Reactome | BRK1 [cytosol]

BRK1 [cytosol]

Stable Identifier

R-BTA-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

BRK1, A8YXX8

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
        
        p-Y,S,T-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
        
        p-Y,S,T-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
      - ABL phosphorylates WAVEs (Bos taurus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        WAVE Regulatory Complex [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
      - Detachment of WASP/WAVE (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
        
        p-Y,S,T-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
        
        p-Y,S,T-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
        
        WAVE Regulatory Complex [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        WAVE Regulatory Complex [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
      - p-ERK phosphorylates WAVEs and ABI (Bos taurus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
        
        p-Y,S,T-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
        
        p-Y-WRC [cytosol] (Bos taurus)
        
        BRK1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A8YXX8

Gene Names

BRK1

Reference Genes

BioGPS Gene:540092 BRK1

ENSEMBL:ENSBTAG00000016098.5

KEGG Gene (Bos taurus):540092 BRK1

Monarch:540092 BRK1

NCBI Gene:540092 BRK1

Reference Transcript

RefSeq:NM_001114510.2 BRK1

Other Identifiers

515845

GO:0005737

GO:0005856

GO:0006281

GO:0007010

GO:0007015

GO:0008064

GO:0031209

GO:0043226

GO:0044877

GO:0048870

Participates

as a candidate of

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001107982.1

OpenTargets

ENSG00000254999

Ensembl

ENSBTAP00000021429, ENSBTAT00000021429, ENSBTAG00000010077

VGNC

26570

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