O2 [cytosol]
Enzymatic degradation of dopamine by COMT (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
O2 [cytosol]
Serotonin clearance from the synaptic cleft (Canis familiaris)
Metabolism of serotonin (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
O2 [cytosol]
Neurotransmitter release cycle (Canis familiaris)
Norepinephrine Neurotransmitter Release Cycle (Canis familiaris)
Metabolism of Noradrenaline (Canis familiaris)
O2 [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
O2 [cytosol]
Transport of small molecules (Canis familiaris)
Intracellular oxygen transport (Canis familiaris)
CYGB binds O2 (Canis familiaris)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
CYGB:O2 dissociates (Canis familiaris)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
Neuroglobin binds oxygen (Canis familiaris)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
Neuroglobin:oxygen dissociates (Canis familiaris)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Canis familiaris)
O2 [cytosol]
Iron uptake and transport (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
O2 [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
O2 [cytosol]
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)
O2 [cytosol]
OxyHbA [cytosol] (Canis familiaris)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Canis familiaris)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Canis familiaris)
O2 [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)
O2 [cytosol]
OxyHbA [cytosol] (Canis familiaris)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Canis familiaris)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Canis familiaris)
O2 [cytosol]
Cellular responses to external stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
O2 [cytosol]
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
O2 [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Danio rerio)
O2 [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
O2 [cytosol]
Cellular response to hypoxia (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
O2 [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Danio rerio)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Danio rerio)
O2 [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Danio rerio)
O2 [cytosol]
Hemostasis (Danio rerio)
Factors involved in megakaryocyte development and platelet production (Danio rerio)
MICAL1 produces NADP+, H2O2 (Danio rerio)
O2 [cytosol]
Platelet homeostasis (Danio rerio)
Nitric oxide stimulates guanylate cyclase (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
O2 [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
ROS and RNS production in phagocytes (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
O2 [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
O2 [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
O2 [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
O2 [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
O2 [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
O2 [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
Amine Oxidase reactions (Danio rerio)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)
MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)
O2 [cytosol]
MAOB:FAD oxidatively deaminates TYR (Danio rerio)
O2 [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Danio rerio)
O2 [cytosol]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
O2 [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
O2 [cytosol]
Endogenous sterols (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
O2 [cytosol]
CYP1B1 4-hydroxylates EST17b (Danio rerio)
O2 [cytosol]
CYP21A2 21-hydroxylates PROG (Danio rerio)
O2 [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
O2 [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
O2 [cytosol]
CYP7A1 7-hydroxylates CHOL (Danio rerio)
O2 [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)
O2 [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
O2 [cytosol]
Vitamins (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
O2 [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)
O2 [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
MIOX oxidises Ins to GlcA (Danio rerio)
O2 [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Carnitine synthesis (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
O2 [cytosol]
Metabolism of amine-derived hormones (Danio rerio)
Catecholamine biosynthesis (Danio rerio)
Tyrosine is hydroxylated to dopa (Danio rerio)
O2 [cytosol]
Serotonin and melatonin biosynthesis (Danio rerio)
Tryptophan is hydroxylated (Danio rerio)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
O2 [cytosol]
Tyrosine catabolism (Danio rerio)
homogentisate + O2 => maleylacetoacetate (Danio rerio)
O2 [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)
O2 [cytosol]
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
ADO oxidises 2AET to HTAU (Danio rerio)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)
O2 [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is oxidized to MOB (Danio rerio)
O2 [cytosol]
Tryptophan catabolism (Danio rerio)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)
O2 [cytosol]
IDO2 dioxygenates L-Trp to NFK (Danio rerio)
O2 [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
O2 [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)
O2 [cytosol]
ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)
O2 [cytosol]
Biosynthesis of D-series resolvins (Danio rerio)
ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)
O2 [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)
O2 [cytosol]
Biosynthesis of maresins (Danio rerio)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)
O2 [cytosol]
Biosynthesis of maresin-like SPMs (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
O2 [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
O2 [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
O2 [cytosol]
Biosynthesis of protectins (Danio rerio)
ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)
O2 [cytosol]
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
O2 [cytosol]
Biosynthesis of DPA-derived SPMs (Danio rerio)
Biosynthesis of DPAn-3 SPMs (Danio rerio)
Biosynthesis of DPAn-3-derived 13-series resolvins (Danio rerio)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)
O2 [cytosol]
Biosynthesis of DPAn-3-derived maresins (Danio rerio)
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)
O2 [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Danio rerio)
ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)
O2 [cytosol]
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)
O2 [cytosol]
Biosynthesis of DPAn-6 SPMs (Danio rerio)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)
O2 [cytosol]
ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)
O2 [cytosol]
Biosynthesis of EPA-derived SPMs (Danio rerio)
Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Danio rerio)
O2 [cytosol]
Biosynthesis of E-series 18(R)-resolvins (Danio rerio)
ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)
O2 [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Danio rerio)
ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)
O2 [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Danio rerio)
ALOX5 oxidises DHA to 7-HDHA (Danio rerio)
O2 [cytosol]
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises EPA to 5-HEPE (Danio rerio)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)
O2 [cytosol]
Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)
O2 [cytosol]
PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)
O2 [cytosol]
PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)
O2 [cytosol]
Synthesis of Lipoxins (LX) (Danio rerio)
ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Danio rerio)
O2 [cytosol]
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)
O2 [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of 12-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)
O2 [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)
O2 [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
O2 [cytosol]
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)
O2 [cytosol]
Synthesis of 5-eicosatetraenoic acids (Danio rerio)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)
O2 [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Danio rerio)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)
O2 [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
O2 [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
O2 [cytosol]
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)
O2 [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
O2 [cytosol]
Fatty acyl-CoA biosynthesis (Danio rerio)
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
O2 [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)
O2 [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
O2 [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)
O2 [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
O2 [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Danio rerio)
27-hydroxycholesterol is 7alpha-hydroxylated (Danio rerio)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
O2 [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
CYP7A1 7-hydroxylates CHOL (Danio rerio)
O2 [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
O2 [cytosol]
Cholesterol biosynthesis (Danio rerio)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
O2 [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
O2 [cytosol]
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
O2 [cytosol]
Cholesterol biosynthesis via lathosterol (Danio rerio)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
O2 [cytosol]
Squalene is oxidized to its epoxide (Danio rerio)
O2 [cytosol]
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
O2 [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
O2 [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
O2 [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
O2 [cytosol]
Estrogen biosynthesis (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
O2 [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
O2 [cytosol]
Glucocorticoid biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates PREG (Danio rerio)
O2 [cytosol]
CYP21A2 oxidises 17HPROG (Danio rerio)
O2 [cytosol]
Mineralocorticoid biosynthesis (Danio rerio)
CYP21A2 21-hydroxylates PROG (Danio rerio)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
O2 [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)
O2 [cytosol]
Sphingolipid metabolism (Danio rerio)
Sphingolipid de novo biosynthesis (Danio rerio)
FA2H hydroxylates CERA (Danio rerio)
O2 [cytosol]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Danio rerio)
O2 [cytosol]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Danio rerio)
O2 [cytosol]
Triglyceride metabolism (Danio rerio)
Triglyceride biosynthesis (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
O2 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
eNOS activation (Danio rerio)
CYGB binds O2 (Danio rerio)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
O2 [cytosol]
CYGB dioxygenates NO (Danio rerio)
CYGB dimer:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Danio rerio)
O2 [cytosol]
eNOS synthesizes NO (Danio rerio)
O2 [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleobase catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Danio rerio)
O2 [cytosol]
Xanthine + H2O + O2 => Urate + H2O2 (Danio rerio)
O2 [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme degradation (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
O2 [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of fat-soluble vitamins (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
O2 [cytosol]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Vitamins B6 activation to pyridoxal phosphate (Danio rerio)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Danio rerio)
O2 [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Danio rerio)
O2 [cytosol]
AOX1 oxidises PXL to PDXate (Danio rerio)
O2 [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
O2 [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter clearance (Danio rerio)
Dopamine clearance from the synaptic cleft (Danio rerio)
Enzymatic degradation of Dopamine by monoamine oxidase (Danio rerio)
MAOA:FAD deaminates DA to DOPAC (Danio rerio)
O2 [cytosol]
Enzymatic degradation of dopamine by COMT (Danio rerio)
MAOA:FAD deaminates 3MT to HVA (Danio rerio)
O2 [cytosol]
Serotonin clearance from the synaptic cleft (Danio rerio)
Metabolism of serotonin (Danio rerio)
MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)
O2 [cytosol]
Neurotransmitter release cycle (Danio rerio)
Norepinephrine Neurotransmitter Release Cycle (Danio rerio)
Metabolism of Noradrenaline (Danio rerio)
O2 [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
O2 [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
O2 [cytosol]
Signal Transduction (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
eNOS synthesizes NO (Danio rerio)
O2 [cytosol]
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
O2 [cytosol]
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
O2 [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFR2 mediated vascular permeability (Danio rerio)
eNOS synthesizes NO (Danio rerio)
O2 [cytosol]
Transport of small molecules (Danio rerio)
Intracellular oxygen transport (Danio rerio)
CYGB binds O2 (Danio rerio)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
O2 [cytosol]
CYGB:O2 dissociates (Danio rerio)
O2 [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Myoglobin binds oxygen (Danio rerio)
O2 [cytosol]
MB:ferroheme b:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Myoglobin:oxygen dissociates (Danio rerio)
O2 [cytosol]
MB:ferroheme b:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Neuroglobin binds oxygen (Danio rerio)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Neuroglobin:oxygen dissociates (Danio rerio)
O2 [cytosol]
NGB:ferroheme b:O2 [cytosol] (Danio rerio)
O2 [cytosol]
Iron uptake and transport (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
O2 [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
O2 [cytosol]
O2/CO2 exchange in erythrocytes (Danio rerio)
Erythrocytes take up carbon dioxide and release oxygen (Danio rerio)
Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)
O2 [cytosol]
OxyHbA [cytosol] (Danio rerio)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Danio rerio)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Danio rerio)
O2 [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Danio rerio)
Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)
O2 [cytosol]
OxyHbA [cytosol] (Danio rerio)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Danio rerio)
O2 [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Danio rerio)
O2 [cytosol]
Cellular responses to external stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
O2 [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
O2 [cytosol]
Hemostasis (Dictyostelium discoideum)
Factors involved in megakaryocyte development and platelet production (Dictyostelium discoideum)
MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
O2 [cytosol]
Platelet homeostasis (Dictyostelium discoideum)
Nitric oxide stimulates guanylate cyclase (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
O2 [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
ROS and RNS production in phagocytes (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
O2 [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
O2 [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
O2 [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Amine Oxidase reactions (Dictyostelium discoideum)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
O2 [cytosol]
MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
O2 [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
O2 [cytosol]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
O2 [cytosol]
Vitamins (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
O2 [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Catecholamine biosynthesis (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
O2 [cytosol]
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Tryptophan is hydroxylated (Dictyostelium discoideum)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
O2 [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)
O2 [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)
O2 [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)
O2 [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is oxidized to MOB (Dictyostelium discoideum)
O2 [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)
O2 [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)
O2 [cytosol]
ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of D-series resolvins (Dictyostelium discoideum)
ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Dictyostelium discoideum)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of maresins (Dictyostelium discoideum)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of maresin-like SPMs (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
O2 [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
O2 [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of protectins (Dictyostelium discoideum)
ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of DPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3 SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3-derived 13-series resolvins (Dictyostelium discoideum)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of DPAn-3-derived maresins (Dictyostelium discoideum)
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Dictyostelium discoideum)
ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of DPAn-6 SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)
O2 [cytosol]
ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of EPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of E-series 18(R)-resolvins (Dictyostelium discoideum)
ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Dictyostelium discoideum)
ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)
O2 [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Dictyostelium discoideum)
ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of Lipoxins (LX) (Dictyostelium discoideum)
ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)
O2 [cytosol]
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)
O2 [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of 12-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)
O2 [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of 5-eicosatetraenoic acids (Dictyostelium discoideum)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Dictyostelium discoideum)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
O2 [cytosol]
Cholesterol biosynthesis (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
O2 [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
O2 [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
O2 [cytosol]
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
O2 [cytosol]
Sphingolipid metabolism (Dictyostelium discoideum)
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
FA2H hydroxylates CERA (Dictyostelium discoideum)
O2 [cytosol]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Dictyostelium discoideum)
O2 [cytosol]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Dictyostelium discoideum)
O2 [cytosol]
Triglyceride metabolism (Dictyostelium discoideum)
Triglyceride biosynthesis (Dictyostelium discoideum)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
O2 [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleobase catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Dictyostelium discoideum)
O2 [cytosol]
Xanthine + H2O + O2 => Urate + H2O2 (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Vitamins B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)
O2 [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
O2 [cytosol]
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
O2 [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
O2 [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter clearance (Dictyostelium discoideum)
Dopamine clearance from the synaptic cleft (Dictyostelium discoideum)
Enzymatic degradation of Dopamine by monoamine oxidase (Dictyostelium discoideum)
MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
O2 [cytosol]
Enzymatic degradation of dopamine by COMT (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
O2 [cytosol]
Serotonin clearance from the synaptic cleft (Dictyostelium discoideum)
Metabolism of serotonin (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
O2 [cytosol]
Neurotransmitter release cycle (Dictyostelium discoideum)
Norepinephrine Neurotransmitter Release Cycle (Dictyostelium discoideum)
Metabolism of Noradrenaline (Dictyostelium discoideum)
O2 [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
O2 [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
O2 [cytosol]
Cellular responses to external stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
O2 [cytosol]
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
O2 [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
O2 [cytosol]
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
O2 [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
O2 [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet homeostasis (Drosophila melanogaster)
Nitric oxide stimulates guanylate cyclase (Drosophila melanogaster)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
O2 [cytosol]
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
ROS and RNS production in phagocytes (Drosophila melanogaster)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
O2 [cytosol]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase I - Functionalization of compounds (Drosophila melanogaster)
Cytochrome P450 - arranged by substrate type (Drosophila melanogaster)
Eicosanoids (Drosophila melanogaster)
CYP4F2, 4F3 20-hydroxylate LTB4 (Drosophila melanogaster)
O2 [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Drosophila melanogaster)
O2 [cytosol]
Endogenous sterols (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
O2 [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
O2 [cytosol]
Vitamins (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
O2 [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
O2 [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Catecholamine biosynthesis (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
O2 [cytosol]
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Tryptophan is hydroxylated (Drosophila melanogaster)
O2 [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
O2 [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)
O2 [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)
O2 [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
ADO oxidises 2AET to HTAU (Drosophila melanogaster)
O2 [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)
O2 [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is oxidized to MOB (Drosophila melanogaster)
O2 [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)
O2 [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
O2 [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Biosynthesis of specialized proresolving mediators (SPMs) (Drosophila melanogaster)
Biosynthesis of DHA-derived SPMs (Drosophila melanogaster)
Biosynthesis of maresins (Drosophila melanogaster)
Biosynthesis of maresin-like SPMs (Drosophila melanogaster)
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
O2 [cytosol]
Fatty acid metabolism (Drosophila melanogaster)
Arachidonic acid metabolism (Drosophila melanogaster)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Drosophila melanogaster)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Drosophila melanogaster)
O2 [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Drosophila melanogaster)
O2 [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Drosophila melanogaster)
O2 [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
O2 [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)
O2 [cytosol]
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
O2 [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
O2 [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Metabolism of steroid hormones (Drosophila melanogaster)
Estrogen biosynthesis (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
O2 [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
O2 [cytosol]
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)
O2 [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
O2 [cytosol]
Sphingolipid metabolism (Drosophila melanogaster)
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
FA2H hydroxylates CERA (Drosophila melanogaster)
O2 [cytosol]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Drosophila melanogaster)
O2 [cytosol]
![O2 [cytosol] icon](/icon/R-ICO-013139.svg){kind=icon}