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PAK1 [cytosol]
Stable Identifier
R-BTA-162629
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q08E52
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
PAK1 binds RAC1:GTP (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Ephrin signaling (Bos taurus)
PAK binds RAC and bPIX (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
PAK1/3, 2 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1/3, 2 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAKs autophosphorylate (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
PAK1/3, 2 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1/3, 2 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
L1CAM interactions (Bos taurus)
Signal transduction by L1 (Bos taurus)
Interaction of PAK1 with Rac1-GTP (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Semaphorin interactions (Bos taurus)
Sema3A PAK dependent Axon repulsion (Bos taurus)
Activation of PAK by Rac1 (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent Vav1 pathway (Bos taurus)
Activation of PAKs by RAC1 and CDC42 (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Generation of second messenger molecules (Bos taurus)
NCK binds PAK (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
p-SLP-76:NCK:PAK [cytosol] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
PAK dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
PAK dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
PAK dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
PAK dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Autophosphorylation of PAK1 (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1 and CDC42 activate PAK1 (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
Activation of PAKs by RAC1 and CDC42 (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Autophosphorylation of PAK1,2,3 (Bos taurus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through CDC42 (Bos taurus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 binds ARHGEF6 (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
PAK1-3 autophosphorylates (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1-3 dimer disassociates (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1 binds PAK1-3 (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1,2,3 dimer [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate PAKs (Bos taurus)
Autophosphorylation of PAK1,2,3 (Bos taurus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
NF2 binds PAK1 (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1:NF2 [plasma membrane] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1 and CDC42 activate PAK1 (Bos taurus)
PAK1 [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 binds effectors at the plasma membrane (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC3 GTPase cycle (Bos taurus)
RAC3 binds effectors at the plasma membrane (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RAC3:GTP:RAC3 effectors [plasma membrane] (Bos taurus)
RAC3 effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOH GTPase cycle (Bos taurus)
RHOH binds effectors at the plasma membrane (Bos taurus)
RHOH effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOH:GTP:RHOH effectors [plasma membrane] (Bos taurus)
RHOH effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOQ GTPase cycle (Bos taurus)
RHOQ binds effectors at the plasma membrane (Bos taurus)
RHOQ effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Bos taurus)
RHOQ effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOU GTPase cycle (Bos taurus)
RHOU binds effectors at the plasma membrane (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOU:GTP:RHOU effectors [plasma membrane] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOV GTPase cycle (Bos taurus)
RHOV binds effectors at the plasma membrane (Bos taurus)
RHOV effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
RHOV:GTP:RHOV effectors [plasma membrane] (Bos taurus)
RHOV effectors [cytosol] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
PAK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q08E52
Reference Genes
BioGPS Gene:533729
ENSEMBL:ENSBTAG00000010191
KEGG:bta:533729
Monarch:533729
NCBI Gene:533729
UCSC:Q08E52
Reference Transcript
RefSeq:XM_015461133.1
RefSeq:XM_010820836.2
RefSeq:XM_010820837.1
RefSeq:XM_010820835.1
RefSeq:NM_001076898.1
Other Identifiers
533729
GO:0001726
GO:0003824
GO:0004672
GO:0004674
GO:0005518
GO:0005654
GO:0005737
GO:0005829
GO:0005884
GO:0005886
GO:0005911
GO:0006325
GO:0006338
GO:0006974
GO:0007010
GO:0008092
GO:0008284
GO:0016477
GO:0016740
GO:0030036
GO:0030335
GO:0031116
GO:0031267
GO:0032991
GO:0033138
GO:0033148
GO:0042060
GO:0043015
GO:0048012
GO:0048754
GO:0048870
GO:0051496
GO:0060244
GO:0090063
GO:0140096
GO:1903608
Participates
as a member of
PAK1/3, 2 [cytosol] (Bos taurus)
PAK1,2,3 [cytosol] (Bos taurus)
as an output of
Interaction of PAK1 with Rac1-GTP (Bos taurus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)
RAC1 and CDC42 activate PAK1 (Bos taurus)
as an input of
PAK1 binds ARHGEF6 (Bos taurus)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Bos taurus)
PAK1 dimer [cytosol] (Bos taurus)
Other forms of this molecule
PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [cytosol]
Inferred From
Active PAK1 [cytosol]
(Homo sapiens)
PAK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_010819139.1
,
XP_010819138.1
,
XP_010819137.1
,
NP_001070366.1
,
XP_015316619.1
ENSEMBL
ENSBTAP00000013448
,
ENSBTAT00000013448
IntEnz
2.7.11.1
VGNC
53657
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