Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ACA [cytosol]
Stable Identifier
R-ALL-29666
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
3-Oxobutanoate, acetoacetate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)
ACA [cytosol]
Metabolism of lipids (Bos taurus)
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Bos taurus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)
ACA [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Proton-coupled monocarboxylate transport (Bos taurus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Tyrosine catabolism (Caenorhabditis elegans)
fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)
ACA [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Ketone body metabolism (Caenorhabditis elegans)
Synthesis of Ketone Bodies (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)
ACA [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Phenylalanine and tyrosine metabolism (Canis familiaris)
Tyrosine catabolism (Canis familiaris)
fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)
ACA [cytosol]
Metabolism of lipids (Canis familiaris)
Ketone body metabolism (Canis familiaris)
Synthesis of Ketone Bodies (Canis familiaris)
BDH2 dehydrogenates 3HBA (Canis familiaris)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)
ACA [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Proton-coupled monocarboxylate transport (Canis familiaris)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Phenylalanine and tyrosine metabolism (Danio rerio)
Tyrosine catabolism (Danio rerio)
fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)
ACA [cytosol]
Metabolism of lipids (Danio rerio)
Ketone body metabolism (Danio rerio)
Synthesis of Ketone Bodies (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Danio rerio)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)
ACA [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Proton-coupled monocarboxylate transport (Danio rerio)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Tyrosine catabolism (Dictyostelium discoideum)
fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)
ACA [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Ketone body metabolism (Dictyostelium discoideum)
Synthesis of Ketone Bodies (Dictyostelium discoideum)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)
ACA [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Tyrosine catabolism (Drosophila melanogaster)
fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)
ACA [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Ketone body metabolism (Drosophila melanogaster)
Synthesis of Ketone Bodies (Drosophila melanogaster)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)
ACA [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Phenylalanine and tyrosine metabolism (Gallus gallus)
Tyrosine catabolism (Gallus gallus)
fumarylacetoacetate => fumarate + acetoacetate (Gallus gallus)
ACA [cytosol]
Metabolism of lipids (Gallus gallus)
Ketone body metabolism (Gallus gallus)
Synthesis of Ketone Bodies (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Gallus gallus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Gallus gallus)
ACA [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Proton-coupled monocarboxylate transport (Gallus gallus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)
ACA [cytosol]
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Homo sapiens)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)
ACA [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Proton-coupled monocarboxylate transport (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Phenylalanine and tyrosine metabolism (Mus musculus)
Tyrosine catabolism (Mus musculus)
fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)
ACA [cytosol]
Metabolism of lipids (Mus musculus)
Ketone body metabolism (Mus musculus)
Synthesis of Ketone Bodies (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Mus musculus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)
ACA [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Proton-coupled monocarboxylate transport (Mus musculus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Tyrosine catabolism (Rattus norvegicus)
fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)
ACA [cytosol]
Metabolism of lipids (Rattus norvegicus)
Ketone body metabolism (Rattus norvegicus)
Synthesis of Ketone Bodies (Rattus norvegicus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)
ACA [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Proton-coupled monocarboxylate transport (Rattus norvegicus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Phenylalanine and tyrosine metabolism (Sus scrofa)
Tyrosine catabolism (Sus scrofa)
fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)
ACA [cytosol]
Metabolism of lipids (Sus scrofa)
Ketone body metabolism (Sus scrofa)
Synthesis of Ketone Bodies (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Sus scrofa)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)
ACA [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Proton-coupled monocarboxylate transport (Sus scrofa)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Tyrosine catabolism (Xenopus tropicalis)
fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)
ACA [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Ketone body metabolism (Xenopus tropicalis)
Synthesis of Ketone Bodies (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)
ACA [cytosol]
External Reference Information
External Reference
acetoacetate [ChEBI:13705]
Participates
as a member of
MCT substrates [cytosol]
as an output of
fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)
fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)
fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)
fumarylacetoacetate => fumarate + acetoacetate (Gallus gallus)
fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)
fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)
fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)
fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)
fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)
fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)
fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)
fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Gallus gallus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)
BDH2 dehydrogenates 3HBA (Gallus gallus)
BDH2 dehydrogenates 3HBA (Danio rerio)
BDH2 dehydrogenates 3HBA (Sus scrofa)
BDH2 dehydrogenates 3HBA (Bos taurus)
BDH2 dehydrogenates 3HBA (Canis familiaris)
BDH2 dehydrogenates 3HBA (Mus musculus)
BDH2 dehydrogenates 3HBA (Homo sapiens)
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
as an input of
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
Cross References
COMPOUND
C00164
HMDB Metabolite
HMDB0304256
ZINC
000000895089
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
