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Ca2+ [extracellular region]
Stable Identifier
R-ALL-74112
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
Common Pathway of Fibrin Clot Formation (Bos taurus)
Factor Xa inhibitors binds Xa (Bos taurus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Bos taurus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Bos taurus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet dense granule content (Bos taurus)
Platelet dense granule content [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Elevation of cytosolic Ca2+ levels (Bos taurus)
Cation influx mediated by TRPC3/6/7 (Bos taurus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Bos taurus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
INTL1 binds bacterial glycans (Bos taurus)
INTL1:bacterial glycan [extracellular region] (Bos taurus)
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Bos taurus)
S100A7 or S100A7A binds Zn2+ (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Complement cascade (Bos taurus)
Initial triggering of complement (Bos taurus)
Creation of C4 and C2 activators (Bos taurus)
Classical antibody-mediated complement activation (Bos taurus)
Activation of C1r (Bos taurus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Bos taurus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Bos taurus)
C-reactive protein homopentamer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 5-eicosatetraenoic acids (Bos taurus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Bos taurus)
PON1:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodelling of PC (Bos taurus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Synthesis of PA (Bos taurus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Phosphate bond hydrolysis by NTPDase proteins (Bos taurus)
NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Acetylcholine binding and downstream events (Bos taurus)
Postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Bos taurus)
Ionotropic activity of kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate Receptor (Bos taurus)
Activation of Ca-permeable Kainate receptors (Bos taurus)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Reproduction (Bos taurus)
Fertilization (Bos taurus)
Sperm Motility And Taxes (Bos taurus)
CatSper Channel Mediated Calcium Transport (Bos taurus)
Ca2+ [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Peptide ligand-binding receptors (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Bos taurus)
TRP channels (Bos taurus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Sodium/Calcium exchangers (Bos taurus)
K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Formation of Fibrin Clot (Clotting Cascade) (Caenorhabditis elegans)
Common Pathway of Fibrin Clot Formation (Caenorhabditis elegans)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Caenorhabditis elegans)
thrombin:cleaved SERPINC1 [extracellular region] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Caenorhabditis elegans)
Factor IIa inhibitors (compounds) binds IIa (Caenorhabditis elegans)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Caenorhabditis elegans)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
Exocytosis of platelet dense granule content (Caenorhabditis elegans)
Platelet dense granule content [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Caenorhabditis elegans)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)
Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
Cations [extracellular region]
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Innate Immune System (Caenorhabditis elegans)
Complement cascade (Caenorhabditis elegans)
Regulation of Complement cascade (Caenorhabditis elegans)
Thrombin, ELANE cleave C5 (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism (Caenorhabditis elegans)
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of 5-eicosatetraenoic acids (Caenorhabditis elegans)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)
PON1,2,3:2xCa2+ dimers [extracellular region] (Caenorhabditis elegans)
PON1:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Acyl chain remodelling of PC (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Synthesis of PA (Caenorhabditis elegans)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Phosphate bond hydrolysis by NTPDase proteins (Caenorhabditis elegans)
NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Acetylcholine binding and downstream events (Caenorhabditis elegans)
Postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
Ionotropic activity of kainate receptors (Caenorhabditis elegans)
Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Caenorhabditis elegans)
Activation of AMPA receptors (Caenorhabditis elegans)
Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Caenorhabditis elegans)
Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Activation of the phototransduction cascade (Caenorhabditis elegans)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)
Ca2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Peptide ligand-binding receptors (Caenorhabditis elegans)
Proteinase-activated receptors can bind thrombin (Caenorhabditis elegans)
Thrombin:Proteinase-activated receptors [plasma membrane] (Caenorhabditis elegans)
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
Stimuli-sensing channels (Caenorhabditis elegans)
TRP channels (Caenorhabditis elegans)
TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Sodium/Calcium exchangers (Caenorhabditis elegans)
K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Hemostasis (Canis familiaris)
Formation of Fibrin Clot (Clotting Cascade) (Canis familiaris)
Common Pathway of Fibrin Clot Formation (Canis familiaris)
Activated protein C binds Protein S (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Canis familiaris)
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR binds Protein C (Canis familiaris)
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Canis familiaris)
Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Canis familiaris)
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Exocytosis of platelet dense granule content (Canis familiaris)
Platelet dense granule content [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Canis familiaris)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Platelet homeostasis (Canis familiaris)
Platelet calcium homeostasis (Canis familiaris)
Elevation of cytosolic Ca2+ levels (Canis familiaris)
Cation influx mediated by TRPC3/6/7 (Canis familiaris)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Canis familiaris)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [extracellular region]
Innate Immune System (Canis familiaris)
Complement cascade (Canis familiaris)
Initial triggering of complement (Canis familiaris)
Conversion of C2 into C2a and C2b (Canis familiaris)
C4 activators [plasma membrane] (Canis familiaris)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Canis familiaris)
C4 activators [plasma membrane] (Canis familiaris)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Canis familiaris)
Classical antibody-mediated complement activation (Canis familiaris)
Activation of C1r (Canis familiaris)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Canis familiaris)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Canis familiaris)
C-reactive protein homopentamer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Canis familiaris)
Activation of MASPs (Canis familiaris)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Canis familiaris)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Canis familiaris)
Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Canis familiaris)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Regulation of Complement cascade (Canis familiaris)
Thrombin, ELANE cleave C5 (Canis familiaris)
Activated thrombin, (ELANE) [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
S100A1 binds TLR4:LY96 (Canis familiaris)
S100A1 dimer:Ca(2+) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Canis familiaris)
S100A1 dimer:Ca(2+) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Metabolism (Canis familiaris)
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)
Ca2+ [extracellular region]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 5-eicosatetraenoic acids (Canis familiaris)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)
PON3:2xCa2+ dimer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodelling of PC (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Synthesis of PA (Canis familiaris)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Phosphate bond hydrolysis by NTPDase proteins (Canis familiaris)
NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
Acetylcholine binding and downstream events (Canis familiaris)
Postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Canis familiaris)
Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
Ca2+ influx into the post-synaptic cell (Canis familiaris)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Canis familiaris)
Ionotropic activity of kainate receptors (Canis familiaris)
Activation of Ca-permeable Kainate Receptor (Canis familiaris)
Activation of Ca-permeable Kainate receptors (Canis familiaris)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
Activation of AMPA receptors (Canis familiaris)
Activation of Ca permeable AMPA receptors (Canis familiaris)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Canis familiaris)
Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)
Ca2+ [extracellular region]
Reproduction (Canis familiaris)
Fertilization (Canis familiaris)
Sperm Motility And Taxes (Canis familiaris)
CatSper Channel Mediated Calcium Transport (Canis familiaris)
Ca2+ [extracellular region]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Activation of the phototransduction cascade (Canis familiaris)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)
Ca2+ [extracellular region]
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
G alpha (q) signalling events (Canis familiaris)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Peptide ligand-binding receptors (Canis familiaris)
Proteinase-activated receptors can bind thrombin (Canis familiaris)
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
CASR binds Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases activate IQGAPs (Canis familiaris)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Canis familiaris)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Canis familiaris)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
Stimuli-sensing channels (Canis familiaris)
TRP channels (Canis familiaris)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Sodium/Calcium exchangers (Canis familiaris)
K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Extracellular matrix organization (Danio rerio)
Degradation of the extracellular matrix (Danio rerio)
E-cadherin degradation by ADAM10, ADAM15 (Danio rerio)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Danio rerio)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
ECM proteoglycans (Danio rerio)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Hemostasis (Danio rerio)
Formation of Fibrin Clot (Clotting Cascade) (Danio rerio)
Common Pathway of Fibrin Clot Formation (Danio rerio)
Activated protein C binds Protein S (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Va [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Danio rerio)
factor Xa:Factor Xa inhibitors [plasma membrane] (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Va [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)
factor Va [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Danio rerio)
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Danio rerio)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Danio rerio)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Danio rerio)
Factor IIa inhibitors (compounds) binds IIa (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Danio rerio)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Danio rerio)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of PTK2 at Y397 (Danio rerio)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)