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VCP [cytosol]
Stable Identifier
R-BTA-1181251
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
VCP, G3X757
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Cellular response to heat stress (Bos taurus)
HSF1 activation (Bos taurus)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)
HDAC6:VCP:protein aggregates [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Bos taurus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
Deglycosylation complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
YOD1 binds VCP (Bos taurus)
VCP [cytosol] (Bos taurus)
YOD1:VCP [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Neddylation (Bos taurus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog ligand biogenesis (Bos taurus)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RHOH GTPase cycle (Bos taurus)
RHOH binds effectors at the plasma membrane (Bos taurus)
RHOH effectors [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
RHOH:GTP:RHOH effectors [plasma membrane] (Bos taurus)
RHOH effectors [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
VCP [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:G3X757
Gene Names
VCP
Reference Genes
ENSEMBL:ENSBTAG00000015000.4
UCSC:G3X757 VCP
Other Identifiers
507345
GO:0000502
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0006281
GO:0006302
GO:0006511
GO:0006734
GO:0006886
GO:0006914
GO:0006974
GO:0008289
GO:0010494
GO:0010498
GO:0010918
GO:0016192
GO:0016236
GO:0016567
GO:0016787
GO:0016887
GO:0019079
GO:0019903
GO:0019904
GO:0019985
GO:0030163
GO:0030970
GO:0031334
GO:0031593
GO:0031625
GO:0032436
GO:0032510
GO:0032991
GO:0034098
GO:0034605
GO:0035331
GO:0035617
GO:0035800
GO:0035861
GO:0036435
GO:0036503
GO:0036513
GO:0042288
GO:0042802
GO:0043161
GO:0043226
GO:0043531
GO:0044389
GO:0045202
GO:0045732
GO:0045879
GO:0046034
GO:0048471
GO:0055086
GO:0060090
GO:0061857
GO:0070842
GO:0071218
GO:0072389
GO:0090263
GO:0097352
GO:0098772
GO:0106300
GO:0120186
GO:0140036
GO:0140455
GO:1901135
GO:1901224
GO:1903006
GO:1903715
GO:1903843
GO:1903862
GO:1904288
GO:1904949
GO:1905634
GO:1990381
GO:1990730
GO:2001171
Participates
as a candidate of
RHOH effectors [cytosol] (Bos taurus)
as an input of
YOD1 binds VCP (Bos taurus)
as a component of
YOD1:VCP [cytosol] (Bos taurus)
HDAC6:VCP:protein aggregates [cytosol] (Bos taurus)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Bos taurus)
VCP hexamer [cytosol] (Bos taurus)
Other forms of this molecule
VCP [cytosol]
VCP [nucleoplasm]
VCP [azurophil granule lumen]
VCP [secretory granule lumen]
VCP [extracellular region]
VCP [ficolin-1-rich granule lumen]
Inferred From
VCP [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAT00000019970
,
ENSBTAP00000019970
,
ENSBTAG00000015000
VGNC
36780
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