Reactome | CD4 [plasma membrane]

CD4 [plasma membrane]

Stable Identifier

R-BTA-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

CD4, F1MJK4

Locations in the PathwayBrowser

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Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - AP-2 directly binds some endocytic cargo (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)
        
        CD4 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MJK4

Gene Names

CD4

Reference Genes

ENSEMBL:ENSBTAG00000003255.6

Other Identifiers

407098

GO:0002250

GO:0002376

GO:0005886

GO:0006955

GO:0007155

GO:0009897

GO:0009986

GO:0015026

GO:0016020

GO:0023052

GO:0035723

GO:0042110

GO:0042289

GO:0045121

GO:0060089

GO:0070374

GO:1990782

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Bos taurus)

as a component of

Other forms of this molecule

CD4 [clathrin-coated endocytic vesicle membrane]

Inferred From

CD4 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000010610

Ensembl

ENSBTAP00000037566, ENSBTAT00000037742, ENSBTAG00000003255

VGNC

27032

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