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What is Reactome ?
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Yohimbine [extracellular region]
Stable Identifier
R-ALL-3296452
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Sensory Perception (Bos taurus)
Sensory perception of taste (Bos taurus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Bos taurus)
Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Bos taurus)
TAS2R (non-orphan):ligand [plasma membrane] (Bos taurus)
TAS2R10:ligand [plasma membrane] (Bos taurus)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Bos taurus)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Bos taurus)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Bos taurus)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Bos taurus)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Bos taurus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
T2Rs bind bitter-tasting compounds (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Canis familiaris)
Sensory perception of taste (Canis familiaris)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Canis familiaris)
Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Canis familiaris)
TAS2R (non-orphan):ligand [plasma membrane] (Canis familiaris)
TAS2R10:ligand [plasma membrane] (Canis familiaris)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Canis familiaris)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Canis familiaris)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Canis familiaris)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Canis familiaris)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Canis familiaris)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
T2Rs bind bitter-tasting compounds (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Danio rerio)
Sensory perception of taste (Danio rerio)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Danio rerio)
Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Danio rerio)
TAS2R (non-orphan):ligand [plasma membrane] (Danio rerio)
TAS2R10:ligand [plasma membrane] (Danio rerio)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Danio rerio)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Danio rerio)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Danio rerio)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Danio rerio)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Danio rerio)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Danio rerio)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Danio rerio)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Danio rerio)
T2Rs bind bitter-tasting compounds (Danio rerio)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Danio rerio)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Gallus gallus)
Sensory perception of taste (Gallus gallus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Gallus gallus)
Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Gallus gallus)
TAS2R (non-orphan):ligand [plasma membrane] (Gallus gallus)
TAS2R10:ligand [plasma membrane] (Gallus gallus)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Gallus gallus)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Gallus gallus)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Gallus gallus)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Gallus gallus)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Gallus gallus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Gallus gallus)
T2Rs bind bitter-tasting compounds (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Gallus gallus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R10:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R10:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R10:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R10:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R10:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Mus musculus)
Sensory perception of taste (Mus musculus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Mus musculus)
Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Mus musculus)
TAS2R (non-orphan):ligand [plasma membrane] (Mus musculus)
TAS2R10:ligand [plasma membrane] (Mus musculus)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Mus musculus)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Mus musculus)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Mus musculus)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Mus musculus)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Mus musculus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Mus musculus)
T2Rs bind bitter-tasting compounds (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Mus musculus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Rattus norvegicus)
Sensory perception of taste (Rattus norvegicus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Rattus norvegicus)
Bitter compound binds bitter taste receptor (TAS2R) (Rattus norvegicus)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Rattus norvegicus)
TAS2R (non-orphan):ligand [plasma membrane] (Rattus norvegicus)
TAS2R10:ligand [plasma membrane] (Rattus norvegicus)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Rattus norvegicus)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R38:ligand [plasma membrane] (Rattus norvegicus)
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Rattus norvegicus)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Rattus norvegicus)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Rattus norvegicus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Rattus norvegicus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Rattus norvegicus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
T2Rs bind bitter-tasting compounds (Rattus norvegicus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Rattus norvegicus)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Sensory Perception (Sus scrofa)
Sensory perception of taste (Sus scrofa)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Sus scrofa)
Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)
Ligand of TAS2R (non-orphan) [extracellular region]
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R38 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Sus scrofa)
TAS2R (non-orphan):ligand [plasma membrane] (Sus scrofa)
TAS2R10:ligand [plasma membrane] (Sus scrofa)
Ligand of TAS2R10 [extracellular region]
Yohimbine [extracellular region]
TAS2R1:ligand [plasma membrane] (Sus scrofa)
Ligand of TAS2R1 [extracellular region]
Yohimbine [extracellular region]
TAS2R46:ligand [plasma membrane] (Sus scrofa)
Ligand of TAS2R46 [extracellular region]
Yohimbine [extracellular region]
TAS2R4:ligand [plasma membrane] (Sus scrofa)
Ligand of TAS2R4 [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Sus scrofa)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Sus scrofa)
T2Rs bind bitter-tasting compounds (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
GPCR ligand binding (Xenopus tropicalis)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Xenopus tropicalis)
T2Rs bind bitter-tasting compounds (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Xenopus tropicalis)
Bitter-tasting compounds [extracellular region]
Yohimbine [extracellular region]
External Reference Information
External Reference
yohimbine [ChEBI:10093]
Participates
as a member of
Ligand of TAS2R38 [extracellular region]
Ligand of TAS2R46 [extracellular region]
Ligand of TAS2R10 [extracellular region]
Ligand of TAS2R1 [extracellular region]
Ligand of TAS2R4 [extracellular region]
Bitter-tasting compounds [extracellular region]
Cross References
Guide to Pharmacology - Ligands
102
COMPOUND
C09256
PubChem Substance
11533345
HMDB Metabolite
HMDB0015464
ZINC
000003860825
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