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lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Stable Identifier
R-ALL-9652360
Type
Set [DefinedSet]
Compartment
cytosol
Synonyms
TKIs (ERBB2)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
Drug-mediated inhibition of ERBB2 signaling (Bos taurus)
ERBB2 binds TKIs (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
ERBB2:TKIs [plasma membrane] (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
ERBB2:TKIs [plasma membrane] (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Drug-mediated inhibition of ERBB2 signaling (Caenorhabditis elegans)
ERBB2 binds TKIs (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:TKIs [plasma membrane] (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:TKIs [plasma membrane] (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Drug-mediated inhibition of ERBB2 signaling (Canis familiaris)
ERBB2 binds TKIs (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
ERBB2:TKIs [plasma membrane] (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
ERBB2:TKIs [plasma membrane] (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Drug-mediated inhibition of ERBB2 signaling (Danio rerio)
ERBB2 binds TKIs (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:TKIs [plasma membrane] (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:TKIs [plasma membrane] (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Drug-mediated inhibition of ERBB2 signaling (Drosophila melanogaster)
ERBB2 binds TKIs (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:TKIs [plasma membrane] (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:TKIs [plasma membrane] (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
Drug-mediated inhibition of ERBB2 signaling (Gallus gallus)
ERBB2 binds TKIs (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:TKIs [plasma membrane] (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:TKIs [plasma membrane] (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Drug-mediated inhibition of ERBB2 signaling (Mus musculus)
ERBB2 binds TKIs (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:TKIs [plasma membrane] (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:TKIs [plasma membrane] (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Drug-mediated inhibition of ERBB2 signaling (Rattus norvegicus)
ERBB2 binds TKIs (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:TKIs [plasma membrane] (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:TKIs [plasma membrane] (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ERBB2 (Sus scrofa)
Drug-mediated inhibition of ERBB2 signaling (Sus scrofa)
ERBB2 binds TKIs (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Sus scrofa)
ERBB2:TKIs [plasma membrane] (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Sus scrofa)
ERBB2:TKIs [plasma membrane] (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Participants
members
AEE788 [cytosol]
AZ5104 [cytosol]
Afatinib [cytosol]
CP-724714 [cytosol]
Canertinib [cytosol]
Lapatinib [cytosol]
neratinib [cytosol]
Sapitinib [cytosol]
Tesevatinib [cytosol]
Participates
as an input of
ERBB2 binds TKIs (Caenorhabditis elegans)
ERBB2 binds TKIs (Drosophila melanogaster)
ERBB2 binds TKIs (Gallus gallus)
ERBB2 binds TKIs (Danio rerio)
ERBB2 binds TKIs (Sus scrofa)
ERBB2 binds TKIs (Bos taurus)
ERBB2 binds TKIs (Canis familiaris)
ERBB2 binds TKIs (Rattus norvegicus)
ERBB2 binds TKIs (Mus musculus)
ERBB2 binds TKIs (Homo sapiens)
as a component of
ERBB2:TKIs [plasma membrane] (Sus scrofa)
ERBB2:TKIs [plasma membrane] (Gallus gallus)
ERBB2:TKIs [plasma membrane] (Rattus norvegicus)
ERBB2:TKIs [plasma membrane] (Mus musculus)
ERBB2:TKIs [plasma membrane] (Caenorhabditis elegans)
ERBB2:TKIs [plasma membrane] (Bos taurus)
ERBB2:TKIs [plasma membrane] (Drosophila melanogaster)
ERBB2:TKIs [plasma membrane] (Danio rerio)
ERBB2:TKIs [plasma membrane] (Canis familiaris)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
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