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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
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Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
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How do I search ?
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NAd [extracellular region]
Stable Identifier
R-ALL-374935
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
(R)-noradrenaline(1+), Noradrenaline, (R)-noradrenaline, Norepinephrine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Adrenaline signalling through Alpha-2 adrenergic receptor (Bos taurus)
ADRA2A,B,C bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Bos taurus)
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Adrenaline,noradrenaline inhibits insulin secretion (Bos taurus)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Bos taurus)
ADRA2A,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism of proteins (Bos taurus)
Surfactant metabolism (Bos taurus)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Bos taurus)
ADRA2A,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Noradrenaline clearance from the synaptic cleft (Bos taurus)
NAd [extracellular region]
Neurotransmitter release cycle (Bos taurus)
Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
Release of noradrenaline at the synapse (Bos taurus)
NAd [extracellular region]
Uptake of Noradrenaline (Bos taurus)
NAd [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Bos taurus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)
Ligands of GPCRs that activate G12/13 [extracellular region]
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Bos taurus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (s) signalling events (Bos taurus)
ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)
ADRB2:Catecholamine:GRK [plasma membrane] (Bos taurus)
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:ARRB1,ARRB2 [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
GRKs bind ADRB2:Catecholamine (Bos taurus)
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine:GRK [plasma membrane] (Bos taurus)
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
ADRB1:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
ADRB1:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (z) signalling events (Bos taurus)
Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gz complex dissociates (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Bos taurus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Adrenoceptors (Bos taurus)
ADRA1A,B,D bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1 bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2 bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3 bind ADR,NAd (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Bos taurus)
NAd [extracellular region]
Uptake of Noradrenaline (Bos taurus)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Bos taurus)
Organic cation transport (Bos taurus)
OCT1 transports organic cations into hepatic cells (Bos taurus)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Bos taurus)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Bos taurus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB bind GPCRs (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
pS-ADRB2:Catecholamine [plasma membrane] (Bos taurus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Adrenaline signalling through Alpha-2 adrenergic receptor (Caenorhabditis elegans)
ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Caenorhabditis elegans)
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Adrenaline,noradrenaline inhibits insulin secretion (Caenorhabditis elegans)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter clearance (Caenorhabditis elegans)
Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)
NAd [extracellular region]
Neurotransmitter release cycle (Caenorhabditis elegans)
Norepinephrine Neurotransmitter Release Cycle (Caenorhabditis elegans)
Release of noradrenaline at the synapse (Caenorhabditis elegans)
NAd [extracellular region]
Uptake of Noradrenaline (Caenorhabditis elegans)
NAd [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (12/13) signalling events (Caenorhabditis elegans)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)
Ligands of GPCRs that activate G12/13 [extracellular region]
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Caenorhabditis elegans)
Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Caenorhabditis elegans)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (z) signalling events (Caenorhabditis elegans)
Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Caenorhabditis elegans)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Amine ligand-binding receptors (Caenorhabditis elegans)
Adrenoceptors (Caenorhabditis elegans)
ADRA1A,B,D bind ADR,NAd (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Caenorhabditis elegans)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Na+/Cl- dependent neurotransmitter transporters (Caenorhabditis elegans)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
NAd [extracellular region]
Uptake of Noradrenaline (Caenorhabditis elegans)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic cation transport (Caenorhabditis elegans)
OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Adrenaline signalling through Alpha-2 adrenergic receptor (Canis familiaris)
ADRA2A,B,C bind ADR,NAd (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Canis familiaris)
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Adrenaline,noradrenaline inhibits insulin secretion (Canis familiaris)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)
ADRA2A,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism of proteins (Canis familiaris)
Surfactant metabolism (Canis familiaris)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Canis familiaris)
ADRA2A,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Noradrenaline clearance from the synaptic cleft (Canis familiaris)
NAd [extracellular region]
Neurotransmitter release cycle (Canis familiaris)
Norepinephrine Neurotransmitter Release Cycle (Canis familiaris)
Release of noradrenaline at the synapse (Canis familiaris)
NAd [extracellular region]
Uptake of Noradrenaline (Canis familiaris)
NAd [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)
Ligands of GPCRs that activate G12/13 [extracellular region]
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Canis familiaris)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (s) signalling events (Canis familiaris)
ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)
ADRB2:Catecholamine:GRK [plasma membrane] (Canis familiaris)
ADRB2:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:ARRB1,ARRB2 [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
GRKs bind ADRB2:Catecholamine (Canis familiaris)
ADRB2:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine:GRK [plasma membrane] (Canis familiaris)
ADRB2:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (z) signalling events (Canis familiaris)
Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gz complex dissociates (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Canis familiaris)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Amine ligand-binding receptors (Canis familiaris)
Adrenoceptors (Canis familiaris)
ADRA1A,B,D bind ADR,NAd (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2 bind ADR,NAd (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3 bind ADR,NAd (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)
NAd [extracellular region]
Uptake of Noradrenaline (Canis familiaris)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic cation transport (Canis familiaris)
OCT1 transports organic cations into hepatic cells (Canis familiaris)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Canis familiaris)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Transport of vitamins, nucleosides, and related molecules (Canis familiaris)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Canis familiaris)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB bind GPCRs (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
pS-ADRB2:Catecholamine [plasma membrane] (Canis familiaris)
ADR, NAd [extracellular region]
NAd [extracellular region]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Adrenaline signalling through Alpha-2 adrenergic receptor (Danio rerio)
ADRA2A,B,C bind ADR,NAd (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Danio rerio)
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Adrenaline,noradrenaline inhibits insulin secretion (Danio rerio)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
ADRA2A,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter clearance (Danio rerio)
Noradrenaline clearance from the synaptic cleft (Danio rerio)
NAd [extracellular region]
Neurotransmitter release cycle (Danio rerio)
Norepinephrine Neurotransmitter Release Cycle (Danio rerio)
Uptake of Noradrenaline (Danio rerio)
NAd [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (12/13) signalling events (Danio rerio)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Danio rerio)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Danio rerio)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Danio rerio)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (s) signalling events (Danio rerio)
ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)
pS-ADRB2:Catecholamine [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:ARRB1,ARRB2 [plasma membrane] (Danio rerio)
pS-ADRB2:Catecholamine [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Amine ligand-binding receptors (Danio rerio)
Adrenoceptors (Danio rerio)
ADRA1A,B,D bind ADR,NAd (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1 bind ADR,NAd (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2 bind ADR,NAd (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Na+/Cl- dependent neurotransmitter transporters (Danio rerio)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)
NAd [extracellular region]
Uptake of Noradrenaline (Danio rerio)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Danio rerio)
Organic cation transport (Danio rerio)
OCT1 transports organic cations into hepatic cells (Danio rerio)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Danio rerio)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Transport of vitamins, nucleosides, and related molecules (Danio rerio)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Danio rerio)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Clathrin-mediated endocytosis (Danio rerio)
Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
ARRB bind GPCRs (Danio rerio)
ARRB-binding GPCRs [plasma membrane] (Danio rerio)
pS-ADRB2:Catecholamine [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
ARRB-binding GPCRs [plasma membrane] (Danio rerio)
pS-ADRB2:Catecholamine [plasma membrane] (Danio rerio)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of vitamins, nucleosides, and related molecules (Dictyostelium discoideum)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Dictyostelium discoideum)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Adrenaline signalling through Alpha-2 adrenergic receptor (Drosophila melanogaster)
ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Drosophila melanogaster)
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Adrenaline,noradrenaline inhibits insulin secretion (Drosophila melanogaster)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Drosophila melanogaster)
ADRA2A,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter clearance (Drosophila melanogaster)
Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)
NAd [extracellular region]
Neurotransmitter release cycle (Drosophila melanogaster)
Norepinephrine Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of noradrenaline at the synapse (Drosophila melanogaster)
NAd [extracellular region]
Uptake of Noradrenaline (Drosophila melanogaster)
NAd [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (12/13) signalling events (Drosophila melanogaster)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:G12/13 complex dissociates (Drosophila melanogaster)
Ligands of GPCRs that activate G12/13 [extracellular region]
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Drosophila melanogaster)
Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Drosophila melanogaster)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Drosophila melanogaster)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (s) signalling events (Drosophila melanogaster)
ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)
ADRB2:Catecholamine:GRK [plasma membrane] (Drosophila melanogaster)
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:ARRB1,ARRB2 [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine:GRK [plasma membrane] (Drosophila melanogaster)
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gs-activating GPCR acts as a GEF for Gs (Drosophila melanogaster)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Drosophila melanogaster)
ADRB1:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Drosophila melanogaster)
ADRB1:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (z) signalling events (Drosophila melanogaster)
Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Drosophila melanogaster)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Amine ligand-binding receptors (Drosophila melanogaster)
Adrenoceptors (Drosophila melanogaster)
ADRA1A,B,D bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1 bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2 bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3 bind ADR,NAd (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Drosophila melanogaster)
NAd [extracellular region]
Uptake of Noradrenaline (Drosophila melanogaster)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic cation transport (Drosophila melanogaster)
OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Transport of vitamins, nucleosides, and related molecules (Drosophila melanogaster)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Drosophila melanogaster)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB bind GPCRs (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
pS-ADRB2:Catecholamine [plasma membrane] (Drosophila melanogaster)
ADR, NAd [extracellular region]
NAd [extracellular region]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Adrenaline signalling through Alpha-2 adrenergic receptor (Gallus gallus)
ADRA2A,B,C bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Gallus gallus)
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Adrenaline,noradrenaline inhibits insulin secretion (Gallus gallus)
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism of proteins (Gallus gallus)
Surfactant metabolism (Gallus gallus)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Gallus gallus)
ADRA2A,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Noradrenaline clearance from the synaptic cleft (Gallus gallus)
NAd [extracellular region]
Neurotransmitter release cycle (Gallus gallus)
Norepinephrine Neurotransmitter Release Cycle (Gallus gallus)
Uptake of Noradrenaline (Gallus gallus)
NAd [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (12/13) signalling events (Gallus gallus)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)
Ligands of GPCRs that activate G12/13 [extracellular region]
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (i) signalling events (Gallus gallus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (q) signalling events (Gallus gallus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (s) signalling events (Gallus gallus)
ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)
ADRB2:Catecholamine:GRK [plasma membrane] (Gallus gallus)
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)
pS-ADRB2:Catecholamine [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
GRKs bind ADRB2:Catecholamine (Gallus gallus)
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:Catecholamine:GRK [plasma membrane] (Gallus gallus)
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
ADRB1:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
ADRB1:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
G alpha (z) signalling events (Gallus gallus)
Liganded Gz-activating GPCR acts as a GEF for Gz (Gallus gallus)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
The Ligand:GPCR:Gz complex dissociates (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Gallus gallus)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Amine ligand-binding receptors (Gallus gallus)
Adrenoceptors (Gallus gallus)
ADRA1A,B,D bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA1A,B,D:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1 bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB1:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2 bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB2:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3 bind ADR,NAd (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRB3:ADR,NAd [plasma membrane] (Gallus gallus)
ADR, NAd [extracellular region]
NAd [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Gallus gallus)
NAd [extracellular region]
Uptake of Noradrenaline (Gallus gallus)
NAd [extracellular region]
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic cation transport (Gallus gallus)
OCT1 transports organic cations into hepatic cells (Gallus gallus)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT1 transports organic cations out of hepatic cells (Gallus gallus)
OCT1 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
NAd [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
NAd [extracellular region]
Transport of vitamins, nucleosides, and related molecules (Gallus gallus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Gallus gallus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
ligands of SLC29A4 [extracellular region]
NAd [extracellular region]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC6A2 causes orthostatic intolerance (OI) (Homo sapiens)
Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)
NAd [extracellular region]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Adrenaline signalling through Alpha-2 adrenergic receptor (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Adrenaline,noradrenaline inhibits insulin secretion (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADR, NAd [extracellular region]
NAd [extracellular region]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Noradrenaline clearance from the synaptic cleft (Homo sapiens)
NAd [extracellular region]
Neurotransmitter release cycle (Homo sapiens)
Norepinephrine Neurotransmitter Release