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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
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Developer's Zone
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Citing us
Tools
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Analyse gene list
Analyse gene expression
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AdoHcy [cytosol]
Stable Identifier
R-ALL-71285
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
S-adenosylhomocysteine, S-adenosyl-L-homocysteine, SAH
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
PKMTs methylate histone lysines (Bos taurus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)
AdoHcy [cytosol]
RMTs methylate histone arginines (Bos taurus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)
AdoHcy [cytosol]
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
AdoHcy [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Methylation (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Bos taurus)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Creatine metabolism (Bos taurus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Bos taurus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)
AdoHcy [cytosol]
Histidine catabolism (Bos taurus)
CARNMT1 methylates CARN to Anserine (Bos taurus)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Noradrenaline is converted to adrenaline (Bos taurus)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
AdoHcy [cytosol]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
PE is methylated to PC by PEMT (Bos taurus)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
AdoHcy [cytosol]
Nicotinate metabolism (Bos taurus)
Nicotinamide salvaging (Bos taurus)
NNMT transfers CH3 from SAM to NAM to form MNA (Bos taurus)
AdoHcy [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Bos taurus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)
AdoHcy [cytosol]
Protein methylation (Bos taurus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)
AdoHcy [cytosol]
Protein repair (Bos taurus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)
AdoHcy [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Termination (Bos taurus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)
AdoHcy [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Dopamine clearance from the synaptic cleft (Bos taurus)
Enzymatic degradation of dopamine by COMT (Bos taurus)
COMT transfers Met to DA to form 3MT (Bos taurus)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Bos taurus)
AdoHcy [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)
AdoHcy [cytosol]
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS processing (Bos taurus)
ICMT methylates S-Farn RAS proteins (Bos taurus)
AdoHcy [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PRMT1 methylates ESRs (Bos taurus)
AdoHcy [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Bos taurus)
AdoHcy [cytosol]
Chromatin organization (Caenorhabditis elegans)
Chromatin modifying enzymes (Caenorhabditis elegans)
PKMTs methylate histone lysines (Caenorhabditis elegans)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)
AdoHcy [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Noradrenaline is converted to adrenaline (Caenorhabditis elegans)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
AdoHcy [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinamide salvaging (Caenorhabditis elegans)
NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)
AdoHcy [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Caenorhabditis elegans)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)
AdoHcy [cytosol]
Protein methylation (Caenorhabditis elegans)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Caenorhabditis elegans)
AdoHcy [cytosol]
Protein repair (Caenorhabditis elegans)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)
AdoHcy [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Termination (Caenorhabditis elegans)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)
AdoHcy [cytosol]
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS processing (Caenorhabditis elegans)
ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)
AdoHcy [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)
AdoHcy [cytosol]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
PKMTs methylate histone lysines (Canis familiaris)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)
AdoHcy [cytosol]
RMTs methylate histone arginines (Canis familiaris)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)
AdoHcy [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
AdoHcy [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Canis familiaris)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Creatine metabolism (Canis familiaris)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Canis familiaris)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)
AdoHcy [cytosol]
Histidine catabolism (Canis familiaris)
CARNMT1 methylates CARN to Anserine (Canis familiaris)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Noradrenaline is converted to adrenaline (Canis familiaris)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
AdoHcy [cytosol]
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Synthesis of PC (Canis familiaris)
PE is methylated to PC by PEMT (Canis familiaris)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
AdoHcy [cytosol]
Nicotinate metabolism (Canis familiaris)
Nicotinamide salvaging (Canis familiaris)
NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)
AdoHcy [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Synthesis of diphthamide-EEF2 (Canis familiaris)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)
AdoHcy [cytosol]
Protein methylation (Canis familiaris)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Canis familiaris)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)
AdoHcy [cytosol]
Protein repair (Canis familiaris)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)
AdoHcy [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Termination (Canis familiaris)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)
AdoHcy [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Dopamine clearance from the synaptic cleft (Canis familiaris)
Enzymatic degradation of dopamine by COMT (Canis familiaris)
COMT transfers Met to DA to form 3MT (Canis familiaris)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)
AdoHcy [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)
AdoHcy [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PRMT1 methylates ESRs (Canis familiaris)
AdoHcy [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)
AdoHcy [cytosol]
Chromatin organization (Danio rerio)
Chromatin modifying enzymes (Danio rerio)
RMTs methylate histone arginines (Danio rerio)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)
AdoHcy [cytosol]
Drug ADME (Danio rerio)
Azathioprine ADME (Danio rerio)
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
AdoHcy [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Methylation (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Danio rerio)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Creatine metabolism (Danio rerio)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Danio rerio)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Danio rerio)
Serotonin and melatonin biosynthesis (Danio rerio)
Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
AdoHcy [cytosol]
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Synthesis of PC (Danio rerio)
PE is methylated to PC by PEMT (Danio rerio)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
Nicotinamide salvaging (Danio rerio)
NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)
AdoHcy [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)
AdoHcy [cytosol]
Protein methylation (Danio rerio)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)
AdoHcy [cytosol]
Protein repair (Danio rerio)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)
AdoHcy [cytosol]
Translation (Danio rerio)
Eukaryotic Translation Termination (Danio rerio)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)
AdoHcy [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter clearance (Danio rerio)
Dopamine clearance from the synaptic cleft (Danio rerio)
Enzymatic degradation of dopamine by COMT (Danio rerio)
COMT transfers Met to DA to form 3MT (Danio rerio)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Danio rerio)
AdoHcy [cytosol]
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS processing (Danio rerio)
ICMT methylates S-Farn RAS proteins (Danio rerio)
AdoHcy [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)
AdoHcy [cytosol]
Chromatin organization (Dictyostelium discoideum)
Chromatin modifying enzymes (Dictyostelium discoideum)
RMTs methylate histone arginines (Dictyostelium discoideum)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Methylation (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Histidine catabolism (Dictyostelium discoideum)
CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Synthesis of PC (Dictyostelium discoideum)
PE is methylated to PC by PEMT (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
AdoHcy [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Dictyostelium discoideum)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)
AdoHcy [cytosol]
Protein methylation (Dictyostelium discoideum)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)
AdoHcy [cytosol]
Protein repair (Dictyostelium discoideum)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)
AdoHcy [cytosol]
Translation (Dictyostelium discoideum)
Eukaryotic Translation Termination (Dictyostelium discoideum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)
AdoHcy [cytosol]
Chromatin organization (Drosophila melanogaster)
Chromatin modifying enzymes (Drosophila melanogaster)
RMTs methylate histone arginines (Drosophila melanogaster)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)
AdoHcy [cytosol]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase II - Conjugation of compounds (Drosophila melanogaster)
Methylation (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Glyoxylate metabolism and glycine degradation (Drosophila melanogaster)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)
AdoHcy [cytosol]
Histidine catabolism (Drosophila melanogaster)
CARNMT1 methylates CARN to Anserine (Drosophila melanogaster)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
AdoHcy [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Drosophila melanogaster)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)
AdoHcy [cytosol]
Protein methylation (Drosophila melanogaster)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)
AdoHcy [cytosol]
Protein repair (Drosophila melanogaster)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)
AdoHcy [cytosol]
Translation (Drosophila melanogaster)
Eukaryotic Translation Termination (Drosophila melanogaster)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)
AdoHcy [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The phototransduction cascade (Drosophila melanogaster)
Inactivation, recovery and regulation of the phototransduction cascade (Drosophila melanogaster)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)
AdoHcy [cytosol]
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS processing (Drosophila melanogaster)
ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)
AdoHcy [cytosol]
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
PRMT1 methylates ESRs (Drosophila melanogaster)
AdoHcy [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)
AdoHcy [cytosol]
Chromatin organization (Gallus gallus)
Chromatin modifying enzymes (Gallus gallus)
RMTs methylate histone arginines (Gallus gallus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)
AdoHcy [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
AdoHcy [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Methylation (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Gallus gallus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Gallus gallus)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Gallus gallus)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Gallus gallus)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Creatine metabolism (Gallus gallus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Gallus gallus)
AdoHcy [cytosol]
Histidine catabolism (Gallus gallus)
CARNMT1 methylates CARN to Anserine (Gallus gallus)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Noradrenaline is converted to adrenaline (Gallus gallus)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Methylation of N-acetyl-5-HT to form melatonin (Gallus gallus)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
AdoHcy [cytosol]
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Synthesis of PC (Gallus gallus)
PE is methylated to PC by PEMT (Gallus gallus)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
AdoHcy [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Gallus gallus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)
AdoHcy [cytosol]
Protein methylation (Gallus gallus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Gallus gallus)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)
AdoHcy [cytosol]
Protein repair (Gallus gallus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)
AdoHcy [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Dopamine clearance from the synaptic cleft (Gallus gallus)
Enzymatic degradation of dopamine by COMT (Gallus gallus)
COMT transfers Met to DA to form 3MT (Gallus gallus)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)
AdoHcy [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
The phototransduction cascade (Gallus gallus)
Inactivation, recovery and regulation of the phototransduction cascade (Gallus gallus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Gallus gallus)
AdoHcy [cytosol]
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS processing (Gallus gallus)
ICMT methylates S-Farn RAS proteins (Gallus gallus)
AdoHcy [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)
AdoHcy [cytosol]
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)
AdoHcy [cytosol]
RMTs methylate histone arginines (Homo sapiens)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)
AdoHcy [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective AHCY causes HMAHCHD (Homo sapiens)
Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)
AdoHcy [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)
AdoHcy [cytosol]
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
MicroRNA (miRNA) biogenesis (Homo sapiens)
BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)
AdoHcy [cytosol]
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)
AdoHcy [cytosol]
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
AdoHcy [cytosol]
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)
AdoHcy [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Methylation (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Homo sapiens)
AdoHcy [cytosol]
TMT transfers CH3 from AdoMet to BME (Homo sapiens)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Creatine metabolism (Homo sapiens)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Homo sapiens)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)
AdoHcy [cytosol]
Histidine catabolism (Homo sapiens)
CARNMT1 methylates CARN to Anserine (Homo sapiens)
AdoHcy [cytosol]
HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Noradrenaline is converted to adrenaline (Homo sapiens)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)
AdoHcy [cytosol]
Selenoamino acid metabolism (Homo sapiens)
Formation of selenosugars for excretion (Homo sapiens)
GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)
AdoHcy [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)
AdoHcy [cytosol]
Methylation of MeSeH for excretion (Homo sapiens)
Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)
AdoHcy [cytosol]
MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
AdoHcy [cytosol]
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PC (Homo sapiens)
PE is methylated to PC by PEMT (Homo sapiens)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
AdoHcy [cytosol]
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)
AdoHcy [cytosol]
Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
AdoHcy [cytosol]
CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)
AdoHcy [cytosol]
FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)
AdoHcy [cytosol]
FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)
AdoHcy [cytosol]
NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)
AdoHcy [cytosol]
TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)
AdoHcy [cytosol]
TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)
AdoHcy [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Homo sapiens)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
AdoHcy [cytosol]
Protein methylation (Homo sapiens)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
AdoHcy [cytosol]
Protein repair (Homo sapiens)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)
AdoHcy [cytosol]
Translation (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)
AdoHcy [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Dopamine clearance from the synaptic cleft (Homo sapiens)
Enzymatic degradation of dopamine by COMT (Homo sapiens)
COMT transfers Met to DA to form 3MT (Homo sapiens)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)
AdoHcy [cytosol]
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
AdoHcy [cytosol]
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
ICMT methylates S-Farn RAS proteins (Homo sapiens)
AdoHcy [cytosol]
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
PRMT1 methylates ESRs (Homo sapiens)
AdoHcy [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)
AdoHcy [cytosol]
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
PKMTs methylate histone lysines (Mus musculus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)
AdoHcy [cytosol]
RMTs methylate histone arginines (Mus musculus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)
AdoHcy [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
AdoHcy [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Methylation (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Mus musculus)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Creatine metabolism (Mus musculus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Mus musculus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)
AdoHcy [cytosol]
Histidine catabolism (Mus musculus)
CARNMT1 methylates CARN to Anserine (Mus musculus)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Mus musculus)
Catecholamine biosynthesis (Mus musculus)
Noradrenaline is converted to adrenaline (Mus musculus)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Mus musculus)
Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
AdoHcy [cytosol]
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
Synthesis of PC (Mus musculus)
PE is methylated to PC by PEMT (Mus musculus)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Mus musculus)
MTRR reduces cob(II)alamin to meCbl (Mus musculus)
AdoHcy [cytosol]
Nicotinate metabolism (Mus musculus)
Nicotinamide salvaging (Mus musculus)
NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)
AdoHcy [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Mus musculus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)
AdoHcy [cytosol]
Protein methylation (Mus musculus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)
AdoHcy [cytosol]
Protein repair (Mus musculus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)
AdoHcy [cytosol]
Translation (Mus musculus)
Eukaryotic Translation Termination (Mus musculus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)
AdoHcy [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter clearance (Mus musculus)
Dopamine clearance from the synaptic cleft (Mus musculus)
Enzymatic degradation of dopamine by COMT (Mus musculus)
COMT transfers Met to DA to form 3MT (Mus musculus)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Mus musculus)
AdoHcy [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The phototransduction cascade (Mus musculus)
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)
AdoHcy [cytosol]
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS processing (Mus musculus)
ICMT methylates S-Farn RAS proteins (Mus musculus)
AdoHcy [cytosol]
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
PRMT1 methylates ESRs (Mus musculus)
AdoHcy [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)
AdoHcy [cytosol]
Chromatin organization (Plasmodium falciparum)
Chromatin modifying enzymes (Plasmodium falciparum)
RMTs methylate histone arginines (Plasmodium falciparum)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)
AdoHcy [cytosol]
Metabolism (Plasmodium falciparum)
Biological oxidations (Plasmodium falciparum)
Phase II - Conjugation of compounds (Plasmodium falciparum)
Methylation (Plasmodium falciparum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Histidine catabolism (Plasmodium falciparum)
CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)
AdoHcy [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Plasmodium falciparum)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)
AdoHcy [cytosol]
Protein methylation (Plasmodium falciparum)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)
AdoHcy [cytosol]
Protein repair (Plasmodium falciparum)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)
AdoHcy [cytosol]
Translation (Plasmodium falciparum)
Eukaryotic Translation Termination (Plasmodium falciparum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)
AdoHcy [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)
AdoHcy [cytosol]
Chromatin organization (Rattus norvegicus)
Chromatin modifying enzymes (Rattus norvegicus)
PKMTs methylate histone lysines (Rattus norvegicus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)
AdoHcy [cytosol]
RMTs methylate histone arginines (Rattus norvegicus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)
AdoHcy [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Methylation (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Creatine metabolism (Rattus norvegicus)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Rattus norvegicus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)
AdoHcy [cytosol]
Histidine catabolism (Rattus norvegicus)
CARNMT1 methylates CARN to Anserine (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Rattus norvegicus)
Catecholamine biosynthesis (Rattus norvegicus)
Noradrenaline is converted to adrenaline (Rattus norvegicus)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
Synthesis of PC (Rattus norvegicus)
PE is methylated to PC by PEMT (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Cobalamin (Cbl) metabolism (Rattus norvegicus)
MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
AdoHcy [cytosol]
Nicotinate metabolism (Rattus norvegicus)
Nicotinamide salvaging (Rattus norvegicus)
NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)
AdoHcy [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Rattus norvegicus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)
AdoHcy [cytosol]
Protein methylation (Rattus norvegicus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)
AdoHcy [cytosol]
Protein repair (Rattus norvegicus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)
AdoHcy [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter clearance (Rattus norvegicus)
Dopamine clearance from the synaptic cleft (Rattus norvegicus)
Enzymatic degradation of dopamine by COMT (Rattus norvegicus)
COMT transfers Met to DA to form 3MT (Rattus norvegicus)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)
AdoHcy [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
The phototransduction cascade (Rattus norvegicus)
Inactivation, recovery and regulation of the phototransduction cascade (Rattus norvegicus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)
AdoHcy [cytosol]
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS processing (Rattus norvegicus)
ICMT methylates S-Farn RAS proteins (Rattus norvegicus)
AdoHcy [cytosol]
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
PRMT1 methylates ESRs (Rattus norvegicus)
AdoHcy [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)
AdoHcy [cytosol]
Chromatin organization (Saccharomyces cerevisiae)
Chromatin modifying enzymes (Saccharomyces cerevisiae)
RMTs methylate histone arginines (Saccharomyces cerevisiae)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Metabolism (Saccharomyces cerevisiae)
Biological oxidations (Saccharomyces cerevisiae)
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Methylation (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Creatine metabolism (Saccharomyces cerevisiae)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Histidine catabolism (Saccharomyces cerevisiae)
CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Metabolism of lipids (Saccharomyces cerevisiae)
Phospholipid metabolism (Saccharomyces cerevisiae)
Glycerophospholipid biosynthesis (Saccharomyces cerevisiae)
Synthesis of PC (Saccharomyces cerevisiae)
PE is methylated to PC by PEMT (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Saccharomyces cerevisiae)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Protein methylation (Saccharomyces cerevisiae)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Translation (Saccharomyces cerevisiae)
Eukaryotic Translation Termination (Saccharomyces cerevisiae)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)
AdoHcy [cytosol]
Chromatin organization (Schizosaccharomyces pombe)
Chromatin modifying enzymes (Schizosaccharomyces pombe)
PKMTs methylate histone lysines (Schizosaccharomyces pombe)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Schizosaccharomyces pombe)
AdoHcy [cytosol]
RMTs methylate histone arginines (Schizosaccharomyces pombe)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Metabolism (Schizosaccharomyces pombe)
Biological oxidations (Schizosaccharomyces pombe)
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Methylation (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Creatine metabolism (Schizosaccharomyces pombe)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Histidine catabolism (Schizosaccharomyces pombe)
CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Metabolism of lipids (Schizosaccharomyces pombe)
Phospholipid metabolism (Schizosaccharomyces pombe)
Glycerophospholipid biosynthesis (Schizosaccharomyces pombe)
Synthesis of PC (Schizosaccharomyces pombe)
PE is methylated to PC by PEMT (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Schizosaccharomyces pombe)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Protein methylation (Schizosaccharomyces pombe)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Protein repair (Schizosaccharomyces pombe)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Translation (Schizosaccharomyces pombe)
Eukaryotic Translation Termination (Schizosaccharomyces pombe)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Neuronal System (Schizosaccharomyces pombe)
Transmission across Chemical Synapses (Schizosaccharomyces pombe)
Neurotransmitter clearance (Schizosaccharomyces pombe)
Dopamine clearance from the synaptic cleft (Schizosaccharomyces pombe)
Enzymatic degradation of dopamine by COMT (Schizosaccharomyces pombe)
COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of inorganic cations/anions and amino acids/oligopeptides (Schizosaccharomyces pombe)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)
AdoHcy [cytosol]
Chromatin organization (Sus scrofa)
Chromatin modifying enzymes (Sus scrofa)
PKMTs methylate histone lysines (Sus scrofa)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)
AdoHcy [cytosol]
RMTs methylate histone arginines (Sus scrofa)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)
AdoHcy [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
AdoHcy [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase II - Conjugation of compounds (Sus scrofa)
Methylation (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Sus scrofa)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Sus scrofa)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Creatine metabolism (Sus scrofa)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Sus scrofa)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)
AdoHcy [cytosol]
Histidine catabolism (Sus scrofa)
CARNMT1 methylates CARN to Anserine (Sus scrofa)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Sus scrofa)
Catecholamine biosynthesis (Sus scrofa)
Noradrenaline is converted to adrenaline (Sus scrofa)
AdoHcy [cytosol]
Serotonin and melatonin biosynthesis (Sus scrofa)
Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
AdoHcy [cytosol]
Metabolism of lipids (Sus scrofa)
Phospholipid metabolism (Sus scrofa)
Glycerophospholipid biosynthesis (Sus scrofa)
Synthesis of PC (Sus scrofa)
PE is methylated to PC by PEMT (Sus scrofa)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Sus scrofa)
Cobalamin (Cbl) metabolism (Sus scrofa)
MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
AdoHcy [cytosol]
Nicotinate metabolism (Sus scrofa)
Nicotinamide salvaging (Sus scrofa)
NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)
AdoHcy [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Synthesis of diphthamide-EEF2 (Sus scrofa)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)
AdoHcy [cytosol]
Protein methylation (Sus scrofa)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)
AdoHcy [cytosol]
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)
AdoHcy [cytosol]
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Sus scrofa)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Sus scrofa)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)
AdoHcy [cytosol]
Protein repair (Sus scrofa)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)
AdoHcy [cytosol]
Translation (Sus scrofa)
Eukaryotic Translation Termination (Sus scrofa)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)
AdoHcy [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter clearance (Sus scrofa)
Dopamine clearance from the synaptic cleft (Sus scrofa)
Enzymatic degradation of dopamine by COMT (Sus scrofa)
COMT transfers Met to DA to form 3MT (Sus scrofa)
AdoHcy [cytosol]
LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)
AdoHcy [cytosol]
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
The phototransduction cascade (Sus scrofa)
Inactivation, recovery and regulation of the phototransduction cascade (Sus scrofa)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)
AdoHcy [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Extra-nuclear estrogen signaling (Sus scrofa)
PRMT1 methylates ESRs (Sus scrofa)
AdoHcy [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)
AdoHcy [cytosol]
Chromatin organization (Xenopus tropicalis)
Chromatin modifying enzymes (Xenopus tropicalis)
RMTs methylate histone arginines (Xenopus tropicalis)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)
AdoHcy [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
AdoHcy [cytosol]
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase II - Conjugation of compounds (Xenopus tropicalis)
Methylation (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)
AdoHcy [cytosol]
AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)
AdoHcy [cytosol]
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Xenopus tropicalis)
AdoHcy [cytosol]
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)
AdoHcy [cytosol]
NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)
AdoHcy [cytosol]
TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Creatine metabolism (Xenopus tropicalis)
guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
AdoHcy [cytosol]
Glyoxylate metabolism and glycine degradation (Xenopus tropicalis)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism of amine-derived hormones (Xenopus tropicalis)
Serotonin and melatonin biosynthesis (Xenopus tropicalis)
Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)
AdoHcy [cytosol]
Sulfur amino acid metabolism (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Phospholipid metabolism (Xenopus tropicalis)
Glycerophospholipid biosynthesis (Xenopus tropicalis)
Synthesis of PC (Xenopus tropicalis)
PE is methylated to PC by PEMT (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Nicotinate metabolism (Xenopus tropicalis)
Nicotinamide salvaging (Xenopus tropicalis)
NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)
AdoHcy [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)
AdoHcy [cytosol]
Synthesis of diphthamide-EEF2 (Xenopus tropicalis)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Xenopus tropicalis)
AdoHcy [cytosol]
Protein methylation (Xenopus tropicalis)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)
AdoHcy [cytosol]
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)
AdoHcy [cytosol]
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)
AdoHcy [cytosol]
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)
AdoHcy [cytosol]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter clearance (Xenopus tropicalis)
Dopamine clearance from the synaptic cleft (Xenopus tropicalis)
Enzymatic degradation of dopamine by COMT (Xenopus tropicalis)
COMT transfers Met to DA to form 3MT (Xenopus tropicalis)
AdoHcy [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Nuclear Receptors (Xenopus tropicalis)
ESR-mediated signaling (Xenopus tropicalis)
Extra-nuclear estrogen signaling (Xenopus tropicalis)
PRMT1 methylates ESRs (Xenopus tropicalis)
AdoHcy [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Xenopus tropicalis)
AdoHcy [cytosol]
External Reference Information
External Reference
S-adenosyl-L-homocysteine zwitterion [ChEBI:57856]
Participates
as an input of
Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
as an output of
CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)
FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
TRM11:TRM112 methylates guanosine-10 in tRNA yielding N(2)-methylguanosine-10 (Saccharomyces cerevisiae)
TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)
FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)
NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)
TRM44 2'-O-methylates uridine-44 in tRNA(Ser) (Saccharomyces cerevisiae)
TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Sus scrofa)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Saccharomyces cerevisiae)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Caenorhabditis elegans)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Sus scrofa)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Canis familiaris)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)
PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)
PE is methylated to PC by PEMT (Saccharomyces cerevisiae)
PE is methylated to PC by PEMT (Schizosaccharomyces pombe)
PE is methylated to PC by PEMT (Dictyostelium discoideum)
PE is methylated to PC by PEMT (Gallus gallus)
PE is methylated to PC by PEMT (Xenopus tropicalis)
PE is methylated to PC by PEMT (Danio rerio)
PE is methylated to PC by PEMT (Sus scrofa)
PE is methylated to PC by PEMT (Bos taurus)
PE is methylated to PC by PEMT (Canis familiaris)
PE is methylated to PC by PEMT (Rattus norvegicus)
PE is methylated to PC by PEMT (Mus musculus)
PE is methylated to PC by PEMT (Homo sapiens)
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-Piwil1:piRNA:Tdrd6:Tdrkh (Mus musculus)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)
BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in MeR-Piwil4:piRNA:Tdrd9:Mael:Tdrkh (Mus musculus)
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12 (Mus musculus)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)
COMT transfers Met to DA to form 3MT (Gallus gallus)
COMT transfers Met to DA to form 3MT (Xenopus tropicalis)
COMT transfers Met to DA to form 3MT (Danio rerio)
COMT transfers Met to DA to form 3MT (Sus scrofa)
COMT transfers Met to DA to form 3MT (Bos taurus)
COMT transfers Met to DA to form 3MT (Canis familiaris)
COMT transfers Met to DA to form 3MT (Rattus norvegicus)
COMT transfers Met to DA to form 3MT (Mus musculus)
COMT transfers Met to DA to form 3MT (Homo sapiens)
LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)
LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)
LRTOMT transfers Met to DA, forming 3MT (Danio rerio)
LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)
LRTOMT transfers Met to DA, forming 3MT (Bos taurus)
LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)
LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)
LRTOMT transfers Met to DA, forming 3MT (Mus musculus)
LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Gallus gallus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Xenopus tropicalis)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)
PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Schizosaccharomyces pombe)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)
MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Gallus gallus)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)
AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)
AS3MT transfers CH3 from AdoMet to methylarsonite (Gallus gallus)
AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)
AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)
AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)
AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)
AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)
AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)
AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
![AdoHcy [cytosol] icon](/icon/R-ICO-013329.svg){kind=icon}