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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Developer's Zone
Graph Database
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Content Service
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Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
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FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
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NAD+ [nucleoplasm]
Stable Identifier
R-ALL-427523
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
NAD, NAD(+), Nicotinamide adenine dinucleotide, DPN, Diphosphopyridine nucleotide
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
SIRT1 deacetylates HSF1 (Bos taurus)
NAD+ [nucleoplasm]
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
SIRT6 deacetylates RBBP8 (Bos taurus)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Bos taurus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
DNA Damage Recognition in GG-NER (Bos taurus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)
NAD+ [nucleoplasm]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
Epigenetic regulation of gene expression (Bos taurus)
Negative epigenetic regulation of rRNA expression (Bos taurus)
SIRT1 negatively regulates rRNA expression (Bos taurus)
eNoSC deacetylates histone H3 (Bos taurus)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
FOXO-mediated transcription (Bos taurus)
Regulation of FOXO transcriptional activity by acetylation (Bos taurus)
SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)
NAD+ [nucleoplasm]
Signal Transduction (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)
NAD+ [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Double-Strand Break Repair (Caenorhabditis elegans)
Homology Directed Repair (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
Processing of DNA double-strand break ends (Caenorhabditis elegans)
SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
DNA Damage Recognition in GG-NER (Caenorhabditis elegans)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)
NAD+ [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of FOXO transcriptional activity by acetylation (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
SIRT1 deacetylates HSF1 (Canis familiaris)
NAD+ [nucleoplasm]
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Canis familiaris)
POLB-Dependent Long Patch Base Excision Repair (Canis familiaris)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
SIRT6 deacetylates RBBP8 (Canis familiaris)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
DNA Damage Recognition in GG-NER (Canis familiaris)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
NAD+ [nucleoplasm]
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
Epigenetic regulation of gene expression (Canis familiaris)
Negative epigenetic regulation of rRNA expression (Canis familiaris)
SIRT1 negatively regulates rRNA expression (Canis familiaris)
eNoSC deacetylates histone H3 (Canis familiaris)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
FOXO-mediated transcription (Canis familiaris)
Regulation of FOXO transcriptional activity by acetylation (Canis familiaris)
SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
NAD+ [nucleoplasm]
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
NAD+ [nucleoplasm]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Danio rerio)
POLB-Dependent Long Patch Base Excision Repair (Danio rerio)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
Processing of DNA double-strand break ends (Danio rerio)
SIRT6 deacetylates RBBP8 (Danio rerio)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
DNA Damage Recognition in GG-NER (Danio rerio)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)
NAD+ [nucleoplasm]
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Dictyostelium discoideum)
POLB-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
DNA Damage Recognition in GG-NER (Dictyostelium discoideum)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)
NAD+ [nucleoplasm]
Developmental Biology (Dictyostelium discoideum)
MITF-M-regulated melanocyte development (Dictyostelium discoideum)
Transcriptional and post-translational regulation of MITF-M expression and activity (Dictyostelium discoideum)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Dictyostelium discoideum)
Epigenetic regulation of gene expression (Dictyostelium discoideum)
Negative epigenetic regulation of rRNA expression (Dictyostelium discoideum)
SIRT1 negatively regulates rRNA expression (Dictyostelium discoideum)
eNoSC deacetylates histone H3 (Dictyostelium discoideum)
NAD+ [nucleoplasm]
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
DNA Damage Recognition in GG-NER (Drosophila melanogaster)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
NAD+ [nucleoplasm]
Developmental Biology (Drosophila melanogaster)
MITF-M-regulated melanocyte development (Drosophila melanogaster)
Transcriptional and post-translational regulation of MITF-M expression and activity (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
Epigenetic regulation of gene expression (Drosophila melanogaster)
Negative epigenetic regulation of rRNA expression (Drosophila melanogaster)
SIRT1 negatively regulates rRNA expression (Drosophila melanogaster)
eNoSC deacetylates histone H3 (Drosophila melanogaster)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
FOXO-mediated transcription (Drosophila melanogaster)
Regulation of FOXO transcriptional activity by acetylation (Drosophila melanogaster)
SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
NAD+ [nucleoplasm]
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to heat stress (Gallus gallus)
Regulation of HSF1-mediated heat shock response (Gallus gallus)
SIRT1 deacetylates HSF1 (Gallus gallus)
NAD+ [nucleoplasm]
DNA Repair (Gallus gallus)
DNA Double-Strand Break Repair (Gallus gallus)
Homology Directed Repair (Gallus gallus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
Processing of DNA double-strand break ends (Gallus gallus)
SIRT6 deacetylates RBBP8 (Gallus gallus)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Gallus gallus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Gallus gallus)
Global Genome Nucleotide Excision Repair (GG-NER) (Gallus gallus)
DNA Damage Recognition in GG-NER (Gallus gallus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)
NAD+ [nucleoplasm]
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
FOXO-mediated transcription (Gallus gallus)
Regulation of FOXO transcriptional activity by acetylation (Gallus gallus)
SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
SIRT1 deacetylates HSF1 (Homo sapiens)
NAD+ [nucleoplasm]
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
SIRT6 deacetylates RBBP8 (Homo sapiens)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
NAD+ [nucleoplasm]
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
NAD+ [nucleoplasm]
eNoSC deacetylates histone H3 (Homo sapiens)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
SIRT1 deacetylates FOXO1 (Homo sapiens)
NAD+ [nucleoplasm]
SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
NAD+ [nucleoplasm]
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
NAD+ [nucleoplasm]
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
SIRT1 deacetylates HSF1 (Mus musculus)
NAD+ [nucleoplasm]
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
SIRT6 deacetylates RBBP8 (Mus musculus)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Mus musculus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
DNA Damage Recognition in GG-NER (Mus musculus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)
NAD+ [nucleoplasm]
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of FOXO transcriptional activity by acetylation (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)
NAD+ [nucleoplasm]
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)
NAD+ [nucleoplasm]
DNA Repair (Plasmodium falciparum)
Nucleotide Excision Repair (Plasmodium falciparum)
Global Genome Nucleotide Excision Repair (GG-NER) (Plasmodium falciparum)
DNA Damage Recognition in GG-NER (Plasmodium falciparum)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Plasmodium falciparum)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
SIRT1 deacetylates HSF1 (Rattus norvegicus)
NAD+ [nucleoplasm]
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
Processing of DNA double-strand break ends (Rattus norvegicus)
SIRT6 deacetylates RBBP8 (Rattus norvegicus)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Rattus norvegicus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
DNA Damage Recognition in GG-NER (Rattus norvegicus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)
NAD+ [nucleoplasm]
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Rattus norvegicus)
Epigenetic regulation of gene expression (Rattus norvegicus)
Negative epigenetic regulation of rRNA expression (Rattus norvegicus)
SIRT1 negatively regulates rRNA expression (Rattus norvegicus)
eNoSC deacetylates histone H3 (Rattus norvegicus)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
FOXO-mediated transcription (Rattus norvegicus)
Regulation of FOXO transcriptional activity by acetylation (Rattus norvegicus)
SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
NAD+ [nucleoplasm]
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Saccharomyces cerevisiae)
Epigenetic regulation of gene expression (Saccharomyces cerevisiae)
Negative epigenetic regulation of rRNA expression (Saccharomyces cerevisiae)
SIRT1 negatively regulates rRNA expression (Saccharomyces cerevisiae)
eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Schizosaccharomyces pombe)
Epigenetic regulation of gene expression (Schizosaccharomyces pombe)
Negative epigenetic regulation of rRNA expression (Schizosaccharomyces pombe)
SIRT1 negatively regulates rRNA expression (Schizosaccharomyces pombe)
eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)
NAD+ [nucleoplasm]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to heat stress (Sus scrofa)
Regulation of HSF1-mediated heat shock response (Sus scrofa)
SIRT1 deacetylates HSF1 (Sus scrofa)
NAD+ [nucleoplasm]
DNA Repair (Sus scrofa)
Base Excision Repair (Sus scrofa)
Resolution of Abasic Sites (AP sites) (Sus scrofa)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
Processing of DNA double-strand break ends (Sus scrofa)
SIRT6 deacetylates RBBP8 (Sus scrofa)
NAD+ [nucleoplasm]
HDR through MMEJ (alt-NHEJ) (Sus scrofa)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Sus scrofa)
Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
DNA Damage Recognition in GG-NER (Sus scrofa)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)
NAD+ [nucleoplasm]
Developmental Biology (Sus scrofa)
MITF-M-regulated melanocyte development (Sus scrofa)
Transcriptional and post-translational regulation of MITF-M expression and activity (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
NAD+ [nucleoplasm]
Gene expression (Transcription) (Sus scrofa)
Epigenetic regulation of gene expression (Sus scrofa)
Negative epigenetic regulation of rRNA expression (Sus scrofa)
SIRT1 negatively regulates rRNA expression (Sus scrofa)
eNoSC deacetylates histone H3 (Sus scrofa)
NAD+ [nucleoplasm]
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
FOXO-mediated transcription (Sus scrofa)
Regulation of FOXO transcriptional activity by acetylation (Sus scrofa)
SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)
NAD+ [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
NAD+ [nucleoplasm]
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
NAD+ [nucleoplasm]
DNA Repair (Xenopus tropicalis)
Base Excision Repair (Xenopus tropicalis)
Resolution of Abasic Sites (AP sites) (Xenopus tropicalis)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Xenopus tropicalis)
POLB-Dependent Long Patch Base Excision Repair (Xenopus tropicalis)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)
NAD+ [nucleoplasm]
DNA Double-Strand Break Repair (Xenopus tropicalis)
Homology Directed Repair (Xenopus tropicalis)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
Processing of DNA double-strand break ends (Xenopus tropicalis)
SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
NAD+ [nucleoplasm]
Nucleotide Excision Repair (Xenopus tropicalis)
Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
DNA Damage Recognition in GG-NER (Xenopus tropicalis)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)
NAD+ [nucleoplasm]
External Reference Information
External Reference
NAD(1-) [ChEBI:57540]
Participates
as an input of
Sirt1 deacetylates Taf1b in SL1 complex (Mus musculus)
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)
eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)
eNoSC deacetylates histone H3 (Dictyostelium discoideum)
eNoSC deacetylates histone H3 (Drosophila melanogaster)
eNoSC deacetylates histone H3 (Sus scrofa)
eNoSC deacetylates histone H3 (Bos taurus)
eNoSC deacetylates histone H3 (Canis familiaris)
eNoSC deacetylates histone H3 (Rattus norvegicus)
eNoSC deacetylates histone H3 (Homo sapiens)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
SIRT1 deacetylates HSF1 (Gallus gallus)
SIRT1 deacetylates HSF1 (Sus scrofa)
SIRT1 deacetylates HSF1 (Bos taurus)
SIRT1 deacetylates HSF1 (Canis familiaris)
SIRT1 deacetylates HSF1 (Rattus norvegicus)
SIRT1 deacetylates HSF1 (Mus musculus)
SIRT1 deacetylates HSF1 (Homo sapiens)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)
SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)
SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)
SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)
SIRT6 deacetylates RBBP8 (Mus musculus)
SIRT6 deacetylates RBBP8 (Homo sapiens)
SIRT6 deacetylates RBBP8 (Rattus norvegicus)
SIRT6 deacetylates RBBP8 (Canis familiaris)
SIRT6 deacetylates RBBP8 (Bos taurus)
SIRT6 deacetylates RBBP8 (Sus scrofa)
SIRT6 deacetylates RBBP8 (Danio rerio)
SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
SIRT6 deacetylates RBBP8 (Gallus gallus)
SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Plasmodium falciparum)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters (Mus musculus)
SIRT1 deacetylates FOXO1 (Homo sapiens)
Sirt1 deacetylates Foxo1 (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)
SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)
Other forms of this molecule
NAD+ [mitochondrial intermembrane space]
NAD+ [cytoplasm]
NAD+ [extracellular region]
NAD+ [Golgi membrane]
NAD+ [mitochondrial matrix]
NAD+ [peroxisomal matrix]
NAD+ [cytosol]
NAD+ [endoplasmic reticulum lumen]
Cross References
COMPOUND
C00003
ZINC
000008214766
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