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About
What is Reactome ?
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Team
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Table of Contents
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H+ [cytosol]
Stable Identifier
R-ALL-70106
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
proton, hydron
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
H+ [cytosol]
Drug ADME (Bos taurus)
Abacavir ADME (Bos taurus)
Abacavir metabolism (Bos taurus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)
H+ [cytosol]
Aspirin ADME (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Atorvastatin ADME (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Bos taurus)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
H+ [cytosol]
Azathioprine ADME (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Bos taurus)
H+ [cytosol]
Ciprofloxacin ADME (Bos taurus)
SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)
H+ [cytosol]
Paracetamol ADME (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
H+ [cytosol]
Prednisone ADME (Bos taurus)
AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)
H+ [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Bos taurus)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Bos taurus)
TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)
H+ [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
H+ [cytosol]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Reduction of cytosolic Ca++ levels (Bos taurus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
H+ [cytosol]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
OAS antiviral response (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
H+ [cytosol]
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
H+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
HV1-mediated H+ transfer (Bos taurus)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Bos taurus)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
H+ [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Bos taurus)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Bos taurus)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Bos taurus)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Bos taurus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Bos taurus)
H+ [cytosol]
Regulation of pyruvate metabolism (Bos taurus)
NEK1 phosphorylates ME1 (Bos taurus)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
Respiratory electron transport (Bos taurus)
Malate-aspartate shuttle (Bos taurus)
MDH1 reduces OA (Bos taurus)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Bos taurus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Bos taurus)
H+ [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
H+ [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Eicosanoids (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
H+ [cytosol]
Endogenous sterols (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Bos taurus)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Bos taurus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H+ [cytosol]
Vitamins (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H+ [cytosol]
Ethanol oxidation (Bos taurus)
ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
H+ [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Glucuronidation (Bos taurus)
Formation of the active cofactor, UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
H+ [cytosol]
Methylation (Bos taurus)
TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)
H+ [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
MIOX oxidises Ins to GlcA (Bos taurus)
H+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
SLC25A12,13 exchange L-Glu and L-Asp (Bos taurus)
H+ [cytosol]
Carnitine synthesis (Bos taurus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
H+ [cytosol]
Creatine metabolism (Bos taurus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
H+ [cytosol]
Glutamate and glutamine metabolism (Bos taurus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
H+ [cytosol]
Histidine catabolism (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
H+ [cytosol]
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Noradrenaline is converted to adrenaline (Bos taurus)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)
H+ [cytosol]
Thyroxine biosynthesis (Bos taurus)
Regulation of thyroid hormone activity (Bos taurus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Bos taurus)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
H+ [cytosol]
Tyrosine catabolism (Bos taurus)
FAH cleaves 4FAA (Bos taurus)
H+ [cytosol]
HGD dioxygenates homogentisate (Bos taurus)
H+ [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
H+ [cytosol]
Serine biosynthesis (Bos taurus)
PHGDH tetramer dehydrogenates 3PG (Bos taurus)
H+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)
H+ [cytosol]
Degradation of cysteine and homocysteine (Bos taurus)
ADO oxidises 2AET to HTAU (Bos taurus)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
H+ [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is created (Bos taurus)
H+ [cytosol]
Tryptophan catabolism (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
H+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)
H+ [cytosol]
Fructose metabolism (Bos taurus)
Fructose biosynthesis (Bos taurus)
AKR1B1 reduces Glc to D-sorbitol (Bos taurus)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Bos taurus)
H+ [cytosol]
Fructose catabolism (Bos taurus)
ALDH1A1 oxidises GA to DGA (Bos taurus)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
H+ [cytosol]
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)
H+ [cytosol]
Glycolysis (Bos taurus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Bos taurus)
H+ [cytosol]
Glycosaminoglycan metabolism (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Pentose phosphate pathway (Bos taurus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
H+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
Biosynthesis of maresins (Bos taurus)
Biosynthesis of maresin-like SPMs (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)
H+ [cytosol]
Biosynthesis of protectins (Bos taurus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Bos taurus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)
H+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Bos taurus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Bos taurus)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)
H+ [cytosol]
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
BDH2 dehydrogenates 3HBA (Bos taurus)
H+ [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H+ [cytosol]
Cholesterol biosynthesis (Bos taurus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Bos taurus)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Bos taurus)
DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Bos taurus)
H+ [cytosol]
Squalene is oxidized to its epoxide (Bos taurus)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)
H+ [cytosol]
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)
H+ [cytosol]
Estrogen biosynthesis (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Bos taurus)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)
H+ [cytosol]
Glucocorticoid biosynthesis (Bos taurus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Bos taurus)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
H+ [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)
H+ [cytosol]
Pregnenolone biosynthesis (Bos taurus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H+ [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PA (Bos taurus)
DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)
H+ [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid biosynthesis (Bos taurus)
CERK phosphorylates CERA to form C1P (Bos taurus)
H+ [cytosol]
Glycosphingolipid catabolism (Bos taurus)
ENPP7 hydrolyzes sphingomyelin (Bos taurus)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Bos taurus)
H+ [cytosol]
Sphingolipid catabolism (Bos taurus)
ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Bos taurus)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Bos taurus)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
H+ [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Bos taurus)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Bos taurus)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Bos taurus)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Bos taurus)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Bos taurus)
H+ [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Bos taurus)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Bos taurus)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Bos taurus)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Bos taurus)
Plasmalogen biosynthesis (Bos taurus)
DHRS7B reduces GO3P to HXDG3P (Bos taurus)
H+ [cytosol]
Wax biosynthesis (Bos taurus)
FAR1 reduces PalmCoA to HXOL (Bos taurus)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Bos taurus)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
CYGB dioxygenates NO (Bos taurus)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
H+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Bos taurus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
H+ [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
H+ [cytosol]
AIR + CO2 => CAIR (Bos taurus)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
H+ [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Bos taurus)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Bos taurus)
H+ [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Bos taurus)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Bos taurus)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Bos taurus)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Bos taurus)
H+ [cytosol]
Pyrimidine catabolism (Bos taurus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
H+ [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)
H+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Bos taurus)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Bos taurus)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Bos taurus)
H+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
NADPH regeneration (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)
H+ [cytosol]
MMACHC dealkylates RCbl (Bos taurus)
H+ [cytosol]
MMACHC decyanates CNCbl (Bos taurus)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
H+ [cytosol]
Metabolism of folate and pterines (Bos taurus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Bos taurus)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Bos taurus)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Bos taurus)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
H+ [cytosol]
Nicotinate metabolism (Bos taurus)
NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Bos taurus)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Bos taurus)
H+ [cytosol]
Nicotinamide salvaging (Bos taurus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
H+ [cytosol]
FLAD1 phosphorylates FMN (Bos taurus)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Bos taurus)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
2xPPCS ligates PPanK with Cys (Bos taurus)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Bos taurus)
H+ [cytosol]
COASY phosphorylates DP-CoA (Bos taurus)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Bos taurus)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Bos taurus)
H+ [cytosol]
PANK2 phosphorylates PanK (Bos taurus)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Bos taurus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Bos taurus)
H+ [cytosol]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
H+ [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)
H+ [cytosol]
Sialic acid metabolism (Bos taurus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Bos taurus)
Synthesis of glycosylphosphatidylinositol (GPI) (Bos taurus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)
H+ [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
H+ [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
Acetylcholine Neurotransmitter Release Cycle (Bos taurus)
Loading of acetylcholine in synaptic vesicles (Bos taurus)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Bos taurus)
GABA synthesis (Bos taurus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)
H+ [cytosol]
Synthesis of GABA by GAD2 (Bos taurus)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Bos taurus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)
H+ [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Bos taurus)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Bos taurus)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Bos taurus)
atRAL is reduced to atROL (Bos taurus)
H+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H+ [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Bos taurus)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Bos taurus)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor recycling (Bos taurus)
Endosome acidification (Bos taurus)
H+ [cytosol]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)
H+ [cytosol]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
H+ [cytosol]
Stimuli-sensing channels (Bos taurus)
CLCN4/5/6 exchange Cl- for H+ (Bos taurus)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Bos taurus)
H+ [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
H+ [cytosol]
Miscellaneous transport and binding events (Bos taurus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Bos taurus)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)
H+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Inositol transporters (Bos taurus)
HMIT co-transports myo-inositol with a proton (Bos taurus)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Bos taurus)
H+ [cytosol]
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Bos taurus)
Organic cation transport (Bos taurus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Bos taurus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Bos taurus)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Bos taurus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Amino acid transport across the plasma membrane (Bos taurus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)
H+ [cytosol]
Bicarbonate transporters (Bos taurus)
Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)
H+ [cytosol]
Multifunctional anion exchangers (Bos taurus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Organic anion transporters (Bos taurus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Bos taurus)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Bos taurus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Proton/oligopeptide cotransporters (Bos taurus)
Proton-coupled di- and tri-peptide cotransport (Bos taurus)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Bos taurus)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)
H+ [cytosol]
Sodium/Proton exchangers (Bos taurus)
Na+/H+ exchanger transport (at cell membrane) (Bos taurus)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Bos taurus)
H+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
Drug ADME (Caenorhabditis elegans)
Abacavir ADME (Caenorhabditis elegans)
Abacavir metabolism (Caenorhabditis elegans)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)
H+ [cytosol]
Aspirin ADME (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Atorvastatin ADME (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
H+ [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
H+ [cytosol]
Ciprofloxacin ADME (Caenorhabditis elegans)
SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)
H+ [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
H+ [cytosol]
Prednisone ADME (Caenorhabditis elegans)
AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)
H+ [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
H+ [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Reduction of cytosolic Ca++ levels (Caenorhabditis elegans)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
H+ [cytosol]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
OAS antiviral response (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
H+ [cytosol]
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
H+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
H+ [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Caenorhabditis elegans)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Caenorhabditis elegans)
Respiratory electron transport (Caenorhabditis elegans)
Malate-aspartate shuttle (Caenorhabditis elegans)
MDH1 reduces OA (Caenorhabditis elegans)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Caenorhabditis elegans)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)
H+ [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
H+ [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Endogenous sterols (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H+ [cytosol]
Vitamins (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H+ [cytosol]
Ethanol oxidation (Caenorhabditis elegans)
ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
H+ [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Glucuronidation (Caenorhabditis elegans)
Formation of the active cofactor, UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
H+ [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
SLC25A12,13 exchange L-Glu and L-Asp (Caenorhabditis elegans)
H+ [cytosol]
Carnitine synthesis (Caenorhabditis elegans)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
H+ [cytosol]
Histidine catabolism (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Noradrenaline is converted to adrenaline (Caenorhabditis elegans)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
H+ [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
FAH cleaves 4FAA (Caenorhabditis elegans)
H+ [cytosol]
HGD dioxygenates homogentisate (Caenorhabditis elegans)
H+ [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
H+ [cytosol]
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
H+ [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)
H+ [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
H+ [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is created (Caenorhabditis elegans)
H+ [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
AKR1A1 reduces D-glucuronate to L-gulonate (Caenorhabditis elegans)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)
H+ [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose biosynthesis (Caenorhabditis elegans)
AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)
H+ [cytosol]
Fructose catabolism (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)
H+ [cytosol]
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)
H+ [cytosol]
Glycolysis (Caenorhabditis elegans)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)
H+ [cytosol]
Glycosaminoglycan metabolism (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of maresins (Caenorhabditis elegans)
Biosynthesis of maresin-like SPMs (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
H+ [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Caenorhabditis elegans)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Caenorhabditis elegans)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)
H+ [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Caenorhabditis elegans)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Caenorhabditis elegans)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Caenorhabditis elegans)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Caenorhabditis elegans)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Caenorhabditis elegans)
DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of steroid hormones (Caenorhabditis elegans)
Androgen biosynthesis (Caenorhabditis elegans)
HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
H+ [cytosol]
Estrogen biosynthesis (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
H+ [cytosol]
Pregnenolone biosynthesis (Caenorhabditis elegans)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H+ [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PA (Caenorhabditis elegans)
DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)
H+ [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid biosynthesis (Caenorhabditis elegans)
CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
H+ [cytosol]
Glycosphingolipid catabolism (Caenorhabditis elegans)
ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Caenorhabditis elegans)
H+ [cytosol]
Sphingolipid catabolism (Caenorhabditis elegans)
ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
H+ [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Caenorhabditis elegans)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Caenorhabditis elegans)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Caenorhabditis elegans)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Caenorhabditis elegans)
H+ [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Caenorhabditis elegans)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Caenorhabditis elegans)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Caenorhabditis elegans)
Plasmalogen biosynthesis (Caenorhabditis elegans)
DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)
H+ [cytosol]
Wax biosynthesis (Caenorhabditis elegans)
FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
CYGB dioxygenates NO (Caenorhabditis elegans)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
H+ [cytosol]
AIR + CO2 => CAIR (Caenorhabditis elegans)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
H+ [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)
H+ [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
H+ [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
H+ [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
NADPH regeneration (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)
H+ [cytosol]
MMACHC dealkylates RCbl (Caenorhabditis elegans)
H+ [cytosol]
MMACHC decyanates CNCbl (Caenorhabditis elegans)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
H+ [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinamide salvaging (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
H+ [cytosol]
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
Coenzyme A biosynthesis (Caenorhabditis elegans)
2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)
H+ [cytosol]
COASY phosphorylates DP-CoA (Caenorhabditis elegans)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)
H+ [cytosol]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
H+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)
H+ [cytosol]
Sialic acid metabolism (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
H+ [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
H+ [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
Acetylcholine Neurotransmitter Release Cycle (Caenorhabditis elegans)
Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Caenorhabditis elegans)
GABA synthesis (Caenorhabditis elegans)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)
H+ [cytosol]
Synthesis of GABA by GAD2 (Caenorhabditis elegans)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Caenorhabditis elegans)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)
H+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Caenorhabditis elegans)
atRAL is reduced to atROL (Caenorhabditis elegans)
H+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H+ [cytosol]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor recycling (Caenorhabditis elegans)
Endosome acidification (Caenorhabditis elegans)
H+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
H+ [cytosol]
Stimuli-sensing channels (Caenorhabditis elegans)
CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)
H+ [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
H+ [cytosol]
Miscellaneous transport and binding events (Caenorhabditis elegans)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Caenorhabditis elegans)
Erythrocytes take up carbon dioxide and release oxygen (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
H+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Inositol transporters (Caenorhabditis elegans)
HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)
H+ [cytosol]
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic cation transport (Caenorhabditis elegans)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Caenorhabditis elegans)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Caenorhabditis elegans)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Caenorhabditis elegans)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Amino acid transport across the plasma membrane (Caenorhabditis elegans)
SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Bicarbonate transporters (Caenorhabditis elegans)
Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Multifunctional anion exchangers (Caenorhabditis elegans)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Organic anion transporters (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Caenorhabditis elegans)
SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Proton/oligopeptide cotransporters (Caenorhabditis elegans)
Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
H+ [cytosol]
Sodium/Proton exchangers (Caenorhabditis elegans)
Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Caenorhabditis elegans)
H+ [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
H+ [cytosol]
Drug ADME (Canis familiaris)
Abacavir ADME (Canis familiaris)
Abacavir metabolism (Canis familiaris)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)
H+ [cytosol]
Aspirin ADME (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Atorvastatin ADME (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
H+ [cytosol]
Azathioprine ADME (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Canis familiaris)
H+ [cytosol]
Ciprofloxacin ADME (Canis familiaris)
SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)
H+ [cytosol]
Paracetamol ADME (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
H+ [cytosol]
Prednisone ADME (Canis familiaris)
CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)
H+ [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Canis familiaris)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Canis familiaris)
TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)
H+ [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
H+ [cytosol]
Platelet homeostasis (Canis familiaris)
Platelet calcium homeostasis (Canis familiaris)
Reduction of cytosolic Ca++ levels (Canis familiaris)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
H+ [cytosol]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
OAS antiviral response (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
H+ [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
H+ [cytosol]
ROS and RNS production in phagocytes (Canis familiaris)
HV1-mediated H+ transfer (Canis familiaris)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Canis familiaris)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
H+ [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Canis familiaris)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Canis familiaris)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Canis familiaris)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Canis familiaris)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Canis familiaris)
H+ [cytosol]
Regulation of pyruvate metabolism (Canis familiaris)
NEK1 phosphorylates ME1 (Canis familiaris)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Canis familiaris)
Respiratory electron transport (Canis familiaris)
Malate-aspartate shuttle (Canis familiaris)
MDH1 reduces OA (Canis familiaris)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Canis familiaris)
H+ [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
H+ [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Eicosanoids (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
H+ [cytosol]
Endogenous sterols (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H+ [cytosol]
Vitamins (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H+ [cytosol]
Ethanol oxidation (Canis familiaris)
ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
H+ [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Glucuronidation (Canis familiaris)
Formation of the active cofactor, UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
H+ [cytosol]
Methylation (Canis familiaris)
TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)
H+ [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
MIOX oxidises Ins to GlcA (Canis familiaris)
H+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)
H+ [cytosol]
Carnitine synthesis (Canis familiaris)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
H+ [cytosol]
Creatine metabolism (Canis familiaris)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)
H+ [cytosol]
Glutamate and glutamine metabolism (Canis familiaris)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
H+ [cytosol]
Histidine catabolism (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
H+ [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Noradrenaline is converted to adrenaline (Canis familiaris)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)
H+ [cytosol]
Thyroxine biosynthesis (Canis familiaris)
Regulation of thyroid hormone activity (Canis familiaris)
Thyroxine is deiodinated to triiodothyronine (Canis familiaris)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
H+ [cytosol]
Tyrosine catabolism (Canis familiaris)
FAH cleaves 4FAA (Canis familiaris)
H+ [cytosol]
HGD dioxygenates homogentisate (Canis familiaris)
H+ [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Selenocysteine synthesis (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
H+ [cytosol]
Serine biosynthesis (Canis familiaris)
PHGDH tetramer dehydrogenates 3PG (Canis familiaris)
H+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)
H+ [cytosol]
Degradation of cysteine and homocysteine (Canis familiaris)
ADO oxidises 2AET to HTAU (Canis familiaris)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
H+ [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is created (Canis familiaris)
H+ [cytosol]
Tryptophan catabolism (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
H+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Formation of xylulose-5-phosphate (Canis familiaris)
AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)
H+ [cytosol]
Fructose metabolism (Canis familiaris)
Fructose biosynthesis (Canis familiaris)
AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Canis familiaris)
H+ [cytosol]
Fructose catabolism (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)
H+ [cytosol]
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)
H+ [cytosol]
Glycolysis (Canis familiaris)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Canis familiaris)
H+ [cytosol]
Glycosaminoglycan metabolism (Canis familiaris)
Transport and synthesis of PAPS (Canis familiaris)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Pentose phosphate pathway (Canis familiaris)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
H+ [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
Biosynthesis of maresins (Canis familiaris)
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Canis familiaris)
LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)
H+ [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
PGE2 is converted to PGF2a by CBR1 (Canis familiaris)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)
H+ [cytosol]
Ketone body metabolism (Canis familiaris)
Synthesis of Ketone Bodies (Canis familiaris)
BDH2 dehydrogenates 3HBA (Canis familiaris)
H+ [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H+ [cytosol]
Cholesterol biosynthesis (Canis familiaris)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Canis familiaris)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Canis familiaris)
DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
H+ [cytosol]
Squalene is oxidized to its epoxide (Canis familiaris)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)
H+ [cytosol]
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)
H+ [cytosol]
Estrogen biosynthesis (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
H+ [cytosol]
Glucocorticoid biosynthesis (Canis familiaris)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Canis familiaris)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
H+ [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)
H+ [cytosol]
Pregnenolone biosynthesis (Canis familiaris)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H+ [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Synthesis of PA (Canis familiaris)
DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)
H+ [cytosol]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid biosynthesis (Canis familiaris)
CERK phosphorylates CERA to form C1P (Canis familiaris)
H+ [cytosol]
Glycosphingolipid catabolism (Canis familiaris)
ENPP7 hydrolyzes sphingomyelin (Canis familiaris)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Canis familiaris)
H+ [cytosol]
Sphingolipid catabolism (Canis familiaris)
ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Canis familiaris)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Canis familiaris)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Canis familiaris)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Canis familiaris)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Canis familiaris)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Canis familiaris)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Canis familiaris)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Canis familiaris)
Plasmalogen biosynthesis (Canis familiaris)
DHRS7B reduces GO3P to HXDG3P (Canis familiaris)
H+ [cytosol]
Wax biosynthesis (Canis familiaris)
FAR1 reduces PalmCoA to HXOL (Canis familiaris)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Canis familiaris)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
CYGB dioxygenates NO (Canis familiaris)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
H+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
H+ [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)
H+ [cytosol]
AIR + CO2 => CAIR (Canis familiaris)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Canis familiaris)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Canis familiaris)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
H+ [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Canis familiaris)
H+ [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Canis familiaris)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Canis familiaris)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Canis familiaris)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Canis familiaris)
H+ [cytosol]
Pyrimidine catabolism (Canis familiaris)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
H+ [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)
H+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Canis familiaris)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Canis familiaris)
H+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
NADPH regeneration (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)
H+ [cytosol]
MMACHC dealkylates RCbl (Canis familiaris)
H+ [cytosol]
MMACHC decyanates CNCbl (Canis familiaris)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
H+ [cytosol]
Metabolism of folate and pterines (Canis familiaris)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Canis familiaris)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Canis familiaris)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
H+ [cytosol]
Nicotinate metabolism (Canis familiaris)
NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Canis familiaris)
H+ [cytosol]
Nicotinamide salvaging (Canis familiaris)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
H+ [cytosol]
FLAD1 phosphorylates FMN (Canis familiaris)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Canis familiaris)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
Coenzyme A biosynthesis (Canis familiaris)
2xPPCS ligates PPanK with Cys (Canis familiaris)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)
H+ [cytosol]
COASY phosphorylates DP-CoA (Canis familiaris)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Canis familiaris)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Canis familiaris)
H+ [cytosol]
PANK2 phosphorylates PanK (Canis familiaris)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Canis familiaris)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)
H+ [cytosol]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
H+ [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)
H+ [cytosol]
Sialic acid metabolism (Canis familiaris)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
H+ [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
H+ [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
Acetylcholine Neurotransmitter Release Cycle (Canis familiaris)
Loading of acetylcholine in synaptic vesicles (Canis familiaris)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Canis familiaris)
GABA synthesis (Canis familiaris)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)
H+ [cytosol]
Synthesis of GABA by GAD2 (Canis familiaris)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Canis familiaris)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)
H+ [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Canis familiaris)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Canis familiaris)
atRAL is reduced to atROL (Canis familiaris)
H+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H+ [cytosol]
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Canis familiaris)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor recycling (Canis familiaris)
Endosome acidification (Canis familiaris)
H+ [cytosol]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
H+ [cytosol]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
H+ [cytosol]
Stimuli-sensing channels (Canis familiaris)
CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)
H+ [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
H+ [cytosol]
Miscellaneous transport and binding events (Canis familiaris)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Canis familiaris)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)
H+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Inositol transporters (Canis familiaris)
HMIT co-transports myo-inositol with a proton (Canis familiaris)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Canis familiaris)
H+ [cytosol]
Metal ion SLC transporters (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic cation transport (Canis familiaris)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Canis familiaris)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Canis familiaris)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Canis familiaris)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Amino acid transport across the plasma membrane (Canis familiaris)
SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)
H+ [cytosol]
Bicarbonate transporters (Canis familiaris)
Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)
H+ [cytosol]
Multifunctional anion exchangers (Canis familiaris)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Organic anion transporters (Canis familiaris)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Canis familiaris)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Canis familiaris)
SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Proton/oligopeptide cotransporters (Canis familiaris)
Proton-coupled di- and tri-peptide cotransport (Canis familiaris)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Canis familiaris)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)
H+ [cytosol]
Sodium/Proton exchangers (Canis familiaris)
Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Canis familiaris)
H+ [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
H+ [cytosol]
Drug ADME (Danio rerio)
Abacavir ADME (Danio rerio)
Abacavir metabolism (Danio rerio)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)
H+ [cytosol]
Atorvastatin ADME (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
H+ [cytosol]
Azathioprine ADME (Danio rerio)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
H+ [cytosol]
Ciprofloxacin ADME (Danio rerio)
SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)
H+ [cytosol]
Paracetamol ADME (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
H+ [cytosol]
Prednisone ADME (Danio rerio)
CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)
H+ [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
ABCC4 accumulation of dense granule contents (Danio rerio)
H+ [cytosol]
Platelet homeostasis (Danio rerio)
Platelet calcium homeostasis (Danio rerio)
Reduction of cytosolic Ca++ levels (Danio rerio)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)
H+ [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
H+ [cytosol]
ROS and RNS production in phagocytes (Danio rerio)
HV1-mediated H+ transfer (Danio rerio)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Danio rerio)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
H+ [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Danio rerio)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Danio rerio)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Danio rerio)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Danio rerio)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Danio rerio)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Danio rerio)
Respiratory electron transport (Danio rerio)
Malate-aspartate shuttle (Danio rerio)
MDH1 reduces OA (Danio rerio)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Danio rerio)
H+ [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
H+ [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
H+ [cytosol]
Endogenous sterols (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Danio rerio)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H+ [cytosol]
Vitamins (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H+ [cytosol]
Ethanol oxidation (Danio rerio)
ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
H+ [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Cytosolic sulfonation of small molecules (Danio rerio)
Transport and synthesis of PAPS (Danio rerio)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Glucuronidation (Danio rerio)
Formation of the active cofactor, UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
H+ [cytosol]
Methylation (Danio rerio)
TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)
H+ [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
MIOX oxidises Ins to GlcA (Danio rerio)
H+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Aspartate and asparagine metabolism (Danio rerio)
SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)
H+ [cytosol]
Carnitine synthesis (Danio rerio)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
H+ [cytosol]
Creatine metabolism (Danio rerio)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
H+ [cytosol]
Glutamate and glutamine metabolism (Danio rerio)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
H+ [cytosol]
Histidine catabolism (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
H+ [cytosol]
Metabolism of amine-derived hormones (Danio rerio)
Serotonin and melatonin biosynthesis (Danio rerio)
Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
H+ [cytosol]
Tyrosine catabolism (Danio rerio)
HGD dioxygenates homogentisate (Danio rerio)
H+ [cytosol]
Selenoamino acid metabolism (Danio rerio)
Selenocysteine synthesis (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
H+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)
H+ [cytosol]
Degradation of cysteine and homocysteine (Danio rerio)
ADO oxidises 2AET to HTAU (Danio rerio)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
H+ [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is created (Danio rerio)
H+ [cytosol]
Tryptophan catabolism (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
H+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Formation of xylulose-5-phosphate (Danio rerio)
AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)
H+ [cytosol]
Fructose metabolism (Danio rerio)
Fructose biosynthesis (Danio rerio)
AKR1B1 reduces Glc to D-sorbitol (Danio rerio)
H+ [cytosol]
Fructose catabolism (Danio rerio)
GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)
H+ [cytosol]
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)
H+ [cytosol]
Glycolysis (Danio rerio)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Danio rerio)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Danio rerio)
H+ [cytosol]
Glycosaminoglycan metabolism (Danio rerio)
Transport and synthesis of PAPS (Danio rerio)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Pentose phosphate pathway (Danio rerio)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)
H+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
Biosynthesis of maresins (Danio rerio)
Biosynthesis of maresin-like SPMs (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)
H+ [cytosol]
Biosynthesis of protectins (Danio rerio)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Danio rerio)
LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)
H+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)
PGE2 is converted to PGF2a by CBR1 (Danio rerio)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Danio rerio)
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Danio rerio)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)
H+ [cytosol]
Ketone body metabolism (Danio rerio)
Synthesis of Ketone Bodies (Danio rerio)
BDH2 dehydrogenates 3HBA (Danio rerio)
H+ [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H+ [cytosol]
Cholesterol biosynthesis (Danio rerio)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Danio rerio)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Danio rerio)
DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)
H+ [cytosol]
Squalene is oxidized to its epoxide (Danio rerio)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)
H+ [cytosol]
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)
H+ [cytosol]
Estrogen biosynthesis (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)
H+ [cytosol]
Glucocorticoid biosynthesis (Danio rerio)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
H+ [cytosol]
Mineralocorticoid biosynthesis (Danio rerio)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)
H+ [cytosol]
Pregnenolone biosynthesis (Danio rerio)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H+ [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Synthesis of PA (Danio rerio)
DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)
H+ [cytosol]
Sphingolipid metabolism (Danio rerio)
Glycosphingolipid metabolism (Danio rerio)
Glycosphingolipid catabolism (Danio rerio)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Danio rerio)
H+ [cytosol]
Sphingolipid catabolism (Danio rerio)
ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Danio rerio)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Danio rerio)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Danio rerio)
CSNK1G2 phosphorylates p-CERT1-2 (Danio rerio)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Danio rerio)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Danio rerio)
H+ [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Danio rerio)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Danio rerio)
Plasmalogen biosynthesis (Danio rerio)
DHRS7B reduces GO3P to HXDG3P (Danio rerio)
H+ [cytosol]
Wax biosynthesis (Danio rerio)
FAR2 reduces PalmCoA to HXOL (Danio rerio)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
eNOS activation (Danio rerio)
CYGB dioxygenates NO (Danio rerio)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
H+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Danio rerio)
H+ [cytosol]
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)
H+ [cytosol]
AIR + CO2 => CAIR (Danio rerio)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Danio rerio)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
H+ [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Danio rerio)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Danio rerio)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Danio rerio)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
H+ [cytosol]
Pyrimidine catabolism (Danio rerio)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
H+ [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)
H+ [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ALAD condenses 2 dALAs to form PBG (Danio rerio)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Danio rerio)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Danio rerio)
H+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
NADPH regeneration (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Danio rerio)
Cobalamin (Cbl) metabolism (Danio rerio)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)
H+ [cytosol]
MMACHC dealkylates RCbl (Danio rerio)
H+ [cytosol]
MMACHC decyanates CNCbl (Danio rerio)
H+ [cytosol]
Metabolism of folate and pterines (Danio rerio)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Danio rerio)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Danio rerio)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Danio rerio)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
H+ [cytosol]
Nicotinate metabolism (Danio rerio)
NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Danio rerio)
H+ [cytosol]
Nicotinamide salvaging (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
H+ [cytosol]
FLAD1 phosphorylates FMN (Danio rerio)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Danio rerio)
Coenzyme A biosynthesis (Danio rerio)
2xPPCS ligates PPanK with Cys (Danio rerio)
H+ [cytosol]
COASY phosphorylates DP-CoA (Danio rerio)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Danio rerio)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Danio rerio)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Danio rerio)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)
H+ [cytosol]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
H+ [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
GDP-fucose biosynthesis (Danio rerio)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)
H+ [cytosol]
Sialic acid metabolism (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
H+ [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
H+ [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter release cycle (Danio rerio)
Acetylcholine Neurotransmitter Release Cycle (Danio rerio)
Loading of acetylcholine in synaptic vesicles (Danio rerio)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Danio rerio)
GABA synthesis (Danio rerio)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Danio rerio)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)
H+ [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Danio rerio)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Danio rerio)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Danio rerio)
atRAL is reduced to atROL (Danio rerio)
H+ [cytosol]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H+ [cytosol]
Signaling by Nuclear Receptors (Danio rerio)
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Danio rerio)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor recycling (Danio rerio)
Endosome acidification (Danio rerio)
H+ [cytosol]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate NADPH Oxidases (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)
H+ [cytosol]
Transport of small molecules (Danio rerio)
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)
H+ [cytosol]
Stimuli-sensing channels (Danio rerio)
CLCN4/5/6 exchange Cl- for H+ (Danio rerio)
H+ [cytosol]
Iron uptake and transport (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Transferrin endocytosis and recycling (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
H+ [cytosol]
Miscellaneous transport and binding events (Danio rerio)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Danio rerio)
Erythrocytes take up carbon dioxide and release oxygen (Danio rerio)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Danio rerio)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Danio rerio)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)
H+ [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
MATEs mediate extrusion of xenobiotics (Danio rerio)
H+ [cytosol]
Metal ion SLC transporters (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Danio rerio)
Organic cation transport (Danio rerio)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Danio rerio)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Danio rerio)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Amino acid transport across the plasma membrane (Danio rerio)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)
H+ [cytosol]
Multifunctional anion exchangers (Danio rerio)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Organic anion transporters (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Danio rerio)
H+ [cytosol]
Proton/oligopeptide cotransporters (Danio rerio)
Proton-coupled di- and tri-peptide cotransport (Danio rerio)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)
H+ [cytosol]
Sodium/Proton exchangers (Danio rerio)
Na+/H+ exchanger transport (at cell membrane) (Danio rerio)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Danio rerio)
H+ [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
H+ [cytosol]
Drug ADME (Dictyostelium discoideum)
Abacavir ADME (Dictyostelium discoideum)
Abacavir metabolism (Dictyostelium discoideum)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)
H+ [cytosol]
Atorvastatin ADME (Dictyostelium discoideum)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Dictyostelium discoideum)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Dictyostelium discoideum)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
H+ [cytosol]
Azathioprine ADME (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
H+ [cytosol]
Paracetamol ADME (Dictyostelium discoideum)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
H+ [cytosol]
Prednisone ADME (Dictyostelium discoideum)
AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Dictyostelium discoideum)
H+ [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Dictyostelium discoideum)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Dictyostelium discoideum)
TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)
H+ [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
H+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Antimicrobial peptides (Dictyostelium discoideum)
Ion influx/efflux at host-pathogen interface (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
H+ [cytosol]
ROS and RNS production in phagocytes (Dictyostelium discoideum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
H+ [cytosol]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Dictyostelium discoideum)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Dictyostelium discoideum)
Respiratory electron transport (Dictyostelium discoideum)
Malate-aspartate shuttle (Dictyostelium discoideum)
MDH1 reduces OA (Dictyostelium discoideum)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Dictyostelium discoideum)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)
H+ [cytosol]
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
H+ [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H+ [cytosol]
Vitamins (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H+ [cytosol]
Ethanol oxidation (Dictyostelium discoideum)
ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
H+ [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Cytosolic sulfonation of small molecules (Dictyostelium discoideum)
Transport and synthesis of PAPS (Dictyostelium discoideum)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Aspartate and asparagine metabolism (Dictyostelium discoideum)
SLC25A12,13 exchange L-Glu and L-Asp (Dictyostelium discoideum)
H+ [cytosol]
Glutamate and glutamine metabolism (Dictyostelium discoideum)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
H+ [cytosol]
Histidine catabolism (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)
H+ [cytosol]
Thyroxine biosynthesis (Dictyostelium discoideum)
Regulation of thyroid hormone activity (Dictyostelium discoideum)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
H+ [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
FAH cleaves 4FAA (Dictyostelium discoideum)
H+ [cytosol]
HGD dioxygenates homogentisate (Dictyostelium discoideum)
H+ [cytosol]
Selenoamino acid metabolism (Dictyostelium discoideum)
Selenocysteine synthesis (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
H+ [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
H+ [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is created (Dictyostelium discoideum)
H+ [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Formation of xylulose-5-phosphate (Dictyostelium discoideum)
AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)
H+ [cytosol]
Fructose metabolism (Dictyostelium discoideum)
Fructose biosynthesis (Dictyostelium discoideum)
AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)
H+ [cytosol]
Fructose catabolism (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)
H+ [cytosol]
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)
H+ [cytosol]
Glycolysis (Dictyostelium discoideum)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Dictyostelium discoideum)
H+ [cytosol]
Glycosaminoglycan metabolism (Dictyostelium discoideum)
Transport and synthesis of PAPS (Dictyostelium discoideum)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Pentose phosphate pathway (Dictyostelium discoideum)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of maresins (Dictyostelium discoideum)
Biosynthesis of maresin-like SPMs (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Dictyostelium discoideum)
H+ [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Dictyostelium discoideum)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Dictyostelium discoideum)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Dictyostelium discoideum)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Dictyostelium discoideum)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Dictyostelium discoideum)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Dictyostelium discoideum)
H+ [cytosol]
Cholesterol biosynthesis (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
H+ [cytosol]
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of steroid hormones (Dictyostelium discoideum)
Androgen biosynthesis (Dictyostelium discoideum)
HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)
H+ [cytosol]
Estrogen biosynthesis (Dictyostelium discoideum)
HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)
H+ [cytosol]
Glucocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)
H+ [cytosol]
Mineralocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H+ [cytosol]
Pregnenolone biosynthesis (Dictyostelium discoideum)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Dictyostelium discoideum)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H+ [cytosol]
Sphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid catabolism (Dictyostelium discoideum)
ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)
H+ [cytosol]
Sphingolipid catabolism (Dictyostelium discoideum)
ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Dictyostelium discoideum)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Dictyostelium discoideum)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Dictyostelium discoideum)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Dictyostelium discoideum)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Dictyostelium discoideum)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Dictyostelium discoideum)
Wax biosynthesis (Dictyostelium discoideum)
FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
H+ [cytosol]
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
H+ [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)
H+ [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
H+ [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
NADPH regeneration (Dictyostelium discoideum)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)
H+ [cytosol]
MMACHC dealkylates RCbl (Dictyostelium discoideum)
H+ [cytosol]
MMACHC decyanates CNCbl (Dictyostelium discoideum)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of folate and pterines (Dictyostelium discoideum)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)
H+ [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NMRK1 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Dictyostelium discoideum)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Dictyostelium discoideum)
H+ [cytosol]
Nicotinamide salvaging (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
H+ [cytosol]
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
Coenzyme A biosynthesis (Dictyostelium discoideum)
2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)
H+ [cytosol]
COASY phosphorylates DP-CoA (Dictyostelium discoideum)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Dictyostelium discoideum)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Dictyostelium discoideum)
H+ [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
GDP-fucose biosynthesis (Dictyostelium discoideum)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)
H+ [cytosol]
Sialic acid metabolism (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
H+ [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (q) signalling events (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H+ [cytosol]
Signaling by Nuclear Receptors (Dictyostelium discoideum)
Signaling by Retinoic Acid (Dictyostelium discoideum)
RA biosynthesis pathway (Dictyostelium discoideum)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor recycling (Dictyostelium discoideum)
Endosome acidification (Dictyostelium discoideum)
H+ [cytosol]
Transport of small molecules (Dictyostelium discoideum)
Ion channel transport (Dictyostelium discoideum)
Stimuli-sensing channels (Dictyostelium discoideum)
CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)
H+ [cytosol]
Iron uptake and transport (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
H+ [cytosol]
Miscellaneous transport and binding events (Dictyostelium discoideum)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
H+ [cytosol]
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Inositol transporters (Dictyostelium discoideum)
HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)
H+ [cytosol]
Metal ion SLC transporters (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Dictyostelium discoideum)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Amino acid transport across the plasma membrane (Dictyostelium discoideum)
SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Multifunctional anion exchangers (Dictyostelium discoideum)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Organic anion transporters (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Dictyostelium discoideum)
SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)
H+ [cytosol]
Proton/oligopeptide cotransporters (Dictyostelium discoideum)
Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)
H+ [cytosol]
Sodium/Proton exchangers (Dictyostelium discoideum)
Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Dictyostelium discoideum)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Dictyostelium discoideum)
H+ [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Drosophila melanogaster)
SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)
H+ [cytosol]
Drug ADME (Drosophila melanogaster)
Abacavir ADME (Drosophila melanogaster)
Abacavir metabolism (Drosophila melanogaster)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)
H+ [cytosol]
Aspirin ADME (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Azathioprine ADME (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
H+ [cytosol]
Ciprofloxacin ADME (Drosophila melanogaster)
SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)
H+ [cytosol]
Paracetamol ADME (Drosophila melanogaster)
CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)
H+ [cytosol]
Prednisone ADME (Drosophila melanogaster)
AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)
H+ [cytosol]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)
H+ [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
H+ [cytosol]
Platelet homeostasis (Drosophila melanogaster)
Platelet calcium homeostasis (Drosophila melanogaster)
Reduction of cytosolic Ca++ levels (Drosophila melanogaster)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)
H+ [cytosol]
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
OAS antiviral response (Drosophila melanogaster)
PDE12 cleaves 2'-5' oligoadenylates (Drosophila melanogaster)
H+ [cytosol]
Innate Immune System (Drosophila melanogaster)
Antimicrobial peptides (Drosophila melanogaster)
Ion influx/efflux at host-pathogen interface (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
H+ [cytosol]
ROS and RNS production in phagocytes (Drosophila melanogaster)
Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
H+ [cytosol]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Drosophila melanogaster)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Drosophila melanogaster)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Drosophila melanogaster)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Drosophila melanogaster)
Respiratory electron transport (Drosophila melanogaster)
Malate-aspartate shuttle (Drosophila melanogaster)
MDH1 reduces OA (Drosophila melanogaster)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)
H+ [cytosol]
Biological oxidations (Drosophila melanogaster)
Aflatoxin activation and detoxification (Drosophila melanogaster)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)
H+ [cytosol]
Phase I - Functionalization of compounds (Drosophila melanogaster)
ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Drosophila melanogaster)
Endogenous sterols (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H+ [cytosol]
Vitamins (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H+ [cytosol]
Ethanol oxidation (Drosophila melanogaster)
ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
H+ [cytosol]
Phase II - Conjugation of compounds (Drosophila melanogaster)
Cytosolic sulfonation of small molecules (Drosophila melanogaster)
Transport and synthesis of PAPS (Drosophila melanogaster)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Glucuronidation (Drosophila melanogaster)
Formation of the active cofactor, UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
H+ [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
H+ [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Aspartate and asparagine metabolism (Drosophila melanogaster)
SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
H+ [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
FAH cleaves 4FAA (Drosophila melanogaster)
H+ [cytosol]
HGD dioxygenates homogentisate (Drosophila melanogaster)
H+ [cytosol]
Selenoamino acid metabolism (Drosophila melanogaster)
Selenocysteine synthesis (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
H+ [cytosol]
Serine biosynthesis (Drosophila melanogaster)
PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)
H+ [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
ADO oxidises 2AET to HTAU (Drosophila melanogaster)
H+ [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is created (Drosophila melanogaster)
H+ [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
H+ [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Formation of xylulose-5-phosphate (Drosophila melanogaster)
AKR1A1 reduces D-glucuronate to L-gulonate (Drosophila melanogaster)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)
H+ [cytosol]
Fructose metabolism (Drosophila melanogaster)
Fructose biosynthesis (Drosophila melanogaster)
AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)
H+ [cytosol]
Fructose catabolism (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)
H+ [cytosol]
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)
H+ [cytosol]
Glycolysis (Drosophila melanogaster)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Drosophila melanogaster)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Drosophila melanogaster)
H+ [cytosol]
Glycosaminoglycan metabolism (Drosophila melanogaster)
Transport and synthesis of PAPS (Drosophila melanogaster)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Pentose phosphate pathway (Drosophila melanogaster)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)
H+ [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Biosynthesis of specialized proresolving mediators (SPMs) (Drosophila melanogaster)
Biosynthesis of DHA-derived SPMs (Drosophila melanogaster)
Biosynthesis of maresins (Drosophila melanogaster)
Biosynthesis of maresin-like SPMs (Drosophila melanogaster)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Drosophila melanogaster)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Drosophila melanogaster)
LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)
H+ [cytosol]
Fatty acid metabolism (Drosophila melanogaster)
Arachidonic acid metabolism (Drosophila melanogaster)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Drosophila melanogaster)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Drosophila melanogaster)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)
H+ [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Drosophila melanogaster)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Drosophila melanogaster)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Drosophila melanogaster)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)
H+ [cytosol]
Cholesterol biosynthesis (Drosophila melanogaster)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
H+ [cytosol]
Metabolism of steroid hormones (Drosophila melanogaster)
Androgen biosynthesis (Drosophila melanogaster)
HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)
H+ [cytosol]
Estrogen biosynthesis (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)
H+ [cytosol]
Glucocorticoid biosynthesis (Drosophila melanogaster)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)
H+ [cytosol]
Pregnenolone biosynthesis (Drosophila melanogaster)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H+ [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Synthesis of PA (Drosophila melanogaster)
DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)
H+ [cytosol]
Sphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid biosynthesis (Drosophila melanogaster)
CERK phosphorylates CERA to form C1P (Drosophila melanogaster)
H+ [cytosol]
Glycosphingolipid catabolism (Drosophila melanogaster)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Drosophila melanogaster)
H+ [cytosol]
Sphingolipid catabolism (Drosophila melanogaster)
ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
H+ [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Drosophila melanogaster)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Drosophila melanogaster)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Drosophila melanogaster)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Drosophila melanogaster)
H+ [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Drosophila melanogaster)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Drosophila melanogaster)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Drosophila melanogaster)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Drosophila melanogaster)
Plasmalogen biosynthesis (Drosophila melanogaster)
DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)
H+ [cytosol]
Wax biosynthesis (Drosophila melanogaster)
FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
H+ [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
H+ [cytosol]
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)
H+ [cytosol]
AIR + CO2 => CAIR (Drosophila melanogaster)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
H+ [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)
H+ [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
H+ [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
H+ [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
H+ [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)
H+ [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
NADPH regeneration (Drosophila melanogaster)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Metabolism of folate and pterines (Drosophila melanogaster)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Drosophila melanogaster)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
H+ [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)
H+ [cytosol]
Nicotinamide salvaging (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Drosophila melanogaster)
Coenzyme A biosynthesis (Drosophila melanogaster)
2xPPCS ligates PPanK with Cys (Drosophila melanogaster)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Drosophila melanogaster)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Drosophila melanogaster)
H+ [cytosol]
PANK2 phosphorylates PanK (Drosophila melanogaster)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Drosophila melanogaster)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)
H+ [cytosol]
Reversible hydration of carbon dioxide (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
H+ [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
GDP-fucose biosynthesis (Drosophila melanogaster)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)
H+ [cytosol]
Sialic acid metabolism (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Hypusine synthesis from eIF5A-lysine (Drosophila melanogaster)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
H+ [cytosol]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Ion homeostasis (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
H+ [cytosol]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
Acetylcholine Neurotransmitter Release Cycle (Drosophila melanogaster)
Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
GABA synthesis (Drosophila melanogaster)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)
H+ [cytosol]
Synthesis of GABA by GAD2 (Drosophila melanogaster)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Drosophila melanogaster)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)
H+ [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Drosophila melanogaster)
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Drosophila melanogaster)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Drosophila melanogaster)
atRAL is reduced to atROL (Drosophila melanogaster)
H+ [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (q) signalling events (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H+ [cytosol]
Signaling by Nuclear Receptors (Drosophila melanogaster)
Signaling by Retinoic Acid (Drosophila melanogaster)
RA biosynthesis pathway (Drosophila melanogaster)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor recycling (Drosophila melanogaster)
Endosome acidification (Drosophila melanogaster)
H+ [cytosol]
Transport of small molecules (Drosophila melanogaster)
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)
H+ [cytosol]
Stimuli-sensing channels (Drosophila melanogaster)
CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)
H+ [cytosol]
Iron uptake and transport (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
H+ [cytosol]
Miscellaneous transport and binding events (Drosophila melanogaster)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Drosophila melanogaster)
Erythrocytes take up carbon dioxide and release oxygen (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
H+ [cytosol]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Drosophila melanogaster)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Drosophila melanogaster)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Drosophila melanogaster)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Drosophila melanogaster)
H+ [cytosol]
Bicarbonate transporters (Drosophila melanogaster)
Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
H+ [cytosol]
Multifunctional anion exchangers (Drosophila melanogaster)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Organic anion transporters (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Drosophila melanogaster)
SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Proton/oligopeptide cotransporters (Drosophila melanogaster)
Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)
H+ [cytosol]
Sodium/Proton exchangers (Drosophila melanogaster)
Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Drosophila melanogaster)
H+ [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
NOX2 generates superoxide from oxygen (Gallus gallus)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Gallus gallus)
Nuclear events mediated by NFE2L2 (Gallus gallus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Gallus gallus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)
H+ [cytosol]
Drug ADME (Gallus gallus)
Abacavir ADME (Gallus gallus)
Abacavir metabolism (Gallus gallus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)
H+ [cytosol]
Aspirin ADME (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Atorvastatin ADME (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
H+ [cytosol]
Azathioprine ADME (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Gallus gallus)
H+ [cytosol]
Ciprofloxacin ADME (Gallus gallus)
SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)
H+ [cytosol]
Paracetamol ADME (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
H+ [cytosol]
Prednisone ADME (Gallus gallus)
CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)
H+ [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Gallus gallus)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Gallus gallus)
TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)
H+ [cytosol]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Arachidonate production from DAG (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Gallus gallus)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
ABCC4 accumulation of dense granule contents (Gallus gallus)
H+ [cytosol]
Platelet homeostasis (Gallus gallus)
Platelet calcium homeostasis (Gallus gallus)
Reduction of cytosolic Ca++ levels (Gallus gallus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)
H+ [cytosol]
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Antiviral mechanism by IFN-stimulated genes (Gallus gallus)
OAS antiviral response (Gallus gallus)
PDE12 cleaves 2'-5' oligoadenylates (Gallus gallus)
H+ [cytosol]
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
H+ [cytosol]
ROS and RNS production in phagocytes (Gallus gallus)
HV1-mediated H+ transfer (Gallus gallus)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Gallus gallus)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
H+ [cytosol]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Pyruvate metabolism (Gallus gallus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Gallus gallus)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Gallus gallus)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Gallus gallus)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Gallus gallus)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Gallus gallus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Gallus gallus)
H+ [cytosol]
Regulation of pyruvate metabolism (Gallus gallus)
NEK1 phosphorylates ME1 (Gallus gallus)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Gallus gallus)
Respiratory electron transport (Gallus gallus)
Malate-aspartate shuttle (Gallus gallus)
MDH1 reduces OA (Gallus gallus)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Gallus gallus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Gallus gallus)
H+ [cytosol]
Biological oxidations (Gallus gallus)
Aflatoxin activation and detoxification (Gallus gallus)
AKR dimers reduce AFBDHO to AFBDOH (Gallus gallus)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)
H+ [cytosol]
Phase I - Functionalization of compounds (Gallus gallus)
ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Gallus gallus)
Endogenous sterols (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H+ [cytosol]
Vitamins (Gallus gallus)
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H+ [cytosol]
Ethanol oxidation (Gallus gallus)
ADH5 oxidises S-HMGSH to S-FGSH (Gallus gallus)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Gallus gallus)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)
H+ [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
Transport and synthesis of PAPS (Gallus gallus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Gallus gallus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Glucuronidation (Gallus gallus)
Formation of the active cofactor, UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
H+ [cytosol]
Methylation (Gallus gallus)
TPMT transfers CH3 from AdoMet to 6MP (Gallus gallus)
H+ [cytosol]
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
MIOX oxidises Ins to GlcA (Gallus gallus)
H+ [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Aspartate and asparagine metabolism (Gallus gallus)
SLC25A12,13 exchange L-Glu and L-Asp (Gallus gallus)
H+ [cytosol]
Carnitine synthesis (Gallus gallus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)
H+ [cytosol]
Creatine metabolism (Gallus gallus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)
H+ [cytosol]
Glutamate and glutamine metabolism (Gallus gallus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Gallus gallus)
H+ [cytosol]
Histidine catabolism (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)
H+ [cytosol]
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Noradrenaline is converted to adrenaline (Gallus gallus)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Methylation of N-acetyl-5-HT to form melatonin (Gallus gallus)
H+ [cytosol]
Thyroxine biosynthesis (Gallus gallus)
Regulation of thyroid hormone activity (Gallus gallus)
Thyroxine is deiodinated to triiodothyronine (Gallus gallus)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)
H+ [cytosol]
Tyrosine catabolism (Gallus gallus)
FAH cleaves 4FAA (Gallus gallus)
H+ [cytosol]
HGD dioxygenates homogentisate (Gallus gallus)
H+ [cytosol]
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
H+ [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Gallus gallus)
H+ [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is created (Gallus gallus)
H+ [cytosol]
Tryptophan catabolism (Gallus gallus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
H+ [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Formation of xylulose-5-phosphate (Gallus gallus)
AKR1A1 reduces D-glucuronate to L-gulonate (Gallus gallus)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Gallus gallus)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Gallus gallus)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Gallus gallus)
H+ [cytosol]
Fructose metabolism (Gallus gallus)
Fructose biosynthesis (Gallus gallus)
AKR1B1 reduces Glc to D-sorbitol (Gallus gallus)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Gallus gallus)
H+ [cytosol]
Fructose catabolism (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Gallus gallus)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Gallus gallus)
H+ [cytosol]
Glucose metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
GAPDH tetramers reduce 1,3BPG to GA3P (Gallus gallus)
H+ [cytosol]
Glycolysis (Gallus gallus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Gallus gallus)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Gallus gallus)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Gallus gallus)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Gallus gallus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Gallus gallus)
H+ [cytosol]
Glycosaminoglycan metabolism (Gallus gallus)
Transport and synthesis of PAPS (Gallus gallus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Gallus gallus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Pentose phosphate pathway (Gallus gallus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Gallus gallus)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Gallus gallus)
H+ [cytosol]
Metabolism of lipids (Gallus gallus)
Biosynthesis of specialized proresolving mediators (SPMs) (Gallus gallus)
Biosynthesis of DHA-derived SPMs (Gallus gallus)
Biosynthesis of maresins (Gallus gallus)
Biosynthesis of maresin-like SPMs (Gallus gallus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Gallus gallus)
H+ [cytosol]
Biosynthesis of protectins (Gallus gallus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Gallus gallus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Gallus gallus)
H+ [cytosol]
Fatty acid metabolism (Gallus gallus)
Arachidonic acid metabolism (Gallus gallus)
Synthesis of 15-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Gallus gallus)
PGE2 is converted to PGF2a by CBR1 (Gallus gallus)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Gallus gallus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Gallus gallus)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Gallus gallus)
SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Gallus gallus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Gallus gallus)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Gallus gallus)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Gallus gallus)
H+ [cytosol]
Ketone body metabolism (Gallus gallus)
Synthesis of Ketone Bodies (Gallus gallus)
BDH2 dehydrogenates 3HBA (Gallus gallus)
H+ [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Synthesis of bile acids and bile salts (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Gallus gallus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Gallus gallus)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Gallus gallus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Gallus gallus)
27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Gallus gallus)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Gallus gallus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Gallus gallus)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Gallus gallus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H+ [cytosol]
Cholesterol biosynthesis (Gallus gallus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Gallus gallus)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Gallus gallus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Gallus gallus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Gallus gallus)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Gallus gallus)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Gallus gallus)
DHCR24 reduces ZYMOL to ZYMSTNL (Gallus gallus)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Gallus gallus)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Gallus gallus)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Gallus gallus)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Gallus gallus)
H+ [cytosol]
Squalene is oxidized to its epoxide (Gallus gallus)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Gallus gallus)
H+ [cytosol]
Metabolism of steroid hormones (Gallus gallus)
Androgen biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Gallus gallus)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Gallus gallus)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Gallus gallus)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Gallus gallus)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Gallus gallus)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Gallus gallus)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Gallus gallus)
H+ [cytosol]
Estrogen biosynthesis (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Gallus gallus)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Gallus gallus)
H+ [cytosol]
Glucocorticoid biosynthesis (Gallus gallus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Gallus gallus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Gallus gallus)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Gallus gallus)
H+ [cytosol]
Mineralocorticoid biosynthesis (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Gallus gallus)
H+ [cytosol]
Pregnenolone biosynthesis (Gallus gallus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Gallus gallus)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Gallus gallus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H+ [cytosol]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Synthesis of PA (Gallus gallus)
DHAP is converted to G3P by GPD1/GPD1L (Gallus gallus)
H+ [cytosol]
Sphingolipid metabolism (Gallus gallus)
Glycosphingolipid metabolism (Gallus gallus)
Glycosphingolipid biosynthesis (Gallus gallus)
CERK phosphorylates CERA to form C1P (Gallus gallus)
H+ [cytosol]
Glycosphingolipid catabolism (Gallus gallus)
ENPP7 hydrolyzes sphingomyelin (Gallus gallus)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Gallus gallus)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Gallus gallus)
H+ [cytosol]
Sphingolipid catabolism (Gallus gallus)
ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Gallus gallus)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Gallus gallus)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Gallus gallus)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Gallus gallus)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Gallus gallus)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Gallus gallus)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Gallus gallus)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Gallus gallus)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Gallus gallus)
Plasmalogen biosynthesis (Gallus gallus)
DHRS7B reduces GO3P to HXDG3P (Gallus gallus)
H+ [cytosol]
Wax biosynthesis (Gallus gallus)
FAR1 reduces PalmCoA to HXOL (Gallus gallus)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Gallus gallus)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
CYGB dioxygenates NO (Gallus gallus)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Gallus gallus)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
H+ [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
H+ [cytosol]
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Gallus gallus)
H+ [cytosol]
AIR + CO2 => CAIR (Gallus gallus)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Gallus gallus)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Gallus gallus)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Gallus gallus)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Gallus gallus)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
H+ [cytosol]
Pyrimidine biosynthesis (Gallus gallus)
UMPS dimer decarboxylates OMP to UMP (Gallus gallus)
H+ [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Gallus gallus)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Gallus gallus)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Gallus gallus)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Gallus gallus)
H+ [cytosol]
Pyrimidine catabolism (Gallus gallus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
H+ [cytosol]
Nucleotide salvage (Gallus gallus)
Purine salvage (Gallus gallus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Gallus gallus)
H+ [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme biosynthesis (Gallus gallus)
ALAD condenses 2 dALAs to form PBG (Gallus gallus)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Gallus gallus)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Gallus gallus)
H+ [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
NADPH regeneration (Gallus gallus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Gallus gallus)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
Salvage - Sepiapterin is reduced to BH2 (Gallus gallus)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Gallus gallus)
H+ [cytosol]
MMACHC dealkylates RCbl (Gallus gallus)
H+ [cytosol]
MMACHC decyanates CNCbl (Gallus gallus)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
H+ [cytosol]
Metabolism of folate and pterines (Gallus gallus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Gallus gallus)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Gallus gallus)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Gallus gallus)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Gallus gallus)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Gallus gallus)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Gallus gallus)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
H+ [cytosol]
Nicotinate metabolism (Gallus gallus)
NMRK1 phosphorylates NAR to yield NAMN (Gallus gallus)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Gallus gallus)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Gallus gallus)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Gallus gallus)
H+ [cytosol]
Nicotinamide salvaging (Gallus gallus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
FLAD1 phosphorylates FMN (Gallus gallus)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Gallus gallus)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
Coenzyme A biosynthesis (Gallus gallus)
2xPPCS ligates PPanK with Cys (Gallus gallus)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Gallus gallus)
H+ [cytosol]
COASY phosphorylates DP-CoA (Gallus gallus)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Gallus gallus)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Gallus gallus)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Gallus gallus)
H+ [cytosol]
PANK2 phosphorylates PanK (Gallus gallus)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Gallus gallus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Gallus gallus)
H+ [cytosol]
Reversible hydration of carbon dioxide (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)
H+ [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
GDP-fucose biosynthesis (Gallus gallus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)
H+ [cytosol]
Sialic acid metabolism (Gallus gallus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Hypusine synthesis from eIF5A-lysine (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Gallus gallus)
Synthesis of glycosylphosphatidylinositol (GPI) (Gallus gallus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)
H+ [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
H+ [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter release cycle (Gallus gallus)
Acetylcholine Neurotransmitter Release Cycle (Gallus gallus)
Loading of acetylcholine in synaptic vesicles (Gallus gallus)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Gallus gallus)
GABA synthesis (Gallus gallus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)
H+ [cytosol]
Synthesis of GABA by GAD2 (Gallus gallus)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Gallus gallus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)
H+ [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Gallus gallus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Gallus gallus)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Gallus gallus)
atRAL is reduced to atROL (Gallus gallus)
H+ [cytosol]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (q) signalling events (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Arachidonate production from DAG (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Gallus gallus)
H+ [cytosol]
Signaling by Nuclear Receptors (Gallus gallus)
Signaling by Retinoic Acid (Gallus gallus)
RA biosynthesis pathway (Gallus gallus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Gallus gallus)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor recycling (Gallus gallus)
Endosome acidification (Gallus gallus)
H+ [cytosol]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate NADPH Oxidases (Gallus gallus)
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)
H+ [cytosol]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)
H+ [cytosol]
Stimuli-sensing channels (Gallus gallus)
CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)
H+ [cytosol]
Iron uptake and transport (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Transferrin endocytosis and recycling (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
H+ [cytosol]
Miscellaneous transport and binding events (Gallus gallus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Gallus gallus)
Erythrocytes take up carbon dioxide and release oxygen (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Gallus gallus)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)
H+ [cytosol]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Inositol transporters (Gallus gallus)
HMIT co-transports myo-inositol with a proton (Gallus gallus)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Gallus gallus)
H+ [cytosol]
Metal ion SLC transporters (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic cation transport (Gallus gallus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Gallus gallus)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Gallus gallus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Amino acid transport across the plasma membrane (Gallus gallus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)
H+ [cytosol]
Bicarbonate transporters (Gallus gallus)
Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)
H+ [cytosol]
Multifunctional anion exchangers (Gallus gallus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Organic anion transporters (Gallus gallus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Gallus gallus)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Gallus gallus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Proton/oligopeptide cotransporters (Gallus gallus)
Proton-coupled di- and tri-peptide cotransport (Gallus gallus)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Gallus gallus)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)
H+ [cytosol]
Sodium/Proton exchangers (Gallus gallus)
Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Gallus gallus)
H+ [cytosol]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
H+ [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
H+ [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (Homo sapiens)
2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)
H+ [cytosol]
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective MMACHC causes MAHCC (Homo sapiens)
Defective MMACHC does not decyanate CNCbl (Homo sapiens)
H+ [cytosol]
Defective MMACHC does not reduce Cbl (Homo sapiens)
H+ [cytosol]
Diseases of carbohydrate metabolism (Homo sapiens)
Essential pentosuria (Homo sapiens)
Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)
H+ [cytosol]
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective CYP17A1 causes AH5 (Homo sapiens)
Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)
H+ [cytosol]
Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)
H+ [cytosol]
Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)
H+ [cytosol]
Defective CYP19A1 causes AEXS (Homo sapiens)
Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)
H+ [cytosol]
Defective CYP1B1 causes Glaucoma (Homo sapiens)
Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)
H+ [cytosol]
Defective CYP21A2 causes AH3 (Homo sapiens)
Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)
H+ [cytosol]
Defective CYP26C1 causes FFDD4 (Homo sapiens)
Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)
H+ [cytosol]
Defective CYP27B1 causes VDDR1A (Homo sapiens)
Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)
H+ [cytosol]
Defective CYP27B1 causes VDDR1B (Homo sapiens)
Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)
H+ [cytosol]
Defective CYP4F22 causes ARCI5 (Homo sapiens)
Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)
H+ [cytosol]
Defective CYP7B1 causes SPG5A and CBAS3 (Homo sapiens)
Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)
H+ [cytosol]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
H+ [cytosol]
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
H+ [cytosol]
Diseases of the neuronal system (Homo sapiens)
Diseases associated with visual transduction (Homo sapiens)
Retinoid cycle disease events (Homo sapiens)
Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)
H+ [cytosol]
Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)
H+ [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) (Homo sapiens)
Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)
H+ [cytosol]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Escape of Mtb from the phagocyte (Homo sapiens)
Phagocyte cell death caused by cytosolic Mtb (Homo sapiens)
CpnT hydrolyses NAD+ (Homo sapiens)
H+ [cytosol]
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Cell redox homeostasis (Homo sapiens)
TrxB reactivates TrxA (Homo sapiens)
H+ [cytosol]
lpdC dimer reactivates dlaT (Homo sapiens)
H+ [cytosol]
Mtb iron assimilation by chelation (Homo sapiens)
BfrA stores iron (Homo sapiens)
H+ [cytosol]
BfrB stores iron (Homo sapiens)
H+ [cytosol]
Iron is reduced and separates from mycobactin (Homo sapiens)
H+ [cytosol]
Tolerance by Mtb to nitric oxide produced by macrophages (Homo sapiens)
MscR reduces nitrosomycothiol to ammonia (Homo sapiens)
H+ [cytosol]
Mycothiol scavenges nitrosyl (Homo sapiens)
H+ [cytosol]
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
H+ [cytosol]
SodC reduces superoxide to H2O2 (Homo sapiens)
H+ [cytosol]
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of autophagy (Homo sapiens)
Eis acetylates DUSP16 (Homo sapiens)
H+ [cytosol]
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Fusion and Uncoating of the Influenza Virion (Homo sapiens)
Uncoating of the Influenza Virion (Homo sapiens)
Ribonucleoprotein release from M1 proteins (Homo sapiens)
H+ [cytosol]
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
nsp3 is glycosylated (Homo sapiens)
H+ [cytosol]
nsp3-4 is glycosylated (Homo sapiens)
H+ [cytosol]
nsp4 is glycosylated (Homo sapiens)
H+ [cytosol]
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
GSK3 phosphorylates Nucleoprotein (Homo sapiens)
H+ [cytosol]
Nucleoprotein is ADP-ribosylated (Homo sapiens)
H+ [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
H+ [cytosol]
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
nsp3 is glycosylated (Homo sapiens)
H+ [cytosol]
nsp3-4 is glycosylated (Homo sapiens)
H+ [cytosol]
nsp4 is glycosylated (Homo sapiens)
H+ [cytosol]
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)
H+ [cytosol]
GSK3 phosphorylates nucleoprotein (Homo sapiens)
H+ [cytosol]
Nucleoprotein is ADP-ribosylated (Homo sapiens)
H+ [cytosol]
Nucleoprotein is methylated by PRMT1 (Homo sapiens)
H+ [cytosol]
SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
H+ [cytosol]
Unknown kinase phosphorylates nucleoprotein (Homo sapiens)
H+ [cytosol]
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir metabolism (Homo sapiens)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)
H+ [cytosol]
Aspirin ADME (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Atorvastatin ADME (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
H+ [cytosol]
PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)
H+ [cytosol]
PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
H+ [cytosol]
Azathioprine ADME (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Homo sapiens)
H+ [cytosol]
Ciprofloxacin ADME (Homo sapiens)
Cipro is imported by organic cation transporters (Homo sapiens)
H+ [cytosol]
SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)
H+ [cytosol]
Paracetamol ADME (Homo sapiens)
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
H+ [cytosol]
Prednisone ADME (Homo sapiens)
AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)
H+ [cytosol]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)
H+ [cytosol]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Arachidonate production from DAG (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Homo sapiens)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
ABCC4 accumulation of dense granule contents (Homo sapiens)
H+ [cytosol]
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Reduction of cytosolic Ca++ levels (Homo sapiens)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
H+ [cytosol]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
OAS antiviral response (Homo sapiens)
PDE12 cleaves 2'-5' oligoadenylates (Homo sapiens)
H+ [cytosol]
Viral 2',5'-PDE cleaves 2'-5' oligoadenylates (Homo sapiens)
H+ [cytosol]
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
H+ [cytosol]
ROS and RNS production in phagocytes (Homo sapiens)
Glutathione scavenges nitrosyl (Homo sapiens)
H+ [cytosol]
HV1-mediated H+ transfer (Homo sapiens)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Homo sapiens)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
H+ [cytosol]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Homo sapiens)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Homo sapiens)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Homo sapiens)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Homo sapiens)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Homo sapiens)
H+ [cytosol]
Regulation of pyruvate metabolism (Homo sapiens)
NEK1 phosphorylates ME1 (Homo sapiens)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
MDH1 reduces OA (Homo sapiens)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Homo sapiens)
H+ [cytosol]
Biological oxidations (Homo sapiens)
Aflatoxin activation and detoxification (Homo sapiens)
AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
H+ [cytosol]
Phase I - Functionalization of compounds (Homo sapiens)
ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)
H+ [cytosol]
Endogenous sterols (Homo sapiens)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Homo sapiens)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Homo sapiens)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Homo sapiens)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
H+ [cytosol]
Vitamins (Homo sapiens)
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
H+ [cytosol]
Ethanol oxidation (Homo sapiens)
ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
H+ [cytosol]
Phase II - Conjugation of compounds (Homo sapiens)
Cytosolic sulfonation of small molecules (Homo sapiens)
Transport and synthesis of PAPS (Homo sapiens)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Glucuronidation (Homo sapiens)
Formation of the active cofactor, UDP-glucuronate (Homo sapiens)
UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)
H+ [cytosol]
Methylation (Homo sapiens)
TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)
H+ [cytosol]
Cytosolic iron-sulfur cluster assembly (Homo sapiens)
NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)
H+ [cytosol]
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
MIOX oxidises Ins to GlcA (Homo sapiens)
H+ [cytosol]
Integration of energy metabolism (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
H+ [cytosol]
Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)
H+ [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
H+ [cytosol]
Carnitine synthesis (Homo sapiens)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)
H+ [cytosol]
Creatine metabolism (Homo sapiens)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)
H+ [cytosol]
Glutamate and glutamine metabolism (Homo sapiens)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)
H+ [cytosol]
Histidine catabolism (Homo sapiens)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)
H+ [cytosol]
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Noradrenaline is converted to adrenaline (Homo sapiens)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)
H+ [cytosol]
Thyroxine biosynthesis (Homo sapiens)
Regulation of thyroid hormone activity (Homo sapiens)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Homo sapiens)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)
H+ [cytosol]
Tyrosine catabolism (Homo sapiens)
FAH cleaves 4FAA (Homo sapiens)
H+ [cytosol]
HGD dioxygenates homogentisate (Homo sapiens)
H+ [cytosol]
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
H+ [cytosol]
PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)
H+ [cytosol]
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
H+ [cytosol]
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
H+ [cytosol]
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
H+ [cytosol]
Selenocysteine synthesis (Homo sapiens)
SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
H+ [cytosol]
Serine biosynthesis (Homo sapiens)
PHGDH tetramer dehydrogenates 3PG (Homo sapiens)
H+ [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)
H+ [cytosol]
Degradation of cysteine and homocysteine (Homo sapiens)
ADO oxidises 2AET to HTAU (Homo sapiens)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)
H+ [cytosol]
Methionine salvage pathway (Homo sapiens)
Acireductone is created (Homo sapiens)
H+ [cytosol]
Tryptophan catabolism (Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)
H+ [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)
H+ [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Formation of xylulose-5-phosphate (Homo sapiens)
AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)
H+ [cytosol]
Fructose metabolism (Homo sapiens)
Fructose biosynthesis (Homo sapiens)
AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Homo sapiens)
H+ [cytosol]
Fructose catabolism (Homo sapiens)
ALDH1A1 oxidises GA to DGA (Homo sapiens)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)
H+ [cytosol]
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)
H+ [cytosol]
Glycolysis (Homo sapiens)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Homo sapiens)
H+ [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
H+ [cytosol]
Glycosaminoglycan metabolism (Homo sapiens)
Transport and synthesis of PAPS (Homo sapiens)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Pentose phosphate pathway (Homo sapiens)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)
H+ [cytosol]
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)
H+ [cytosol]
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
H+ [cytosol]
CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)
H+ [cytosol]
Biosynthesis of protectins (Homo sapiens)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)
H+ [cytosol]
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)
H+ [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Homo sapiens)
5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)
H+ [cytosol]
5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)
H+ [cytosol]
5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Homo sapiens)
15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)
H+ [cytosol]
LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)
H+ [cytosol]
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)
H+ [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
H+ [cytosol]
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)
H+ [cytosol]
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
H+ [cytosol]
LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)
H+ [cytosol]
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)
H+ [cytosol]
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Homo sapiens)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Homo sapiens)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Homo sapiens)
SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Homo sapiens)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)
H+ [cytosol]
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
BDH2 dehydrogenates 3HBA (Homo sapiens)
H+ [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
H+ [cytosol]
Cholesterol biosynthesis (Homo sapiens)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Homo sapiens)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Homo sapiens)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Homo sapiens)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Homo sapiens)
DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Homo sapiens)
H+ [cytosol]
Squalene is oxidized to its epoxide (Homo sapiens)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)
H+ [cytosol]
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Homo sapiens)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)
H+ [cytosol]
Estrogen biosynthesis (Homo sapiens)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
H+ [cytosol]
Glucocorticoid biosynthesis (Homo sapiens)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Homo sapiens)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Homo sapiens)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)
H+ [cytosol]
Mineralocorticoid biosynthesis (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)
H+ [cytosol]
Pregnenolone biosynthesis (Homo sapiens)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Homo sapiens)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
H+ [cytosol]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PA (Homo sapiens)
DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)
H+ [cytosol]
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid biosynthesis (Homo sapiens)
CERK phosphorylates CERA to form C1P (Homo sapiens)
H+ [cytosol]
Glycosphingolipid catabolism (Homo sapiens)
ENPP7 hydrolyzes sphingomyelin (Homo sapiens)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Homo sapiens)
H+ [cytosol]
Sphingolipid catabolism (Homo sapiens)
ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Homo sapiens)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Homo sapiens)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
H+ [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Homo sapiens)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Homo sapiens)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Homo sapiens)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Homo sapiens)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Homo sapiens)
H+ [cytosol]
PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Homo sapiens)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Homo sapiens)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Homo sapiens)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Homo sapiens)
Plasmalogen biosynthesis (Homo sapiens)
DHRS7B reduces GO3P to HXDG3P (Homo sapiens)
H+ [cytosol]
Wax biosynthesis (Homo sapiens)
FAR1 reduces PalmCoA to HXOL (Homo sapiens)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Homo sapiens)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
CYGB dioxygenates NO (Homo sapiens)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
H+ [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Homo sapiens)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
H+ [cytosol]
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)
H+ [cytosol]
AIR + CO2 => CAIR (Homo sapiens)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Homo sapiens)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
H+ [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Homo sapiens)
H+ [cytosol]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
Guanine + H2O => Xanthine + NH4+ (Homo sapiens)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Homo sapiens)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Homo sapiens)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Homo sapiens)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Homo sapiens)
H+ [cytosol]
Pyrimidine catabolism (Homo sapiens)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
H+ [cytosol]
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)
H+ [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Homo sapiens)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Homo sapiens)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Homo sapiens)
H+ [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
NADPH regeneration (Homo sapiens)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)
H+ [cytosol]
RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)
H+ [cytosol]
MMACHC dealkylates RCbl (Homo sapiens)
H+ [cytosol]
MMACHC decyanates CNCbl (Homo sapiens)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
H+ [cytosol]
Metabolism of folate and pterines (Homo sapiens)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Homo sapiens)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Homo sapiens)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
H+ [cytosol]
Molybdenum cofactor biosynthesis (Homo sapiens)
Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)
H+ [cytosol]
Nicotinate metabolism (Homo sapiens)
NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Homo sapiens)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Homo sapiens)
H+ [cytosol]
Nicotinamide salvaging (Homo sapiens)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
H+ [cytosol]
FLAD1 phosphorylates FMN (Homo sapiens)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Homo sapiens)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
Coenzyme A biosynthesis (Homo sapiens)
2xPPCS ligates PPanK with Cys (Homo sapiens)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)
H+ [cytosol]
COASY phosphorylates DP-CoA (Homo sapiens)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Homo sapiens)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Homo sapiens)
H+ [cytosol]
PANK2 phosphorylates PanK (Homo sapiens)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Homo sapiens)
2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)
H+ [cytosol]
Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)
H+ [cytosol]
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)
H+ [cytosol]
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
H+ [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
GDP-fucose biosynthesis (Homo sapiens)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)
H+ [cytosol]
Sialic acid metabolism (Homo sapiens)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Synthesis of glycosylphosphatidylinositol (GPI) (Homo sapiens)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)
H+ [cytosol]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
H+ [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)
Loading of acetylcholine in synaptic vesicles (Homo sapiens)
H+ [cytosol]
Re-acidification of acetylcholine transport vesicles (Homo sapiens)
H+ [cytosol]
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA synthesis (Homo sapiens)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)
H+ [cytosol]
Synthesis of GABA by GAD2 (Homo sapiens)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
H+ [cytosol]
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
H+ [cytosol]
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
H+ [cytosol]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sour taste (Homo sapiens)
KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)
H+ [cytosol]
OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)
H+ [cytosol]
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)
H+ [cytosol]
RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Homo sapiens)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)
H+ [cytosol]
RDH8 reduces atRAL to atROL (Homo sapiens)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Homo sapiens)
11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)
H+ [cytosol]
A REH hydrolyses 11cRE to 11cROL (Homo sapiens)
H+ [cytosol]
atRAL is reduced to atROL (Homo sapiens)
H+ [cytosol]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Arachidonate production from DAG (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Homo sapiens)
H+ [cytosol]
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
RA biosynthesis pathway (Homo sapiens)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Homo sapiens)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Homo sapiens)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
Endosome acidification (Homo sapiens)
H+ [cytosol]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)
H+ [cytosol]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
H+ [cytosol]
Stimuli-sensing channels (Homo sapiens)
CLCN3 exchanges Cl- for H+ (Homo sapiens)
H+ [cytosol]
CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)
H+ [cytosol]
Iron uptake and transport (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Transferrin endocytosis and recycling (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
H+ [cytosol]
Miscellaneous transport and binding events (Homo sapiens)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Homo sapiens)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)
H+ [cytosol]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Inositol transporters (Homo sapiens)
HMIT co-transports myo-inositol with a proton (Homo sapiens)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Homo sapiens)
H+ [cytosol]
Metal ion SLC transporters (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Homo sapiens)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Homo sapiens)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)
H+ [cytosol]
Bicarbonate transporters (Homo sapiens)
Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)
H+ [cytosol]
Multifunctional anion exchangers (Homo sapiens)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Organic anion transporters (Homo sapiens)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Homo sapiens)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Homo sapiens)
SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Proton/oligopeptide cotransporters (Homo sapiens)
Proton-coupled di- and tri-peptide cotransport (Homo sapiens)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Homo sapiens)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
H+ [cytosol]
Sodium/Proton exchangers (Homo sapiens)
Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Homo sapiens)
H+ [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
NOX2 generates superoxide from oxygen (Mus musculus)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Mus musculus)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Mus musculus)
Nuclear events mediated by NFE2L2 (Mus musculus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Mus musculus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)
H+ [cytosol]
Drug ADME (Mus musculus)
Abacavir ADME (Mus musculus)
Abacavir metabolism (Mus musculus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)
H+ [cytosol]
Aspirin ADME (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Atorvastatin ADME (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
H+ [cytosol]
Azathioprine ADME (Mus musculus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Mus musculus)
H+ [cytosol]
Ciprofloxacin ADME (Mus musculus)
SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)
H+ [cytosol]
Paracetamol ADME (Mus musculus)
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
H+ [cytosol]
Prednisone ADME (Mus musculus)
AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Mus musculus)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)
H+ [cytosol]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
H+ [cytosol]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Arachidonate production from DAG (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Mus musculus)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
ABCC4 accumulation of dense granule contents (Mus musculus)
H+ [cytosol]
Platelet homeostasis (Mus musculus)
Platelet calcium homeostasis (Mus musculus)
Reduction of cytosolic Ca++ levels (Mus musculus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)
H+ [cytosol]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
OAS antiviral response (Mus musculus)
PDE12 cleaves 2'-5' oligoadenylates (Mus musculus)
H+ [cytosol]
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Ion influx/efflux at host-pathogen interface (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
H+ [cytosol]
ROS and RNS production in phagocytes (Mus musculus)
HV1-mediated H+ transfer (Mus musculus)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Mus musculus)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
H+ [cytosol]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Pyruvate metabolism (Mus musculus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Mus musculus)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Mus musculus)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Mus musculus)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Mus musculus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Mus musculus)
H+ [cytosol]
Regulation of pyruvate metabolism (Mus musculus)
NEK1 phosphorylates ME1 (Mus musculus)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Mus musculus)
Respiratory electron transport (Mus musculus)
Malate-aspartate shuttle (Mus musculus)
MDH1 reduces OA (Mus musculus)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Mus musculus)
H+ [cytosol]
Biological oxidations (Mus musculus)
Aflatoxin activation and detoxification (Mus musculus)
AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)
H+ [cytosol]
Phase I - Functionalization of compounds (Mus musculus)
ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Mus musculus)
Eicosanoids (Mus musculus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Mus musculus)
H+ [cytosol]
Endogenous sterols (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Mus musculus)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Mus musculus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Mus musculus)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Mus musculus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Mus musculus)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
H+ [cytosol]
Vitamins (Mus musculus)
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
H+ [cytosol]
Ethanol oxidation (Mus musculus)
ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)
H+ [cytosol]
Phase II - Conjugation of compounds (Mus musculus)
Cytosolic sulfonation of small molecules (Mus musculus)
Transport and synthesis of PAPS (Mus musculus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Glucuronidation (Mus musculus)
Formation of the active cofactor, UDP-glucuronate (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
H+ [cytosol]
Methylation (Mus musculus)
TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)
H+ [cytosol]
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP2, IP, and Ins in the cytosol (Mus musculus)
MIOX oxidises Ins to GlcA (Mus musculus)
H+ [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Aspartate and asparagine metabolism (Mus musculus)
SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)
H+ [cytosol]
Carnitine synthesis (Mus musculus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)
H+ [cytosol]
Creatine metabolism (Mus musculus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
H+ [cytosol]
Glutamate and glutamine metabolism (Mus musculus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)
H+ [cytosol]
Histidine catabolism (Mus musculus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
H+ [cytosol]
Metabolism of amine-derived hormones (Mus musculus)
Catecholamine biosynthesis (Mus musculus)
Noradrenaline is converted to adrenaline (Mus musculus)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Mus musculus)
Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)
H+ [cytosol]
Thyroxine biosynthesis (Mus musculus)
Regulation of thyroid hormone activity (Mus musculus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Mus musculus)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
H+ [cytosol]
Tyrosine catabolism (Mus musculus)
FAH cleaves 4FAA (Mus musculus)
H+ [cytosol]
HGD dioxygenates homogentisate (Mus musculus)
H+ [cytosol]
Selenoamino acid metabolism (Mus musculus)
Metabolism of ingested MeSeO2H into MeSeH (Mus musculus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
H+ [cytosol]
Selenocysteine synthesis (Mus musculus)
SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
H+ [cytosol]
Serine biosynthesis (Mus musculus)
PHGDH tetramer dehydrogenates 3PG (Mus musculus)
H+ [cytosol]
Sulfur amino acid metabolism (Mus musculus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)
H+ [cytosol]
Degradation of cysteine and homocysteine (Mus musculus)
ADO oxidises 2AET to HTAU (Mus musculus)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Mus musculus)
H+ [cytosol]
Methionine salvage pathway (Mus musculus)
Acireductone is created (Mus musculus)
H+ [cytosol]
Tryptophan catabolism (Mus musculus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
H+ [cytosol]
Metabolism of carbohydrates (Mus musculus)
Formation of xylulose-5-phosphate (Mus musculus)
AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)
H+ [cytosol]
Fructose metabolism (Mus musculus)
Fructose biosynthesis (Mus musculus)
AKR1B1 reduces Glc to D-sorbitol (Mus musculus)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Mus musculus)
H+ [cytosol]
Fructose catabolism (Mus musculus)
ALDH1A1 oxidises GA to DGA (Mus musculus)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)
H+ [cytosol]
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)
H+ [cytosol]
Glycolysis (Mus musculus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Mus musculus)
H+ [cytosol]
Glycosaminoglycan metabolism (Mus musculus)
Transport and synthesis of PAPS (Mus musculus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Pentose phosphate pathway (Mus musculus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Mus musculus)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)
H+ [cytosol]
Metabolism of lipids (Mus musculus)
Biosynthesis of specialized proresolving mediators (SPMs) (Mus musculus)
Biosynthesis of DHA-derived SPMs (Mus musculus)
Biosynthesis of maresins (Mus musculus)
Biosynthesis of maresin-like SPMs (Mus musculus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)
H+ [cytosol]
Biosynthesis of protectins (Mus musculus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Mus musculus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)
H+ [cytosol]
Fatty acid metabolism (Mus musculus)
Arachidonic acid metabolism (Mus musculus)
Synthesis of 15-eicosatetraenoic acid derivatives (Mus musculus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Mus musculus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Mus musculus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Mus musculus)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Mus musculus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Mus musculus)
SCD desaturates ST-CoA to OLE-CoA (Mus musculus)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Mus musculus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)
H+ [cytosol]
Ketone body metabolism (Mus musculus)
Synthesis of Ketone Bodies (Mus musculus)
BDH2 dehydrogenates 3HBA (Mus musculus)
H+ [cytosol]
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Synthesis of bile acids and bile salts (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Mus musculus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Mus musculus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Mus musculus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
H+ [cytosol]
Cholesterol biosynthesis (Mus musculus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Mus musculus)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Mus musculus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Mus musculus)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Mus musculus)
DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Mus musculus)
H+ [cytosol]
Squalene is oxidized to its epoxide (Mus musculus)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)
H+ [cytosol]
Metabolism of steroid hormones (Mus musculus)
Androgen biosynthesis (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Mus musculus)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)
H+ [cytosol]
Estrogen biosynthesis (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Mus musculus)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Mus musculus)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)
H+ [cytosol]
Glucocorticoid biosynthesis (Mus musculus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Mus musculus)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Mus musculus)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)
H+ [cytosol]
Mineralocorticoid biosynthesis (Mus musculus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)
H+ [cytosol]
Pregnenolone biosynthesis (Mus musculus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
H+ [cytosol]
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
Synthesis of PA (Mus musculus)
DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)
H+ [cytosol]
Sphingolipid metabolism (Mus musculus)
Glycosphingolipid metabolism (Mus musculus)
Glycosphingolipid biosynthesis (Mus musculus)
CERK phosphorylates CERA to form C1P (Mus musculus)
H+ [cytosol]
Glycosphingolipid catabolism (Mus musculus)
ENPP7 hydrolyzes sphingomyelin (Mus musculus)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Mus musculus)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Mus musculus)
H+ [cytosol]
Sphingolipid catabolism (Mus musculus)
ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Mus musculus)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Mus musculus)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Mus musculus)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Mus musculus)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Mus musculus)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Mus musculus)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Mus musculus)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Mus musculus)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Mus musculus)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Mus musculus)
Plasmalogen biosynthesis (Mus musculus)
DHRS7B reduces GO3P to HXDG3P (Mus musculus)
H+ [cytosol]
Wax biosynthesis (Mus musculus)
FAR1 reduces PalmCoA to HXOL (Mus musculus)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Mus musculus)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
eNOS activation (Mus musculus)
CYGB dioxygenates NO (Mus musculus)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Mus musculus)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
H+ [cytosol]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Mus musculus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
H+ [cytosol]
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)
H+ [cytosol]
AIR + CO2 => CAIR (Mus musculus)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Mus musculus)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
H+ [cytosol]
Pyrimidine biosynthesis (Mus musculus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Mus musculus)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Mus musculus)
H+ [cytosol]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
Guanine + H2O => Xanthine + NH4+ (Mus musculus)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Mus musculus)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Mus musculus)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Mus musculus)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Mus musculus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Mus musculus)
H+ [cytosol]
Pyrimidine catabolism (Mus musculus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
H+ [cytosol]
Nucleotide salvage (Mus musculus)
Purine salvage (Mus musculus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)
H+ [cytosol]
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Mus musculus)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Mus musculus)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Mus musculus)
H+ [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
NADPH regeneration (Mus musculus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
Salvage - Sepiapterin is reduced to BH2 (Mus musculus)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Mus musculus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)
H+ [cytosol]
MMACHC dealkylates RCbl (Mus musculus)
H+ [cytosol]
MMACHC decyanates CNCbl (Mus musculus)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Mus musculus)
H+ [cytosol]
Metabolism of folate and pterines (Mus musculus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Mus musculus)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Mus musculus)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Mus musculus)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
H+ [cytosol]
Nicotinate metabolism (Mus musculus)
NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Mus musculus)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Mus musculus)
H+ [cytosol]
Nicotinamide salvaging (Mus musculus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
H+ [cytosol]
FLAD1 phosphorylates FMN (Mus musculus)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Mus musculus)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Mus musculus)
Coenzyme A biosynthesis (Mus musculus)
2xPPCS ligates PPanK with Cys (Mus musculus)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Mus musculus)
H+ [cytosol]
COASY phosphorylates DP-CoA (Mus musculus)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Mus musculus)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Mus musculus)
H+ [cytosol]
PANK2 phosphorylates PanK (Mus musculus)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Mus musculus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)
H+ [cytosol]
Reversible hydration of carbon dioxide (Mus musculus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)
H+ [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
GDP-fucose biosynthesis (Mus musculus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)
H+ [cytosol]
Sialic acid metabolism (Mus musculus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Hypusine synthesis from eIF5A-lysine (Mus musculus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Mus musculus)
Synthesis of glycosylphosphatidylinositol (GPI) (Mus musculus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)
H+ [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
H+ [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter release cycle (Mus musculus)
Acetylcholine Neurotransmitter Release Cycle (Mus musculus)
Loading of acetylcholine in synaptic vesicles (Mus musculus)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Mus musculus)
GABA synthesis (Mus musculus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)
H+ [cytosol]
Synthesis of GABA by GAD2 (Mus musculus)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Mus musculus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)
H+ [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Mus musculus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Mus musculus)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Mus musculus)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Mus musculus)
atRAL is reduced to atROL (Mus musculus)
H+ [cytosol]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Arachidonate production from DAG (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Mus musculus)
H+ [cytosol]
Signaling by Nuclear Receptors (Mus musculus)
Signaling by Retinoic Acid (Mus musculus)
RA biosynthesis pathway (Mus musculus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Mus musculus)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Mus musculus)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor recycling (Mus musculus)
Endosome acidification (Mus musculus)
H+ [cytosol]
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate NADPH Oxidases (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)
H+ [cytosol]
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
H+ [cytosol]
Stimuli-sensing channels (Mus musculus)
CLCN4/5/6 exchange Cl- for H+ (Mus musculus)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Mus musculus)
H+ [cytosol]
Iron uptake and transport (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Transferrin endocytosis and recycling (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
H+ [cytosol]
Miscellaneous transport and binding events (Mus musculus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Mus musculus)
Erythrocytes take up carbon dioxide and release oxygen (Mus musculus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Mus musculus)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Mus musculus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)
H+ [cytosol]
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Inositol transporters (Mus musculus)
HMIT co-transports myo-inositol with a proton (Mus musculus)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Mus musculus)
H+ [cytosol]
Metal ion SLC transporters (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Mus musculus)
Organic cation transport (Mus musculus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Mus musculus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Mus musculus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Amino acid transport across the plasma membrane (Mus musculus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)
H+ [cytosol]
Bicarbonate transporters (Mus musculus)
Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)
H+ [cytosol]
Multifunctional anion exchangers (Mus musculus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Organic anion transporters (Mus musculus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Mus musculus)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Mus musculus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Proton/oligopeptide cotransporters (Mus musculus)
Proton-coupled di- and tri-peptide cotransport (Mus musculus)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Mus musculus)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)
H+ [cytosol]
Sodium/Proton exchangers (Mus musculus)
Na+/H+ exchanger transport (at cell membrane) (Mus musculus)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Mus musculus)
H+ [cytosol]
Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Chorismate via Shikimate Pathway (Mycobacterium tuberculosis)
DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)
H+ [cytosol]
Shikimate results from hydration of DHS (Mycobacterium tuberculosis)
H+ [cytosol]
Dimycocersyl phthiocerol biosynthesis (Mycobacterium tuberculosis)
FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)
H+ [cytosol]
FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)
H+ [cytosol]
Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)
H+ [cytosol]
Mycothiol metabolism (Mycobacterium tuberculosis)
Mycothiol-dependent detoxification (Mycobacterium tuberculosis)
formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)
H+ [cytosol]
mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)
H+ [cytosol]
mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)
H+ [cytosol]
mycothione is reduced to mycothiol (Mycobacterium tuberculosis)
H+ [cytosol]
Sulfur compound metabolism (Mycobacterium tuberculosis)
Sulfate assimilation (Mycobacterium tuberculosis)
APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
H+ [cytosol]
Sulfur amino acid metabolism (Mycobacterium tuberculosis)
Cysteine synthesis from O-acetylserine (Mycobacterium tuberculosis)
sulfite is reduced to sulfide (Mycobacterium tuberculosis)
H+ [cytosol]
sulfite results from reduction of APS (Mycobacterium tuberculosis)
H+ [cytosol]
Trehalose biosynthesis (Mycobacterium tuberculosis)
Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)
H+ [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
Cellular response to chemical stress (Plasmodium falciparum)
Detoxification of Reactive Oxygen Species (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
H+ [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)
H+ [cytosol]
Gene expression (Transcription) (Plasmodium falciparum)
RNA Polymerase II Transcription (Plasmodium falciparum)
Generic Transcription Pathway (Plasmodium falciparum)
Transcriptional Regulation by TP53 (Plasmodium falciparum)
TP53 Regulates Metabolic Genes (Plasmodium falciparum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
H+ [cytosol]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
Effects of PIP2 hydrolysis (Plasmodium falciparum)
Arachidonate production from DAG (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Plasmodium falciparum)
Platelet degranulation (Plasmodium falciparum)
ABCC4 accumulation of dense granule contents (Plasmodium falciparum)
H+ [cytosol]
Platelet homeostasis (Plasmodium falciparum)
Platelet calcium homeostasis (Plasmodium falciparum)
Reduction of cytosolic Ca++ levels (Plasmodium falciparum)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)
H+ [cytosol]
Immune System (Plasmodium falciparum)
Innate Immune System (Plasmodium falciparum)
Antimicrobial peptides (Plasmodium falciparum)
Ion influx/efflux at host-pathogen interface (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
H+ [cytosol]
ROS and RNS production in phagocytes (Plasmodium falciparum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
H+ [cytosol]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Pyruvate metabolism (Plasmodium falciparum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Plasmodium falciparum)
H+ [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Glutamate and glutamine metabolism (Plasmodium falciparum)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)
H+ [cytosol]
Selenoamino acid metabolism (Plasmodium falciparum)
Metabolism of ingested MeSeO2H into MeSeH (Plasmodium falciparum)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
H+ [cytosol]
Selenocysteine synthesis (Plasmodium falciparum)
SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
H+ [cytosol]
Metabolism of carbohydrates (Plasmodium falciparum)
Glucose metabolism (Plasmodium falciparum)
Gluconeogenesis (Plasmodium falciparum)
GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)
H+ [cytosol]
Glycolysis (Plasmodium falciparum)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Plasmodium falciparum)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Plasmodium falciparum)
H+ [cytosol]
Pentose phosphate pathway (Plasmodium falciparum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)
H+ [cytosol]
Metabolism of lipids (Plasmodium falciparum)
Biosynthesis of specialized proresolving mediators (SPMs) (Plasmodium falciparum)
Biosynthesis of DHA-derived SPMs (Plasmodium falciparum)
Biosynthesis of maresins (Plasmodium falciparum)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Plasmodium falciparum)
H+ [cytosol]
Fatty acid metabolism (Plasmodium falciparum)
Fatty acyl-CoA biosynthesis (Plasmodium falciparum)
SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Plasmodium falciparum)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)
H+ [cytosol]
Metabolism of steroids (Plasmodium falciparum)
Metabolism of steroid hormones (Plasmodium falciparum)
Androgen biosynthesis (Plasmodium falciparum)
HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)
H+ [cytosol]
Phospholipid metabolism (Plasmodium falciparum)
Glycerophospholipid biosynthesis (Plasmodium falciparum)
Synthesis of PA (Plasmodium falciparum)
DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)
H+ [cytosol]
Sphingolipid metabolism (Plasmodium falciparum)
Glycosphingolipid metabolism (Plasmodium falciparum)
Glycosphingolipid catabolism (Plasmodium falciparum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Plasmodium falciparum)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
H+ [cytosol]
CSNK1G2 phosphorylates p-CERT1-2 (Plasmodium falciparum)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Plasmodium falciparum)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Plasmodium falciparum)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Plasmodium falciparum)
eNOS activation (Plasmodium falciparum)
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
H+ [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
H+ [cytosol]
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
H+ [cytosol]
Pyrimidine biosynthesis (Plasmodium falciparum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
H+ [cytosol]
Nucleotide catabolism (Plasmodium falciparum)
Purine catabolism (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
H+ [cytosol]
Metabolism of porphyrins (Plasmodium falciparum)
Heme biosynthesis (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)
H+ [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Metabolism of folate and pterines (Plasmodium falciparum)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
H+ [cytosol]
Nicotinate metabolism (Plasmodium falciparum)
Nicotinamide salvaging (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Plasmodium falciparum)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Plasmodium falciparum)
Coenzyme A biosynthesis (Plasmodium falciparum)
2xPPCS ligates PPanK with Cys (Plasmodium falciparum)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Plasmodium falciparum)
H+ [cytosol]
Reversible hydration of carbon dioxide (Plasmodium falciparum)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)
H+ [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Asparagine N-linked glycosylation (Plasmodium falciparum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Plasmodium falciparum)
Synthesis of substrates in N-glycan biosythesis (Plasmodium falciparum)
GDP-fucose biosynthesis (Plasmodium falciparum)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
Hypusine synthesis from eIF5A-lysine (Plasmodium falciparum)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
H+ [cytosol]
Muscle contraction (Plasmodium falciparum)
Cardiac conduction (Plasmodium falciparum)
Ion homeostasis (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
H+ [cytosol]
Signal Transduction (Plasmodium falciparum)
Signaling by GPCR (Plasmodium falciparum)
GPCR downstream signalling (Plasmodium falciparum)
G alpha (q) signalling events (Plasmodium falciparum)
Effects of PIP2 hydrolysis (Plasmodium falciparum)
Arachidonate production from DAG (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by Insulin receptor (Plasmodium falciparum)
Insulin receptor recycling (Plasmodium falciparum)
Endosome acidification (Plasmodium falciparum)
H+ [cytosol]
Transport of small molecules (Plasmodium falciparum)
Ion channel transport (Plasmodium falciparum)
Ion transport by P-type ATPases (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)
H+ [cytosol]
Iron uptake and transport (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
H+ [cytosol]
Transferrin endocytosis and recycling (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Plasmodium falciparum)
Erythrocytes take up carbon dioxide and release oxygen (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)
H+ [cytosol]
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)
H+ [cytosol]
Metal ion SLC transporters (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Plasmodium falciparum)
Organic cation transport (Plasmodium falciparum)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)
H+ [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Rattus norvegicus)
Nuclear events mediated by NFE2L2 (Rattus norvegicus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Rattus norvegicus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)
H+ [cytosol]
Drug ADME (Rattus norvegicus)
Abacavir ADME (Rattus norvegicus)
Abacavir metabolism (Rattus norvegicus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)
H+ [cytosol]
Aspirin ADME (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Atorvastatin ADME (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Rattus norvegicus)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
H+ [cytosol]
Azathioprine ADME (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Rattus norvegicus)
H+ [cytosol]
Ciprofloxacin ADME (Rattus norvegicus)
SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)
H+ [cytosol]
Paracetamol ADME (Rattus norvegicus)
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
H+ [cytosol]
Prednisone ADME (Rattus norvegicus)
AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)
H+ [cytosol]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
H+ [cytosol]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Arachidonate production from DAG (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
ABCC4 accumulation of dense granule contents (Rattus norvegicus)
H+ [cytosol]
Platelet homeostasis (Rattus norvegicus)
Platelet calcium homeostasis (Rattus norvegicus)
Reduction of cytosolic Ca++ levels (Rattus norvegicus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)
H+ [cytosol]
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
OAS antiviral response (Rattus norvegicus)
PDE12 cleaves 2'-5' oligoadenylates (Rattus norvegicus)
H+ [cytosol]
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
Ion influx/efflux at host-pathogen interface (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
H+ [cytosol]
ROS and RNS production in phagocytes (Rattus norvegicus)
HV1-mediated H+ transfer (Rattus norvegicus)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Rattus norvegicus)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
H+ [cytosol]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism (Rattus norvegicus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Rattus norvegicus)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Rattus norvegicus)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Rattus norvegicus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Rattus norvegicus)
H+ [cytosol]
Regulation of pyruvate metabolism (Rattus norvegicus)
NEK1 phosphorylates ME1 (Rattus norvegicus)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Rattus norvegicus)
Respiratory electron transport (Rattus norvegicus)
Malate-aspartate shuttle (Rattus norvegicus)
MDH1 reduces OA (Rattus norvegicus)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Rattus norvegicus)
H+ [cytosol]
Biological oxidations (Rattus norvegicus)
Aflatoxin activation and detoxification (Rattus norvegicus)
AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)
H+ [cytosol]
Phase I - Functionalization of compounds (Rattus norvegicus)
ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Eicosanoids (Rattus norvegicus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
H+ [cytosol]
Endogenous sterols (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Rattus norvegicus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
H+ [cytosol]
Vitamins (Rattus norvegicus)
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
H+ [cytosol]
Ethanol oxidation (Rattus norvegicus)
ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)
H+ [cytosol]
Phase II - Conjugation of compounds (Rattus norvegicus)
Cytosolic sulfonation of small molecules (Rattus norvegicus)
Transport and synthesis of PAPS (Rattus norvegicus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Glucuronidation (Rattus norvegicus)
Formation of the active cofactor, UDP-glucuronate (Rattus norvegicus)
UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
H+ [cytosol]
Methylation (Rattus norvegicus)
TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)
H+ [cytosol]
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP2, IP, and Ins in the cytosol (Rattus norvegicus)
MIOX oxidises Ins to GlcA (Rattus norvegicus)
H+ [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Aspartate and asparagine metabolism (Rattus norvegicus)
SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)
H+ [cytosol]
Carnitine synthesis (Rattus norvegicus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)
H+ [cytosol]
Creatine metabolism (Rattus norvegicus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
H+ [cytosol]
Glutamate and glutamine metabolism (Rattus norvegicus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)
H+ [cytosol]
Histidine catabolism (Rattus norvegicus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
H+ [cytosol]
Metabolism of amine-derived hormones (Rattus norvegicus)
Catecholamine biosynthesis (Rattus norvegicus)
Noradrenaline is converted to adrenaline (Rattus norvegicus)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)
H+ [cytosol]
Thyroxine biosynthesis (Rattus norvegicus)
Regulation of thyroid hormone activity (Rattus norvegicus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
H+ [cytosol]
Tyrosine catabolism (Rattus norvegicus)
FAH cleaves 4FAA (Rattus norvegicus)
H+ [cytosol]
HGD dioxygenates homogentisate (Rattus norvegicus)
H+ [cytosol]
Selenoamino acid metabolism (Rattus norvegicus)
Metabolism of ingested MeSeO2H into MeSeH (Rattus norvegicus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
H+ [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
H+ [cytosol]
Selenocysteine synthesis (Rattus norvegicus)
SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)
H+ [cytosol]
Serine biosynthesis (Rattus norvegicus)
PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)
H+ [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)
H+ [cytosol]
Degradation of cysteine and homocysteine (Rattus norvegicus)
ADO oxidises 2AET to HTAU (Rattus norvegicus)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)
H+ [cytosol]
Methionine salvage pathway (Rattus norvegicus)
Acireductone is created (Rattus norvegicus)
H+ [cytosol]
Tryptophan catabolism (Rattus norvegicus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
H+ [cytosol]
Metabolism of carbohydrates (Rattus norvegicus)
Formation of xylulose-5-phosphate (Rattus norvegicus)
AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)
H+ [cytosol]
Fructose metabolism (Rattus norvegicus)
Fructose biosynthesis (Rattus norvegicus)
AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)
H+ [cytosol]
Fructose catabolism (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)
H+ [cytosol]
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)
H+ [cytosol]
Glycolysis (Rattus norvegicus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Rattus norvegicus)
H+ [cytosol]
Glycosaminoglycan metabolism (Rattus norvegicus)
Transport and synthesis of PAPS (Rattus norvegicus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Pentose phosphate pathway (Rattus norvegicus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)
H+ [cytosol]
Metabolism of lipids (Rattus norvegicus)
Biosynthesis of specialized proresolving mediators (SPMs) (Rattus norvegicus)
Biosynthesis of DHA-derived SPMs (Rattus norvegicus)
Biosynthesis of maresins (Rattus norvegicus)
Biosynthesis of maresin-like SPMs (Rattus norvegicus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)
H+ [cytosol]
Biosynthesis of protectins (Rattus norvegicus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Rattus norvegicus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)
H+ [cytosol]
Fatty acid metabolism (Rattus norvegicus)
Arachidonic acid metabolism (Rattus norvegicus)
Synthesis of 15-eicosatetraenoic acid derivatives (Rattus norvegicus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Rattus norvegicus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Rattus norvegicus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Rattus norvegicus)
SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Rattus norvegicus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)
H+ [cytosol]
Ketone body metabolism (Rattus norvegicus)
Synthesis of Ketone Bodies (Rattus norvegicus)
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
H+ [cytosol]
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Synthesis of bile acids and bile salts (Rattus norvegicus)
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Rattus norvegicus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Rattus norvegicus)
27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
H+ [cytosol]
Cholesterol biosynthesis (Rattus norvegicus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Rattus norvegicus)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Rattus norvegicus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Rattus norvegicus)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Rattus norvegicus)
DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
H+ [cytosol]
Squalene is oxidized to its epoxide (Rattus norvegicus)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)
H+ [cytosol]
Metabolism of steroid hormones (Rattus norvegicus)
Androgen biosynthesis (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)
H+ [cytosol]
Estrogen biosynthesis (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
H+ [cytosol]
Glucocorticoid biosynthesis (Rattus norvegicus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Rattus norvegicus)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)
H+ [cytosol]
Mineralocorticoid biosynthesis (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)
H+ [cytosol]
Pregnenolone biosynthesis (Rattus norvegicus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
H+ [cytosol]
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
Synthesis of PA (Rattus norvegicus)
DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)
H+ [cytosol]
Sphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid biosynthesis (Rattus norvegicus)
CERK phosphorylates CERA to form C1P (Rattus norvegicus)
H+ [cytosol]
Glycosphingolipid catabolism (Rattus norvegicus)
ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Rattus norvegicus)
H+ [cytosol]
Sphingolipid catabolism (Rattus norvegicus)
ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Rattus norvegicus)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Rattus norvegicus)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Rattus norvegicus)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Rattus norvegicus)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Rattus norvegicus)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Rattus norvegicus)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Rattus norvegicus)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Rattus norvegicus)
Plasmalogen biosynthesis (Rattus norvegicus)
DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)
H+ [cytosol]
Wax biosynthesis (Rattus norvegicus)
FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
CYGB dioxygenates NO (Rattus norvegicus)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
H+ [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
H+ [cytosol]
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
H+ [cytosol]
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)
H+ [cytosol]
AIR + CO2 => CAIR (Rattus norvegicus)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
H+ [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)
H+ [cytosol]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
H+ [cytosol]
Pyrimidine catabolism (Rattus norvegicus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)
H+ [cytosol]
Nucleotide salvage (Rattus norvegicus)
Purine salvage (Rattus norvegicus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)
H+ [cytosol]
Metabolism of porphyrins (Rattus norvegicus)
Heme biosynthesis (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)
H+ [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
NADPH regeneration (Rattus norvegicus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Cobalamin (Cbl) metabolism (Rattus norvegicus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)
H+ [cytosol]
MMACHC dealkylates RCbl (Rattus norvegicus)
H+ [cytosol]
MMACHC decyanates CNCbl (Rattus norvegicus)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
H+ [cytosol]
Metabolism of folate and pterines (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Rattus norvegicus)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Rattus norvegicus)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
H+ [cytosol]
Nicotinate metabolism (Rattus norvegicus)
NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)
H+ [cytosol]
Nicotinamide salvaging (Rattus norvegicus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
H+ [cytosol]
FLAD1 phosphorylates FMN (Rattus norvegicus)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Rattus norvegicus)
Coenzyme A biosynthesis (Rattus norvegicus)
2xPPCS ligates PPanK with Cys (Rattus norvegicus)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)
H+ [cytosol]
COASY phosphorylates DP-CoA (Rattus norvegicus)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Rattus norvegicus)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Rattus norvegicus)
H+ [cytosol]
PANK2 phosphorylates PanK (Rattus norvegicus)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Rattus norvegicus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)
H+ [cytosol]
Reversible hydration of carbon dioxide (Rattus norvegicus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)
H+ [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
GDP-fucose biosynthesis (Rattus norvegicus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
Hypusine synthesis from eIF5A-lysine (Rattus norvegicus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Rattus norvegicus)
Synthesis of glycosylphosphatidylinositol (GPI) (Rattus norvegicus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)
H+ [cytosol]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
H+ [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter release cycle (Rattus norvegicus)
Acetylcholine Neurotransmitter Release Cycle (Rattus norvegicus)
Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Rattus norvegicus)
GABA synthesis (Rattus norvegicus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)
H+ [cytosol]
Synthesis of GABA by GAD2 (Rattus norvegicus)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Rattus norvegicus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)
H+ [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Rattus norvegicus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Rattus norvegicus)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Rattus norvegicus)
atRAL is reduced to atROL (Rattus norvegicus)
H+ [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Arachidonate production from DAG (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
H+ [cytosol]
Signaling by Nuclear Receptors (Rattus norvegicus)
Signaling by Retinoic Acid (Rattus norvegicus)
RA biosynthesis pathway (Rattus norvegicus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Rattus norvegicus)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Rattus norvegicus)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor recycling (Rattus norvegicus)
Endosome acidification (Rattus norvegicus)
H+ [cytosol]
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate NADPH Oxidases (Rattus norvegicus)
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)
H+ [cytosol]
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
H+ [cytosol]
Stimuli-sensing channels (Rattus norvegicus)
CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)
H+ [cytosol]
Iron uptake and transport (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Transferrin endocytosis and recycling (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
H+ [cytosol]
Miscellaneous transport and binding events (Rattus norvegicus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Rattus norvegicus)
Erythrocytes take up carbon dioxide and release oxygen (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Rattus norvegicus)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)
H+ [cytosol]
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Inositol transporters (Rattus norvegicus)
HMIT co-transports myo-inositol with a proton (Rattus norvegicus)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Rattus norvegicus)
H+ [cytosol]
Metal ion SLC transporters (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic cation transport (Rattus norvegicus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Rattus norvegicus)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Rattus norvegicus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Amino acid transport across the plasma membrane (Rattus norvegicus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)
H+ [cytosol]
Bicarbonate transporters (Rattus norvegicus)
Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)
H+ [cytosol]
Multifunctional anion exchangers (Rattus norvegicus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Organic anion transporters (Rattus norvegicus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Rattus norvegicus)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Rattus norvegicus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Proton/oligopeptide cotransporters (Rattus norvegicus)
Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)
H+ [cytosol]
Sodium/Proton exchangers (Rattus norvegicus)
Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Rattus norvegicus)
H+ [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
NOX4, NOX5 reduce O2 to O2.- (Saccharomyces cerevisiae)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
Nuclear events mediated by NFE2L2 (Saccharomyces cerevisiae)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Saccharomyces cerevisiae)
SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)
H+ [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Abacavir ADME (Saccharomyces cerevisiae)
Abacavir metabolism (Saccharomyces cerevisiae)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Azathioprine ADME (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)
H+ [cytosol]
Prednisone ADME (Saccharomyces cerevisiae)
AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)
H+ [cytosol]
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
Generic Transcription Pathway (Saccharomyces cerevisiae)
Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
TP53 Regulates Metabolic Genes (Saccharomyces cerevisiae)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
H+ [cytosol]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
Effects of PIP2 hydrolysis (Saccharomyces cerevisiae)
Arachidonate production from DAG (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
H+ [cytosol]
Immune System (Saccharomyces cerevisiae)
Innate Immune System (Saccharomyces cerevisiae)
ROS and RNS production in phagocytes (Saccharomyces cerevisiae)
Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Pyruvate metabolism (Saccharomyces cerevisiae)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Saccharomyces cerevisiae)
Respiratory electron transport (Saccharomyces cerevisiae)
Malate-aspartate shuttle (Saccharomyces cerevisiae)
SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Biological oxidations (Saccharomyces cerevisiae)
Phase I - Functionalization of compounds (Saccharomyces cerevisiae)
ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Saccharomyces cerevisiae)
Endogenous sterols (Saccharomyces cerevisiae)
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
H+ [cytosol]
Ethanol oxidation (Saccharomyces cerevisiae)
ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Cytosolic sulfonation of small molecules (Saccharomyces cerevisiae)
Transport and synthesis of PAPS (Saccharomyces cerevisiae)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)
H+ [cytosol]
Creatine metabolism (Saccharomyces cerevisiae)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
H+ [cytosol]
Glutamate and glutamine metabolism (Saccharomyces cerevisiae)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)
H+ [cytosol]
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
Methionine salvage pathway (Saccharomyces cerevisiae)
Acireductone is created (Saccharomyces cerevisiae)
H+ [cytosol]
Tryptophan catabolism (Saccharomyces cerevisiae)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Formation of xylulose-5-phosphate (Saccharomyces cerevisiae)
AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)
H+ [cytosol]
Fructose metabolism (Saccharomyces cerevisiae)
Fructose biosynthesis (Saccharomyces cerevisiae)
AKR1B1 reduces Glc to D-sorbitol (Saccharomyces cerevisiae)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)
H+ [cytosol]
Fructose catabolism (Saccharomyces cerevisiae)
ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
H+ [cytosol]
Glucose metabolism (Saccharomyces cerevisiae)
Gluconeogenesis (Saccharomyces cerevisiae)
GAPDH tetramers reduce 1,3BPG to GA3P (Saccharomyces cerevisiae)
H+ [cytosol]
Glycolysis (Saccharomyces cerevisiae)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Saccharomyces cerevisiae)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)
H+ [cytosol]
Glycosaminoglycan metabolism (Saccharomyces cerevisiae)
Transport and synthesis of PAPS (Saccharomyces cerevisiae)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
Pentose phosphate pathway (Saccharomyces cerevisiae)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of lipids (Saccharomyces cerevisiae)
Fatty acid metabolism (Saccharomyces cerevisiae)
Arachidonic acid metabolism (Saccharomyces cerevisiae)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Saccharomyces cerevisiae)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Saccharomyces cerevisiae)
SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Saccharomyces cerevisiae)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of steroids (Saccharomyces cerevisiae)
Bile acid and bile salt metabolism (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Saccharomyces cerevisiae)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Saccharomyces cerevisiae)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Saccharomyces cerevisiae)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Saccharomyces cerevisiae)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Saccharomyces cerevisiae)
H+ [cytosol]
Cholesterol biosynthesis (Saccharomyces cerevisiae)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Saccharomyces cerevisiae)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Saccharomyces cerevisiae)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
H+ [cytosol]
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of steroid hormones (Saccharomyces cerevisiae)
Androgen biosynthesis (Saccharomyces cerevisiae)
SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)
H+ [cytosol]
Estrogen biosynthesis (Saccharomyces cerevisiae)
HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)
H+ [cytosol]
Pregnenolone biosynthesis (Saccharomyces cerevisiae)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Saccharomyces cerevisiae)
H+ [cytosol]
Phospholipid metabolism (Saccharomyces cerevisiae)
Glycerophospholipid biosynthesis (Saccharomyces cerevisiae)
Synthesis of PA (Saccharomyces cerevisiae)
DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)
H+ [cytosol]
Sphingolipid metabolism (Saccharomyces cerevisiae)
Glycosphingolipid metabolism (Saccharomyces cerevisiae)
Glycosphingolipid catabolism (Saccharomyces cerevisiae)
ENPP7 hydrolyzes sphingomyelin (Saccharomyces cerevisiae)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Saccharomyces cerevisiae)
H+ [cytosol]
Sphingolipid catabolism (Saccharomyces cerevisiae)
ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Saccharomyces cerevisiae)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Saccharomyces cerevisiae)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Saccharomyces cerevisiae)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Saccharomyces cerevisiae)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
eNOS activation (Saccharomyces cerevisiae)
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
H+ [cytosol]
Nucleotide biosynthesis (Saccharomyces cerevisiae)
Purine ribonucleoside monophosphate biosynthesis (Saccharomyces cerevisiae)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
H+ [cytosol]
Pyrimidine biosynthesis (Saccharomyces cerevisiae)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
H+ [cytosol]
Nucleotide catabolism (Saccharomyces cerevisiae)
Purine catabolism (Saccharomyces cerevisiae)
Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of porphyrins (Saccharomyces cerevisiae)
Heme biosynthesis (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
NADPH regeneration (Saccharomyces cerevisiae)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of folate and pterines (Saccharomyces cerevisiae)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
H+ [cytosol]
Nicotinate metabolism (Saccharomyces cerevisiae)
Nicotinamide salvaging (Saccharomyces cerevisiae)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Saccharomyces cerevisiae)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
H+ [cytosol]
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Saccharomyces cerevisiae)
Coenzyme A biosynthesis (Saccharomyces cerevisiae)
2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)
H+ [cytosol]
COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Saccharomyces cerevisiae)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Saccharomyces cerevisiae)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Saccharomyces cerevisiae)
H+ [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
Hypusine synthesis from eIF5A-lysine (Saccharomyces cerevisiae)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
H+ [cytosol]
Sensory Perception (Saccharomyces cerevisiae)
Visual phototransduction (Saccharomyces cerevisiae)
The retinoid cycle in cones (daylight vision) (Saccharomyces cerevisiae)
atRAL is reduced to atROL (Saccharomyces cerevisiae)
H+ [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
Signaling by GPCR (Saccharomyces cerevisiae)
GPCR downstream signalling (Saccharomyces cerevisiae)
G alpha (q) signalling events (Saccharomyces cerevisiae)
Effects of PIP2 hydrolysis (Saccharomyces cerevisiae)
Arachidonate production from DAG (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
H+ [cytosol]
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
Signaling by Retinoic Acid (Saccharomyces cerevisiae)
RA biosynthesis pathway (Saccharomyces cerevisiae)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by Insulin receptor (Saccharomyces cerevisiae)
Insulin receptor recycling (Saccharomyces cerevisiae)
Endosome acidification (Saccharomyces cerevisiae)
H+ [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
Ion channel transport (Saccharomyces cerevisiae)
Stimuli-sensing channels (Saccharomyces cerevisiae)
CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Iron uptake and transport (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
H+ [cytosol]
Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
H+ [cytosol]
Miscellaneous transport and binding events (Saccharomyces cerevisiae)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of bile salts and organic acids, metal ions and amine compounds (Saccharomyces cerevisiae)
Inositol transporters (Saccharomyces cerevisiae)
HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
Amino acid transport across the plasma membrane (Saccharomyces cerevisiae)
SLC36A1-mediated uptake of glycine, proline, and alanine (Saccharomyces cerevisiae)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Saccharomyces cerevisiae)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Saccharomyces cerevisiae)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
Multifunctional anion exchangers (Saccharomyces cerevisiae)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
Organic anion transporters (Saccharomyces cerevisiae)
SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Saccharomyces cerevisiae)
SLC36A1-mediated uptake of glycine, proline, and alanine (Saccharomyces cerevisiae)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
H+ [cytosol]
Proton/oligopeptide cotransporters (Saccharomyces cerevisiae)
Proton-coupled histidine and di-peptide cotransport (Saccharomyces cerevisiae)
H+ [cytosol]
Sodium/Proton exchangers (Saccharomyces cerevisiae)
Na+/H+ exchanger transport (at cell membrane) (Saccharomyces cerevisiae)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)
H+ [cytosol]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Schizosaccharomyces pombe)
Nuclear events mediated by NFE2L2 (Schizosaccharomyces pombe)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Schizosaccharomyces pombe)
SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)
H+ [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Abacavir ADME (Schizosaccharomyces pombe)
Abacavir metabolism (Schizosaccharomyces pombe)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)
H+ [cytosol]
Azathioprine ADME (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)
H+ [cytosol]
Prednisone ADME (Schizosaccharomyces pombe)
AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)
H+ [cytosol]
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
H+ [cytosol]
Hemostasis (Schizosaccharomyces pombe)
Platelet activation, signaling and aggregation (Schizosaccharomyces pombe)
Effects of PIP2 hydrolysis (Schizosaccharomyces pombe)
Arachidonate production from DAG (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
H+ [cytosol]
Immune System (Schizosaccharomyces pombe)
Innate Immune System (Schizosaccharomyces pombe)
ROS and RNS production in phagocytes (Schizosaccharomyces pombe)
Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Pyruvate metabolism (Schizosaccharomyces pombe)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Schizosaccharomyces pombe)
H+ [cytosol]
Biological oxidations (Schizosaccharomyces pombe)
Phase I - Functionalization of compounds (Schizosaccharomyces pombe)
Cytochrome P450 - arranged by substrate type (Schizosaccharomyces pombe)
Endogenous sterols (Schizosaccharomyces pombe)
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
H+ [cytosol]
Ethanol oxidation (Schizosaccharomyces pombe)
ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Cytosolic sulfonation of small molecules (Schizosaccharomyces pombe)
Transport and synthesis of PAPS (Schizosaccharomyces pombe)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Creatine metabolism (Schizosaccharomyces pombe)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
H+ [cytosol]
Glutamate and glutamine metabolism (Schizosaccharomyces pombe)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)
H+ [cytosol]
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
Methionine salvage pathway (Schizosaccharomyces pombe)
Acireductone is created (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Formation of xylulose-5-phosphate (Schizosaccharomyces pombe)
AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)
H+ [cytosol]
Fructose metabolism (Schizosaccharomyces pombe)
Fructose biosynthesis (Schizosaccharomyces pombe)
AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)
H+ [cytosol]
Fructose catabolism (Schizosaccharomyces pombe)
ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
H+ [cytosol]
Glucose metabolism (Schizosaccharomyces pombe)
Gluconeogenesis (Schizosaccharomyces pombe)
GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)
H+ [cytosol]
Glycolysis (Schizosaccharomyces pombe)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Schizosaccharomyces pombe)
H+ [cytosol]
Glycosaminoglycan metabolism (Schizosaccharomyces pombe)
Transport and synthesis of PAPS (Schizosaccharomyces pombe)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
H+ [cytosol]
Pentose phosphate pathway (Schizosaccharomyces pombe)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of lipids (Schizosaccharomyces pombe)
Fatty acid metabolism (Schizosaccharomyces pombe)
Arachidonic acid metabolism (Schizosaccharomyces pombe)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Schizosaccharomyces pombe)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Schizosaccharomyces pombe)
SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Schizosaccharomyces pombe)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of steroids (Schizosaccharomyces pombe)
Bile acid and bile salt metabolism (Schizosaccharomyces pombe)
Synthesis of bile acids and bile salts (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Schizosaccharomyces pombe)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Schizosaccharomyces pombe)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Schizosaccharomyces pombe)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)
H+ [cytosol]
Cholesterol biosynthesis (Schizosaccharomyces pombe)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Schizosaccharomyces pombe)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Schizosaccharomyces pombe)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
H+ [cytosol]
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of steroid hormones (Schizosaccharomyces pombe)
Androgen biosynthesis (Schizosaccharomyces pombe)
SRD5A1 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
H+ [cytosol]
Estrogen biosynthesis (Schizosaccharomyces pombe)
HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)
H+ [cytosol]
Glucocorticoid biosynthesis (Schizosaccharomyces pombe)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)
H+ [cytosol]
Pregnenolone biosynthesis (Schizosaccharomyces pombe)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)
H+ [cytosol]
Phospholipid metabolism (Schizosaccharomyces pombe)
Glycerophospholipid biosynthesis (Schizosaccharomyces pombe)
Synthesis of PA (Schizosaccharomyces pombe)
DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)
H+ [cytosol]
Sphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid catabolism (Schizosaccharomyces pombe)
ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Schizosaccharomyces pombe)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Schizosaccharomyces pombe)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Schizosaccharomyces pombe)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Schizosaccharomyces pombe)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Schizosaccharomyces pombe)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
H+ [cytosol]
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Purine ribonucleoside monophosphate biosynthesis (Schizosaccharomyces pombe)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
H+ [cytosol]
Pyrimidine biosynthesis (Schizosaccharomyces pombe)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
H+ [cytosol]
Nucleotide catabolism (Schizosaccharomyces pombe)
Purine catabolism (Schizosaccharomyces pombe)
Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
H+ [cytosol]
Pyrimidine catabolism (Schizosaccharomyces pombe)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of porphyrins (Schizosaccharomyces pombe)
Heme biosynthesis (Schizosaccharomyces pombe)
ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
NADPH regeneration (Schizosaccharomyces pombe)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of folate and pterines (Schizosaccharomyces pombe)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
H+ [cytosol]
Nicotinate metabolism (Schizosaccharomyces pombe)
Nicotinamide salvaging (Schizosaccharomyces pombe)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
H+ [cytosol]
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Schizosaccharomyces pombe)
Coenzyme A biosynthesis (Schizosaccharomyces pombe)
2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)
H+ [cytosol]
COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Schizosaccharomyces pombe)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Schizosaccharomyces pombe)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Schizosaccharomyces pombe)
H+ [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
Hypusine synthesis from eIF5A-lysine (Schizosaccharomyces pombe)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
H+ [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
Signaling by GPCR (Schizosaccharomyces pombe)
GPCR downstream signalling (Schizosaccharomyces pombe)
G alpha (q) signalling events (Schizosaccharomyces pombe)
Effects of PIP2 hydrolysis (Schizosaccharomyces pombe)
Arachidonate production from DAG (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
H+ [cytosol]
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
Signaling by Retinoic Acid (Schizosaccharomyces pombe)
RA biosynthesis pathway (Schizosaccharomyces pombe)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by Insulin receptor (Schizosaccharomyces pombe)
Insulin receptor recycling (Schizosaccharomyces pombe)
Endosome acidification (Schizosaccharomyces pombe)
H+ [cytosol]
Transport of small molecules (Schizosaccharomyces pombe)
Ion channel transport (Schizosaccharomyces pombe)
Stimuli-sensing channels (Schizosaccharomyces pombe)
CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)
H+ [cytosol]
Iron uptake and transport (Schizosaccharomyces pombe)
Transferrin endocytosis and recycling (Schizosaccharomyces pombe)
Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
H+ [cytosol]
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
Inositol transporters (Schizosaccharomyces pombe)
HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Schizosaccharomyces pombe)
Multifunctional anion exchangers (Schizosaccharomyces pombe)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
H+ [cytosol]
Proton/oligopeptide cotransporters (Schizosaccharomyces pombe)
Proton-coupled histidine and di-peptide cotransport (Schizosaccharomyces pombe)
H+ [cytosol]
Sodium/Proton exchangers (Schizosaccharomyces pombe)
Na+/H+ exchanger transport (at cell membrane) (Schizosaccharomyces pombe)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)
H+ [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Detoxification of Reactive Oxygen Species (Sus scrofa)
NOX2 generates superoxide from oxygen (Sus scrofa)
H+ [cytosol]
NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
H+ [cytosol]
KEAP1-NFE2L2 pathway (Sus scrofa)
Nuclear events mediated by NFE2L2 (Sus scrofa)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Sus scrofa)
SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)
H+ [cytosol]
Drug ADME (Sus scrofa)
Abacavir ADME (Sus scrofa)
Abacavir metabolism (Sus scrofa)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)
H+ [cytosol]
Aspirin ADME (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Atorvastatin ADME (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
H+ [cytosol]
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)
H+ [cytosol]
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)
H+ [cytosol]
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
H+ [cytosol]
Azathioprine ADME (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Sus scrofa)
H+ [cytosol]
Ciprofloxacin ADME (Sus scrofa)
SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)
H+ [cytosol]
Paracetamol ADME (Sus scrofa)
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
H+ [cytosol]
Prednisone ADME (Sus scrofa)
AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)
H+ [cytosol]
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)
H+ [cytosol]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
TP53 Regulates Metabolic Genes (Sus scrofa)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Sus scrofa)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Sus scrofa)
TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)
H+ [cytosol]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Arachidonate production from DAG (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Sus scrofa)
H+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
Platelet degranulation (Sus scrofa)
ABCC4 accumulation of dense granule contents (Sus scrofa)
H+ [cytosol]
Platelet homeostasis (Sus scrofa)
Platelet calcium homeostasis (Sus scrofa)
Reduction of cytosolic Ca++ levels (Sus scrofa)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)
H+ [cytosol]
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
OAS antiviral response (Sus scrofa)
PDE12 cleaves 2'-5' oligoadenylates (Sus scrofa)
H+ [cytosol]
Innate Immune System (Sus scrofa)
Antimicrobial peptides (Sus scrofa)
Ion influx/efflux at host-pathogen interface (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
H+ [cytosol]
ROS and RNS production in phagocytes (Sus scrofa)
HV1-mediated H+ transfer (Sus scrofa)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Sus scrofa)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
H+ [cytosol]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Pyruvate metabolism (Sus scrofa)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Sus scrofa)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Sus scrofa)
H+ [cytosol]
ME1 tetramer decarboxylates MAL to PYR (Sus scrofa)
H+ [cytosol]
ME1 tetramer decarboxylates OA to PYR (Sus scrofa)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Sus scrofa)
H+ [cytosol]
Regulation of pyruvate metabolism (Sus scrofa)
NEK1 phosphorylates ME1 (Sus scrofa)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Sus scrofa)
Respiratory electron transport (Sus scrofa)
Malate-aspartate shuttle (Sus scrofa)
MDH1 reduces OA (Sus scrofa)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Sus scrofa)
H+ [cytosol]
Biological oxidations (Sus scrofa)
Aflatoxin activation and detoxification (Sus scrofa)
AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)
H+ [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
H+ [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)
H+ [cytosol]
Phase I - Functionalization of compounds (Sus scrofa)
ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)
H+ [cytosol]
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Eicosanoids (Sus scrofa)
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)
H+ [cytosol]
Endogenous sterols (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
H+ [cytosol]
CYP1B1 4-hydroxylates EST17b (Sus scrofa)
H+ [cytosol]
CYP21A2 21-hydroxylates PROG (Sus scrofa)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Sus scrofa)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
H+ [cytosol]
Vitamins (Sus scrofa)
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
H+ [cytosol]
Ethanol oxidation (Sus scrofa)
ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)
H+ [cytosol]
Phase II - Conjugation of compounds (Sus scrofa)
Cytosolic sulfonation of small molecules (Sus scrofa)
Transport and synthesis of PAPS (Sus scrofa)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Glucuronidation (Sus scrofa)
Formation of the active cofactor, UDP-glucuronate (Sus scrofa)
UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
H+ [cytosol]
Methylation (Sus scrofa)
TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)
H+ [cytosol]
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP2, IP, and Ins in the cytosol (Sus scrofa)
MIOX oxidises Ins to GlcA (Sus scrofa)
H+ [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Aspartate and asparagine metabolism (Sus scrofa)
SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)
H+ [cytosol]
Carnitine synthesis (Sus scrofa)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)
H+ [cytosol]
Creatine metabolism (Sus scrofa)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
H+ [cytosol]
Glutamate and glutamine metabolism (Sus scrofa)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)
H+ [cytosol]
Histidine catabolism (Sus scrofa)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
H+ [cytosol]
Metabolism of amine-derived hormones (Sus scrofa)
Catecholamine biosynthesis (Sus scrofa)
Noradrenaline is converted to adrenaline (Sus scrofa)
H+ [cytosol]
Serotonin and melatonin biosynthesis (Sus scrofa)
Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)
H+ [cytosol]
Thyroxine biosynthesis (Sus scrofa)
Regulation of thyroid hormone activity (Sus scrofa)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)
H+ [cytosol]
Thyroxine is deiodinated to triiodothyronine (Sus scrofa)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
H+ [cytosol]
Tyrosine catabolism (Sus scrofa)
FAH cleaves 4FAA (Sus scrofa)
H+ [cytosol]
HGD dioxygenates homogentisate (Sus scrofa)
H+ [cytosol]
Selenoamino acid metabolism (Sus scrofa)
Selenocysteine synthesis (Sus scrofa)
SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)
H+ [cytosol]
Serine biosynthesis (Sus scrofa)
PHGDH tetramer dehydrogenates 3PG (Sus scrofa)
H+ [cytosol]
Sulfur amino acid metabolism (Sus scrofa)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Sus scrofa)
H+ [cytosol]
Degradation of cysteine and homocysteine (Sus scrofa)
ADO oxidises 2AET to HTAU (Sus scrofa)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)
H+ [cytosol]
Methionine salvage pathway (Sus scrofa)
Acireductone is created (Sus scrofa)
H+ [cytosol]
Tryptophan catabolism (Sus scrofa)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
H+ [cytosol]
Metabolism of carbohydrates (Sus scrofa)
Formation of xylulose-5-phosphate (Sus scrofa)
AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)
H+ [cytosol]
Fructose metabolism (Sus scrofa)
Fructose biosynthesis (Sus scrofa)
AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Sus scrofa)
H+ [cytosol]
Fructose catabolism (Sus scrofa)
ALDH1A1 oxidises GA to DGA (Sus scrofa)
H+ [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)
H+ [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)
H+ [cytosol]
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
GAPDH tetramers reduce 1,3BPG to GA3P (Sus scrofa)
H+ [cytosol]
Glycolysis (Sus scrofa)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)
H+ [cytosol]
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Sus scrofa)
H+ [cytosol]
Glycosaminoglycan metabolism (Sus scrofa)
Transport and synthesis of PAPS (Sus scrofa)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Pentose phosphate pathway (Sus scrofa)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)
H+ [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)
H+ [cytosol]
Metabolism of lipids (Sus scrofa)
Biosynthesis of specialized proresolving mediators (SPMs) (Sus scrofa)
Biosynthesis of DHA-derived SPMs (Sus scrofa)
Biosynthesis of maresins (Sus scrofa)
Biosynthesis of maresin-like SPMs (Sus scrofa)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)
H+ [cytosol]
Biosynthesis of protectins (Sus scrofa)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Sus scrofa)
LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)
H+ [cytosol]
Fatty acid metabolism (Sus scrofa)
Arachidonic acid metabolism (Sus scrofa)
Synthesis of 15-eicosatetraenoic acid derivatives (Sus scrofa)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Sus scrofa)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Sus scrofa)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Sus scrofa)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Sus scrofa)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Sus scrofa)
SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)
H+ [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Sus scrofa)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)
H+ [cytosol]
Ketone body metabolism (Sus scrofa)
Synthesis of Ketone Bodies (Sus scrofa)
BDH2 dehydrogenates 3HBA (Sus scrofa)
H+ [cytosol]
Metabolism of steroids (Sus scrofa)
Bile acid and bile salt metabolism (Sus scrofa)
Synthesis of bile acids and bile salts (Sus scrofa)
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Sus scrofa)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Sus scrofa)
27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Sus scrofa)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
H+ [cytosol]
Cholesterol biosynthesis (Sus scrofa)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)
H+ [cytosol]
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
H+ [cytosol]
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)
H+ [cytosol]
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
H+ [cytosol]
CYP51A1 demethylates LNSOL (Sus scrofa)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Sus scrofa)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Sus scrofa)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Sus scrofa)
DHCR24 reduces ZYMOL to ZYMSTNL (Sus scrofa)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Sus scrofa)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)
H+ [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Sus scrofa)
H+ [cytosol]
Squalene is oxidized to its epoxide (Sus scrofa)
H+ [cytosol]
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)
H+ [cytosol]
Metabolism of steroid hormones (Sus scrofa)
Androgen biosynthesis (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Sus scrofa)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)
H+ [cytosol]
HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)
H+ [cytosol]
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)
H+ [cytosol]
Estrogen biosynthesis (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Sus scrofa)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)
H+ [cytosol]
Glucocorticoid biosynthesis (Sus scrofa)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Sus scrofa)
H+ [cytosol]
CYP21A2 oxidises 17HPROG (Sus scrofa)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)
H+ [cytosol]
Mineralocorticoid biosynthesis (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
H+ [cytosol]
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)
H+ [cytosol]
Pregnenolone biosynthesis (Sus scrofa)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
H+ [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
H+ [cytosol]
Phospholipid metabolism (Sus scrofa)
Glycerophospholipid biosynthesis (Sus scrofa)
Synthesis of PA (Sus scrofa)
DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)
H+ [cytosol]
Sphingolipid metabolism (Sus scrofa)
Glycosphingolipid metabolism (Sus scrofa)
Glycosphingolipid biosynthesis (Sus scrofa)
CERK phosphorylates CERA to form C1P (Sus scrofa)
H+ [cytosol]
Glycosphingolipid catabolism (Sus scrofa)
ENPP7 hydrolyzes sphingomyelin (Sus scrofa)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)
H+ [cytosol]
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Sus scrofa)
H+ [cytosol]
Sphingolipid catabolism (Sus scrofa)
ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)
H+ [cytosol]
ALDH3B1 oxidises HXAL to PALM (Sus scrofa)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Sus scrofa)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Sus scrofa)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Sus scrofa)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Sus scrofa)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Sus scrofa)
H+ [cytosol]
SPHK1 phosphorylates sphingoid (Sus scrofa)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Sus scrofa)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Sus scrofa)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Sus scrofa)
Plasmalogen biosynthesis (Sus scrofa)
DHRS7B reduces GO3P to HXDG3P (Sus scrofa)
H+ [cytosol]
Wax biosynthesis (Sus scrofa)
FAR1 reduces PalmCoA to HXOL (Sus scrofa)
H+ [cytosol]
FAR2 reduces PalmCoA to HXOL (Sus scrofa)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Sus scrofa)
eNOS activation (Sus scrofa)
CYGB dioxygenates NO (Sus scrofa)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)
H+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
H+ [cytosol]
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
H+ [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
H+ [cytosol]
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
H+ [cytosol]
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)
H+ [cytosol]
AIR + CO2 => CAIR (Sus scrofa)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Sus scrofa)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
H+ [cytosol]
Pyrimidine biosynthesis (Sus scrofa)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Sus scrofa)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Sus scrofa)
H+ [cytosol]
Nucleotide catabolism (Sus scrofa)
Purine catabolism (Sus scrofa)
Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Sus scrofa)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Sus scrofa)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Sus scrofa)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Sus scrofa)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Sus scrofa)
H+ [cytosol]
Pyrimidine catabolism (Sus scrofa)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)
H+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)
H+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)
H+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)
H+ [cytosol]
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)
H+ [cytosol]
Nucleotide salvage (Sus scrofa)
Purine salvage (Sus scrofa)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)
H+ [cytosol]
Metabolism of porphyrins (Sus scrofa)
Heme biosynthesis (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Sus scrofa)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Sus scrofa)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Sus scrofa)
H+ [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
NADPH regeneration (Sus scrofa)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Sus scrofa)
Cobalamin (Cbl) metabolism (Sus scrofa)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)
H+ [cytosol]
MMACHC dealkylates RCbl (Sus scrofa)
H+ [cytosol]
MMACHC decyanates CNCbl (Sus scrofa)
H+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
H+ [cytosol]
Metabolism of folate and pterines (Sus scrofa)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
H+ [cytosol]
DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)
H+ [cytosol]
DHFR dimer reduces FOLA to DHF (Sus scrofa)
H+ [cytosol]
DHFR2 reduces FOLA to DHF (Sus scrofa)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
H+ [cytosol]
Nicotinate metabolism (Sus scrofa)
NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)
H+ [cytosol]
NMRK1 phosphorylates NR to yield NMN (Sus scrofa)
H+ [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)
H+ [cytosol]
NMRK2 phosphorylates NR to yield NMN (Sus scrofa)
H+ [cytosol]
Nicotinamide salvaging (Sus scrofa)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Sus scrofa)
H+ [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
H+ [cytosol]
FLAD1 phosphorylates FMN (Sus scrofa)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Sus scrofa)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Sus scrofa)
Coenzyme A biosynthesis (Sus scrofa)
2xPPCS ligates PPanK with Cys (Sus scrofa)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)
H+ [cytosol]
COASY phosphorylates DP-CoA (Sus scrofa)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Sus scrofa)
H+ [cytosol]
PANK1/3 phosphorylate PanK (Sus scrofa)
H+ [cytosol]
PANK2 phosphorylates PanK (Sus scrofa)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Sus scrofa)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)
H+ [cytosol]
Reversible hydration of carbon dioxide (Sus scrofa)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)
H+ [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
GDP-fucose biosynthesis (Sus scrofa)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)
H+ [cytosol]
Sialic acid metabolism (Sus scrofa)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
H+ [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Hypusine synthesis from eIF5A-lysine (Sus scrofa)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Sus scrofa)
Synthesis of glycosylphosphatidylinositol (GPI) (Sus scrofa)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)
H+ [cytosol]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Ion homeostasis (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
H+ [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter release cycle (Sus scrofa)
Acetylcholine Neurotransmitter Release Cycle (Sus scrofa)
Loading of acetylcholine in synaptic vesicles (Sus scrofa)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Sus scrofa)
GABA synthesis (Sus scrofa)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)
H+ [cytosol]
Synthesis of GABA by GAD2 (Sus scrofa)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Sus scrofa)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)
H+ [cytosol]
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)
H+ [cytosol]
RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Sus scrofa)
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)
H+ [cytosol]
RDH12 reduces atRAL to atROL (Sus scrofa)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Sus scrofa)
atRAL is reduced to atROL (Sus scrofa)
H+ [cytosol]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (q) signalling events (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Arachidonate production from DAG (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Sus scrofa)
H+ [cytosol]
Signaling by Nuclear Receptors (Sus scrofa)
Signaling by Retinoic Acid (Sus scrofa)
RA biosynthesis pathway (Sus scrofa)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Sus scrofa)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Sus scrofa)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor recycling (Sus scrofa)
Endosome acidification (Sus scrofa)
H+ [cytosol]
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate NADPH Oxidases (Sus scrofa)
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)
H+ [cytosol]
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Ion transport by P-type ATPases (Sus scrofa)
ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)
H+ [cytosol]
Stimuli-sensing channels (Sus scrofa)
CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)
H+ [cytosol]
Iron uptake and transport (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Transferrin endocytosis and recycling (Sus scrofa)
Acidification of Tf:TfR1 containing endosome (Sus scrofa)
H+ [cytosol]
Miscellaneous transport and binding events (Sus scrofa)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Sus scrofa)
Erythrocytes take up carbon dioxide and release oxygen (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Sus scrofa)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)
H+ [cytosol]
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Inositol transporters (Sus scrofa)
HMIT co-transports myo-inositol with a proton (Sus scrofa)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Sus scrofa)
H+ [cytosol]
Metal ion SLC transporters (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic cation transport (Sus scrofa)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Sus scrofa)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Sus scrofa)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Sus scrofa)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Amino acid transport across the plasma membrane (Sus scrofa)
SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)
H+ [cytosol]
Bicarbonate transporters (Sus scrofa)
Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)
H+ [cytosol]
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)
H+ [cytosol]
Multifunctional anion exchangers (Sus scrofa)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Organic anion transporters (Sus scrofa)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Sus scrofa)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Sus scrofa)
SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Proton/oligopeptide cotransporters (Sus scrofa)
Proton-coupled di- and tri-peptide cotransport (Sus scrofa)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Sus scrofa)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)
H+ [cytosol]
Sodium/Proton exchangers (Sus scrofa)
Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)
H+ [cytosol]
Vesicular inhibitory amino acid transport (Sus scrofa)
H+ [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
H+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
H+ [cytosol]
Drug ADME (Xenopus tropicalis)
Abacavir ADME (Xenopus tropicalis)
Abacavir metabolism (Xenopus tropicalis)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)
H+ [cytosol]
Aspirin ADME (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Atorvastatin ADME (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
H+ [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
H+ [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
H+ [cytosol]
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
H+ [cytosol]
Azathioprine ADME (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
H+ [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)
H+ [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
H+ [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
H+ [cytosol]
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
H+ [cytosol]
Paracetamol ADME (Xenopus tropicalis)
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
H+ [cytosol]
Prednisone ADME (Xenopus tropicalis)
AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)
H+ [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)
H+ [cytosol]
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)
H+ [cytosol]
HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)
H+ [cytosol]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
TP53 Regulates Metabolic Genes (Xenopus tropicalis)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
H+ [cytosol]
TP53 Regulates Transcription of Cell Death Genes (Xenopus tropicalis)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Xenopus tropicalis)
TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)
H+ [cytosol]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Arachidonate production from DAG (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
H+ [cytosol]
Platelet homeostasis (Xenopus tropicalis)
Platelet calcium homeostasis (Xenopus tropicalis)
Reduction of cytosolic Ca++ levels (Xenopus tropicalis)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)
H+ [cytosol]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Antimicrobial peptides (Xenopus tropicalis)
Ion influx/efflux at host-pathogen interface (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
H+ [cytosol]
ROS and RNS production in phagocytes (Xenopus tropicalis)
HV1-mediated H+ transfer (Xenopus tropicalis)
H+ [cytosol]
Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)
H+ [cytosol]
NOX2 generates superoxide anion from oxygen (Xenopus tropicalis)
H+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
H+ [cytosol]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Pyruvate metabolism (Xenopus tropicalis)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)
H+ [cytosol]
LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)
H+ [cytosol]
LDH tetramer reduces PYR to LACT (Xenopus tropicalis)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Xenopus tropicalis)
H+ [cytosol]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Xenopus tropicalis)
Respiratory electron transport (Xenopus tropicalis)
Malate-aspartate shuttle (Xenopus tropicalis)
MDH1 reduces OA (Xenopus tropicalis)
H+ [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Xenopus tropicalis)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)
H+ [cytosol]
Biological oxidations (Xenopus tropicalis)
Aflatoxin activation and detoxification (Xenopus tropicalis)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)
H+ [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)
H+ [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)
H+ [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)
H+ [cytosol]
Phase I - Functionalization of compounds (Xenopus tropicalis)
Cytochrome P450 - arranged by substrate type (Xenopus tropicalis)
Eicosanoids (Xenopus tropicalis)
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
H+ [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)
H+ [cytosol]
Endogenous sterols (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
H+ [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
H+ [cytosol]
Vitamins (Xenopus tropicalis)
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
H+ [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
H+ [cytosol]
Ethanol oxidation (Xenopus tropicalis)
ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)
H+ [cytosol]
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
H+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)
H+ [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)
H+ [cytosol]
Phase II - Conjugation of compounds (Xenopus tropicalis)
Cytosolic sulfonation of small molecules (Xenopus tropicalis)
Transport and synthesis of PAPS (Xenopus tropicalis)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Glucuronidation (Xenopus tropicalis)
Formation of the active cofactor, UDP-glucuronate (Xenopus tropicalis)
UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
H+ [cytosol]
Methylation (Xenopus tropicalis)
TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)
H+ [cytosol]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Aspartate and asparagine metabolism (Xenopus tropicalis)
SLC25A12,13 exchange L-Glu and L-Asp (Xenopus tropicalis)
H+ [cytosol]
Carnitine synthesis (Xenopus tropicalis)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)
H+ [cytosol]
Creatine metabolism (Xenopus tropicalis)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
H+ [cytosol]
Histidine catabolism (Xenopus tropicalis)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
H+ [cytosol]
Metabolism of amine-derived hormones (Xenopus tropicalis)
Serotonin and melatonin biosynthesis (Xenopus tropicalis)
Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)
H+ [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
H+ [cytosol]
Tyrosine catabolism (Xenopus tropicalis)
FAH cleaves 4FAA (Xenopus tropicalis)
H+ [cytosol]
Serine biosynthesis (Xenopus tropicalis)
PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)
H+ [cytosol]
Sulfur amino acid metabolism (Xenopus tropicalis)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)
H+ [cytosol]
Degradation of cysteine and homocysteine (Xenopus tropicalis)
ADO oxidises 2AET to HTAU (Xenopus tropicalis)
H+ [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)
H+ [cytosol]
Methionine salvage pathway (Xenopus tropicalis)
Acireductone is created (Xenopus tropicalis)
H+ [cytosol]
Tryptophan catabolism (Xenopus tropicalis)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
H+ [cytosol]
Metabolism of carbohydrates (Xenopus tropicalis)
Formation of xylulose-5-phosphate (Xenopus tropicalis)
AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)
H+ [cytosol]
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)
H+ [cytosol]
DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)
H+ [cytosol]
SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)
H+ [cytosol]
Fructose metabolism (Xenopus tropicalis)
Fructose biosynthesis (Xenopus tropicalis)
AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)
H+ [cytosol]
SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)
H+ [cytosol]
Fructose catabolism (Xenopus tropicalis)
ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
H+ [cytosol]
Glucose metabolism (Xenopus tropicalis)
Gluconeogenesis (Xenopus tropicalis)
GAPDH tetramers reduce 1,3BPG to GA3P (Xenopus tropicalis)
H+ [cytosol]
Glycolysis (Xenopus tropicalis)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)
H+ [cytosol]
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Xenopus tropicalis)
H+ [cytosol]
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)
H+ [cytosol]
PKM dephosphorylates PEP to PYR (Xenopus tropicalis)
H+ [cytosol]
Glycosaminoglycan metabolism (Xenopus tropicalis)
Transport and synthesis of PAPS (Xenopus tropicalis)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)
H+ [cytosol]
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
H+ [cytosol]
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Pentose phosphate pathway (Xenopus tropicalis)
SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)
H+ [cytosol]
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)
H+ [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Biosynthesis of specialized proresolving mediators (SPMs) (Xenopus tropicalis)
Biosynthesis of DHA-derived SPMs (Xenopus tropicalis)
Biosynthesis of maresins (Xenopus tropicalis)
Biosynthesis of maresin-like SPMs (Xenopus tropicalis)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)
H+ [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)
H+ [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)
H+ [cytosol]
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Xenopus tropicalis)
H+ [cytosol]
Synthesis of Lipoxins (LX) (Xenopus tropicalis)
LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)
H+ [cytosol]
Fatty acid metabolism (Xenopus tropicalis)
Arachidonic acid metabolism (Xenopus tropicalis)
Synthesis of 15-eicosatetraenoic acid derivatives (Xenopus tropicalis)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
H+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Xenopus tropicalis)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
H+ [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
H+ [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
H+ [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Xenopus tropicalis)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)
H+ [cytosol]
PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)
H+ [cytosol]
PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)
H+ [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)
H+ [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)
H+ [cytosol]
Fatty acyl-CoA biosynthesis (Xenopus tropicalis)
SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)
H+ [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Xenopus tropicalis)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)
H+ [cytosol]
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)
H+ [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)
H+ [cytosol]
Metabolism of steroids (Xenopus tropicalis)
Bile acid and bile salt metabolism (Xenopus tropicalis)
Synthesis of bile acids and bile salts (Xenopus tropicalis)
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
H+ [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
H+ [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Xenopus tropicalis)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Xenopus tropicalis)
H+ [cytosol]
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Xenopus tropicalis)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)
H+ [cytosol]
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)
H+ [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)
H+ [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Xenopus tropicalis)
27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)
H+ [cytosol]
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Xenopus tropicalis)
H+ [cytosol]
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Xenopus tropicalis)
H+ [cytosol]
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)
H+ [cytosol]
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
H+ [cytosol]
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)
H+ [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Xenopus tropicalis)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)
H+ [cytosol]
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Xenopus tropicalis)
H+ [cytosol]
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)
H+ [cytosol]
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)
H+ [cytosol]
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)
H+ [cytosol]
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
H+ [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
H+ [cytosol]
Cholesterol biosynthesis (Xenopus tropicalis)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
H+ [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
H+ [cytosol]
Cholesterol biosynthesis via desmosterol (Xenopus tropicalis)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)
H+ [cytosol]
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)
H+ [cytosol]
Reduction of desmosterol to cholesterol (Xenopus tropicalis)
H+ [cytosol]
Cholesterol biosynthesis via lathosterol (Xenopus tropicalis)
DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)
H+ [cytosol]
DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)
H+ [cytosol]
SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)
H+ [cytosol]
DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)
H+ [cytosol]
HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)
H+ [cytosol]
Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
H+ [cytosol]
Squalene is oxidized to its epoxide (Xenopus tropicalis)
H+ [cytosol]
Metabolism of steroid hormones (Xenopus tropicalis)
Androgen biosynthesis (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
H+ [cytosol]
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
H+ [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)
H+ [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)
H+ [cytosol]
SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
H+ [cytosol]
SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
H+ [cytosol]
SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
H+ [cytosol]
Estrogen biosynthesis (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
H+ [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)
H+ [cytosol]
HSD17B1 hydrogenates E1 to EST17b (Xenopus tropicalis)
H+ [cytosol]
HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)
H+ [cytosol]
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
H+ [cytosol]
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
H+ [cytosol]
Glucocorticoid biosynthesis (Xenopus tropicalis)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
H+ [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)
H+ [cytosol]
Pregnenolone biosynthesis (Xenopus tropicalis)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)
H+ [cytosol]
Vitamin D (calciferol) metabolism (Xenopus tropicalis)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
H+ [cytosol]
Phospholipid metabolism (Xenopus tropicalis)
Glycerophospholipid biosynthesis (Xenopus tropicalis)
Synthesis of PA (Xenopus tropicalis)
DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)
H+ [cytosol]
Sphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid biosynthesis (Xenopus tropicalis)
CERK phosphorylates CERA to form C1P (Xenopus tropicalis)
H+ [cytosol]
Glycosphingolipid catabolism (Xenopus tropicalis)
ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)
H+ [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)
H+ [cytosol]
Sphingolipid catabolism (Xenopus tropicalis)
ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)
H+ [cytosol]
ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)
H+ [cytosol]
Sphingolipid de novo biosynthesis (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
H+ [cytosol]
Ceramide synthases transfer acyl-CoA onto sphingoid (Xenopus tropicalis)
H+ [cytosol]
DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)
H+ [cytosol]
DEGS2 oxygenates dihydroceramide (Xenopus tropicalis)
H+ [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)
H+ [cytosol]
KDSR reduces 3-ketosphingoid (Xenopus tropicalis)
H+ [cytosol]
SPHK2 phosphorylates sphingoid (Xenopus tropicalis)
H+ [cytosol]
SPTLC complexes transfer acyl-CoA onto serine (Xenopus tropicalis)
H+ [cytosol]
Wax and plasmalogen biosynthesis (Xenopus tropicalis)
Plasmalogen biosynthesis (Xenopus tropicalis)
DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)
H+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Xenopus tropicalis)
eNOS activation (Xenopus tropicalis)
CYGB dioxygenates NO (Xenopus tropicalis)
H+ [cytosol]
Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)
H+ [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Interconversion of nucleotide di- and triphosphates (Xenopus tropicalis)
dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
H+ [cytosol]
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
H+ [cytosol]
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)
H+ [cytosol]
AIR + CO2 => CAIR (Xenopus tropicalis)
H+ [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)
H+ [cytosol]
FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)
H+ [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
H+ [cytosol]
GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)
H+ [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
H+ [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)
H+ [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
H+ [cytosol]
Pyrimidine biosynthesis (Xenopus tropicalis)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)
H+ [cytosol]
CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)
H+ [cytosol]
CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
H+ [cytosol]
UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)
H+ [cytosol]
Nucleotide catabolism (Xenopus tropicalis)
Purine catabolism (Xenopus tropicalis)
Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
H+ [cytosol]
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
H+ [cytosol]
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
H+ [cytosol]
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
H+ [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
H+ [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
H+ [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
H+ [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
H+ [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
H+ [cytosol]
XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
H+ [cytosol]
Pyrimidine catabolism (Xenopus tropicalis)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)
H+ [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)
H+ [cytosol]
Nucleotide salvage (Xenopus tropicalis)
Purine salvage (Xenopus tropicalis)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)
H+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)
H+ [cytosol]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)
H+ [cytosol]
Metabolism of porphyrins (Xenopus tropicalis)
Heme biosynthesis (Xenopus tropicalis)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
H+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)
H+ [cytosol]
UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)
H+ [cytosol]
UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)
H+ [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of cofactors (Xenopus tropicalis)
NADPH regeneration (Xenopus tropicalis)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)
H+ [cytosol]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Xenopus tropicalis)
Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)
H+ [cytosol]
Metabolism of fat-soluble vitamins (Xenopus tropicalis)
Retinoid metabolism and transport (Xenopus tropicalis)
AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)
H+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Xenopus tropicalis)
Cobalamin (Cbl) metabolism (Xenopus tropicalis)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)
H+ [cytosol]
MMACHC dealkylates RCbl (Xenopus tropicalis)
H+ [cytosol]
MMACHC decyanates CNCbl (Xenopus tropicalis)
H+ [cytosol]
Metabolism of folate and pterines (Xenopus tropicalis)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)
H+ [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
H+ [cytosol]
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)
H+ [cytosol]
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)
H+ [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
H+ [cytosol]
Nicotinate metabolism (Xenopus tropicalis)
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
H+ [cytosol]
Vitamin B2 (riboflavin) metabolism (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
H+ [cytosol]
RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)
H+ [cytosol]
Vitamin B5 (pantothenate) metabolism (Xenopus tropicalis)
Coenzyme A biosynthesis (Xenopus tropicalis)
2xPPCS ligates PPanK with Cys (Xenopus tropicalis)
H+ [cytosol]
3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)
H+ [cytosol]
COASY phosphorylates DP-CoA (Xenopus tropicalis)
H+ [cytosol]
COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)
H+ [cytosol]
DCAKD phosphorylates DP-CoA (Xenopus tropicalis)
H+ [cytosol]
PANK2 phosphorylates PanK (Xenopus tropicalis)
H+ [cytosol]
Vitamin C (ascorbate) metabolism (Xenopus tropicalis)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)
H+ [cytosol]
Reversible hydration of carbon dioxide (Xenopus tropicalis)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)
H+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)
H+ [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
GDP-fucose biosynthesis (Xenopus tropicalis)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)
H+ [cytosol]
Sialic acid metabolism (Xenopus tropicalis)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
H+ [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
Hypusine synthesis from eIF5A-lysine (Xenopus tropicalis)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Xenopus tropicalis)
H+ [cytosol]
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Xenopus tropicalis)
H+ [cytosol]
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
H+ [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Xenopus tropicalis)
Synthesis of glycosylphosphatidylinositol (GPI) (Xenopus tropicalis)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)
H+ [cytosol]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Ion homeostasis (Xenopus tropicalis)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
H+ [cytosol]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter release cycle (Xenopus tropicalis)
Acetylcholine Neurotransmitter Release Cycle (Xenopus tropicalis)
Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)
H+ [cytosol]
GABA synthesis, release, reuptake and degradation (Xenopus tropicalis)
GABA synthesis (Xenopus tropicalis)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)
H+ [cytosol]
Synthesis of GABA by GAD2 (Xenopus tropicalis)
H+ [cytosol]
Glutamate Neurotransmitter Release Cycle (Xenopus tropicalis)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)
H+ [cytosol]
Sensory Perception (Xenopus tropicalis)
Visual phototransduction (Xenopus tropicalis)
Retinoid metabolism and transport (Xenopus tropicalis)
AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)
H+ [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Xenopus tropicalis)
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
H+ [cytosol]
RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
H+ [cytosol]
RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)
H+ [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)
H+ [cytosol]
The retinoid cycle in cones (daylight vision) (Xenopus tropicalis)
atRAL is reduced to atROL (Xenopus tropicalis)
H+ [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (q) signalling events (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Arachidonate production from DAG (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
H+ [cytosol]
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
H+ [cytosol]
Signaling by Nuclear Receptors (Xenopus tropicalis)
Signaling by Retinoic Acid (Xenopus tropicalis)
RA biosynthesis pathway (Xenopus tropicalis)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)
H+ [cytosol]
AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)
H+ [cytosol]
ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
H+ [cytosol]
ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
H+ [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)
H+ [cytosol]
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
H+ [cytosol]
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)
H+ [cytosol]
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Xenopus tropicalis)
H+ [cytosol]
RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
H+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor recycling (Xenopus tropicalis)
Endosome acidification (Xenopus tropicalis)
H+ [cytosol]
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
H+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
Signaling by Rho GTPases (Xenopus tropicalis)
RHO GTPase Effectors (Xenopus tropicalis)
RHO GTPases Activate NADPH Oxidases (Xenopus tropicalis)
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
H+ [cytosol]
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)
H+ [cytosol]
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)
H+ [cytosol]
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Xenopus tropicalis)
H+ [cytosol]
Transport of small molecules (Xenopus tropicalis)
Ion channel transport (Xenopus tropicalis)
Ion transport by P-type ATPases (Xenopus tropicalis)
ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
H+ [cytosol]
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
H+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)
H+ [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
H+ [cytosol]
Stimuli-sensing channels (Xenopus tropicalis)
CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)
H+ [cytosol]
CLCN7:OSTM1 exchanges Cl- for H+ (Xenopus tropicalis)
H+ [cytosol]
SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)
H+ [cytosol]
Iron uptake and transport (Xenopus tropicalis)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
H+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Transferrin endocytosis and recycling (Xenopus tropicalis)
Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
H+ [cytosol]
O2/CO2 exchange in erythrocytes (Xenopus tropicalis)
Erythrocytes take up carbon dioxide and release oxygen (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)
H+ [cytosol]
CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)
H+ [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)
H+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)
H+ [cytosol]
Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)
H+ [cytosol]
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Inositol transporters (Xenopus tropicalis)
HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)
H+ [cytosol]
MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)
H+ [cytosol]
Metal ion SLC transporters (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
H+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic cation transport (Xenopus tropicalis)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)
H+ [cytosol]
Proton-coupled monocarboxylate transport (Xenopus tropicalis)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Xenopus tropicalis)
H+ [cytosol]
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Rhesus glycoproteins mediate ammonium transport. (Xenopus tropicalis)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)
H+ [cytosol]
RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
H+ [cytosol]
RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)
H+ [cytosol]
RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
H+ [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Xenopus tropicalis)
H+ [cytosol]
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)
H+ [cytosol]
Bicarbonate transporters (Xenopus tropicalis)
Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)
H+ [cytosol]
Multifunctional anion exchangers (Xenopus tropicalis)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Organic anion transporters (Xenopus tropicalis)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
H+ [cytosol]
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)
H+ [cytosol]
SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)
H+ [cytosol]
Proton-coupled neutral amino acid transporters (Xenopus tropicalis)
SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)
H+ [cytosol]
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Proton/oligopeptide cotransporters (Xenopus tropicalis)
Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)
H+ [cytosol]
Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)
H+ [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)
H+ [cytosol]
Sodium/Proton exchangers (Xenopus tropicalis)
Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)
H+ [cytosol]
Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)
H+ [cytosol]
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)
H+ [cytosol]
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)
H+ [cytosol]
External Reference Information
External Reference
hydron [ChEBI:15378]
Participates
as an input of
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)
3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)
N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)
lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)
1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)
pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)
pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Xenopus tropicalis)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)
RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)
CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)
CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)
CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)
CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)
AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)
AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)
AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)
AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)
AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)
AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)
AKR1C3 reduces atRAL to atROL (Sus scrofa)
AKR1C3 reduces atRAL to atROL (Bos taurus)
AKR1C3 reduces atRAL to atROL (Rattus norvegicus)
AKR1C3 reduces atRAL to atROL (Mus musculus)
AKR1C3 reduces atRAL to atROL (Homo sapiens)
FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)
Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)
Shikimate results from hydration of DHS (Mycobacterium tuberculosis)
mycothione is reduced to mycothiol (Mycobacterium tuberculosis)
sulfite is reduced to sulfide (Mycobacterium tuberculosis)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Plasmodium falciparum)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Dictyostelium discoideum)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Gallus gallus)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Xenopus tropicalis)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)
EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)
CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Drosophila melanogaster)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)
CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)
CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)
15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Sus scrofa)
15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Gallus gallus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
15k-PGE2/F2a is reduced to dhk-PGE2/F2a by Ptgr2 (Mus musculus)
15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)
PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)
PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)
PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)
PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)
PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)
PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)
PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)
PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)
PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)
PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)
PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)
PGE2 is converted to PGF2a by CBR1 (Gallus gallus)
PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)
PGE2 is converted to PGF2a by CBR1 (Danio rerio)
PGE2 is converted to PGF2a by CBR1 (Sus scrofa)
PGE2 is converted to PGF2a by CBR1 (Bos taurus)
PGE2 is converted to PGF2a by CBR1 (Canis familiaris)
PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)
PGE2 is converted to PGF2a by CBR1 (Mus musculus)
PGE2 is converted to PGF2a by CBR1 (Homo sapiens)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)
AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)
AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)
AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)
AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)
AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)
AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)
AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)
AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)
AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)
AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)
HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)
Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)
Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)
Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)
atRAL is reduced to atROL (Saccharomyces cerevisiae)
atRAL is reduced to atROL (Caenorhabditis elegans)
atRAL is reduced to atROL (Drosophila melanogaster)
atRAL is reduced to atROL (Gallus gallus)
atRAL is reduced to atROL (Xenopus tropicalis)
atRAL is reduced to atROL (Danio rerio)
atRAL is reduced to atROL (Sus scrofa)
atRAL is reduced to atROL (Bos taurus)
atRAL is reduced to atROL (Canis familiaris)
atRAL is reduced to atROL (Rattus norvegicus)
atRAL is reduced to atROL (Mus musculus)
atRAL is reduced to atROL (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)
AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)
AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)
RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)
Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)
2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)
Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)
Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)
Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Gallus gallus)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Xenopus tropicalis)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Gallus gallus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Xenopus tropicalis)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Saccharomyces cerevisiae)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Dictyostelium discoideum)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Gallus gallus)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Xenopus tropicalis)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Saccharomyces cerevisiae)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Gallus gallus)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Xenopus tropicalis)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Gallus gallus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Gallus gallus)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Xenopus tropicalis)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)
Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)
Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)
CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)
CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)
CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)
AKR dimers reduce AFBDHO to AFBDOH (Gallus gallus)
AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)
AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)
AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)
AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)
AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)
AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)
AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)
27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)
27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)
27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
CYP7A1 7-hydroxylates CHOL (Bos taurus)
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
CYP7A1 7-hydroxylates CHOL (Mus musculus)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
CYP46A1 24-hydroxylates CHOL (Danio rerio)
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
CYP46A1 24-hydroxylates CHOL (Bos taurus)
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
CYP46A1 24-hydroxylates CHOL (Mus musculus)
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
CYP1B1 4-hydroxylates EST17b (Danio rerio)
CYP1B1 4-hydroxylates EST17b (Sus scrofa)
CYP1B1 4-hydroxylates EST17b (Bos taurus)
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
CYP1B1 4-hydroxylates EST17b (Mus musculus)
CYP1B1 4-hydroxylates EST17b (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
CYP4F22 20-hydroxylates TrXA3 (Mus musculus)
CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)
MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)
MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)
MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)
MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)
MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Saccharomyces cerevisiae)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Dictyostelium discoideum)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Gallus gallus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)
Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Bos taurus)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)
HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)
HSD17B1 hydrogenates E1 to EST17b (Xenopus tropicalis)
HSD17B1 hydrogenates E1 to EST17b (Sus scrofa)
HSD17B1 hydrogenates E1 to EST17b (Bos taurus)
HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)
HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)
HSD17B1 hydrogenates E1 to EST17b (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)
CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)
CYP19A1 hydroxylates TEST to EST17b (Mus musculus)
CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)
CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)
CYP21A2 oxidises 17HPROG (Gallus gallus)
CYP21A2 oxidises 17HPROG (Sus scrofa)
CYP21A2 oxidises 17HPROG (Bos taurus)
CYP21A2 oxidises 17HPROG (Canis familiaris)
CYP21A2 oxidises 17HPROG (Rattus norvegicus)
CYP21A2 oxidises 17HPROG (Mus musculus)
CYP21A2 oxidises 17HPROG (Homo sapiens)
Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)
Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)
Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)
Defective MMACHC does not decyanate CNCbl (Homo sapiens)
Defective MMACHC does not reduce Cbl (Homo sapiens)
FLAD1 phosphorylates FMN (Plasmodium falciparum)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Gallus gallus)
FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FLAD1 phosphorylates FMN (Danio rerio)
FLAD1 phosphorylates FMN (Sus scrofa)
FLAD1 phosphorylates FMN (Bos taurus)
FLAD1 phosphorylates FMN (Canis familiaris)
FLAD1 phosphorylates FMN (Rattus norvegicus)
FLAD1 phosphorylates FMN (Mus musculus)
FLAD1 phosphorylates FMN (Homo sapiens)
COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)
COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)
COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)
COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
COASY transfers an adenylyl group from ATP to PPANT (Gallus gallus)
COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)
COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)
COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)
COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)
COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)
3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)
3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)
3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)
3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)
3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)
3xPPCDC:3FMN decarboxylates PPC (Gallus gallus)
3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)
3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)
3xPPCDC:3FMN decarboxylates PPC (Bos taurus)
3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)
3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)
3xPPCDC:3FMN decarboxylates PPC (Mus musculus)
3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)
COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Saccharomyces cerevisiae)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Schizosaccharomyces pombe)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Dictyostelium discoideum)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Gallus gallus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Bos taurus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)
CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)
Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)
FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Xenopus tropicalis)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)
DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)
SRD5A1 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
SRD5A1 dehydrogenates TEST to DHTEST (Gallus gallus)
SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)
SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)
SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)
SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)
SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)
SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)
SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)
SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)
SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)
SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)
SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)
SRD5A3 dehydrogenates TEST to DHTEST (Gallus gallus)
SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)
SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)
SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)
SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)
SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)
SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)
SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)
SRD5A2 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
SRD5A2 dehydrogenates TEST to DHTEST (Gallus gallus)
SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)
SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)
SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)
SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)
SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)
SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)
HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)
HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)
HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)
HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)
HSD17B3-like proteins reducde ANDST to TEST (Gallus gallus)
HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)
HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)
HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)
HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)
HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)
CYP17A1 cleaves 17aHPROG to ANDST (Gallus gallus)
CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)
CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA (Gallus gallus)
CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)
CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
CYP17A1 17-hydroxylates PREG (Danio rerio)
CYP17A1 17-hydroxylates PREG (Sus scrofa)
CYP17A1 17-hydroxylates PREG (Bos taurus)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
CYP17A1 17-hydroxylates PREG (Mus musculus)
CYP17A1 17-hydroxylates PREG (Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)
CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)
CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)
CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)
CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)
CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)
CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)
CLCN4/5/6 exchange Cl- for H+ (Danio rerio)
CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)
CLCN4/5/6 exchange Cl- for H+ (Bos taurus)
CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)
CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)
CLCN4/5/6 exchange Cl- for H+ (Mus musculus)
CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)
CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)
CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)
CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)
CLCN7:OSTM1 exchanges Cl- for H+ (Xenopus tropicalis)
CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)
CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)
CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)
CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)
CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)
CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)
SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)
SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)
SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)
SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)
SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)
SLC9B1/C2 exchange Na+ for H+ (Bos taurus)
SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)
SLC9B1/C2 exchange Na+ for H+ (Mus musculus)
SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)
Clcn3 exchanges Cl- for H+ (Mus musculus)
CLCN3 exchanges Cl- for H+ (Homo sapiens)
RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Caenorhabditis elegans)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Xenopus tropicalis)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Sus scrofa)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Bos taurus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Canis familiaris)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)
SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)
Rdh8 reduces atRAL to atROL (Bos taurus)
RDH8 reduces atRAL to atROL (Homo sapiens)
RDH12 reduces atRAL to atROL (Drosophila melanogaster)
RDH12 reduces atRAL to atROL (Gallus gallus)
RDH12 reduces atRAL to atROL (Danio rerio)
RDH12 reduces atRAL to atROL (Sus scrofa)
RDH12 reduces atRAL to atROL (Bos taurus)
RDH12 reduces atRAL to atROL (Canis familiaris)
RDH12 reduces atRAL to atROL (Rattus norvegicus)
RDH12 reduces atRAL to atROL (Mus musculus)
RDH12 reduces atRAL to atROL (Homo sapiens)
Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)
Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)
Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)
Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)
Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)
Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)
Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)
Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)
UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)
UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)
UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)
UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)
UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)
UROD decarboxylates URO3 to COPRO3 (Gallus gallus)
UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)
UROD decarboxylates URO3 to COPRO3 (Danio rerio)
UROD decarboxylates URO3 to COPRO3 (Sus scrofa)
UROD decarboxylates URO3 to COPRO3 (Bos taurus)
UROD decarboxylates URO3 to COPRO3 (Canis familiaris)
UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)
UROD decarboxylates URO3 to COPRO3 (Mus musculus)
UROD decarboxylates URO3 to COPRO3 (Homo sapiens)
UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)
UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)
UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)
UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)
UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)
UROD decarboxylates URO1 to COPRO1 (Gallus gallus)
UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)
UROD decarboxylates URO1 to COPRO1 (Danio rerio)
UROD decarboxylates URO1 to COPRO1 (Sus scrofa)
UROD decarboxylates URO1 to COPRO1 (Bos taurus)
UROD decarboxylates URO1 to COPRO1 (Canis familiaris)
UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)
UROD decarboxylates URO1 to COPRO1 (Mus musculus)
UROD decarboxylates URO1 to COPRO1 (Homo sapiens)
lpdC dimer reactivates dlaT (Homo sapiens)
TrxB reactivates TrxA (Homo sapiens)
MscR reduces nitrosomycothiol to ammonia (Homo sapiens)
BfrB stores iron (Homo sapiens)
BfrA stores iron (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
SodC reduces superoxide to H2O2 (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)
Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)
Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)
Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)
Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)
Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)
Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)
Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)
Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
HV1-mediated H+ transfer (Gallus gallus)
HV1-mediated H+ transfer (Xenopus tropicalis)
HV1-mediated H+ transfer (Danio rerio)
HV1-mediated H+ transfer (Sus scrofa)
HV1-mediated H+ transfer (Bos taurus)
HV1-mediated H+ transfer (Canis familiaris)
HV1-mediated H+ transfer (Rattus norvegicus)
HV1-mediated H+ transfer (Homo sapiens)
HV1-mediated H+ transfer (Mus musculus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Gallus gallus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
dCMP + H2O => dUMP + NH4+ (Danio rerio)
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
dCMP + H2O => dUMP + NH4+ (Bos taurus)
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
dCMP + H2O => dUMP + NH4+ (Mus musculus)
UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)
UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)
UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)
UMPS dimer decarboxylates OMP to UMP (Gallus gallus)
UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)
UMPS dimer decarboxylates OMP to UMP (Sus scrofa)
UMPS dimer decarboxylates OMP to UMP (Bos taurus)
UMPS dimer decarboxylates OMP to UMP (Canis familiaris)
UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)
UMPS dimer decarboxylates OMP to UMP (Mus musculus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
UMPS dimer decarboxylates OMP to UMP (Homo sapiens)
dCMP + H2O => dUMP + NH4+ (Homo sapiens)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Gallus gallus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)
FA2H hydroxylates 1,2-saturated fatty acids (Saccharomyces cerevisiae)
FA2H hydroxylates 1,2-saturated fatty acids (Schizosaccharomyces pombe)
FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)
FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)
FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)
FA2H hydroxylates 1,2-saturated fatty acids (Gallus gallus)
FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)
FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)
FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)
FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)
FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)
FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)
FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)
DEGS1 dehydrogenates dihydroceramide (Schizosaccharomyces pombe)
DEGS1 dehydrogenates dihydroceramide (Dictyostelium discoideum)
DEGS1 dehydrogenates dihydroceramide (Caenorhabditis elegans)
DEGS1 dehydrogenates dihydroceramide (Drosophila melanogaster)
DEGS1 dehydrogenates dihydroceramide (Gallus gallus)
DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)
DEGS1 dehydrogenates dihydroceramide (Danio rerio)
DEGS1 dehydrogenates dihydroceramide (Sus scrofa)
DEGS1 dehydrogenates dihydroceramide (Bos taurus)
DEGS1 dehydrogenates dihydroceramide (Canis familiaris)
DEGS1 dehydrogenates dihydroceramide (Rattus norvegicus)
DEGS1 dehydrogenates dihydroceramide (Mus musculus)
DEGS1 dehydrogenates dihydroceramide (Homo sapiens)
DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)
DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)
DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)
DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)
DEGS2 oxygenates dihydroceramide (Gallus gallus)
DEGS2 oxygenates dihydroceramide (Xenopus tropicalis)
DEGS2 oxygenates dihydroceramide (Sus scrofa)
DEGS2 oxygenates dihydroceramide (Bos taurus)
DEGS2 oxygenates dihydroceramide (Canis familiaris)
DEGS2 oxygenates dihydroceramide (Rattus norvegicus)
DEGS2 oxygenates dihydroceramide (Mus musculus)
KDSR reduces 3-ketosphingoid (Plasmodium falciparum)
KDSR reduces 3-ketosphingoid (Saccharomyces cerevisiae)
KDSR reduces 3-ketosphingoid (Schizosaccharomyces pombe)
KDSR reduces 3-ketosphingoid (Dictyostelium discoideum)
KDSR reduces 3-ketosphingoid (Caenorhabditis elegans)
KDSR reduces 3-ketosphingoid (Drosophila melanogaster)
KDSR reduces 3-ketosphingoid (Xenopus tropicalis)
KDSR reduces 3-ketosphingoid (Sus scrofa)
KDSR reduces 3-ketosphingoid (Bos taurus)
KDSR reduces 3-ketosphingoid (Canis familiaris)
KDSR reduces 3-ketosphingoid (Rattus norvegicus)
KDSR reduces 3-ketosphingoid (Mus musculus)
SPTLC complexes transfer acyl-CoA onto serine (Drosophila melanogaster)
SPTLC complexes transfer acyl-CoA onto serine (Gallus gallus)
SPTLC complexes transfer acyl-CoA onto serine (Xenopus tropicalis)
SPTLC complexes transfer acyl-CoA onto serine (Danio rerio)
SPTLC complexes transfer acyl-CoA onto serine (Sus scrofa)
SPTLC complexes transfer acyl-CoA onto serine (Bos taurus)
SPTLC complexes transfer acyl-CoA onto serine (Canis familiaris)
SPTLC complexes transfer acyl-CoA onto serine (Rattus norvegicus)
SPTLC complexes transfer acyl-CoA onto serine (Mus musculus)
SPTLC complexes transfer acyl-CoA onto serine (Homo sapiens)
KDSR reduces 3-ketosphingoid (Homo sapiens)
DEGS2 oxygenates dihydroceramide (Homo sapiens)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)
TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)
Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)
Thyroxine is deiodinated to triiodothyronine (Gallus gallus)
Thyroxine is deiodinated to triiodothyronine (Sus scrofa)
Thyroxine is deiodinated to triiodothyronine (Bos taurus)
Thyroxine is deiodinated to triiodothyronine (Canis familiaris)
Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)
Thyroxine is deiodinated to triiodothyronine (Mus musculus)
Thyroxine is deiodinated to triiodothyronine (Homo sapiens)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)
Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)
FMO1:FAD oxidizes HTAU to TAU (Mus musculus)
FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Gallus gallus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Gallus gallus)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)
DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)
DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)
DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)
DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)
DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)
DHF is reduced to tetrahydrofolate (THF) (Gallus gallus)
DHF is reduced to tetrahydrofolate (THF) (Danio rerio)
DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)
DHF is reduced to tetrahydrofolate (THF) (Bos taurus)
DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)
DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)
DHF is reduced to tetrahydrofolate (THF) (Mus musculus)
DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)
DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)
DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)
DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)
DHFR dimer reduces FOLA to DHF (Gallus gallus)
DHFR dimer reduces FOLA to DHF (Danio rerio)
DHFR dimer reduces FOLA to DHF (Sus scrofa)
DHFR dimer reduces FOLA to DHF (Bos taurus)
DHFR dimer reduces FOLA to DHF (Canis familiaris)
DHFR dimer reduces FOLA to DHF (Rattus norvegicus)
DHFR dimer reduces FOLA to DHF (Mus musculus)
DHFR dimer reduces FOLA to DHF (Homo sapiens)
DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)
DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)
DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)
DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
DHFR2 reduces FOLA to DHF (Drosophila melanogaster)
DHFR2 reduces FOLA to DHF (Gallus gallus)
DHFR2 reduces FOLA to DHF (Danio rerio)
DHFR2 reduces FOLA to DHF (Sus scrofa)
DHFR2 reduces FOLA to DHF (Bos taurus)
DHFR2 reduces FOLA to DHF (Canis familiaris)
DHFR2 reduces FOLA to DHF (Rattus norvegicus)
DHFR2 reduces FOLA to DHF (Mus musculus)
DHFR2 reduces FOLA to DHF (Homo sapiens)
DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Gallus gallus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)
PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)
SeO3(2-) is reduced to H2Se by TXNRD1 (Bos taurus)
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
GSSeSG is reduced to GSSeH and GSH by Gsr (Rattus norvegicus)
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Rattus norvegicus)
PAPSe is reduced to SeO3(2-) by MET16 (Saccharomyces cerevisiae)
PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Saccharomyces cerevisiae)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Sus scrofa)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Schizosaccharomyces pombe)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)
Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
Guanine + H2O => Xanthine + NH4+ (Mus musculus)
Guanine + H2O => Xanthine + NH4+ (Homo sapiens)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)
DHCR24 reduces LAN to 24,25-dhLAN (Gallus gallus)
DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)
DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)
DHCR24 reduces LAN to 24,25-dhLAN (Sus scrofa)
DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)
DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)
DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)
DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)
DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)
DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)
DHCR7 reduces 7-dehydroCHOL to CHOL (Gallus gallus)
DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)
DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)
DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)
DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)
DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)
DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)
DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)
DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)
DHCR24 reduces ZYMOL to ZYMSTNL (Gallus gallus)
DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)
DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)
DHCR24 reduces ZYMOL to ZYMSTNL (Sus scrofa)
DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)
DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)
DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)
DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)
DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)
DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)
Reduction of desmosterol to cholesterol (Caenorhabditis elegans)
Reduction of desmosterol to cholesterol (Gallus gallus)
Reduction of desmosterol to cholesterol (Xenopus tropicalis)
Reduction of desmosterol to cholesterol (Danio rerio)
Reduction of desmosterol to cholesterol (Sus scrofa)
Reduction of desmosterol to cholesterol (Bos taurus)
Reduction of desmosterol to cholesterol (Canis familiaris)
Reduction of desmosterol to cholesterol (Rattus norvegicus)
Reduction of desmosterol to cholesterol (Mus musculus)
Reduction of desmosterol to cholesterol (Homo sapiens)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Gallus gallus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Gallus gallus)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Gallus gallus)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
CYP51A1 demethylates LNSOL (Gallus gallus)
CYP51A1 demethylates LNSOL (Danio rerio)
CYP51A1 demethylates LNSOL (Sus scrofa)
CYP51A1 demethylates LNSOL (Bos taurus)
CYP51A1 demethylates LNSOL (Canis familiaris)
CYP51A1 demethylates LNSOL (Rattus norvegicus)
CYP51A1 demethylates LNSOL (Mus musculus)
CYP51A1 demethylates LNSOL (Homo sapiens)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
Squalene is oxidized to its epoxide (Gallus gallus)
Squalene is oxidized to its epoxide (Xenopus tropicalis)
Squalene is oxidized to its epoxide (Danio rerio)
Squalene is oxidized to its epoxide (Sus scrofa)
Squalene is oxidized to its epoxide (Bos taurus)
Squalene is oxidized to its epoxide (Canis familiaris)
Squalene is oxidized to its epoxide (Rattus norvegicus)
Squalene is oxidized to its epoxide (Mus musculus)
Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
Reduction of presqualene diphosphate to form squalene (Gallus gallus)
Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
Reduction of presqualene diphosphate to form squalene (Sus scrofa)
Reduction of presqualene diphosphate to form squalene (Bos taurus)
Reduction of presqualene diphosphate to form squalene (Canis familiaris)
Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
Reduction of presqualene diphosphate to form squalene (Mus musculus)
HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)
HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)
HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)
HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)
HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)
HMGCR dimer reduces bHMG-CoA to MVA (Gallus gallus)
HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)
HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)
HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)
HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)
HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)
HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)
HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)
HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
Reduction of presqualene diphosphate to form squalene (Homo sapiens)
Squalene is oxidized to its epoxide (Homo sapiens)
SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)
SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)
SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)
SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)
SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)
SCD desaturates ST-CoA to OLE-CoA (Mus musculus)
SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Gallus gallus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Gallus gallus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Gallus gallus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)
Na+/H+ exchanger transport (at cell membrane) (Saccharomyces cerevisiae)
Na+/H+ exchanger transport (at cell membrane) (Schizosaccharomyces pombe)
Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)
Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)
Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)
Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)
Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)
Na+/H+ exchanger transport (at cell membrane) (Danio rerio)
Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)
Na+/H+ exchanger transport (at cell membrane) (Bos taurus)
Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)
Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)
Na+/H+ exchanger transport (at cell membrane) (Mus musculus)
Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Saccharomyces cerevisiae)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Drosophila melanogaster)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)
SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Saccharomyces cerevisiae)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Drosophila melanogaster)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Xenopus tropicalis)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)
SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)
Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)
Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)
Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)
Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)
Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)
Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)
Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)
Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)
Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)
Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)
ME1 tetramer decarboxylates OA to PYR (Caenorhabditis elegans)
ME1 tetramer decarboxylates OA to PYR (Drosophila melanogaster)
ME1 tetramer decarboxylates OA to PYR (Gallus gallus)
ME1 tetramer decarboxylates OA to PYR (Danio rerio)
ME1 tetramer decarboxylates OA to PYR (Sus scrofa)
ME1 tetramer decarboxylates OA to PYR (Bos taurus)
ME1 tetramer decarboxylates OA to PYR (Canis familiaris)
ME1 tetramer decarboxylates OA to PYR (Rattus norvegicus)
ME1 tetramer decarboxylates OA to PYR (Mus musculus)
ME1 tetramer decarboxylates OA to PYR (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
Re-acidification of acetylcholine transport vesicles (Homo sapiens)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)
TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)
TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)
TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)
TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)
TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)
TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Sus scrofa)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
Salvage - BH2 is reduced to BH4 by Dhfr (Mus musculus)
Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
CYGB dioxygenates NO (Caenorhabditis elegans)
CYGB dioxygenates NO (Gallus gallus)
CYGB dioxygenates NO (Xenopus tropicalis)
CYGB dioxygenates NO (Danio rerio)
CYGB dioxygenates NO (Sus scrofa)
CYGB dioxygenates NO (Bos taurus)
CYGB dioxygenates NO (Canis familiaris)
CYGB dioxygenates NO (Rattus norvegicus)
CYGB dioxygenates NO (Mus musculus)
CYGB dioxygenates NO (Homo sapiens)
Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)
Salvage - Sepiapterin is reduced to BH2 (Gallus gallus)
Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)
Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)
Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)
Salvage - Sepiapterin is reduced to BH2 (Mus musculus)
Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)
nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
Endosome acidification (Plasmodium falciparum)
Endosome acidification (Saccharomyces cerevisiae)
Endosome acidification (Schizosaccharomyces pombe)
Endosome acidification (Dictyostelium discoideum)
Endosome acidification (Caenorhabditis elegans)
Endosome acidification (Drosophila melanogaster)
Endosome acidification (Gallus gallus)
Endosome acidification (Xenopus tropicalis)
Endosome acidification (Danio rerio)
Endosome acidification (Sus scrofa)
Endosome acidification (Bos taurus)
Endosome acidification (Canis familiaris)
Endosome acidification (Rattus norvegicus)
Endosome acidification (Mus musculus)
Endosome acidification (Homo sapiens)
Synthesis of GABA by GAD2 (Caenorhabditis elegans)
Synthesis of GABA by GAD2 (Drosophila melanogaster)
Synthesis of GABA by GAD2 (Gallus gallus)
Synthesis of GABA by GAD2 (Xenopus tropicalis)
Synthesis of GABA by GAD2 (Sus scrofa)
Synthesis of GABA by GAD2 (Bos taurus)
Synthesis of GABA by GAD2 (Canis familiaris)
Synthesis of GABA by GAD2 (Rattus norvegicus)
Synthesis of GABA by GAD2 (Mus musculus)
Synthesis of GABA by GAD2 (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)
GAPDH tetramers reduce 1,3BPG to GA3P (Saccharomyces cerevisiae)
GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)
GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)
MDH1 reduces OA (Dictyostelium discoideum)
SLC25A18,22 import L-Glu, H+ (Rattus norvegicus)
Cytosolic PYR is transported to the mitochondrial matrix (Rattus norvegicus)
LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)
LDH tetramer reduces PYR to LACT (Drosophila melanogaster)
LDH tetramer reduces PYR to LACT (Gallus gallus)
LDH tetramer reduces PYR to LACT (Xenopus tropicalis)
LDH tetramer reduces PYR to LACT (Danio rerio)
LDH tetramer reduces PYR to LACT (Sus scrofa)
LDH tetramer reduces PYR to LACT (Bos taurus)
LDH tetramer reduces PYR to LACT (Canis familiaris)
LDH tetramer reduces PYR to LACT (Rattus norvegicus)
LDH tetramer reduces PYR to LACT (Mus musculus)
LDH tetramer reduces PYR to LACT (Homo sapiens)
PKM dephosphorylates PEP to PYR (Plasmodium falciparum)
PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)
PKM dephosphorylates PEP to PYR (Schizosaccharomyces pombe)
PKM dephosphorylates PEP to PYR (Dictyostelium discoideum)
PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)
PKM dephosphorylates PEP to PYR (Drosophila melanogaster)
PKM dephosphorylates PEP to PYR (Gallus gallus)
PKM dephosphorylates PEP to PYR (Xenopus tropicalis)
PKM dephosphorylates PEP to PYR (Danio rerio)
PKM dephosphorylates PEP to PYR (Sus scrofa)
PKM dephosphorylates PEP to PYR (Bos taurus)
PKM dephosphorylates PEP to PYR (Canis familiaris)
PKM dephosphorylates PEP to PYR (Rattus norvegicus)
PKM dephosphorylates PEP to PYR (Mus musculus)
GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)
GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)
GAPDH tetramers reduce 1,3BPG to GA3P (Gallus gallus)
GAPDH tetramers reduce 1,3BPG to GA3P (Xenopus tropicalis)
GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)
GAPDH tetramers reduce 1,3BPG to GA3P (Sus scrofa)
GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)
GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)
GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)
SLC25A18,22 import L-Glu, H+ (Canis familiaris)
MDH1 reduces OA (Danio rerio)
SLC25A18,22 import L-Glu, H+ (Danio rerio)
MDH1 reduces OA (Drosophila melanogaster)
SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)
SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)
SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)
SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)
SLC25A12,13 exchange L-Glu and L-Asp (Dictyostelium discoideum)
SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)
MDH1 reduces OA (Caenorhabditis elegans)
SLC25A12,13 exchange L-Glu and L-Asp (Caenorhabditis elegans)
MDH1 reduces OA (Gallus gallus)
SLC25A18,22 import L-Glu, H+ (Gallus gallus)
SLC25A12,13 exchange L-Glu and L-Asp (Gallus gallus)
SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)
MDH1 reduces OA (Xenopus tropicalis)
SLC25A12,13 exchange L-Glu and L-Asp (Xenopus tropicalis)
SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)
MDH1 reduces OA (Bos taurus)
SLC25A18,22 import L-Glu, H+ (Bos taurus)
SLC25A12,13 exchange L-Glu and L-Asp (Bos taurus)
SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)
SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)
SLC25A18,22 import L-Glu, H+ (Sus scrofa)
SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)
MDH1 reduces OA (Sus scrofa)
MDH1 reduces OA (Canis familiaris)
SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)
PKM dephosphorylates PEP to PYR (Homo sapiens)
MDH1 reduces OA (Rattus norvegicus)
MDH1 reduces OA (Homo sapiens)
SLC25A18,22 import L-Glu, H+ (Homo sapiens)
SLC25A18,22 import L-Glu, H+ (Mus musculus)
SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)
MDH1 reduces OA (Mus musculus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Gallus gallus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)
MMACHC decyanates CNCbl (Dictyostelium discoideum)
MMACHC decyanates CNCbl (Caenorhabditis elegans)
MMACHC decyanates CNCbl (Gallus gallus)
MMACHC decyanates CNCbl (Xenopus tropicalis)
MMACHC decyanates CNCbl (Danio rerio)
MMACHC decyanates CNCbl (Sus scrofa)
MMACHC decyanates CNCbl (Bos taurus)
MMACHC decyanates CNCbl (Canis familiaris)
MMACHC decyanates CNCbl (Rattus norvegicus)
MMACHC decyanates CNCbl (Homo sapiens)
MMACHC decyanates CNCbl (Mus musculus)
GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)
GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)
AKR1B1 reduces Glc to D-sorbitol (Saccharomyces cerevisiae)
AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)
AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)
AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)
AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)
AKR1B1 reduces Glc to D-sorbitol (Gallus gallus)
AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)
AKR1B1 reduces Glc to D-sorbitol (Danio rerio)
AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)
AKR1B1 reduces Glc to D-sorbitol (Bos taurus)
AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)
AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)
AKR1B1 reduces Glc to D-sorbitol (Mus musculus)
AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)
DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)
DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)
DCXR tetramer reduces L-xylulose to xylitol (Gallus gallus)
DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)
DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)
DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)
DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)
DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)
DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)
DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)
AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)
AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)
AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)
AKR1A1 reduces D-glucuronate to L-gulonate (Caenorhabditis elegans)
AKR1A1 reduces D-glucuronate to L-gulonate (Drosophila melanogaster)
AKR1A1 reduces D-glucuronate to L-gulonate (Gallus gallus)
AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)
AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)
AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)
AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)
AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)
AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)
AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)
AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)
DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)
DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)
DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)
DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)
DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)
DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)
DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)
DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)
DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)
DHAP is converted to G3P by GPD1/GPD1L (Gallus gallus)
DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)
DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)
DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)
DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)
DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)
DHRS7B reduces GO3P to HXDG3P (Canis familiaris)
DHRS7B reduces GO3P to HXDG3P (Homo sapiens)
FAR2 reduces PalmCoA to HXOL (Homo sapiens)
FAR2 reduces PalmCoA to HXOL (Mus musculus)
FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)
FAR2 reduces PalmCoA to HXOL (Canis familiaris)
FAR2 reduces PalmCoA to HXOL (Bos taurus)
FAR2 reduces PalmCoA to HXOL (Sus scrofa)
FAR2 reduces PalmCoA to HXOL (Danio rerio)
FAR2 reduces PalmCoA to HXOL (Gallus gallus)
FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)
FAR2 reduces PalmCoA to HXOL (Caenorhabditis elegans)
FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)
FAR1 reduces PalmCoA to HXOL (Homo sapiens)
FAR1 reduces PalmCoA to HXOL (Mus musculus)
FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)
FAR1 reduces PalmCoA to HXOL (Canis familiaris)
FAR1 reduces PalmCoA to HXOL (Bos taurus)
FAR1 reduces PalmCoA to HXOL (Sus scrofa)
FAR1 reduces PalmCoA to HXOL (Gallus gallus)
FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)
FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)
FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)
DHRS7B reduces GO3P to HXDG3P (Mus musculus)
DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)
DHRS7B reduces GO3P to HXDG3P (Bos taurus)
DHRS7B reduces GO3P to HXDG3P (Sus scrofa)
DHRS7B reduces GO3P to HXDG3P (Danio rerio)
DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)
DHRS7B reduces GO3P to HXDG3P (Gallus gallus)
DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)
DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)
as an output of
hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)
xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)
inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)
lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)
lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)
glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)
malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)
RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)
ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
ALDHs oxidise atRAL to atRA (Gallus gallus)
ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
ALDHs oxidise atRAL to atRA (Danio rerio)
ALDHs oxidise atRAL to atRA (Sus scrofa)
ALDHs oxidise atRAL to atRA (Bos taurus)
ALDHs oxidise atRAL to atRA (Canis familiaris)
ALDHs oxidise atRAL to atRA (Rattus norvegicus)
ALDHs oxidise atRAL to atRA (Mus musculus)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)
RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)
ALDHs oxidise atRAL to atRA (Homo sapiens)
Otop1 transports H+ from the extracellular region to the cytosol (Mus musculus)
OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)
FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)
Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)
DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)
mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)
formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)
mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)
sulfite results from reduction of APS (Mycobacterium tuberculosis)
APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)
NADPH reduces TAH18:DRE2 (Saccharomyces cerevisiae)
NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)
5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)
5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)
5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)
LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)
LXA4 is oxidised to 15k-LXA4 by HPGD (Gallus gallus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)
LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)
LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)
LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)
LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)
15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)
LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Sus scrofa)
LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)
5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Gallus gallus)
MIOX oxidises Ins to GlcA (Danio rerio)
MIOX oxidises Ins to GlcA (Sus scrofa)
MIOX oxidises Ins to GlcA (Bos taurus)
MIOX oxidises Ins to GlcA (Canis familiaris)
MIOX oxidises Ins to GlcA (Rattus norvegicus)
MIOX oxidises Ins to GlcA (Mus musculus)
MIOX oxidises Ins to GlcA (Homo sapiens)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
ABCC4 accumulation of dense granule contents (Plasmodium falciparum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Gallus gallus)
ABCC4 accumulation of dense granule contents (Danio rerio)
ABCC4 accumulation of dense granule contents (Sus scrofa)
ABCC4 accumulation of dense granule contents (Bos taurus)
ABCC4 accumulation of dense granule contents (Canis familiaris)
ABCC4 accumulation of dense granule contents (Rattus norvegicus)
ABCC4 accumulation of dense granule contents (Mus musculus)
ABCC4 accumulation of dense granule contents (Homo sapiens)
SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)
SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)
SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)
SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)
SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)
SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)
SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)
SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)
SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)
SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)
Cipro is imported by organic cation transporters (Homo sapiens)
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
XDH oxidises 6MP to 6TU (Gallus gallus)
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
XDH oxidises 6MP to 6TU (Sus scrofa)
XDH oxidises 6MP to 6TU (Bos taurus)
XDH oxidises 6MP to 6TU (Canis familiaris)
XDH oxidises 6MP to 6TU (Rattus norvegicus)
XDH oxidises 6MP to 6TU (Mus musculus)
XDH oxidises 6MP to 6TU (Homo sapiens)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Dictyostelium discoideum)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)
PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Dictyostelium discoideum)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Bos taurus)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Rattus norvegicus)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)
UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Oryctolagus cuniculus)
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Dictyostelium discoideum)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)
CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)
CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)
CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)
CYP3A4 oxidizes PREDN,PREDL (Mus musculus)
HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)
HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)
HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)
HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)
HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)
HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)
HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)
HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)
HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)
HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)
HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)
CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)
Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)
An REH hydrolyses 11cRE to 11cROL (Gallus gallus)
A REH hydrolyses 11cRE to 11cROL (Homo sapiens)
11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)
Retsat reduces atROL to at-13,14-dhROL (Mus musculus)
RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)
7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)
ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)
ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)
ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)
ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)
ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)
ADH5 oxidises S-HMGSH to S-FGSH (Gallus gallus)
ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)
ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)
ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)
ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)
ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)
ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)
ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)
ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)
ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)
ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)
ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Gallus gallus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)
HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)
HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)
HSD17B11 dehydrogenates EST17b to E1 (Gallus gallus)
HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)
HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)
HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)
HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)
HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Gallus gallus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Gallus gallus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)
RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)
RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)
RFK:Mg2+ phosphorylates RIB (Gallus gallus)
RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)
RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
RFK:Mg2+ phosphorylates RIB (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
RFK:Mg2+ phosphorylates RIB (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
RFK:Mg2+ phosphorylates RIB (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
RFK:Mg2+ phosphorylates RIB (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
RFK:Mg2+ phosphorylates RIB (Homo sapiens)
DCAKD phosphorylates DP-CoA (Plasmodium falciparum)
DCAKD phosphorylates DP-CoA (Saccharomyces cerevisiae)
DCAKD phosphorylates DP-CoA (Schizosaccharomyces pombe)
DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)
DCAKD phosphorylates DP-CoA (Drosophila melanogaster)
DCAKD phosphorylates DP-CoA (Gallus gallus)
DCAKD phosphorylates DP-CoA (Xenopus tropicalis)
DCAKD phosphorylates DP-CoA (Danio rerio)
DCAKD phosphorylates DP-CoA (Sus scrofa)
DCAKD phosphorylates DP-CoA (Bos taurus)
DCAKD phosphorylates DP-CoA (Canis familiaris)
DCAKD phosphorylates DP-CoA (Rattus norvegicus)
DCAKD phosphorylates DP-CoA (Mus musculus)
DCAKD phosphorylates DP-CoA (Homo sapiens)
COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)
COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)
COASY phosphorylates DP-CoA (Dictyostelium discoideum)
COASY phosphorylates DP-CoA (Caenorhabditis elegans)
COASY phosphorylates DP-CoA (Gallus gallus)
COASY phosphorylates DP-CoA (Xenopus tropicalis)
COASY phosphorylates DP-CoA (Danio rerio)
COASY phosphorylates DP-CoA (Sus scrofa)
COASY phosphorylates DP-CoA (Bos taurus)
COASY phosphorylates DP-CoA (Canis familiaris)
COASY phosphorylates DP-CoA (Rattus norvegicus)
COASY phosphorylates DP-CoA (Mus musculus)
2xPPCS ligates PPanK with Cys (Plasmodium falciparum)
2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)
2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)
2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)
2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
2xPPCS ligates PPanK with Cys (Drosophila melanogaster)
2xPPCS ligates PPanK with Cys (Gallus gallus)
2xPPCS ligates PPanK with Cys (Xenopus tropicalis)
2xPPCS ligates PPanK with Cys (Danio rerio)
2xPPCS ligates PPanK with Cys (Sus scrofa)
2xPPCS ligates PPanK with Cys (Bos taurus)
2xPPCS ligates PPanK with Cys (Canis familiaris)
2xPPCS ligates PPanK with Cys (Rattus norvegicus)
2xPPCS ligates PPanK with Cys (Mus musculus)
PANK2 phosphorylates PanK (Drosophila melanogaster)
PANK2 phosphorylates PanK (Gallus gallus)
PANK2 phosphorylates PanK (Xenopus tropicalis)
PANK2 phosphorylates PanK (Sus scrofa)
PANK2 phosphorylates PanK (Bos taurus)
PANK2 phosphorylates PanK (Canis familiaris)
PANK2 phosphorylates PanK (Rattus norvegicus)
PANK2 phosphorylates PanK (Mus musculus)
PANK2 phosphorylates PanK (Homo sapiens)
PANK1/3 phosphorylate PanK (Drosophila melanogaster)
PANK1/3 phosphorylate PanK (Gallus gallus)
PANK1/3 phosphorylate PanK (Danio rerio)
PANK1/3 phosphorylate PanK (Sus scrofa)
PANK1/3 phosphorylate PanK (Bos taurus)
PANK1/3 phosphorylate PanK (Canis familiaris)
PANK1/3 phosphorylate PanK (Rattus norvegicus)
PANK1/3 phosphorylate PanK (Mus musculus)
PANK1/3 phosphorylate PanK (Homo sapiens)
2xPPCS ligates PPanK with Cys (Homo sapiens)
COASY phosphorylates DP-CoA (Homo sapiens)
2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)
NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)
CpnT hydrolyses NAD+ (Homo sapiens)
Eis acetylates DUSP16 (Homo sapiens)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Xenopus tropicalis)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)
DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Gallus gallus)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Gallus gallus)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)
HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)
HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)
HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)
HMIT co-transports myo-inositol with a proton (Gallus gallus)
HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)
HMIT co-transports myo-inositol with a proton (Sus scrofa)
HMIT co-transports myo-inositol with a proton (Bos taurus)
HMIT co-transports myo-inositol with a proton (Canis familiaris)
HMIT co-transports myo-inositol with a proton (Rattus norvegicus)
HMIT co-transports myo-inositol with a proton (Mus musculus)
HMIT co-transports myo-inositol with a proton (Homo sapiens)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)
RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)
RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)
MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)
MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)
MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)
MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)
MATEs mediate extrusion of xenobiotics (Gallus gallus)
MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)
MATEs mediate extrusion of xenobiotics (Danio rerio)
MATEs mediate extrusion of xenobiotics (Sus scrofa)
MATEs mediate extrusion of xenobiotics (Bos taurus)
MATEs mediate extrusion of xenobiotics (Canis familiaris)
MATEs mediate extrusion of xenobiotics (Rattus norvegicus)
MATEs mediate extrusion of xenobiotics (Mus musculus)
MATEs mediate extrusion of xenobiotics (Homo sapiens)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Caenorhabditis elegans)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Drosophila melanogaster)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Xenopus tropicalis)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Bos taurus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)
RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)
RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)
RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)
RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)
RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)
RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)
RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)
RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)
RDH5 oxidises 11cROL to 11cRAL (Danio rerio)
RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)
RDH5 oxidises 11cROL to 11cRAL (Bos taurus)
RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)
RDH5 oxidises 11cROL to 11cRAL (Mus musculus)
RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)
RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)
RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)
RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)
RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)
RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)
CYB5Rs reduce MetHb to HbA (Gallus gallus)
CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)
CYB5Rs reduce MetHb to HbA (Danio rerio)
CYB5Rs reduce MetHb to HbA (Sus scrofa)
CYB5Rs reduce MetHb to HbA (Bos taurus)
CYB5Rs reduce MetHb to HbA (Canis familiaris)
CYB5Rs reduce MetHb to HbA (Rattus norvegicus)
CYB5Rs reduce MetHb to HbA (Mus musculus)
CYB5Rs reduce MetHb to HbA (Homo sapiens)
Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)
Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)
Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)
Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)
Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)
Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)
Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)
Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)
Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)
ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)
ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)
ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
ALAD condenses 2 dALAs to form PBG (Gallus gallus)
ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)
ALAD condenses 2 dALAs to form PBG (Danio rerio)
ALAD condenses 2 dALAs to form PBG (Sus scrofa)
ALAD condenses 2 dALAs to form PBG (Bos taurus)
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)
ALAD condenses 2 dALAs to form PBG (Mus musculus)
ALAD condenses 2 dALAs to form PBG (Homo sapiens)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Drosophila melanogaster)
PDE12 cleaves 2'-5' oligoadenylates (Gallus gallus)
PDE12 cleaves 2'-5' oligoadenylates (Sus scrofa)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Rattus norvegicus)
PDE12 cleaves 2'-5' oligoadenylates (Mus musculus)
PDE12 cleaves 2'-5' oligoadenylates (Homo sapiens)
Viral 2',5'-PDE cleaves 2'-5' oligoadenylates (Homo sapiens)
Ribonucleoprotein release from M1 proteins (Homo sapiens)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Xenopus tropicalis)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)
Mycothiol scavenges nitrosyl (Homo sapiens)
Iron is reduced and separates from enterobactin (Escherichia coli)
Iron is reduced and separates from mycobactin (Homo sapiens)
Glutathione scavenges nitrosyl (Homo sapiens)
NOX2 generates superoxide anion from oxygen (Gallus gallus)
NOX2 generates superoxide anion from oxygen (Xenopus tropicalis)
NOX2 generates superoxide anion from oxygen (Danio rerio)
NOX2 generates superoxide anion from oxygen (Sus scrofa)
NOX2 generates superoxide anion from oxygen (Bos taurus)
NOX2 generates superoxide anion from oxygen (Canis familiaris)
NOX2 generates superoxide anion from oxygen (Rattus norvegicus)
NOX2 generates superoxide anion from oxygen (Homo sapiens)
NOX2 generates superoxide anion from oxygen (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Gallus gallus)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)
ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
ITPA hydrolyses dITP to dIMP (Gallus gallus)
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
ITPA hydrolyses dITP to dIMP (Danio rerio)
ITPA hydrolyses dITP to dIMP (Sus scrofa)
ITPA hydrolyses dITP to dIMP (Bos taurus)
ITPA hydrolyses dITP to dIMP (Canis familiaris)
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
ITPA hydrolyses dITP to dIMP (Mus musculus)
ITPA hydrolyses dITP to dIMP (Homo sapiens)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
ITPA hydrolyses ITP to IMP (Gallus gallus)
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
ITPA hydrolyses ITP to IMP (Danio rerio)
ITPA hydrolyses ITP to IMP (Sus scrofa)
ITPA hydrolyses ITP to IMP (Bos taurus)
ITPA hydrolyses ITP to IMP (Canis familiaris)
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
ITPA hydrolyses ITP to IMP (Mus musculus)
ITPA hydrolyses ITP to IMP (Homo sapiens)
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
ITPA hydrolyses XTP to XMP (Gallus gallus)
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
ITPA hydrolyses XTP to XMP (Danio rerio)
ITPA hydrolyses XTP to XMP (Sus scrofa)
ITPA hydrolyses XTP to XMP (Bos taurus)
ITPA hydrolyses XTP to XMP (Canis familiaris)
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
ITPA hydrolyses XTP to XMP (Mus musculus)
ITPA hydrolyses XTP to XMP (Homo sapiens)
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
XDH dehydrogenates xanthine to form urate (Gallus gallus)
XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
XDH dehydrogenates xanthine to form urate (Sus scrofa)
XDH dehydrogenates xanthine to form urate (Bos taurus)
XDH dehydrogenates xanthine to form urate (Canis familiaris)
XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
XDH dehydrogenates xanthine to form urate (Mus musculus)
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
XDH dehydrogenates xanthine to form urate (Homo sapiens)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)
CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)
CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)
CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)
CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)
CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)
CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)
CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)
CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)
CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)
CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)
CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
CAD hexamer transforms L-Gln to CAP (Sus scrofa)
CAD hexamer transforms L-Gln to CAP (Bos taurus)
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
CAD hexamer transforms L-Gln to CAP (Mus musculus)
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)
SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)
SHPK phosphorylates Sedo to Sedo7P (Gallus gallus)
SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)
SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)
SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)
SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)
SHPK phosphorylates Sedo to Sedo7P (Mus musculus)
SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Gallus gallus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Gallus gallus)
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
ABHD6,12 hydrolyse 3AG (Danio rerio)
ABHD6,12 hydrolyse 3AG (Sus scrofa)
ABHD6,12 hydrolyse 3AG (Bos taurus)
ABHD6,12 hydrolyse 3AG (Canis familiaris)
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
ABHD6,12 hydrolyse 3AG (Mus musculus)
ABHD6,12 hydrolyse 3AG (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
CERK phosphorylates CERA to form C1P (Drosophila melanogaster)
CERK phosphorylates CERA to form C1P (Gallus gallus)
CERK phosphorylates CERA to form C1P (Xenopus tropicalis)
CERK phosphorylates CERA to form C1P (Sus scrofa)
CERK phosphorylates CERA to form C1P (Bos taurus)
CERK phosphorylates CERA to form C1P (Canis familiaris)
CERK phosphorylates CERA to form C1P (Rattus norvegicus)
CERK phosphorylates CERA to form C1P (Mus musculus)
CERK phosphorylates CERA to form C1P (Homo sapiens)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Plasmodium falciparum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Saccharomyces cerevisiae)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)
ENPP7 hydrolyzes sphingomyelin (Saccharomyces cerevisiae)
ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)
ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)
ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Gallus gallus)
ENPP7 hydrolyzes sphingomyelin (Gallus gallus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)
ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)
ENPP7 hydrolyzes sphingomyelin (Sus scrofa)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)
ENPP7 hydrolyzes sphingomyelin (Bos taurus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)
ENPP7 hydrolyzes sphingomyelin (Canis familiaris)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)
ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)
ENPP7 hydrolyzes sphingomyelin (Homo sapiens)
ENPP7 hydrolyzes sphingomyelin (Mus musculus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Mus musculus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)
CSNK1G2 phosphorylates p-CERT1-2 (Plasmodium falciparum)
CSNK1G2 phosphorylates p-CERT1-2 (Caenorhabditis elegans)
PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)
PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)
CSNK1G2 phosphorylates p-CERT1-2 (Drosophila melanogaster)
PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)
CSNK1G2 phosphorylates p-CERT1-2 (Danio rerio)
PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)
CSNK1G2 phosphorylates p-CERT1-2 (Bos taurus)
PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)
CSNK1G2 phosphorylates p-CERT1-2 (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)
ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
ALDH3B1 oxidises HXAL to PALM (Gallus gallus)
ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)
ALDH3B1 oxidises HXAL to PALM (Danio rerio)
ALDH3B1 oxidises HXAL to PALM (Sus scrofa)
ALDH3B1 oxidises HXAL to PALM (Bos taurus)
ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)
ALDH3B1 oxidises HXAL to PALM (Mus musculus)
ALDH3B1 oxidises HXAL to PALM (Homo sapiens)
ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)
ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)
ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)
ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)
ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)
ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)
ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)
ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
ALDH3B2 oxidises HXAL to PALM (Gallus gallus)
ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)
ALDH3B2 oxidises HXAL to PALM (Danio rerio)
ALDH3B2 oxidises HXAL to PALM (Sus scrofa)
ALDH3B2 oxidises HXAL to PALM (Bos taurus)
ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)
ALDH3B2 oxidises HXAL to PALM (Mus musculus)
SPHK1 phosphorylates sphingoid (Gallus gallus)
SPHK1 phosphorylates sphingoid (Saccharomyces cerevisiae)
SPHK2 phosphorylates sphingoid (Saccharomyces cerevisiae)
SPHK1 phosphorylates sphingoid (Schizosaccharomyces pombe)
SPHK2 phosphorylates sphingoid (Schizosaccharomyces pombe)
SPHK1 phosphorylates sphingoid (Dictyostelium discoideum)
SPHK2 phosphorylates sphingoid (Dictyostelium discoideum)
SPHK1 phosphorylates sphingoid (Caenorhabditis elegans)
SPHK2 phosphorylates sphingoid (Caenorhabditis elegans)
SPHK1 phosphorylates sphingoid (Drosophila melanogaster)
SPHK2 phosphorylates sphingoid (Drosophila melanogaster)
SPHK2 phosphorylates sphingoid (Xenopus tropicalis)
SPHK1 phosphorylates sphingoid (Sus scrofa)
SPHK2 phosphorylates sphingoid (Sus scrofa)
SPHK1 phosphorylates sphingoid (Bos taurus)
SPHK2 phosphorylates sphingoid (Bos taurus)
SPHK1 phosphorylates sphingoid (Canis familiaris)
SPHK2 phosphorylates sphingoid (Canis familiaris)
SPHK1 phosphorylates sphingoid (Rattus norvegicus)
SPHK2 phosphorylates sphingoid (Rattus norvegicus)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Caenorhabditis elegans)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Drosophila melanogaster)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Gallus gallus)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Danio rerio)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Sus scrofa)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Bos taurus)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Canis familiaris)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Rattus norvegicus)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Homo sapiens)
SMPD4 hydrolyzes sphingomyelin (ER membrane) (Mus musculus)
SPHK1 phosphorylates sphingoid (Mus musculus)
SPHK2 phosphorylates sphingoid (Mus musculus)
SPHK2 phosphorylates sphingoid (Homo sapiens)
SPHK1 phosphorylates sphingoid (Homo sapiens)
ALDH3B2 oxidises HXAL to PALM (Homo sapiens)
Ceramide synthases transfer acyl-CoA onto sphingoid (Plasmodium falciparum)
Ceramide synthases transfer acyl-CoA onto sphingoid (Saccharomyces cerevisiae)
Ceramide synthases transfer acyl-CoA onto sphingoid (Schizosaccharomyces pombe)
Ceramide synthases transfer acyl-CoA onto sphingoid (Dictyostelium discoideum)
Ceramide synthases transfer acyl-CoA onto sphingoid (Caenorhabditis elegans)
Ceramide synthases transfer acyl-CoA onto sphingoid (Drosophila melanogaster)
Ceramide synthases transfer acyl-CoA onto sphingoid (Gallus gallus)
Ceramide synthases transfer acyl-CoA onto sphingoid (Xenopus tropicalis)
Ceramide synthases transfer acyl-CoA onto sphingoid (Danio rerio)
Ceramide synthases transfer acyl-CoA onto sphingoid (Sus scrofa)
Ceramide synthases transfer acyl-CoA onto sphingoid (Bos taurus)
Ceramide synthases transfer acyl-CoA onto sphingoid (Canis familiaris)
Ceramide synthases transfer acyl-CoA onto sphingoid (Rattus norvegicus)
Ceramide synthases transfer acyl-CoA onto sphingoid (Mus musculus)
Ceramide synthases transfer acyl-CoA onto sphingoid (Homo sapiens)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)
Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)
Methylation of N-acetyl-5-HT to form melatonin (Gallus gallus)
Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)
Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)
Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)
Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)
Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)
Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)
Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)
Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)
Noradrenaline is converted to adrenaline (Caenorhabditis elegans)
Noradrenaline is converted to adrenaline (Gallus gallus)
Noradrenaline is converted to adrenaline (Sus scrofa)
Noradrenaline is converted to adrenaline (Bos taurus)
Noradrenaline is converted to adrenaline (Canis familiaris)
Noradrenaline is converted to adrenaline (Rattus norvegicus)
Noradrenaline is converted to adrenaline (Mus musculus)
Noradrenaline is converted to adrenaline (Homo sapiens)
Acireductone is created (Saccharomyces cerevisiae)
Acireductone is created (Schizosaccharomyces pombe)
Acireductone is created (Dictyostelium discoideum)
Acireductone is created (Caenorhabditis elegans)
Acireductone is created (Drosophila melanogaster)
Acireductone is created (Gallus gallus)
Acireductone is created (Xenopus tropicalis)
Acireductone is created (Danio rerio)
Acireductone is created (Sus scrofa)
Acireductone is created (Bos taurus)
Acireductone is created (Canis familiaris)
Acireductone is created (Rattus norvegicus)
Acireductone is created (Mus musculus)
Acireductone is created (Homo sapiens)
ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
ADO oxidises 2AET to HTAU (Drosophila melanogaster)
ADO oxidises 2AET to HTAU (Xenopus tropicalis)
ADO oxidises 2AET to HTAU (Danio rerio)
ADO oxidises 2AET to HTAU (Sus scrofa)
ADO oxidises 2AET to HTAU (Bos taurus)
ADO oxidises 2AET to HTAU (Canis familiaris)
ADO oxidises 2AET to HTAU (Rattus norvegicus)
ADO oxidises 2AET to HTAU (Mus musculus)
ADO oxidises 2AET to HTAU (Homo sapiens)
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
MTRR reduces cob(II)alamin to meCbl (Mus musculus)
MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Gallus gallus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Gallus gallus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Sus scrofa)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)
SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)
SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
NMRK2 phosphorylates NR to yield NMN (Dictyostelium discoideum)
NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)
NMRK2 phosphorylates NR to yield NMN (Gallus gallus)
NMRK2 phosphorylates NR to yield NMN (Danio rerio)
NMRK2 phosphorylates NR to yield NMN (Sus scrofa)
NMRK2 phosphorylates NR to yield NMN (Bos taurus)
NMRK2 phosphorylates NR to yield NMN (Mus musculus)
NMRK2 phosphorylates NR to yield NMN (Homo sapiens)
NMRK1 phosphorylates NR to yield NMN (Dictyostelium discoideum)
NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)
NMRK1 phosphorylates NR to yield NMN (Gallus gallus)
NMRK1 phosphorylates NR to yield NMN (Sus scrofa)
NMRK1 phosphorylates NR to yield NMN (Bos taurus)
NMRK1 phosphorylates NR to yield NMN (Canis familiaris)
NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)
NMRK1 phosphorylates NR to yield NMN (Mus musculus)
NMRK1 phosphorylates NR to yield NMN (Homo sapiens)
NMRK1 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)
NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
NMRK1 phosphorylates NAR to yield NAMN (Gallus gallus)
NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)
NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)
NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)
NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)
NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)
NMRK2 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)
NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
NMRK2 phosphorylates NAR to yield NAMN (Gallus gallus)
NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)
NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)
NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)
NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Felis catus)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)
NOX4, NOX5 reduce O2 to O2.- (Saccharomyces cerevisiae)
NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)
NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)
NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)
NOX4, NOX5 reduce O2 to O2.- (Mus musculus)
NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX2 generates superoxide from oxygen (Xenopus tropicalis)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 generates superoxide from oxygen (Sus scrofa)
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 generates superoxide from oxygen (Rattus norvegicus)
NOX2 generates superoxide from oxygen (Mus musculus)
NOX2 generates superoxide from oxygen (Homo sapiens)
BDH2 dehydrogenates 3HBA (Gallus gallus)
BDH2 dehydrogenates 3HBA (Danio rerio)
BDH2 dehydrogenates 3HBA (Bos taurus)
BDH2 dehydrogenates 3HBA (Canis familiaris)
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
BDH2 dehydrogenates 3HBA (Mus musculus)
BDH2 dehydrogenates 3HBA (Homo sapiens)
BDH2 dehydrogenates 3HBA (Sus scrofa)
FAH cleaves 4FAA (Dictyostelium discoideum)
FAH cleaves 4FAA (Caenorhabditis elegans)
FAH cleaves 4FAA (Drosophila melanogaster)
FAH cleaves 4FAA (Gallus gallus)
FAH cleaves 4FAA (Xenopus tropicalis)
FAH cleaves 4FAA (Sus scrofa)
FAH cleaves 4FAA (Bos taurus)
FAH cleaves 4FAA (Rattus norvegicus)
FAH cleaves 4FAA (Mus musculus)
FAH cleaves 4FAA (Homo sapiens)
HGD dioxygenates homogentisate (Dictyostelium discoideum)
HGD dioxygenates homogentisate (Caenorhabditis elegans)
HGD dioxygenates homogentisate (Drosophila melanogaster)
HGD dioxygenates homogentisate (Gallus gallus)
HGD dioxygenates homogentisate (Danio rerio)
HGD dioxygenates homogentisate (Sus scrofa)
HGD dioxygenates homogentisate (Bos taurus)
HGD dioxygenates homogentisate (Rattus norvegicus)
HGD dioxygenates homogentisate (Mus musculus)
HGD dioxygenates homogentisate (Homo sapiens)
HGD dioxygenates homogentisate (Canis familiaris)
FAH cleaves 4FAA (Canis familiaris)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Gallus gallus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Gallus gallus)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Canis familiaris)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)
AIR + CO2 => CAIR (Caenorhabditis elegans)
AIR + CO2 => CAIR (Drosophila melanogaster)
AIR + CO2 => CAIR (Gallus gallus)
AIR + CO2 => CAIR (Xenopus tropicalis)
AIR + CO2 => CAIR (Danio rerio)
AIR + CO2 => CAIR (Sus scrofa)
AIR + CO2 => CAIR (Bos taurus)
AIR + CO2 => CAIR (Canis familiaris)
AIR + CO2 => CAIR (Mus musculus)
FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)
FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)
FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)
FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)
FGAM + ATP => AIR + ADP + Pi (Gallus gallus)
FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)
FGAM + ATP => AIR + ADP + Pi (Danio rerio)
FGAM + ATP => AIR + ADP + Pi (Sus scrofa)
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
FGAM + ATP => AIR + ADP + Pi (Canis familiaris)
FGAM + ATP => AIR + ADP + Pi (Mus musculus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)
GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)
GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)
GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)
GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)
GAR + 10-Formyl-THF => FGAR + THF (Gallus gallus)
GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)
GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)
GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)
GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)
GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)
GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Gallus gallus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)
GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
FGAM + ATP => AIR + ADP + Pi (Homo sapiens)
AIR + CO2 => CAIR (Homo sapiens)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)
GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)
AIR + CO2 => CAIR (Rattus norvegicus)
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)
GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)
GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)
GLYCTK phosphorylates DGA to 3PDGA (Gallus gallus)
GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)
GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)
GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)
GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)
GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)
GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)
ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
ALDH1A1 oxidises GA to DGA (Sus scrofa)
ALDH1A1 oxidises GA to DGA (Bos taurus)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Mus musculus)
ALDH1A1 oxidises GA to DGA (Homo sapiens)
GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Caenorhabditis elegans)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Gallus gallus)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Caenorhabditis elegans)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Gallus gallus)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)
Vesicular inhibitory amino acid transport (Caenorhabditis elegans)
Vesicular inhibitory amino acid transport (Drosophila melanogaster)
Vesicular inhibitory amino acid transport (Gallus gallus)
Vesicular inhibitory amino acid transport (Danio rerio)
Vesicular inhibitory amino acid transport (Sus scrofa)
Vesicular inhibitory amino acid transport (Bos taurus)
Vesicular inhibitory amino acid transport (Canis familiaris)
Vesicular inhibitory amino acid transport (Rattus norvegicus)
Vesicular inhibitory amino acid transport (Mus musculus)
Vesicular inhibitory amino acid transport (Homo sapiens)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)
CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
TPMT transfers CH3 from AdoMet to 6MP (Gallus gallus)
TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)
TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)
TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)
TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)
TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)
TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)
TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)
TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Dictyostelium discoideum)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)
SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)
Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)
Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)
Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)
Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)
Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)
Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)
Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)
Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)
Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)
Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)
Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)
Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)
Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)
Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Dictyostelium discoideum)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)
SLC36A1-mediated uptake of glycine, proline, and alanine (Saccharomyces cerevisiae)
SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)
SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)
SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)
SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)
SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)
SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)
SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)
SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)
Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)
Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)
Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)
Proton-coupled di- and tri-peptide cotransport (Gallus gallus)
Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)
Proton-coupled di- and tri-peptide cotransport (Danio rerio)
Proton-coupled di- and tri-peptide cotransport (Sus scrofa)
Proton-coupled di- and tri-peptide cotransport (Bos taurus)
Proton-coupled di- and tri-peptide cotransport (Canis familiaris)
Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)
Proton-coupled di- and tri-peptide cotransport (Mus musculus)
Proton-coupled di- and tri-peptide cotransport (Homo sapiens)
Proton-coupled histidine and di-peptide cotransport (Saccharomyces cerevisiae)
Proton-coupled histidine and di-peptide cotransport (Schizosaccharomyces pombe)
Proton-coupled histidine and di-peptide cotransport (Gallus gallus)
Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)
Proton-coupled histidine and di-peptide cotransport (Sus scrofa)
Proton-coupled histidine and di-peptide cotransport (Bos taurus)
Proton-coupled histidine and di-peptide cotransport (Canis familiaris)
Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)
Proton-coupled histidine and di-peptide cotransport (Mus musculus)
Proton-coupled histidine and di-peptide cotransport (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Gallus gallus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)
NEK1 phosphorylates ME1 (Gallus gallus)
NEK1 phosphorylates ME1 (Sus scrofa)
NEK1 phosphorylates ME1 (Bos taurus)
NEK1 phosphorylates ME1 (Canis familiaris)
NEK1 phosphorylates ME1 (Rattus norvegicus)
NEK1 phosphorylates ME1 (Mus musculus)
NEK1 phosphorylates ME1 (Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)
SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)
SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)
SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)
SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)
SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)
Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)
Loading of acetylcholine in synaptic vesicles (Gallus gallus)
Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)
Loading of acetylcholine in synaptic vesicles (Danio rerio)
Loading of acetylcholine in synaptic vesicles (Sus scrofa)
Loading of acetylcholine in synaptic vesicles (Bos taurus)
Loading of acetylcholine in synaptic vesicles (Canis familiaris)
Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)
Loading of acetylcholine in synaptic vesicles (Mus musculus)
Loading of acetylcholine in synaptic vesicles (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Gallus gallus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)
nsp4 is glycosylated (Homo sapiens)
nsp3 is glycosylated (Homo sapiens)
nsp3-4 is glycosylated (Homo sapiens)
nsp3-4 is glycosylated (Homo sapiens)
nsp3 is glycosylated (Homo sapiens)
nsp4 is glycosylated (Homo sapiens)
GSK3 phosphorylates Nucleoprotein (Homo sapiens)
Nucleoprotein is ADP-ribosylated (Homo sapiens)
SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
GSK3 phosphorylates nucleoprotein (Homo sapiens)
CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)
Unknown kinase phosphorylates nucleoprotein (Homo sapiens)
Nucleoprotein is methylated by PRMT1 (Homo sapiens)
Nucleoprotein is ADP-ribosylated (Homo sapiens)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Gallus gallus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)
LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)
LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)
LDH tetramer oxidises LACT to PYR (Gallus gallus)
LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)
LDH tetramer oxidises LACT to PYR (Danio rerio)
LDH tetramer oxidises LACT to PYR (Sus scrofa)
LDH tetramer oxidises LACT to PYR (Bos taurus)
LDH tetramer oxidises LACT to PYR (Canis familiaris)
LDH tetramer oxidises LACT to PYR (Rattus norvegicus)
LDH tetramer oxidises LACT to PYR (Mus musculus)
LDH tetramer oxidises LACT to PYR (Homo sapiens)
ME1 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
ME1 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
ME1 tetramer decarboxylates MAL to PYR (Gallus gallus)
ME1 tetramer decarboxylates MAL to PYR (Danio rerio)
ME1 tetramer decarboxylates MAL to PYR (Sus scrofa)
ME1 tetramer decarboxylates MAL to PYR (Bos taurus)
ME1 tetramer decarboxylates MAL to PYR (Canis familiaris)
ME1 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
ME1 tetramer decarboxylates MAL to PYR (Mus musculus)
ME1 tetramer decarboxylates MAL to PYR (Homo sapiens)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Gallus gallus)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)
PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)
PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)
PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)
PHGDH tetramer dehydrogenates 3PG (Sus scrofa)
PHGDH tetramer dehydrogenates 3PG (Bos taurus)
PHGDH tetramer dehydrogenates 3PG (Canis familiaris)
PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)
PHGDH tetramer dehydrogenates 3PG (Mus musculus)
PHGDH tetramer dehydrogenates 3PG (Homo sapiens)
MMACHC dealkylates RCbl (Dictyostelium discoideum)
MMACHC dealkylates RCbl (Caenorhabditis elegans)
MMACHC dealkylates RCbl (Gallus gallus)
MMACHC dealkylates RCbl (Xenopus tropicalis)
MMACHC dealkylates RCbl (Danio rerio)
MMACHC dealkylates RCbl (Sus scrofa)
MMACHC dealkylates RCbl (Bos taurus)
MMACHC dealkylates RCbl (Canis familiaris)
MMACHC dealkylates RCbl (Rattus norvegicus)
MMACHC dealkylates RCbl (Mus musculus)
MMACHC dealkylates RCbl (Homo sapiens)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)
PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Gallus gallus)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)
KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)
KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)
KHK dimer phosphorylates Fru to Fru 1-P (Gallus gallus)
KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)
KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)
KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)
SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)
SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)
SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)
SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)
SORD oxidizes D-sorbitol to Fru (Gallus gallus)
SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)
SORD oxidizes D-sorbitol to Fru (Sus scrofa)
SORD oxidizes D-sorbitol to Fru (Bos taurus)
SORD oxidizes D-sorbitol to Fru (Canis familiaris)
SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)
SORD oxidizes D-sorbitol to Fru (Mus musculus)
SORD oxidizes D-sorbitol to Fru (Homo sapiens)
KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Gallus gallus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Plasmodium falciparum)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Saccharomyces cerevisiae)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Drosophila melanogaster)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Gallus gallus)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Xenopus tropicalis)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Danio rerio)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)
SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)
SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)
SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)
SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)
SORD tetramer oxidizes xylitol to D-xylulose (Gallus gallus)
SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)
SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)
SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)
SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)
SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)
SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Gallus gallus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)
SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)
This entity regulates
Negatively
Kcnj2 transports K+ from the extracellular region to the cytosol
(Mus musculus)
KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol
(Homo sapiens)
Other forms of this molecule
H+ [early endosome]
H+ [synaptic vesicle lumen]
H+ [platelet dense tubular network lumen]
H+ [sperm flagellum]
H+ [phagolysosome]
H+ [cytoplasm]
H+ [endocytic vesicle lumen]
H+ [melanosome lumen]
H+ [nuclear envelope]
H+ [mitochondrial inner membrane]
H+ [synaptic vesicle]
H+ [late endosome lumen]
H+ [Golgi lumen]
H+ [early endosome lumen]
H+ [lysosomal lumen]
H+ [clathrin-sculpted acetylcholine transport vesicle lumen]
H+ [phagocytic vesicle lumen]
H+ [endolysosome lumen]
H+ [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum-Golgi intermediate compartment]
H+ [endosome lumen]
H+ [extracellular region]
H+ [clathrin-sculpted monoamine transport vesicle lumen]
H+ [mitochondrial intermembrane space]
H+ [peroxisomal matrix]
H+ [mitochondrial matrix]
H+ [nucleoplasm]
Cross References
COMPOUND
C00080
PubChem Substance
8145820
HMDB Metabolite
HMDB0059597
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