Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-T185,Y187-MAPK1 [cytosol]
Stable Identifier
R-BTA-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
P46196
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Golgi Cisternae Pericentriolar Stack Reorganization (Bos taurus)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)
p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
Constitutive phosphorylation by pERK1/2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
MAPK-dependent phosphorylation of KARS (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAPK1 phosphorylates SOX10 (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAPK1-dependent phosphorylation of MITF-M (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
L1CAM interactions (Bos taurus)
Recycling pathway of L1 (Bos taurus)
Phosphorylation of L1 by ERK (Bos taurus)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signal transduction by L1 (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by NODAL (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Growth hormone receptor signaling (Bos taurus)
Lyn activates ERK (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
IFNG signaling activates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Formation of apoptosome (Bos taurus)
Regulation of the apoptosome activity (Bos taurus)
CASP9 is phosphorylated at T412 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAPKs phosphorylate PP2A (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
PEA15 binds MAPK monomers and dimers (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPKs phosphorylate BRAF (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
PTPN7 binds p-T,Y-MAPK (Bos taurus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
PEA15 binds MAPK monomers and dimers (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Bos taurus)
p-T,Y MAPK monomers and dimers [cytosol] (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
phospho-PLA2 pathway (Bos taurus)
Phosphorylation of cPLA2 by ERK-2 (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
Estrogen-stimulated signaling through PRKCZ (Bos taurus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPK dimers translocate to nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs dimerize (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
p-T,Y MAPKs [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by Activin (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-T,Y MAPK dimers [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P46196
Reference Genes
BioGPS Gene:327672
ENSEMBL:ENSBTAG00000010312
KEGG Gene (Bos taurus):327672
Monarch:327672
NCBI Gene:327672
Reference Transcript
RefSeq:NM_175793.2
Other Identifiers
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006468
GO:0006915
GO:0007010
GO:0007049
GO:0007166
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0023052
GO:0031410
GO:0031647
GO:0032872
GO:0035556
GO:0036211
GO:0043226
GO:0051493
GO:0070161
GO:0070849
GO:0072584
GO:0072686
GO:0090170
GO:0106310
GO:0140096
GO:2000641
Participates
as an input of
Phosphorylation of L1 by ERK (Bos taurus)
as a component of
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Bos taurus)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Bos taurus)
p-T185,Y187 MAPK1 dimer [cytosol] (Bos taurus)
as an output of
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)
as a member of
p-T,Y MAPKs [cytosol] (Bos taurus)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
phospho-p-T185-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_786987.1
Ensembl
ENSBTAP00000013623
,
ENSBTAG00000010312
,
ENSBTAT00000013623
VGNC
31212
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text