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SUCCSA [mitochondrial matrix]
Stable Identifier
R-ALL-880046
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
succinate semialdehyde, succinic semialdehyde, 4-oxobutanoate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Bos taurus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
SUCCSA [mitochondrial matrix]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
GABA synthesis, release, reuptake and degradation (Bos taurus)
Degradation of GABA (Bos taurus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
SUCCSA [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
SUCCSA [mitochondrial matrix]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
GABA synthesis, release, reuptake and degradation (Caenorhabditis elegans)
Degradation of GABA (Caenorhabditis elegans)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
SUCCSA [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Canis familiaris)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
SUCCSA [mitochondrial matrix]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
GABA synthesis, release, reuptake and degradation (Canis familiaris)
Degradation of GABA (Canis familiaris)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
SUCCSA [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Danio rerio)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
SUCCSA [mitochondrial matrix]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter release cycle (Danio rerio)
GABA synthesis, release, reuptake and degradation (Danio rerio)
Degradation of GABA (Danio rerio)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
SUCCSA [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Dictyostelium discoideum)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
SUCCSA [mitochondrial matrix]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter release cycle (Dictyostelium discoideum)
GABA synthesis, release, reuptake and degradation (Dictyostelium discoideum)
Degradation of GABA (Dictyostelium discoideum)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
SUCCSA [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Drosophila melanogaster)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
SUCCSA [mitochondrial matrix]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
Degradation of GABA (Drosophila melanogaster)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
SUCCSA [mitochondrial matrix]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Gallus gallus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Gallus gallus)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Gallus gallus)
SUCCSA [mitochondrial matrix]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter release cycle (Gallus gallus)
GABA synthesis, release, reuptake and degradation (Gallus gallus)
Degradation of GABA (Gallus gallus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
SUCCSA [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Homo sapiens)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)
SUCCSA [mitochondrial matrix]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Degradation of GABA (Homo sapiens)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)
SUCCSA [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Mus musculus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
SUCCSA [mitochondrial matrix]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter release cycle (Mus musculus)
GABA synthesis, release, reuptake and degradation (Mus musculus)
Degradation of GABA (Mus musculus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
SUCCSA [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Rattus norvegicus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
SUCCSA [mitochondrial matrix]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter release cycle (Rattus norvegicus)
GABA synthesis, release, reuptake and degradation (Rattus norvegicus)
Degradation of GABA (Rattus norvegicus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
SUCCSA [mitochondrial matrix]
Neuronal System (Saccharomyces cerevisiae)
Transmission across Chemical Synapses (Saccharomyces cerevisiae)
Neurotransmitter release cycle (Saccharomyces cerevisiae)
GABA synthesis, release, reuptake and degradation (Saccharomyces cerevisiae)
Degradation of GABA (Saccharomyces cerevisiae)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
SUCCSA [mitochondrial matrix]
Neuronal System (Schizosaccharomyces pombe)
Transmission across Chemical Synapses (Schizosaccharomyces pombe)
Neurotransmitter release cycle (Schizosaccharomyces pombe)
GABA synthesis, release, reuptake and degradation (Schizosaccharomyces pombe)
Degradation of GABA (Schizosaccharomyces pombe)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
SUCCSA [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Sus scrofa)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
SUCCSA [mitochondrial matrix]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter release cycle (Sus scrofa)
GABA synthesis, release, reuptake and degradation (Sus scrofa)
Degradation of GABA (Sus scrofa)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
SUCCSA [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Xenopus tropicalis)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)
SUCCSA [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)
SUCCSA [mitochondrial matrix]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter release cycle (Xenopus tropicalis)
GABA synthesis, release, reuptake and degradation (Xenopus tropicalis)
Degradation of GABA (Xenopus tropicalis)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)
SUCCSA [mitochondrial matrix]
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
SUCCSA [mitochondrial matrix]
External Reference Information
External Reference
4-oxobutanoate [ChEBI:57706]
Participates
as an input of
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)
ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Gallus gallus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)
as an output of
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Gallus gallus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)
Cross References
Guide to Pharmacology - Ligands
6608
ZINC
000001532577
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