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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
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Developer's Zone
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Citing us
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L-Cit [cytosol]
Stable Identifier
R-ALL-29968
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
L-Citrulline, L-Citrulline, 2-Amino-5-ureidovaleric acid, L-citrulline
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet homeostasis (Bos taurus)
Nitric oxide stimulates guanylate cyclase (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
L-Cit [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
ROS and RNS production in phagocytes (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
L-Cit [cytosol]
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Urea cycle (Bos taurus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
L-Cit [cytosol]
eNOS synthesizes NO (Bos taurus)
L-Cit [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
eNOS synthesizes NO (Bos taurus)
L-Cit [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Urea cycle (Caenorhabditis elegans)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
L-Cit [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
L-Cit [cytosol]
Hemostasis (Canis familiaris)
Platelet homeostasis (Canis familiaris)
Nitric oxide stimulates guanylate cyclase (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
L-Cit [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
ROS and RNS production in phagocytes (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
L-Cit [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Urea cycle (Canis familiaris)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
L-Cit [cytosol]
eNOS synthesizes NO (Canis familiaris)
L-Cit [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
eNOS synthesizes NO (Canis familiaris)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFR2 mediated vascular permeability (Canis familiaris)
eNOS synthesizes NO (Canis familiaris)
L-Cit [cytosol]
Hemostasis (Danio rerio)
Platelet homeostasis (Danio rerio)
Nitric oxide stimulates guanylate cyclase (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
L-Cit [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
ROS and RNS production in phagocytes (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
L-Cit [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Urea cycle (Danio rerio)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
eNOS activation (Danio rerio)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Danio rerio)
L-Cit [cytosol]
eNOS synthesizes NO (Danio rerio)
L-Cit [cytosol]
Signal Transduction (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
eNOS synthesizes NO (Danio rerio)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFR2 mediated vascular permeability (Danio rerio)
eNOS synthesizes NO (Danio rerio)
L-Cit [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet homeostasis (Dictyostelium discoideum)
Nitric oxide stimulates guanylate cyclase (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
L-Cit [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
ROS and RNS production in phagocytes (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
L-Cit [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Urea cycle (Dictyostelium discoideum)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
L-Cit [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
L-Cit [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet homeostasis (Drosophila melanogaster)
Nitric oxide stimulates guanylate cyclase (Drosophila melanogaster)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
L-Cit [cytosol]
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
ROS and RNS production in phagocytes (Drosophila melanogaster)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
L-Cit [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Urea cycle (Drosophila melanogaster)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
L-Cit [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
L-Cit [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
L-Cit [cytosol]
Hemostasis (Gallus gallus)
Platelet homeostasis (Gallus gallus)
Nitric oxide stimulates guanylate cyclase (Gallus gallus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)
L-Cit [cytosol]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
ROS and RNS production in phagocytes (Gallus gallus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)
L-Cit [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Urea cycle (Gallus gallus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Gallus gallus)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)
L-Cit [cytosol]
eNOS synthesizes NO (Gallus gallus)
L-Cit [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
L-Cit [cytosol]
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
L-Cit [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
L-Cit [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Urea cycle (Homo sapiens)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)
L-Cit [cytosol]
eNOS synthesizes NO (Homo sapiens)
L-Cit [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
L-Cit [cytosol]
Hemostasis (Mus musculus)
Platelet homeostasis (Mus musculus)
Nitric oxide stimulates guanylate cyclase (Mus musculus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)
L-Cit [cytosol]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
ROS and RNS production in phagocytes (Mus musculus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)
L-Cit [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Urea cycle (Mus musculus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
eNOS activation (Mus musculus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)
L-Cit [cytosol]
eNOS synthesizes NO (Mus musculus)
L-Cit [cytosol]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
eNOS synthesizes NO (Mus musculus)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
eNOS synthesizes NO (Mus musculus)
L-Cit [cytosol]
Hemostasis (Plasmodium falciparum)
Platelet homeostasis (Plasmodium falciparum)
Nitric oxide stimulates guanylate cyclase (Plasmodium falciparum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)
L-Cit [cytosol]
Immune System (Plasmodium falciparum)
Innate Immune System (Plasmodium falciparum)
ROS and RNS production in phagocytes (Plasmodium falciparum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)
L-Cit [cytosol]
Hemostasis (Rattus norvegicus)
Platelet homeostasis (Rattus norvegicus)
Nitric oxide stimulates guanylate cyclase (Rattus norvegicus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)
L-Cit [cytosol]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
ROS and RNS production in phagocytes (Rattus norvegicus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)
L-Cit [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Urea cycle (Rattus norvegicus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)
L-Cit [cytosol]
eNOS synthesizes NO (Rattus norvegicus)
L-Cit [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
L-Cit [cytosol]
Hemostasis (Saccharomyces cerevisiae)
Platelet homeostasis (Saccharomyces cerevisiae)
Nitric oxide stimulates guanylate cyclase (Saccharomyces cerevisiae)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)
L-Cit [cytosol]
Immune System (Saccharomyces cerevisiae)
Innate Immune System (Saccharomyces cerevisiae)
ROS and RNS production in phagocytes (Saccharomyces cerevisiae)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)
L-Cit [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Urea cycle (Saccharomyces cerevisiae)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
eNOS activation (Saccharomyces cerevisiae)
eNOS synthesizes NO (Saccharomyces cerevisiae)
L-Cit [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
ESR-mediated signaling (Saccharomyces cerevisiae)
Extra-nuclear estrogen signaling (Saccharomyces cerevisiae)
eNOS synthesizes NO (Saccharomyces cerevisiae)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by VEGF (Saccharomyces cerevisiae)
VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
eNOS synthesizes NO (Saccharomyces cerevisiae)
L-Cit [cytosol]
Hemostasis (Schizosaccharomyces pombe)
Platelet homeostasis (Schizosaccharomyces pombe)
Nitric oxide stimulates guanylate cyclase (Schizosaccharomyces pombe)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)
L-Cit [cytosol]
Immune System (Schizosaccharomyces pombe)
Innate Immune System (Schizosaccharomyces pombe)
ROS and RNS production in phagocytes (Schizosaccharomyces pombe)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)
L-Cit [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Urea cycle (Schizosaccharomyces pombe)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
L-Cit [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
L-Cit [cytosol]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
L-Cit [cytosol]
Hemostasis (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Nitric oxide stimulates guanylate cyclase (Sus scrofa)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)
L-Cit [cytosol]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
ROS and RNS production in phagocytes (Sus scrofa)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)
L-Cit [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Urea cycle (Sus scrofa)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Sus scrofa)
eNOS activation (Sus scrofa)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)
L-Cit [cytosol]
Hemostasis (Xenopus tropicalis)
Platelet homeostasis (Xenopus tropicalis)
Nitric oxide stimulates guanylate cyclase (Xenopus tropicalis)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)
L-Cit [cytosol]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
ROS and RNS production in phagocytes (Xenopus tropicalis)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)
L-Cit [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Urea cycle (Xenopus tropicalis)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Xenopus tropicalis)
L-Cit [cytosol]
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)
L-Cit [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Xenopus tropicalis)
eNOS activation (Xenopus tropicalis)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)
L-Cit [cytosol]
External Reference Information
External Reference
L-citrulline zwitterion [ChEBI:57743]
Participates
as an input of
ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Gallus gallus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Xenopus tropicalis)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)
as an output of
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Danio rerio)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
eNOS synthesizes NO (Homo sapiens)
eNOS synthesizes NO (Mus musculus)
eNOS synthesizes NO (Rattus norvegicus)
eNOS synthesizes NO (Canis familiaris)
eNOS synthesizes NO (Bos taurus)
eNOS synthesizes NO (Danio rerio)
eNOS synthesizes NO (Gallus gallus)
eNOS synthesizes NO (Drosophila melanogaster)
eNOS synthesizes NO (Caenorhabditis elegans)
eNOS synthesizes NO (Dictyostelium discoideum)
eNOS synthesizes NO (Schizosaccharomyces pombe)
eNOS synthesizes NO (Saccharomyces cerevisiae)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)
ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)
Other forms of this molecule
L-Cit [mitochondrial matrix]
Cross References
COMPOUND
C00327
ZINC
000001532614
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