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Ca2+ [cytosol]
Stable Identifier
R-ALL-74016
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)
PADIs:Ca2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [cytosol]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Elevation of cytosolic Ca2+ levels (Bos taurus)
Cation influx mediated by TRPC3/6/7 (Bos taurus)
Cations [cytosol]
Ca2+ [cytosol]
P2X1-mediated entry of Ca++ from plasma (Bos taurus)
Ca2+ [cytosol]
Reduction of cytosolic Ca++ levels (Bos taurus)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Rap1 signalling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [cytosol]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
ITPKA/B/C [cytosol] (Bos taurus)
ITPKA:Ca2+:CALM1 [cytosol] (Bos taurus)
Ca2+ [cytosol]
ITPKB:Ca2+:CALM1 [cytosol] (Bos taurus)
Ca2+ [cytosol]
ITPKC:Ca2+:CALM1 [cytosol] (Bos taurus)
Ca2+ [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PLCbz [cytosol] (Bos taurus)
PLCB2:Ca2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
PLCZ1:Ca2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
CPNEs bind PL (Bos taurus)
Ca2+ [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)
PIK3C2A/G [cytosol] (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Bos taurus)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Bos taurus)
Ca2+/Mg2+/Mn2+ [cytosol]
Ca2+ [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Calcium Binds Troponin-C (Bos taurus)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Myosin Binds ATP (Bos taurus)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Release Of ADP From Myosin (Bos taurus)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
Thin Filament With Troponin Bound Calcium [cytosol] (Bos taurus)
Calcium:Troponin Complex [cytosol] (Bos taurus)
Troponin C:Calcium Complex [cytosol] (Bos taurus)
Ca2+ [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Acetylcholine binding and downstream events (Bos taurus)
Postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [cytosol]
Presynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [cytosol]
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
Activation of RAC1 downstream of NMDARs (Bos taurus)
CAMK1 binds calmodulin (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
CAMK1:CALM1:4xCa2+ [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
CaMKK autophosphorylates in the cytosol (Bos taurus)
CaMKK:CALM1:4xCa2+ [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
p-CaMKK:CALM1:4xCa2+ [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Activation of kainate receptors upon glutamate binding (Bos taurus)
Ionotropic activity of kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate Receptor (Bos taurus)
Activation of Ca-permeable Kainate receptors (Bos taurus)
Ca2+ [cytosol]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)
Ca2+ [cytosol]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)
Ca2+ [cytosol]
Reproduction (Bos taurus)
Fertilization (Bos taurus)
Sperm Motility And Taxes (Bos taurus)
CatSper Channel Mediated Calcium Transport (Bos taurus)
Ca2+ [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GUCA binds Ca2+ to form GUCA:Ca2+ (Bos taurus)
Ca2+ [cytosol]
GUCA1A:Ca2+ [photoreceptor disc membrane] (Bos taurus)
Ca2+ [cytosol]
GUCYs converts GTP to cGMP (Bos taurus)
GCAP1:Ca2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
GUCA1A:Ca2+ [photoreceptor disc membrane] (Bos taurus)
Ca2+ [cytosol]
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
Ca2+ [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
Calmodulin activates Cam-PDE 1 (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAF activation (Bos taurus)
Phosphorylation of RAF (Bos taurus)
RAF activating kinases [plasma membrane] (Bos taurus)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
Calmodulin activates Cam-PDE 1 (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Bos taurus)
PKA activation (Bos taurus)
Adenylate cyclase produces cAMP (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated cell proliferation (Bos taurus)
DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)
Ca2+ [cytosol]
DAG:active PKC:Ca+2 [plasma membrane] (Bos taurus)
Ca2+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)
NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Bos taurus)
S100A8:S100A9:AA:Ca2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Active calmodulin binds CAMK2 (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
CAMK2:CaM [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Autophosphorylation and activation of CAMK2 (Bos taurus)
CAMK2:CaM [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Bos taurus)
CALM1:4xCa2+ [cytosol] (Bos taurus)
Ca2+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
Ca2+ [cytosol]
Stimuli-sensing channels (Bos taurus)
ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)
Ca2+ [cytosol]
ANOs transport cytosolic Cl- to extracellular region (Bos taurus)
Ca2+ [cytosol]
BESTs transport cytosolic Cl- to extracellular region (Bos taurus)
Ca2+ [cytosol]
TPCN1/2 transport lysosomal Ca2+ to cytosol (Bos taurus)
Ca2+ [cytosol]
TRP channels (Bos taurus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [cytosol]
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
Ca2+ [cytosol]
TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)
Ca2+ [cytosol]
UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)
Ca2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Sodium/Calcium exchangers (Bos taurus)
K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
Ca2+ [cytosol]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
Ca2+ [cytosol]
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Activation of conventional Protein Kinase C (Caenorhabditis elegans)
Ca2+ [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)
Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
Cations [cytosol]
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Reduction of cytosolic Ca++ levels (Caenorhabditis elegans)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Rap1 signalling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
STIM1 oligomerizes (Caenorhabditis elegans)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Caenorhabditis elegans)
Activation of NF-kappaB in B cells (Caenorhabditis elegans)
PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)
Ca2+ [cytosol]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
CLEC7A (Dectin-1) induces NFAT activation (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated Ca+2 mobilization (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
ITPKA/B/C [cytosol] (Caenorhabditis elegans)
ITPKA:Ca2+:CALM1 [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
ITPKB:Ca2+:CALM1 [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PLCbz [cytosol] (Caenorhabditis elegans)
PLCB4:Ca2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PLCZ1:Ca2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glycogen metabolism (Caenorhabditis elegans)
Glycogen breakdown (glycogenolysis) (Caenorhabditis elegans)
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)
PIK3C2A/G [cytosol] (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)
PIK3C2A/3 [cytosol] (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
PIK3(2) [cytosol] (Caenorhabditis elegans)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Caenorhabditis elegans)
Ca2+/Mg2+/Mn2+ [cytosol]
Ca2+ [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Phase 0 - rapid depolarisation (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Phase 2 - plateau phase (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Acetylcholine binding and downstream events (Caenorhabditis elegans)
Postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [cytosol]
Presynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [cytosol]
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Post NMDA receptor activation events (Caenorhabditis elegans)
Activation of RAC1 downstream of NMDARs (Caenorhabditis elegans)
CAMK1 binds calmodulin (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
CAMK1:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)
CaMKK:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-CaMKK:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
Ca2+ [cytosol]
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
Ionotropic activity of kainate receptors (Caenorhabditis elegans)
Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
Ca2+ [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Caenorhabditis elegans)
Activation of AMPA receptors (Caenorhabditis elegans)
Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
Ca2+ [cytosol]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
Neurotransmitter release cycle (Caenorhabditis elegans)
Glutamate Neurotransmitter Release Cycle (Caenorhabditis elegans)
Release of L-Glutamate at the synapse (Caenorhabditis elegans)
Ca2+ [cytosol]
SNARE complex:Ca2+ [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
Presynaptic depolarization and calcium channel opening (Caenorhabditis elegans)
Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)
Ca2+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Sensory perception of taste (Caenorhabditis elegans)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Caenorhabditis elegans)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Activation of the phototransduction cascade (Caenorhabditis elegans)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)
Ca2+ [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
CALM1:Ca2+:CNG channel [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
GUCA binds Ca2+ to form GUCA:Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
GUCA:Ca2+ [photoreceptor disc membrane] (Caenorhabditis elegans)
GUCA1A:Ca2+ [photoreceptor disc membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
GUCA1B:Ca2+ [photoreceptor disc membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
GUCA1C:Ca2+ [photoreceptor disc membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
GRK2:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
active PKC (alpha, gamma, delta) [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PKC phosphorylates GRK2 (Caenorhabditis elegans)
active PKC (alpha, gamma, delta) [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS processing (Caenorhabditis elegans)
ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Caenorhabditis elegans)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
GRK2:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
active PKC (alpha, gamma, delta) [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Caenorhabditis elegans)
PKA activation (Caenorhabditis elegans)
Adenylate cyclase produces cAMP (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PKC phosphorylates GRK2 (Caenorhabditis elegans)
active PKC (alpha, gamma, delta) [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated cell proliferation (Caenorhabditis elegans)
DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)
Ca2+ [cytosol]
DAG:active PKC:Ca+2 [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)
DAG:active PKC:Ca+2 [plasma membrane] (Caenorhabditis elegans)
Ca2+ [cytosol]
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Active calmodulin binds CAMK2 (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
CAMK2:CaM [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)
CAMK2:CaM [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)
NFATC1:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
CALM1:4xCa2+ [cytosol] (Caenorhabditis elegans)
Ca2+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
Ca2+ [cytosol]
Stimuli-sensing channels (Caenorhabditis elegans)
ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
BESTs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
TRP channels (Caenorhabditis elegans)
TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
Ca2+ [cytosol]
TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Sodium/Calcium exchangers (Caenorhabditis elegans)
K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
Ca2+ [cytosol]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [cytosol]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)
PADIs:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)
Ca2+ [cytosol]
CAPN:4xCa2+:CAPNS [cytosol] (Canis familiaris)
CAPN:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)
Ca2+ [cytosol]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Activation of conventional Protein Kinase C (Canis familiaris)
Ca2+ [cytosol]
Platelet homeostasis (Canis familiaris)
Platelet calcium homeostasis (Canis familiaris)
Elevation of cytosolic Ca2+ levels (Canis familiaris)
Cation influx mediated by TRPC3/6/7 (Canis familiaris)
Cations [cytosol]
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)
Ca2+ [cytosol]
P2X1-mediated entry of Ca++ from plasma (Canis familiaris)
Ca2+ [cytosol]
Reduction of cytosolic Ca++ levels (Canis familiaris)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Rap1 signalling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
STIM1 oligomerizes (Canis familiaris)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)
Ca2+ [cytosol]
Calcineurin activates NFAT (Canis familiaris)
Calcineurin binds NFATC1,2,3 (Canis familiaris)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin:p-NFATC1,2,3 [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)
ITPKA/B/C [cytosol] (Canis familiaris)
ITPKA:Ca2+:CALM1 [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ITPKB:Ca2+:CALM1 [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ITPKC:Ca2+:CALM1 [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PLCbz [cytosol] (Canis familiaris)
PLCB1:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PLCB2:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PLCB3:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PLCB4:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PLCZ1:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)
Ca2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Glycogen metabolism (Canis familiaris)
Glycogen breakdown (glycogenolysis) (Canis familiaris)
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)
Ca2+ [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)
Ca2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Hydrolysis of phosphatidylcholine (Canis familiaris)
Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] (Canis familiaris)
Ca2+ [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodelling of PC (Canis familiaris)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)
PLA2(7) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)
PLA2(5) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Acyl chain remodelling of PE (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)
PLA2(2) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)
PLA2(4) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)
PLA2(1) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Acyl chain remodelling of PI (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
PLA2(11) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Acyl chain remodelling of PS (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)
PLA2(9) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)
PLA2(10) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
CPNEs bind PL (Canis familiaris)
Ca2+ [cytosol]
Hydrolysis of LPC (Canis familiaris)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
PLA2(8) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
PLA2(8) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Synthesis of PA (Canis familiaris)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)
PLA2(1) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)
PLA2(1) [cytosol] (Canis familiaris)
PLA2G4A:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)
PIK3C2A/G [cytosol] (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)
PIK3C2A/3 [cytosol] (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Canis familiaris)
Ca2+/Mg2+/Mn2+ [cytosol]
Ca2+ [cytosol]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)
Ca2+ [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [cytosol]
Phase 0 - rapid depolarisation (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [cytosol]
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Canis familiaris)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Phase 2 - plateau phase (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [cytosol]
Smooth Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
p-S759, S789 CALD1:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
p-S759, S789 CALD1:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcium Binds Caldesmon (Canis familiaris)
Ca2+ [cytosol]
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
Caldesmon:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
DYSF, CAV3 and TRIM72 bind (Canis familiaris)
Ca2+ [cytosol]
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Myosin Binds ATP (Canis familiaris)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
p-S759, S789 CALD1:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
p-S759, S789 CALD1:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Release Of ADP From Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
p-S759, S789 CALD1:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
Caldesmon:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Striated Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcium Binds Troponin-C (Canis familiaris)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Myosin Binds ATP (Canis familiaris)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Release Of ADP From Myosin (Canis familiaris)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
Calcium:Troponin Complex [cytosol] (Canis familiaris)
Troponin C:Calcium Complex [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
Acetylcholine binding and downstream events (Canis familiaris)
Postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [cytosol]
Presynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [cytosol]
Activation of NMDA receptors and postsynaptic events (Canis familiaris)
Post NMDA receptor activation events (Canis familiaris)
Activation of RAC1 downstream of NMDARs (Canis familiaris)
CAMK1 binds calmodulin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
CAMK1:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
CaMKK autophosphorylates in the cytosol (Canis familiaris)
CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
p-CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
Ca2+ influx into the post-synaptic cell (Canis familiaris)
Ca2+ [cytosol]
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Activation of kainate receptors upon glutamate binding (Canis familiaris)
Ionotropic activity of kainate receptors (Canis familiaris)
Activation of Ca-permeable Kainate Receptor (Canis familiaris)
Activation of Ca-permeable Kainate receptors (Canis familiaris)
Ca2+ [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
Activation of AMPA receptors (Canis familiaris)
Activation of Ca permeable AMPA receptors (Canis familiaris)
Ca2+ [cytosol]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [cytosol]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [cytosol]
Presynaptic depolarization and calcium channel opening (Canis familiaris)
Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)
Ca2+ [cytosol]
Reproduction (Canis familiaris)
Fertilization (Canis familiaris)
Sperm Motility And Taxes (Canis familiaris)
CatSper Channel Mediated Calcium Transport (Canis familiaris)
Ca2+ [cytosol]
Sensory Perception (Canis familiaris)
Sensory perception of taste (Canis familiaris)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Canis familiaris)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)
Ca2+ [cytosol]
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Activation of the phototransduction cascade (Canis familiaris)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)
Ca2+ [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
CALM1:Ca2+ binds CNG channel (Canis familiaris)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
CALM1:Ca2+:CNG channel [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)
Ca2+ [cytosol]
GUCA:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
GUCA1A:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
Ca2+ [cytosol]
GUCA1C:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
Ca2+ [cytosol]
GUCYs converts GTP to cGMP (Canis familiaris)
GCAP1:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GUCA:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
GUCA1A:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
Ca2+ [cytosol]
GUCA1C:Ca2+ [photoreceptor disc membrane] (Canis familiaris)
Ca2+ [cytosol]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
Calmodulin activates Cam-PDE 1 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GRK2:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
active PKC (alpha, gamma, delta) [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PKC phosphorylates GRK2 (Canis familiaris)
active PKC (alpha, gamma, delta) [cytosol] (Canis familiaris)
Ca2+ [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAF activation (Canis familiaris)
Phosphorylation of RAF (Canis familiaris)
RAF activating kinases [plasma membrane] (Canis familiaris)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
RAS processing (Canis familiaris)
ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
KRAS4B recycles to the plasma membrane (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
Calmodulin activates Cam-PDE 1 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
GRK2:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
active PKC (alpha, gamma, delta) [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PKC phosphorylates GRK2 (Canis familiaris)
active PKC (alpha, gamma, delta) [cytosol] (Canis familiaris)
Ca2+ [cytosol]
phospho-PLA2 pathway (Canis familiaris)
Hydrolysis of phosphatidylcholine (Canis familiaris)
Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] (Canis familiaris)
Ca2+ [cytosol]
Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)
Ca2+ [cytosol]
Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] (Canis familiaris)
Ca2+ [cytosol]
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)
Ca2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
SHC1 events in ERBB2 signaling (Canis familiaris)
Activated PKC phosphorylates SHC1 (Canis familiaris)
Activated PRKCA,(PRKCD,PRKCE) [plasma membrane] (Canis familiaris)
activated PKC alpha [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFR2 mediated cell proliferation (Canis familiaris)
DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)
Ca2+ [cytosol]
DAG:active PKC:Ca+2 [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
PKC phosphorylates sphingosine kinase 1 (Canis familiaris)
DAG:active PKC:Ca+2 [plasma membrane] (Canis familiaris)
Ca2+ [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Canis familiaris)
S100A8:S100A9:AA:Ca2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
RHO GTPases activate PAKs (Canis familiaris)
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Active calmodulin binds CAMK2 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Autophosphorylation and activation of CAMK2 (Canis familiaris)
CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
p-T286 CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Canis familiaris)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Ca2+ [cytosol]
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
Ca2+ [cytosol]
Stimuli-sensing channels (Canis familiaris)
ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)
Ca2+ [cytosol]
ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)
Ca2+ [cytosol]
BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)
Ca2+ [cytosol]
CLCAs self cleave (Canis familiaris)
Ca2+ [cytosol]
TPCN1/2 transport lysosomal Ca2+ to cytosol (Canis familiaris)
Ca2+ [cytosol]
TRP channels (Canis familiaris)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [cytosol]
TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)
Ca2+ [cytosol]
TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)
Ca2+ [cytosol]
UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)
Ca2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Sodium/Calcium exchangers (Canis familiaris)
K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)
Ca2+ [cytosol]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)
Ca2+ [cytosol]
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [cytosol]
Chromatin organization (Danio rerio)
Chromatin modifying enzymes (Danio rerio)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Danio rerio)
PADIs:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Extracellular matrix organization (Danio rerio)
Degradation of the extracellular matrix (Danio rerio)
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)
Ca2+ [cytosol]
CAPN:4xCa2+:CAPNS [cytosol] (Danio rerio)
CAPN:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)
Ca2+ [cytosol]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Activation of Rap1 by cytosolic GEFs (Danio rerio)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Danio rerio)
Ca2+ [cytosol]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Activation of conventional Protein Kinase C (Danio rerio)
Ca2+ [cytosol]
Platelet homeostasis (Danio rerio)
Platelet calcium homeostasis (Danio rerio)
Elevation of cytosolic Ca2+ levels (Danio rerio)
Cation influx mediated by TRPC3/6/7 (Danio rerio)
Cations [cytosol]
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)
Ca2+ [cytosol]
P2X1-mediated entry of Ca++ from plasma (Danio rerio)
Ca2+ [cytosol]
Reduction of cytosolic Ca++ levels (Danio rerio)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
Ca2+ [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Rap1 signalling (Danio rerio)
Activation of Rap1 by cytosolic GEFs (Danio rerio)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Danio rerio)
Ca2+ [cytosol]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
STIM1 oligomerizes (Danio rerio)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)
Ca2+ [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Danio rerio)
Activation of NF-kappaB in B cells (Danio rerio)
PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)
Ca2+ [cytosol]
Calcineurin activates NFAT (Danio rerio)
Calcineurin binds NFATC1,2,3 (Danio rerio)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Calcineurin:p-NFATC1,2,3 [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Innate Immune System (Danio rerio)
C-type lectin receptors (CLRs) (Danio rerio)
CLEC7A (Dectin-1) signaling (Danio rerio)
CLEC7A (Dectin-1) induces NFAT activation (Danio rerio)
Activation of Calcineurin (Danio rerio)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated Ca+2 mobilization (Danio rerio)
Activation of Calcineurin (Danio rerio)
Ca2+ [cytosol]
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Danio rerio)
Ca2+ [cytosol]
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)
ITPKA/B/C [cytosol] (Danio rerio)
ITPKA:Ca2+:CALM1 [cytosol] (Danio rerio)
Ca2+ [cytosol]
ITPKB:Ca2+:CALM1 [cytosol] (Danio rerio)
Ca2+ [cytosol]
ITPKC:Ca2+:CALM1 [cytosol] (Danio rerio)
Ca2+ [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)
PLCbz [cytosol] (Danio rerio)
PLCB1:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PLCB3:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PLCB4:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Calcium Influx through Voltage-gated Calcium Channels (Danio rerio)
Ca2+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glycogen metabolism (Danio rerio)
Glycogen breakdown (glycogenolysis) (Danio rerio)
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Danio rerio)
Ca2+ [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Danio rerio)
Ca2+ [cytosol]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Hydrolysis of phosphatidylcholine (Danio rerio)
Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] (Danio rerio)
Ca2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)
ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Acyl chain remodelling of PC (Danio rerio)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)
PLA2(7) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)
PLA2(5) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Acyl chain remodelling of PE (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)
PLA2(2) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)
PLA2(4) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Acyl chain remodelling of PG (Danio rerio)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)
PLA2(1) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Acyl chain remodelling of PI (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
PLA2(11) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Acyl chain remodelling of PS (Danio rerio)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)
PLA2(9) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)
PLA2(10) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
CPNEs bind PL (Danio rerio)
Ca2+ [cytosol]
Hydrolysis of LPC (Danio rerio)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
PLA2(8) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
PLA2(8) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Synthesis of PA (Danio rerio)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)
PLA2(1) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)
PLA2(1) [cytosol] (Danio rerio)
PLA2G4A:Ca2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
PI Metabolism (Danio rerio)
Synthesis of PIPs at the Golgi membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Danio rerio)
PIK3C2A/G [cytosol] (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the early endosome membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the late endosome membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)
PIK3C2A/3 [cytosol] (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Danio rerio)
Ca2+/Mg2+ [cytosol]
Ca2+ [cytosol]
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Danio rerio)
Ca2+/Mg2+/Mn2+ [cytosol]
Ca2+ [cytosol]
Sphingolipid metabolism (Danio rerio)
Glycosphingolipid metabolism (Danio rerio)
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Danio rerio)
Ca2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
eNOS activation (Danio rerio)
AKT1 phosphorylates eNOS (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
eNOS synthesizes NO (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
BH2 binding can lead to eNOS uncoupling (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Danio rerio)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
Ca2+ [cytosol]
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
Ca2+ [cytosol]
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)
Ca2+ [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Danio rerio)
Ca2+ [cytosol]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
Ca2+ [cytosol]
TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)
Ca2+ [cytosol]
Phase 0 - rapid depolarisation (Danio rerio)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Danio rerio)
Ca2+ [cytosol]
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Danio rerio)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Danio rerio)
CALM1:4xCa2+ [cytosol] (Danio rerio)
Ca2+ [cytosol]
Phase 2 - plateau phase (Danio rerio)
![Ca2+ [cytosol] icon](/icon/R-ICO-012501.svg){kind=icon}