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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Cytomics
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C18-S1P [extracellular region]
Stable Identifier
R-ALL-419305
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
S1P, SPGP, sphingosine 1-phosphate, Sphingosine-1-phosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Sphingolipid metabolism (Bos taurus)
Sphingolipid catabolism (Bos taurus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Bos taurus)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
C18-S1P [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Lysosphingolipid and LPA receptors (Bos taurus)
S1PR1 bind S1P (Bos taurus)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Bos taurus)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Bos taurus)
C18-S1P [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Sphingolipid metabolism (Caenorhabditis elegans)
Sphingolipid catabolism (Caenorhabditis elegans)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Caenorhabditis elegans)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
C18-S1P [extracellular region]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Sphingolipid metabolism (Canis familiaris)
Sphingolipid catabolism (Canis familiaris)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Canis familiaris)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
C18-S1P [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Lysosphingolipid and LPA receptors (Canis familiaris)
S1PR1 bind S1P (Canis familiaris)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Canis familiaris)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
C18-S1P [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
S1PR2-5:S1P [plasma membrane] (Danio rerio)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
S1PR2-5:S1P [plasma membrane] (Danio rerio)
C18-S1P [extracellular region]
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Lysosphingolipid and LPA receptors (Danio rerio)
S1PR1 bind S1P (Danio rerio)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Danio rerio)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Danio rerio)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Danio rerio)
C18-S1P [extracellular region]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Sphingolipid metabolism (Dictyostelium discoideum)
Sphingolipid catabolism (Dictyostelium discoideum)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Dictyostelium discoideum)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
C18-S1P [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Sphingolipid metabolism (Drosophila melanogaster)
Sphingolipid catabolism (Drosophila melanogaster)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Drosophila melanogaster)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
C18-S1P [extracellular region]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Sphingolipid metabolism (Gallus gallus)
Sphingolipid catabolism (Gallus gallus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Gallus gallus)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
C18-S1P [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Lysosphingolipid and LPA receptors (Gallus gallus)
S1PR1 bind S1P (Gallus gallus)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Gallus gallus)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
C18-S1P [extracellular region]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid catabolism (Homo sapiens)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Homo sapiens)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
C18-S1P [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR1 bind S1P (Homo sapiens)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Homo sapiens)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
C18-S1P [extracellular region]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Sphingolipid metabolism (Mus musculus)
Sphingolipid catabolism (Mus musculus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Mus musculus)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
C18-S1P [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Lysosphingolipid and LPA receptors (Mus musculus)
S1PR1 bind S1P (Mus musculus)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Mus musculus)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Mus musculus)
C18-S1P [extracellular region]
Metabolism (Plasmodium falciparum)
Metabolism of lipids (Plasmodium falciparum)
Sphingolipid metabolism (Plasmodium falciparum)
Sphingolipid de novo biosynthesis (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
C18-S1P [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Sphingolipid metabolism (Rattus norvegicus)
Sphingolipid catabolism (Rattus norvegicus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Rattus norvegicus)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
C18-S1P [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
S1PR2-5:S1P [plasma membrane] (Rattus norvegicus)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
S1PR2-5:S1P [plasma membrane] (Rattus norvegicus)
C18-S1P [extracellular region]
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Lysosphingolipid and LPA receptors (Rattus norvegicus)
S1PR1 bind S1P (Rattus norvegicus)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Rattus norvegicus)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Rattus norvegicus)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Rattus norvegicus)
C18-S1P [extracellular region]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Sphingolipid metabolism (Saccharomyces cerevisiae)
Sphingolipid catabolism (Saccharomyces cerevisiae)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Saccharomyces cerevisiae)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
C18-S1P [extracellular region]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Sphingolipid metabolism (Schizosaccharomyces pombe)
Sphingolipid catabolism (Schizosaccharomyces pombe)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Schizosaccharomyces pombe)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
C18-S1P [extracellular region]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Sphingolipid metabolism (Sus scrofa)
Sphingolipid catabolism (Sus scrofa)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Sus scrofa)
C18-S1P [extracellular region]
Sphingolipid de novo biosynthesis (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
C18-S1P [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Lysosphingolipid and LPA receptors (Sus scrofa)
S1PR1 bind S1P (Sus scrofa)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Sus scrofa)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
C18-S1P [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Sphingolipid metabolism (Xenopus tropicalis)
Sphingolipid de novo biosynthesis (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
C18-S1P [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
GPCR ligand binding (Xenopus tropicalis)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Lysosphingolipid and LPA receptors (Xenopus tropicalis)
S1PR1 bind S1P (Xenopus tropicalis)
C18-S1P [extracellular region]
S1PR1:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
S1PR2-5 bind S1P (Xenopus tropicalis)
C18-S1P [extracellular region]
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
C18-S1P [extracellular region]
External Reference Information
External Reference
sphingosine 1-phosphate(1-) [ChEBI:60119]
Participates
as a component of
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Xenopus tropicalis)
S1PR2-5:S1P [plasma membrane] (Bos taurus)
S1PR2-5:S1P [plasma membrane] (Mus musculus)
S1PR2-5:S1P [plasma membrane] (Rattus norvegicus)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Canis familiaris)
S1PR2-5:S1P [plasma membrane] (Gallus gallus)
S1PR2-5:S1P [plasma membrane] (Danio rerio)
S1PR1:S1P [plasma membrane] (Homo sapiens)
S1PR1:S1P [plasma membrane] (Sus scrofa)
S1PR1:S1P [plasma membrane] (Gallus gallus)
S1PR1:S1P [plasma membrane] (Bos taurus)
S1PR1:S1P [plasma membrane] (Rattus norvegicus)
S1PR1:S1P [plasma membrane] (Xenopus tropicalis)
S1PR1:S1P [plasma membrane] (Canis familiaris)
S1PR1:S1P [plasma membrane] (Mus musculus)
S1PR1:S1P [plasma membrane] (Danio rerio)
as an input of
S1PR2-5 bind S1P (Gallus gallus)
S1PR2-5 bind S1P (Xenopus tropicalis)
S1PR2-5 bind S1P (Danio rerio)
S1PR2-5 bind S1P (Sus scrofa)
S1PR2-5 bind S1P (Bos taurus)
S1PR2-5 bind S1P (Canis familiaris)
S1PR2-5 bind S1P (Rattus norvegicus)
S1PR2-5 bind S1P (Mus musculus)
S1PR2-5 bind S1P (Homo sapiens)
S1PR1 bind S1P (Gallus gallus)
S1PR1 bind S1P (Xenopus tropicalis)
S1PR1 bind S1P (Danio rerio)
S1PR1 bind S1P (Sus scrofa)
S1PR1 bind S1P (Bos taurus)
S1PR1 bind S1P (Canis familiaris)
S1PR1 bind S1P (Rattus norvegicus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Homo sapiens)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Mus musculus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Rattus norvegicus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Canis familiaris)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Bos taurus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Sus scrofa)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Gallus gallus)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Drosophila melanogaster)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Caenorhabditis elegans)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Dictyostelium discoideum)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Schizosaccharomyces pombe)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Saccharomyces cerevisiae)
S1PR1 bind S1P (Homo sapiens)
S1PR1 bind S1P (Mus musculus)
as an output of
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
Other forms of this molecule
S1P [plasma membrane]
C18-S1P [cytosol]
Cross References
ZINC
000008860500
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