Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
cya [extracellular region]
Stable Identifier
R-BAN-5205734
Type
Protein [EntityWithAccessionedSequence]
Species
Bacillus anthracis
Compartment
extracellular region
Synonyms
EF, EF(34-800), Edema factor, Calmodulin-sensitive adenylate cyclase, cya(34-800)
Icon
Locations in the PathwayBrowser for interactor UniProt:P62158 CALM
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)
cya [extracellular region] (Bacillus anthracis)
cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)
cya [extracellular region] (Bacillus anthracis)
Literature References
PubMed ID
Title
Journal
Year
3149607
Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
Robertson, DL
,
Leppla, SH
,
Tippetts, MT
Gene
1988
External Reference Information
External Reference
UniProt:P40136 cya
Gene Names
cya, pXO1-122, BXA0141, GBAA_pXO1_0142
Chain
signal peptide:1-33, chain:34-800
Reference Genes
BioGPS Gene:45025501 cya
KEGG Gene (Bacillus anthracis Ames Ancestor):GBAA_pXO1_0142 cya
Monarch:45025501 cya
NCBI Gene:45025501 cya
Reference Transcript
RefSeq:NC_001496.1 cya
RefSeq:NZ_VTZH01000015.1 cya
Participates
as an input of
cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)
cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)
Other forms of this molecule
cya [cytosol]
EF [endosome membrane]
cya [plasma membrane]
Disease
Name
Identifier
Synonyms
anthrax disease
DOID:7427
Cross References
RefSeq
WP_000197748.1
,
NP_052818.1
ZINC - Substances
CYAA_BACAN
ZINC target
P40136
PRO
P40136
ZINC - Predictions - Purchasable
CYAA_BACAN
PDB
6UZE
,
1K93
,
1K8T
,
6VRA
,
1SK6
,
1K90
,
1LVC
,
1S26
,
1PK0
,
1XFZ
,
1XFY
,
1XFX
,
1XFW
,
6UZB
,
1XFV
,
1XFU
,
1Y0V
,
6UZD
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62158 CALM
0.871
10
UniProt:P62155 CALM
0.623
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text