Reactome | phospho-SHC1 [cytosol]

phospho-SHC1 [cytosol]

Stable Identifier

R-BTA-162568

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

p-Y-SHC1, Q0IIE2

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by CSF3 (G-CSF) (Bos taurus)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-2 family signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits SHIP (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
      - Interleukin-15 signaling (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Bos taurus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
      - Interleukin-2 signaling (Bos taurus)
        
        SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Phosphorylated SHC1 recruits SHIP (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - RAS GEFs promote RAS nucleotide exchange (Bos taurus)
        
        RAS GEFs [plasma membrane] (Bos taurus)
        
        GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
        
        p-Y-SHC [cytosol] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
- Signaling by Erythropoietin (Bos taurus)
  - Erythropoietin activates RAS (Bos taurus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Bos taurus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by NTRKs (Bos taurus)
    - Signaling by NTRK1 (TRKA) (Bos taurus)
      - Signalling to ERKs (Bos taurus)
        
        Signalling to RAS (Bos taurus)
        
        GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)
        
        GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
        
        p-Y-SHC [cytosol] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)
        
        p-Y-SHC [cytosol] (Bos taurus)
        
        phospho-SHC1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q0IIE2

Gene Names

SHC1

Reference Genes

BioGPS Gene:507196 SHC1

ENSEMBL:ENSBTAG00000019838

KEGG Gene (Bos taurus):507196 SHC1

Monarch:507196 SHC1

NCBI Gene:507196 SHC1

Reference Transcript

Other Identifiers

507196

GO:0001525

GO:0005515

GO:0005737

GO:0005886

GO:0005925

GO:0007173

GO:0008286

GO:0023052

GO:0030971

GO:0035556

GO:0035924

GO:0048856

GO:0070161

GO:0071363

Participates

as a component of

as a member of

p-Y-SHC [cytosol] (Bos taurus)

Other forms of this molecule

SHC1 [plasma membrane]

phospho-SHC1 [cytosol]

SHC1 [cytosol]

phospho-SHC1 [cytosol]

phospho-SHC1 [plasma membrane]

phospho-SHC1 [cytosol]

SHC1 [cytosol]

Inferred From

p-Y-SHC1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001068773.1, NP_001157533.1

OpenTargets

ENSG00000160691

Ensembl

ENSBTAP00000040041, ENSBTAT00000040264, ENSBTAT00000075224, ENSBTAG00000019838, ENSBTAP00000062285

VGNC

34590

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