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ST (hepatocyte) [endoplasmic reticulum lumen]
Stable Identifier
R-ALL-9749790
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum lumen
Synonyms
salicylate (hepatocyte)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
CES1,CES2 hydrolyze ASA- to ST (Bos taurus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Caenorhabditis elegans)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Caenorhabditis elegans)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Danio rerio)
Aspirin ADME (Danio rerio)
CES1,CES2 hydrolyze ASA- to ST (Danio rerio)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Dictyostelium discoideum)
Aspirin ADME (Dictyostelium discoideum)
CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGT1A6 glucuronates ST (Dictyostelium discoideum)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Dictyostelium discoideum)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glucuronidation (Dictyostelium discoideum)
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Dictyostelium discoideum)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Drosophila melanogaster)
Aspirin ADME (Drosophila melanogaster)
CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Drosophila melanogaster)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Drosophila melanogaster)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Gallus gallus)
Aspirin ADME (Gallus gallus)
CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGT1A6 glucuronates ST (Gallus gallus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Glucuronidation (Gallus gallus)
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)
ASA-, ST (hepatocyte) [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
ST (hepatocyte) [endoplasmic reticulum lumen]
Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGT1A6 glucuronates ST (Homo sapiens)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glucuronidation (Homo sapiens)
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Mus musculus)
Aspirin ADME (Mus musculus)
CES1,CES2 hydrolyze ASA- to ST (Mus musculus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGT1A6 glucuronates ST (Mus musculus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Glucuronidation (Mus musculus)
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGT1A6 glucuronates ST (Rattus norvegicus)
ST (hepatocyte) [endoplasmic reticulum lumen]
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Glucuronidation (Rattus norvegicus)
UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)
O-centre functional group substrate [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Sus scrofa)
Aspirin ADME (Sus scrofa)
CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)
ST (hepatocyte) [endoplasmic reticulum lumen]
Drug ADME (Xenopus tropicalis)
Aspirin ADME (Xenopus tropicalis)
CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)
ST (hepatocyte) [endoplasmic reticulum lumen]
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)
ST (hepatocyte) [endoplasmic reticulum lumen]
External Reference Information
External Reference
salicylate [ChEBI:30762]
Participates
as an input of
UGT1A6 glucuronates ST (Dictyostelium discoideum)
UGT1A6 glucuronates ST (Gallus gallus)
UGT1A6 glucuronates ST (Rattus norvegicus)
UGT1A6 glucuronates ST (Mus musculus)
UGT1A6 glucuronates ST (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Caenorhabditis elegans)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Drosophila melanogaster)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Caenorhabditis elegans)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Drosophila melanogaster)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)
as an output of
CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)
CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)
CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)
CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)
CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)
CES1,CES2 hydrolyze ASA- to ST (Danio rerio)
CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)
CES1,CES2 hydrolyze ASA- to ST (Bos taurus)
CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)
CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)
CES1,CES2 hydrolyze ASA- to ST (Mus musculus)
CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)
as a member of
O-centre functional group substrate [endoplasmic reticulum lumen]
ASA-, ST (hepatocyte) [endoplasmic reticulum lumen]
Other forms of this molecule
ST [mitochondrial matrix]
ST (GI cell) [endoplasmic reticulum lumen]
ST (hepatocyte) [cytosol]
ST (GI cell) [cytosol]
ST [extracellular region]
ST [cytosol]
Cross References
HMDB Metabolite
HMDB0302214
ZINC
000000001554
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