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What is Reactome ?
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phospho-p-Y542,Y580-PTPN11 [cytosol]
Stable Identifier
R-BTA-162573
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
F1N339
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by CSF3 (G-CSF) (Bos taurus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
PTPN11 is phosphorylated (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
MAP2K2 binds MAPK1 (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
MAPK3 (ERK1) activation (Bos taurus)
MAP2K1 binds MAPK3 (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2 phosphorylates PPTN11 (Bos taurus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3 phosphorylates PPTN11 (Bos taurus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Indirect recruitment of GAB2 to p-KIT (Bos taurus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Phosphorylation of GAB2 by SFKs (Bos taurus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Phosphorylation of SHP2 by SFKs (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N339
Reference Genes
BioGPS Gene:533590
ENSEMBL:ENSBTAG00000002048.5
ENSEMBL:ENSBTAG00000002048.6
KEGG Gene (Bos taurus):533590
Monarch:533590
NCBI Gene:533590
Reference Transcript
RefSeq:XM_015467160.1
RefSeq:XM_002694590.5
Other Identifiers
533590
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005515
GO:0005737
GO:0016311
GO:0016787
GO:0023052
GO:0030971
GO:0050839
GO:0070374
GO:0071310
GO:0140096
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Other forms of this molecule
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
Inferred From
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 542 (in Homo sapiens)
Coordinate
542
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 580 (in Homo sapiens)
Coordinate
580
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_002694636.2
,
XP_015322646.1
Ensembl
ENSBTAP00000002653
,
ENSBTAT00000002653
,
ENSBTAG00000002048
VGNC
33530
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