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Zn2+ [endoplasmic reticulum membrane]
Stable Identifier
R-ALL-6788653
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum membrane
Synonyms
Zn++, zinc(2+), Zinc ion, Zn(II)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Sphingolipid metabolism (Bos taurus)
Sphingolipid catabolism (Bos taurus)
ACER3 hydrolyzes phytoceramide (Bos taurus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS processing (Bos taurus)
ICMT methylates S-Farn RAS proteins (Bos taurus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Bos taurus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS processing (Caenorhabditis elegans)
ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Caenorhabditis elegans)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Sphingolipid metabolism (Canis familiaris)
Sphingolipid catabolism (Canis familiaris)
ACER3 hydrolyzes phytoceramide (Canis familiaris)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Canis familiaris)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Danio rerio)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS processing (Danio rerio)
ICMT methylates S-Farn RAS proteins (Danio rerio)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Danio rerio)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Danio rerio)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Danio rerio)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Sphingolipid metabolism (Dictyostelium discoideum)
Sphingolipid catabolism (Dictyostelium discoideum)
ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Dictyostelium discoideum)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Dictyostelium discoideum)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Drosophila melanogaster)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS processing (Drosophila melanogaster)
ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Drosophila melanogaster)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Drosophila melanogaster)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Drosophila melanogaster)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Sphingolipid metabolism (Gallus gallus)
Sphingolipid catabolism (Gallus gallus)
ACER3 hydrolyzes phytoceramide (Gallus gallus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS processing (Gallus gallus)
ICMT methylates S-Farn RAS proteins (Gallus gallus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Gallus gallus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid catabolism (Homo sapiens)
ACER3 hydrolyzes phytoceramide (Homo sapiens)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
Cysmethynil binds ICMT:Zn2+ (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
ICMT methylates S-Farn RAS proteins (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Sphingolipid metabolism (Mus musculus)
Sphingolipid catabolism (Mus musculus)
ACER3 hydrolyzes phytoceramide (Mus musculus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS processing (Mus musculus)
ICMT methylates S-Farn RAS proteins (Mus musculus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Mus musculus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Plasmodium falciparum)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Sphingolipid metabolism (Rattus norvegicus)
Sphingolipid catabolism (Rattus norvegicus)
ACER3 hydrolyzes phytoceramide (Rattus norvegicus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
Zn2+ [endoplasmic reticulum membrane]
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS processing (Rattus norvegicus)
ICMT methylates S-Farn RAS proteins (Rattus norvegicus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
Zn2+ [endoplasmic reticulum membrane]
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Rattus norvegicus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Sphingolipid metabolism (Saccharomyces cerevisiae)
Sphingolipid catabolism (Saccharomyces cerevisiae)
ACER3 hydrolyzes phytoceramide (Saccharomyces cerevisiae)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Sphingolipid metabolism (Sus scrofa)
Sphingolipid catabolism (Sus scrofa)
ACER3 hydrolyzes phytoceramide (Sus scrofa)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Sus scrofa)
Zn2+ [endoplasmic reticulum membrane]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Sphingolipid metabolism (Xenopus tropicalis)
Sphingolipid catabolism (Xenopus tropicalis)
ACER3 hydrolyzes phytoceramide (Xenopus tropicalis)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Xenopus tropicalis)
Zn2+ [endoplasmic reticulum membrane]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Xenopus tropicalis)
Zn2+ [endoplasmic reticulum membrane]
External Reference Information
External Reference
zinc(2+) [ChEBI:29105]
Participates
as a component of
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Sus scrofa)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Xenopus tropicalis)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Dictyostelium discoideum)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane] (Canis familiaris)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Danio rerio)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Bos taurus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Plasmodium falciparum)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Mus musculus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Gallus gallus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Rattus norvegicus)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Caenorhabditis elegans)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Drosophila melanogaster)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Xenopus tropicalis)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Dictyostelium discoideum)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
Zn2+ [endocytic vesicle membrane]
Zn2+ [clathrin-coated endocytic vesicle membrane]
Zn2+ [synaptic vesicle membrane]
Zn2+ [endosome membrane]
Zn2+ [synaptic vesicle]
Zn2+ [secretory granule lumen]
Zn2+ [endoplasmic reticulum lumen]
Zn2+ [Golgi membrane]
Zn2+ [lysosomal lumen]
Zn2+ [melanosome membrane]
Zn2+ [mitochondrial intermembrane space]
Zn2+ [Golgi lumen]
Zn2+ [mitochondrial matrix]
Zn2+ [phagocytic vesicle lumen]
Zn2+ [endosome lumen]
Zn2+ [mitochondrial inner membrane]
Zn2+ [extracellular region]
Zn2+ [cytosol]
Zn2+ [plasma membrane]
Zn2+ [nucleoplasm]
Cross References
COMPOUND
C00038
PubChem Substance
11533263
HMDB Metabolite
HMDB0015532
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