Reactome | MAP2K4 [cytosol]

MAP2K4 [cytosol]

Stable Identifier

R-BTA-168107

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

MAP2K4, A5PJP8

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-17 signaling (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Phosphorylation of MEK4 by MEKK1 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - MyD88-independent TLR4 cascade (Bos taurus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)
    - Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
        
        MAP2K4 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A5PJP8

Gene Names

MAP2K4

Reference Genes

BioGPS Gene:526469 MAP2K4

ENSEMBL:ENSBTAG00000012103.5

KEGG:bta:526469 MAP2K4

Monarch:526469 MAP2K4

NCBI Gene:526469 MAP2K4

UCSC:A5PJP8 MAP2K4

Reference Transcript

RefSeq:NM_001099038.1 MAP2K4

Participates

as an input of

Other forms of this molecule

phospho-MAP2K4 [cytosol]

Inferred From

MAP2K7,MAP2K4 [cytosol] (Homo sapiens)

MAP2K4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001092508.1

VGNC

31185